4??-carboxy-5??-cholesta-8,24-dien-3??-ol



Compound IDCDAMM01875
Common name4??-carboxy-5??-cholesta-8,24-dien-3??-ol
IUPAC name3-hydroxy-10,13-dimethyl-17-(6-methylhept-5-en-2-yl)-2,3,4,5,6,7,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-4-carboxylic acid
Molecular formulaC28H44O3

Experimental data

Retention time11.63
Adduct[M+H]+
Actual mz429.332
Theoretical mz429.336
Error9.49
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.0273

Identifiers and class information

Inchi keyJHIWIFRQJXLNEU-CEDIQTLQSA-N
SmilesO=C(O)C1C(O)CCC2(C3=C(CCC12)C4CCC(C(C)CCC=C(C)C)C4(C)CC3)C
SuperclassLipids and lipid-like molecules
ClassSteroids and steroid derivatives

Plant source

  • Curcuma longa L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)3
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)1
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)6
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)428.654
    Computed dipole moment(dipole)7.205
    Total solvent accessible surface area (SASA)757.779
    Hydrophobic component of SASA (FOSA)618.506
    Hydrophilic component of SASA (FISA)126.313
    Pie component of the SASA (PISA)12.96
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1455.67
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)2.7
    Free energy of solvation of dipole (dip^2/V)0.0356618
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.003563
    Globularity descriptor (glob)0.819719
    Predicted polarizability in cubic angstroms (QPpolrz)48.373
    Predicted hexadecane/gas partition coefficient (QPlogPC16)12.902
    Predicted octanol/gas partition coefficient (QPlogPoct)19.151
    Predicted water/gas partition coefficient (QPlogPw)5.291
    Predicted octanol/water partition coefficient (QPlogPo/w)6.992
    Predicted aqueous solubility (QPlogS)-8.141
    Conformation-independent predicted aqueous solubility (CIQPlogS)-6.919
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-2.703
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)159.103
    Predicted brain/blood partition coefficient (QPlogBB)-1.051
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)86.277
    Predicted skin permeability, log Kp (QPlogKp)-3.226
    PM3 calculated ionization potential (IP(ev))9.217
    PM3 calculated electron affinity (EA(eV))-0.859
    Number of likely metabolic reactions (#metab)8
    Prediction of binding to human serum albumin (QPlogKhsa)1.675
    Predicted qualitative human oral absorption (HumanOralAbsorption)1
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)94.332
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)67.029
    Number of nitrogen and oxygen atoms (#NandO)3
    Number of violations of Lipinski’s rule of five (RuleOfFive)1
    Number of violations of Jorgensen’s rule of three (RuleOfThree)2

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P22303ACHEAcetylcholinesteraseT30082SwissTargetPrediction
    P35228NOS2Nitric oxide synthase, inducibleT02703SwissTargetPrediction
    Q99720SIGMAR1Sigma opioid receptorT46360SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P04054PLA2G1BPhospholipase A2 group 1BT31479SwissTargetPrediction
    Q96RI1NR1H4Bile acid receptor FXRT51426SwissTargetPrediction and SEA
    P31213SRD5A2Steroid 5-alpha-reductase 2T71390SwissTargetPrediction and SEA
    P21554CNR1Cannabinoid receptor 1 (by homology)T76685SwissTargetPrediction
    P31645SLC6A4Serotonin transporter (by homology)T27812SwissTargetPrediction
    Q01959SLC6A3Dopamine transporterT55959SwissTargetPrediction
    Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
    P35354PTGS2Cyclooxygenase-2T66665SwissTargetPrediction
    P10275ARAndrogen ReceptorT11211SwissTargetPrediction
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction
    O00519FAAHAnandamide amidohydrolaseT11754SwissTargetPrediction
    P08235NR3C2Mineralocorticoid receptorT72168SwissTargetPrediction
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P06401PGRProgesterone receptorT22939SwissTargetPrediction
    P08185SERPINA6Corticosteroid binding globulinT88452SwissTargetPrediction
    O75469NR1I2Pregnane X receptorT82702SwissTargetPrediction
    P07148FABP1Fatty acid-binding protein, liver (by homology)T73712SwissTargetPrediction
    P18405SRD5A1Steroid 5-alpha-reductase 1T70309SwissTargetPrediction and SEA
    P11511CYP19A1Cytochrome P450 19A1T13260SwissTargetPrediction
    P07339CTSDCathepsin DT67102SwissTargetPrediction
    Q9UHC9NPC1L1Niemann-Pick C1-like protein 1T33901SwissTargetPrediction and SEA
    O14684PTGESProstaglandin E synthaseT02562SwissTargetPrediction
    P29350PTPN6Protein-tyrosine phosphatase 1CT98264SwissTargetPrediction
    P18031PTPN1Protein-tyrosine phosphatase 1BT16347SwissTargetPrediction
    P17706PTPN2T-cell protein-tyrosine phosphataseT49156SwissTargetPrediction
    P15090FABP4Fatty acid binding protein adipocyteT07217SwissTargetPrediction
    Q07869PPARAPeroxisome proliferator-activated receptor alphaT86591SwissTargetPrediction
    Q01469FABP5Fatty acid binding protein epidermalT21507SwissTargetPrediction
    Q03181PPARDPeroxisome proliferator-activated receptor deltaT36557SwissTargetPrediction
    O14842FFAR1Free fatty acid receptor 1T25608SwissTargetPrediction
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SwissTargetPrediction and SEA
    P28845HSD11B111-beta-hydroxysteroid dehydrogenase 1T65200SwissTargetPrediction
    P11473VDRVitamin D receptorT34234SEA
    Q8TDU6GPBAR1G-protein coupled bile acid receptor 1T86273SEA
    P06746POLBDNA polymerase beta (by homology)T06958SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    P03372ESR1Estrogen receptor alphaT02506SwissTargetPrediction
    Q13133NR1H3LXR-alphaT52297SwissTargetPrediction
    P09917ALOX5Arachidonate 5-lipoxygenaseT00140SwissTargetPrediction
    P23975SLC6A2Norepinephrine transporterT21945SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    P56817BACE1Beta-secretase 1T79031SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P09237MMP7Matrix metalloproteinase 7T73475SwissTargetPrediction
    P18054ALOX12Arachidonate 12-lipoxygenaseT35527SwissTargetPrediction
    P37288AVPR1AVasopressin V1a receptor (by homology)T79232SwissTargetPrediction
    P30518AVPR2Vasopressin V2 receptor (by homology)T66237SwissTargetPrediction
    P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SwissTargetPrediction
    O14746TERTTelomerase reverse transcriptaseT86052SwissTargetPrediction
    O00767SCDAcyl-CoA desaturaseT10897SwissTargetPrediction
    P48147PREPProlyl endopeptidaseT86161SwissTargetPrediction
    P51449RORCNuclear receptor ROR-gammaT25307SwissTargetPrediction
    Q08499PDE4DPhosphodiesterase 4DT02001SwissTargetPrediction
    P43116PTGER2Prostanoid EP2 receptorT38529SwissTargetPrediction
    Q9Y5Y4PTGDR2G protein-coupled receptor 44T61722SwissTargetPrediction
    P49356FNTBFarnesyl protein transferaseT13127SwissTargetPrediction
    P24723PRKCHProtein kinase C etaT40149SwissTargetPrediction
    P80365HSD11B211-beta-hydroxysteroid dehydrogenase 2T43721SwissTargetPrediction
    Q06124PTPN11Protein-tyrosine phosphatase 2CT13057SwissTargetPrediction
    P04035HMGCRHMG-CoA reductaseT53585SwissTargetPrediction
    P11413G6PDGlucose-6-phosphate 1-dehydrogenaseT63484SwissTargetPrediction
    Q16850CYP51A1Cytochrome P450 51 (by homology)T32972SwissTargetPrediction
    Q15722LTB4RLeukotriene B4 receptor 1T59626SwissTargetPrediction
    P05093CYP17A1Cytochrome P450 17A1T89041SwissTargetPrediction
    P11137MAP2Microtubule-associated protein 2T23276SwissTargetPrediction
    P11387TOP1DNA topoisomerase IT09826SwissTargetPrediction
    P11388TOP2ADNA topoisomerase II alphaT17048SwissTargetPrediction
    P35408PTGER4Prostanoid EP4 receptorT18876SwissTargetPrediction
    P43115PTGER3Prostanoid EP3 receptorT85467SwissTargetPrediction
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SwissTargetPrediction and SEA
    P34995PTGER1Prostanoid EP1 receptorT15497SwissTargetPrediction
    Q13258PTGDRProstanoid DP receptorT68782SwissTargetPrediction
    P35398RORANuclear receptor ROR-alphaT43206SwissTargetPrediction and SEA
    P43119PTGIRProstanoid IP receptorT99954SwissTargetPrediction
    Q07973CYP24A1Cytochrome P450 24A1T92458SEA
    Q14973SLC10A1Bile acid transporterT99189SEA
    O00141SGK1Serine/threonine-protein kinase Sgk1T64682SwissTargetPrediction
    Q12772SREBF2Sterol regulatory element-binding protein 2T03385SwissTargetPrediction
    P21757MSR1Macrophage scavenger receptor types I and IIT50007SEA
    P01730CD4T-cell surface glycoprotein CD4T10191SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T02703DI0083Chronic kidney disease[ICD-11: GB61]P35228NOS2
    T02703DI0320Osteoarthritis[ICD-11: FA00-FA05]P35228NOS2
    T02703DI0375Sepsis[ICD-11: 1G40-1G41]P35228NOS2
    T02703DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35228NOS2
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T31479DI0230Leishmaniasis[ICD-11: 1F54]P04054PLA2G1B
    T31479DI0335Peroxisomal disease[ICD-11: 5C57]P04054PLA2G1B
    T31479DI0367Rosacea[ICD-11: ED90]P04054PLA2G1B
    T31479DI0398Synthesis disorder[ICD-11: 5C52-5C59]P04054PLA2G1B
    T51426DI0043Autoimmune liver disease[ICD-11: DB96]Q96RI1NR1H4
    T51426DI0077Cholelithiasis[ICD-11: DC11]Q96RI1NR1H4
    T51426DI0320Osteoarthritis[ICD-11: FA00-FA05]Q96RI1NR1H4
    T71390DI0348Prostate hyperplasia[ICD-11: GA90]P31213SRD5A2
    T76685DI0031Anorexia nervosa[ICD-11: 6B80]P21554CNR1
    T76685DI0214Insomnia[ICD-11: 7A00-7A0Z]P21554CNR1
    T76685DI0308Obesity[ICD-11: 5B80-5B81]P21554CNR1
    T27812DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P31645SLC6A4
    T27812DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P31645SLC6A4
    T27812DI0087Chronic pain[ICD-11: MG30]P31645SLC6A4
    T27812DI0096concerning food/fluid intake symptom[ICD-11: MG43]P31645SLC6A4
    T27812DI0101Corneal disease[ICD-11: 9A76-9A78]P31645SLC6A4
    T27812DI0105Cough[ICD-11: MD12]P31645SLC6A4
    T27812DI0117Depression[ICD-11: 6A70-6A7Z]P31645SLC6A4
    T27812DI0264Migraine[ICD-11: 8A80]P31645SLC6A4
    T27812DI0301Nicotine use disorder[ICD-11: 6C4A]P31645SLC6A4
    T27812DI0308Obesity[ICD-11: 5B80-5B81]P31645SLC6A4
    T27812DI0324Pain[ICD-11: MG30-MG3Z]P31645SLC6A4
    T55959DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q01959SLC6A3
    T55959DI0051Bipolar disorder[ICD-11: 6A60]Q01959SLC6A3
    T55959DI0101Corneal disease[ICD-11: 9A76-9A78]Q01959SLC6A3
    T55959DI0290Narcolepsy[ICD-11: 7A20]Q01959SLC6A3
    T55959DI0308Obesity[ICD-11: 5B80-5B81]Q01959SLC6A3
    T55959DI0331Parkinsonism[ICD-11: 8A00]Q01959SLC6A3
    T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
    T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
    T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
    T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
    T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
    T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
    T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
    T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
    T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
    T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
    T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
    T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
    T66665DI0087Chronic pain[ICD-11: MG30]P35354PTGS2
    T66665DI0145Female pelvic pain[ICD-11: GA34]P35354PTGS2
    T66665DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P35354PTGS2
    T66665DI0207Indeterminate colitis[ICD-11: DD72]P35354PTGS2
    T66665DI0227Knee osteoarthritis[ICD-11: FA01]P35354PTGS2
    T66665DI0320Osteoarthritis[ICD-11: FA00-FA05]P35354PTGS2
    T66665DI0324Pain[ICD-11: MG30-MG3Z]P35354PTGS2
    T66665DI0366Rheumatoid arthritis[ICD-11: FA20]P35354PTGS2
    T66665DI0416Tuberculosis[ICD-11: 1B10-1B12]P35354PTGS2
    T11211DI0005Acne vulgaris[ICD-11: ED80]P10275AR
    T11211DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10275AR
    T11211DI0021Alcoholic liver disease[ICD-11: DB94]P10275AR
    T11211DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10275AR
    T11211DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P10275AR
    T11211DI0145Female pelvic pain[ICD-11: GA34]P10275AR
    T11211DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P10275AR
    T11211DI0237Low bone mass disorder[ICD-11: FB83]P10275AR
    T11211DI0247Mammary tumour[ICD-11: 2C60-2C6Z]P10275AR
    T11211DI0346Prostate cancer[ICD-11: 2C82]P10275AR
    T11211DI0401Testicular dysfunction[ICD-11: 5A81]P10275AR
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
    T72168DI0018Adrenocortical insufficiency[ICD-11: 5A74]P08235NR3C2
    T72168DI0083Chronic kidney disease[ICD-11: GB61]P08235NR3C2
    T72168DI0100Contraceptive management[ICD-11: QA21]P08235NR3C2
    T72168DI0175Heart failure[ICD-11: BD10-BD1Z]P08235NR3C2
    T72168DI0190Hypertension[ICD-11: BA00-BA04]P08235NR3C2
    T72168DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P08235NR3C2
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T22939DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06401PGR
    T22939DI0100Contraceptive management[ICD-11: QA21]P06401PGR
    T22939DI0255Menstrual cycle bleeding disorder[ICD-11: GA20]P06401PGR
    T22939DI0344Preterm labour/delivery[ICD-11: JB00]P06401PGR
    T22939DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06401PGR
    T88452DI0037Asthma[ICD-11: CA23]P08185SERPINA6
    T88452DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P08185SERPINA6
    T88452DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08185SERPINA6
    T73712DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P07148FABP1
    T70309DI0347Prostate disease[ICD-11: GA91]P18405SRD5A1
    T13260DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11511CYP19A1
    T13260DI0108Cushing syndrome[ICD-11: 5A70]P11511CYP19A1
    T67102DI0275Multiple sclerosis[ICD-11: 8A40]P07339CTSD
    T33901DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q9UHC9NPC1L1
    T02562DI0025Alzheimer disease[ICD-11: 8A20]O14684PTGES
    T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
    T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
    T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
    T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
    T49156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P17706PTPN2
    T86591DI0187Hyperlipidemia[ICD-11: 5C80]Q07869PPARA
    T86591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q07869PPARA
    T86591DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q07869PPARA
    T36557DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]Q03181PPARD
    T36557DI0308Obesity[ICD-11: 5B80-5B81]Q03181PPARD
    T25608DI0417Type 2 diabetes mellitus[ICD-11: 5A11]O14842FFAR1
    T65200DI0210Influenza[ICD-11: 1E30-1E32]P28845HSD11B1
    T65200DI0239Lupus erythematosus[ICD-11: 4A40]P28845HSD11B1
    T65200DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P28845HSD11B1
    T34234DI0083Chronic kidney disease[ICD-11: GB61]P11473VDR
    T34234DI0171Hair/hair growth developmental defect[ICD-11: LC30]P11473VDR
    T34234DI0189Hyper-parathyroidism[ICD-11: 5A51]P11473VDR
    T34234DI0195Hypo-parathyroidism[ICD-11: 5A50]P11473VDR
    T34234DI0266Mineral deficiency[ICD-11: 5B5K]P11473VDR
    T34234DI0351Psoriasis[ICD-11: EA90]P11473VDR
    T34234DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]P11473VDR
    T86273DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q8TDU6GPBAR1
    T06958DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06746POLB
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
    T52297DI0117Depression[ICD-11: 6A70-6A7Z]Q13133NR1H3
    T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
    T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
    T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
    T21945DI0013Acute pain[ICD-11: MG31]P23975SLC6A2
    T21945DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P23975SLC6A2
    T21945DI0087Chronic pain[ICD-11: MG30]P23975SLC6A2
    T21945DI0101Corneal disease[ICD-11: 9A76-9A78]P23975SLC6A2
    T21945DI0117Depression[ICD-11: 6A70-6A7Z]P23975SLC6A2
    T21945DI0166Glaucoma[ICD-11: 9C61]P23975SLC6A2
    T21945DI0264Migraine[ICD-11: 8A80]P23975SLC6A2
    T21945DI0301Nicotine use disorder[ICD-11: 6C4A]P23975SLC6A2
    T21945DI0308Obesity[ICD-11: 5B80-5B81]P23975SLC6A2
    T21945DI0324Pain[ICD-11: MG30-MG3Z]P23975SLC6A2
    T21945DI0395Stomach cancer[ICD-11: 2B72]P23975SLC6A2
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T79031DI0025Alzheimer disease[ICD-11: 8A20]P56817BACE1
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
    T79232DI0009Acute diabete complication[ICD-11: 5A2Y]P37288AVPR1A
    T79232DI0041Autism spectrum disorder[ICD-11: 6A02]P37288AVPR1A
    T79232DI0190Hypertension[ICD-11: BA00-BA04]P37288AVPR1A
    T79232DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P37288AVPR1A
    T79232DI0236Localisation[ICD-11: N.A.]P37288AVPR1A
    T66237DI0009Acute diabete complication[ICD-11: 5A2Y]P30518AVPR2
    T66237DI0041Autism spectrum disorder[ICD-11: 6A02]P30518AVPR2
    T66237DI0131Enuresis[ICD-11: 6C00]P30518AVPR2
    T66237DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P30518AVPR2
    T66237DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30518AVPR2
    T66237DI0338Polyuria[ICD-11: MF55]P30518AVPR2
    T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
    T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
    T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
    T86052DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]O14746TERT
    T86052DI0284Myelodysplastic syndrome[ICD-11: 2A37]O14746TERT
    T86052DI0326Pancreatic cancer[ICD-11: 2C10]O14746TERT
    T10897DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O00767SCD
    T86161DI0092Coeliac disease[ICD-11: DA95]P48147PREP
    T86161DI0210Influenza[ICD-11: 1E30-1E32]P48147PREP
    T86161DI0238Lung cancer[ICD-11: 2C25]P48147PREP
    T86161DI0265Mild neurocognitive disorder[ICD-11: 6D71]P48147PREP
    T25307DI0042Autoimmune disease[ICD-11: 4A40-4A45]P51449RORC
    T25307DI0107Crohn disease[ICD-11: DD70]P51449RORC
    T25307DI0238Lung cancer[ICD-11: 2C25]P51449RORC
    T25307DI0275Multiple sclerosis[ICD-11: 8A40]P51449RORC
    T25307DI0351Psoriasis[ICD-11: EA90]P51449RORC
    T25307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P51449RORC
    T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
    T38529DI0003Abortion[ICD-11: JA00]P43116PTGER2
    T38529DI0102Coronary atherosclerosis[ICD-11: BA52]P43116PTGER2
    T38529DI0121Diabetic foot ulcer[ICD-11: BD54]P43116PTGER2
    T38529DI0166Glaucoma[ICD-11: 9C61]P43116PTGER2
    T38529DI0356Pulmonary hypertension[ICD-11: BB01]P43116PTGER2
    T38529DI0378Sexual dysfunction[ICD-11: HA00-HA01]P43116PTGER2
    T38529DI0413Transplant rejection[ICD-11: NE84]P43116PTGER2
    T61722DI0102Coronary atherosclerosis[ICD-11: BA52]Q9Y5Y4PTGDR2
    T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
    T40149DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P24723PRKCH
    T43721DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P80365HSD11B2
    T13057DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06124PTPN11
    T53585DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P04035HMGCR
    T53585DI0102Coronary atherosclerosis[ICD-11: BA52]P04035HMGCR
    T53585DI0128Dyslipidemia[ICD-11: 5C80-5C81]P04035HMGCR
    T53585DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P04035HMGCR
    T53585DI0275Multiple sclerosis[ICD-11: 8A40]P04035HMGCR
    T53585DI0287Myocardial infarction[ICD-11: BA41-BA43]P04035HMGCR
    T53585DI0324Pain[ICD-11: MG30-MG3Z]P04035HMGCR
    T63484DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P11413G6PD
    T32972DI0209Infectious meningitis[ICD-11: 1D01]Q16850CYP51A1
    T32972DI0289Nail/perionychium infection[ICD-11: EE12]Q16850CYP51A1
    T32972DI0316Onchocerciasis[ICD-11: 1F6A]Q16850CYP51A1
    T59626DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]Q15722LTB4R
    T59626DI0355Pulmonary disease[ICD-11: 1B10-1F85]Q15722LTB4R
    T59626DI0361Renal cell carcinoma[ICD-11: 2C90]Q15722LTB4R
    T89041DI0346Prostate cancer[ICD-11: 2C82]P05093CYP17A1
    T23276DI0036Arteries/arterioles disorder[ICD-11: BD52]P11137MAP2
    T23276DI0252Melanoma[ICD-11: 2C30]P11137MAP2
    T23276DI0326Pancreatic cancer[ICD-11: 2C10]P11137MAP2
    T23276DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11137MAP2
    T09826DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P11387TOP1
    T09826DI0095Colorectal cancer[ICD-11: 2B91]P11387TOP1
    T09826DI0238Lung cancer[ICD-11: 2C25]P11387TOP1
    T09826DI0321Ovarian cancer[ICD-11: 2C73]P11387TOP1
    T09826DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11387TOP1
    T17048DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11388TOP2A
    T17048DI0225Kaposi sarcoma[ICD-11: 2B57]P11388TOP2A
    T17048DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11388TOP2A
    T18876DI0037Asthma[ICD-11: CA23]P35408PTGER4
    T18876DI0175Heart failure[ICD-11: BD10-BD1Z]P35408PTGER4
    T18876DI0264Migraine[ICD-11: 8A80]P35408PTGER4
    T18876DI0303Non-small-cell lung cancer[ICD-11: 2C25]P35408PTGER4
    T18876DI0324Pain[ICD-11: MG30-MG3Z]P35408PTGER4
    T18876DI0360Rectum cancer[ICD-11: 2B92]P35408PTGER4
    T18876DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35408PTGER4
    T18876DI0414Transplanted organ/tissue[ICD-11: QB63]P35408PTGER4
    T85467DI0166Glaucoma[ICD-11: 9C61]P43115PTGER3
    T85467DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43115PTGER3
    T85467DI0414Transplanted organ/tissue[ICD-11: QB63]P43115PTGER3
    T15497DI0405Thrombosis[ICD-11: DB61-GB90]P34995PTGER1
    T68782DI0102Coronary atherosclerosis[ICD-11: BA52]Q13258PTGDR
    T43206DI0235Liver cancer[ICD-11: 2C12]P35398RORA
    T43206DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P35398RORA
    T99954DI0003Abortion[ICD-11: JA00]P43119PTGIR
    T99954DI0102Coronary atherosclerosis[ICD-11: BA52]P43119PTGIR
    T99954DI0356Pulmonary hypertension[ICD-11: BB01]P43119PTGIR
    T92458DI0351Psoriasis[ICD-11: EA90]Q07973CYP24A1
    T99189DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]Q14973SLC10A1
    T64682DI0346Prostate cancer[ICD-11: 2C82]O00141SGK1
    T10191DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P01730CD4

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