5,3\',4\'-Trihydroxy-3,6,7,8-tetramethoxyflavone



Compound IDCDAMM01856
Common name5,3\',4\'-Trihydroxy-3,6,7,8-tetramethoxyflavone
IUPAC name2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxychromen-4-one
Molecular formulaC19H18O9

Experimental data

Retention time16.25
Adduct[2M+H]+
Actual mz781.198
Theoretical mz781.197
Error1.05
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.6294

Identifiers and class information

Inchi keyWQDGAXUSPJAKPY-UHFFFAOYSA-N
SmilesO=C1C(OC)=C(OC2=C(OC)C(OC)=C(OC)C(O)=C12)C=3C=CC(O)=C(O)C3
SuperclassPhenylpropanoids and polyketides
ClassFlavonoids

Plant source

  • Curcuma longa L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)7
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)390.346
    Computed dipole moment(dipole)4.57
    Total solvent accessible surface area (SASA)625.175
    Hydrophobic component of SASA (FOSA)314.568
    Hydrophilic component of SASA (FISA)177.508
    Pie component of the SASA (PISA)133.099
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1124.86
    Number of hydrogen bond donors (donorHB)2
    Number of hydrogen bond acceptors (accptHB)6.75
    Free energy of solvation of dipole (dip^2/V)0.0185695
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0152692
    Globularity descriptor (glob)0.836687
    Predicted polarizability in cubic angstroms (QPpolrz)35.639
    Predicted hexadecane/gas partition coefficient (QPlogPC16)11.309
    Predicted octanol/gas partition coefficient (QPlogPoct)18.458
    Predicted water/gas partition coefficient (QPlogPw)11.37
    Predicted octanol/water partition coefficient (QPlogPo/w)2.351
    Predicted aqueous solubility (QPlogS)-4.113
    Conformation-independent predicted aqueous solubility (CIQPlogS)-5.379
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.809
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)205.397
    Predicted brain/blood partition coefficient (QPlogBB)-1.549
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)89.402
    Predicted skin permeability, log Kp (QPlogKp)-3.65
    PM3 calculated ionization potential (IP(ev))8.831
    PM3 calculated electron affinity (EA(eV))0.842
    Number of likely metabolic reactions (#metab)7
    Prediction of binding to human serum albumin (QPlogKhsa)0.073
    Predicted qualitative human oral absorption (HumanOralAbsorption)2
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)82.104
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)122.265
    Number of nitrogen and oxygen atoms (#NandO)9
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P22303ACHEAcetylcholinesteraseT30082SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    O43570CA12Carbonic anhydrase XIIT16987SwissTargetPrediction
    Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction
    P35228NOS2Nitric oxide synthase, inducibleT02703SwissTargetPrediction
    Q07820MCL1Induced myeloid leukemia cell differentiation protein Mcl-1T14912SwissTargetPrediction
    P00734F2ThrombinT94033SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P21917DRD4Dopamine D4 receptorT24983SwissTargetPrediction
    P21397MAOAMonoamine oxidase AT83875SwissTargetPrediction and SEA
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P05067APPBeta amyloid A4 proteinT87024SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P04054PLA2G1BPhospholipase A2 group 1BT31479SwissTargetPrediction
    P43166CA7Carbonic anhydrase VIIT37541SwissTargetPrediction and SEA
    P23280CA6Carbonic anhydrase VIT06569SwissTargetPrediction
    Q9ULX7CA14Carbonic anhydrase XIVT31992SwissTargetPrediction
    P22748CA4Carbonic anhydrase IVT53378SwissTargetPrediction and SEA
    P00747PLGPlasminogenT89034SwissTargetPrediction
    P15121AKR1B1Aldose reductaseT26623SwissTargetPrediction and SEA
    P05164MPOMyeloperoxidaseT23471SwissTargetPrediction
    P35354PTGS2Cyclooxygenase-2T66665SwissTargetPrediction
    P42330AKR1C3Aldo-keto-reductase family 1 member C3T60857SwissTargetPrediction
    Q6B0I6KDM4DLysine-specific demethylase 4DT17036SwissTargetPrediction
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction and SEA
    P35968KDRVascular endothelial growth factor receptor 2T80975SwissTargetPrediction
    P11511CYP19A1Cytochrome P450 19A1T13260SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    P03372ESR1Estrogen receptor alphaT02506SEA
    P09917ALOX5Arachidonate 5-lipoxygenaseT00140SwissTargetPrediction and SEA
    P35869AHRAryl hydrocarbon receptorT23666SwissTargetPrediction
    P08069IGF1RInsulin-like growth factor I receptorT48069SwissTargetPrediction
    Q9UM73ALKALK tyrosine kinase receptorT56418SwissTargetPrediction
    Q9HC97GPR35G-protein coupled receptor 35T56143SwissTargetPrediction and SEA
    P33527ABCC1Multidrug resistance-associated protein 1T11288SwissTargetPrediction and SEA
    P08183ABCB1P-glycoprotein 1T25258SwissTargetPrediction and SEA
    P35372OPRM1Mu opioid receptorT47768SwissTargetPrediction
    P27695APEX1DNA-(apurinic or apyrimidinic site) lyaseT13348SwissTargetPrediction
    P11309PIM1Serine/threonine-protein kinase PIM1T50594SwissTargetPrediction
    P14061HSD17B1Estradiol 17-beta-dehydrogenase 1T44011SwissTargetPrediction
    P06213INSRInsulin receptorT85435SwissTargetPrediction
    P24941CDK2Cyclin-dependent kinase 2T70176SwissTargetPrediction
    P36888FLT3Tyrosine-protein kinase receptor FLT3T74312SwissTargetPrediction
    P56817BACE1Beta-secretase 1T79031SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P16050ALOX15Arachidonate 15-lipoxygenaseT16042SwissTargetPrediction and SEA
    P18054ALOX12Arachidonate 12-lipoxygenaseT35527SwissTargetPrediction and SEA
    P30518AVPR2Vasopressin V2 receptor (by homology)T66237SwissTargetPrediction
    P41143OPRD1Delta opioid receptorT58992SwissTargetPrediction
    O14746TERTTelomerase reverse transcriptaseT86052SwissTargetPrediction and SEA
    Q96S37SLC22A12Solute carrier family 22 member 12T86057SwissTargetPrediction
    P11388TOP2ADNA topoisomerase II alphaT17048SwissTargetPrediction
    P31749AKT1Serine/threonine-protein kinase AKTT67619SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    Q05397PTK2Focal adhesion kinase 1T15068SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    P51955NEK2Serine/threonine-protein kinase NEK2T49102SwissTargetPrediction
    P10721KITStem cell growth factor receptorT57700SwissTargetPrediction
    Q15078CDK5R1Cyclin-dependent kinase 5/CDK5 activator 1T09513SwissTargetPrediction
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    P06493CDK1Cyclin-dependent kinase 1/cyclin B1T49898SwissTargetPrediction
    P25024CXCR1Interleukin-8 receptor AT00884SwissTargetPrediction
    P06737PYGLLiver glycogen phosphorylaseT19184SwissTargetPrediction
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SwissTargetPrediction
    P60568IL2Interleukin-2T61698SEA
    P53350PLK1Serine/threonine-protein kinase PLK1T40694SwissTargetPrediction
    P68400CSNK2A1Casein kinase II alphaT51565SwissTargetPrediction
    Q16875PFKFB36-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3T23787SwissTargetPrediction
    Q96GD4AURKBSerine/threonine-protein kinase Aurora-BT46781SwissTargetPrediction
    Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SwissTargetPrediction and SEA
    Q9NPH5NOX4NADPH oxidase 4T29741SwissTargetPrediction and SEA
    Q9GZQ4NMUR2Neuromedin-U receptor 2T04210SEA
    P47989XDHXanthine dehydrogenaseT40954SwissTargetPrediction and SEA
    Q15746MYLKMyosin light chain kinase, smooth muscleT97141SwissTargetPrediction
    Q16678CYP1B1Cytochrome P450 1B1T92521SwissTargetPrediction and SEA
    P10636MAPTMicrotubule-associated protein tauT45593SwissTargetPrediction and SEA
    Q04760GLO1Glyoxalase IT88285SwissTargetPrediction and SEA
    P30530AXLTyrosine-protein kinase receptor UFOT82383SwissTargetPrediction
    Q9UNI1CELA1Elastase 1T22839SEA
    O60911CTSVCathepsin (V and K)T93653SEA
    P37840SNCAAlpha-synucleinT03644SEA
    Q16512PKN1Protein kinase N1T60003SwissTargetPrediction and SEA
    Q9UQM7CAMK2ACaM kinase II alphaT18299SwissTargetPrediction
    Q9HC98NEK6Serine/threonine-protein kinase NEK6T78992SwissTargetPrediction and SEA
    O60285NUAK1NUAK family SNF1-like kinase 1T21653SwissTargetPrediction and SEA
    P16152CBR1Carbonyl reductase [NADPH] 1T70518SEA
    Q13332PTPRSReceptor-type tyrosine-protein phosphatase ST10147SwissTargetPrediction and SEA
    P05089ARG1Arginase-1 (by homology)T63224SwissTargetPrediction
    O35273SMAD3Mothers against decapentaplegic homolog 3T35445SEA
    P16220CREB1Cyclic AMP-responsive element-binding proteinT92098SEA
    Q15717ELAVL1ELAV-like protein 1T78349SEA
    Q9UK17KCND3Voltage-gated potassium channel Kv4.3T74500SEA
    H3BPQ1TCF4Transcription factor 7-like 2T54646SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
    T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T02703DI0083Chronic kidney disease[ICD-11: GB61]P35228NOS2
    T02703DI0320Osteoarthritis[ICD-11: FA00-FA05]P35228NOS2
    T02703DI0375Sepsis[ICD-11: 1G40-1G41]P35228NOS2
    T02703DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35228NOS2
    T14912DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q07820MCL1
    T14912DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]Q07820MCL1
    T14912DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q07820MCL1
    T14912DI0252Melanoma[ICD-11: 2C30]Q07820MCL1
    T14912DI0274Multiple myeloma[ICD-11: 2A83]Q07820MCL1
    T14912DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q07820MCL1
    T94033DI0052Bleeding disorder[ICD-11: GA20-GA21]P00734F2
    T94033DI0091Coagulation defect[ICD-11: 3B10]P00734F2
    T94033DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P00734F2
    T94033DI0275Multiple sclerosis[ICD-11: 8A40]P00734F2
    T94033DI0287Myocardial infarction[ICD-11: BA41-BA43]P00734F2
    T94033DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00734F2
    T94033DI0403Thrombocytopenia[ICD-11: 3B64]P00734F2
    T94033DI0405Thrombosis[ICD-11: DB61-GB90]P00734F2
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T24983DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21917DRD4
    T24983DI0370Schizophrenia[ICD-11: 6A20]P21917DRD4
    T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
    T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T87024DI0025Alzheimer disease[ICD-11: 8A20]P05067APP
    T87024DI0122Diagnostic imaging[ICD-11: N.A.]P05067APP
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T31479DI0230Leishmaniasis[ICD-11: 1F54]P04054PLA2G1B
    T31479DI0335Peroxisomal disease[ICD-11: 5C57]P04054PLA2G1B
    T31479DI0367Rosacea[ICD-11: ED90]P04054PLA2G1B
    T31479DI0398Synthesis disorder[ICD-11: 5C52-5C59]P04054PLA2G1B
    T06569DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P23280CA6
    T06569DI0372Seborrhoeic dermatitis[ICD-11: EA81]P23280CA6
    T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
    T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
    T53378DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P22748CA4
    T53378DI0166Glaucoma[ICD-11: 9C61]P22748CA4
    T53378DI0372Seborrhoeic dermatitis[ICD-11: EA81]P22748CA4
    T89034DI0030Angina pectoris[ICD-11: BA40]P00747PLG
    T89034DI0052Bleeding disorder[ICD-11: GA20-GA21]P00747PLG
    T89034DI0254Menopausal disorder[ICD-11: GA30]P00747PLG
    T89034DI0287Myocardial infarction[ICD-11: BA41-BA43]P00747PLG
    T89034DI0345Procedure injury[ICD-11: NE81]P00747PLG
    T89034DI0357Pulmonary thromboembolism[ICD-11: BB00]P00747PLG
    T26623DI0298Neuropathy[ICD-11: 8C0Z]P15121AKR1B1
    T26623DI0366Rheumatoid arthritis[ICD-11: FA20]P15121AKR1B1
    T23471DI0229Left ventricular failure[ICD-11: BD11]P05164MPO
    T23471DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P05164MPO
    T66665DI0087Chronic pain[ICD-11: MG30]P35354PTGS2
    T66665DI0145Female pelvic pain[ICD-11: GA34]P35354PTGS2
    T66665DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P35354PTGS2
    T66665DI0207Indeterminate colitis[ICD-11: DD72]P35354PTGS2
    T66665DI0227Knee osteoarthritis[ICD-11: FA01]P35354PTGS2
    T66665DI0320Osteoarthritis[ICD-11: FA00-FA05]P35354PTGS2
    T66665DI0324Pain[ICD-11: MG30-MG3Z]P35354PTGS2
    T66665DI0366Rheumatoid arthritis[ICD-11: FA20]P35354PTGS2
    T66665DI0416Tuberculosis[ICD-11: 1B10-1B12]P35354PTGS2
    T60857DI0145Female pelvic pain[ICD-11: GA34]P42330AKR1C3
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T80975DI0062Breast cancer[ICD-11: 2C60-2C6Y]P35968KDR
    T80975DI0095Colorectal cancer[ICD-11: 2B91]P35968KDR
    T80975DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P35968KDR
    T80975DI0244Malignant digestive organ neoplasm[ICD-11: 2C11]P35968KDR
    T80975DI0361Renal cell carcinoma[ICD-11: 2C90]P35968KDR
    T80975DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35968KDR
    T80975DI0395Stomach cancer[ICD-11: 2B72]P35968KDR
    T80975DI0403Thrombocytopenia[ICD-11: 3B64]P35968KDR
    T80975DI0407Thyroid cancer[ICD-11: 2D10]P35968KDR
    T13260DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11511CYP19A1
    T13260DI0108Cushing syndrome[ICD-11: 5A70]P11511CYP19A1
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
    T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
    T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
    T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
    T23666DI0351Psoriasis[ICD-11: EA90]P35869AHR
    T23666DI0403Thrombocytopenia[ICD-11: 3B64]P35869AHR
    T48069DI0276Multiple structural anomalies syndrome[ICD-11: LD2F]P08069IGF1R
    T48069DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P08069IGF1R
    T48069DI0408Thyrotoxicosis[ICD-11: 5A02]P08069IGF1R
    T56418DI0238Lung cancer[ICD-11: 2C25]Q9UM73ALK
    T56418DI0251Mature T-cell lymphoma[ICD-11: 2A90]Q9UM73ALK
    T56418DI0303Non-small-cell lung cancer[ICD-11: 2C25]Q9UM73ALK
    T11288DI0167Gout[ICD-11: FA25]P33527ABCC1
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
    T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
    T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
    T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
    T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
    T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
    T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
    T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
    T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
    T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
    T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
    T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
    T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
    T13348DI0365Retinopathy[ICD-11: 9B71]P27695APEX1
    T13348DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P27695APEX1
    T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
    T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
    T85435DI0009Acute diabete complication[ICD-11: 5A2Y]P06213INSR
    T85435DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P06213INSR
    T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
    T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
    T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
    T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
    T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
    T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
    T74312DI0012Acute myeloid leukaemia[ICD-11: 2A60]P36888FLT3
    T74312DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P36888FLT3
    T74312DI0095Colorectal cancer[ICD-11: 2B91]P36888FLT3
    T74312DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P36888FLT3
    T74312DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P36888FLT3
    T74312DI0248Mastocytosis[ICD-11: 2A21]P36888FLT3
    T74312DI0250Mature B-cell lymphoma[ICD-11: 2A85]P36888FLT3
    T74312DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P36888FLT3
    T79031DI0025Alzheimer disease[ICD-11: 8A20]P56817BACE1
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T66237DI0009Acute diabete complication[ICD-11: 5A2Y]P30518AVPR2
    T66237DI0041Autism spectrum disorder[ICD-11: 6A02]P30518AVPR2
    T66237DI0131Enuresis[ICD-11: 6C00]P30518AVPR2
    T66237DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P30518AVPR2
    T66237DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30518AVPR2
    T66237DI0338Polyuria[ICD-11: MF55]P30518AVPR2
    T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
    T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
    T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
    T86052DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]O14746TERT
    T86052DI0284Myelodysplastic syndrome[ICD-11: 2A37]O14746TERT
    T86052DI0326Pancreatic cancer[ICD-11: 2C10]O14746TERT
    T86057DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q96S37SLC22A12
    T17048DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11388TOP2A
    T17048DI0225Kaposi sarcoma[ICD-11: 2B57]P11388TOP2A
    T17048DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11388TOP2A
    T67619DI0062Breast cancer[ICD-11: 2C60-2C6Y]P31749AKT1
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T15068DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q05397PTK2
    T15068DI0321Ovarian cancer[ICD-11: 2C73]Q05397PTK2
    T15068DI0326Pancreatic cancer[ICD-11: 2C10]Q05397PTK2
    T15068DI0334Peritoneal cancer[ICD-11: 2C51]Q05397PTK2
    T15068DI0356Pulmonary hypertension[ICD-11: BB01]Q05397PTK2
    T15068DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q05397PTK2
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T57700DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P10721KIT
    T57700DI0095Colorectal cancer[ICD-11: 2B91]P10721KIT
    T57700DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P10721KIT
    T57700DI0250Mature B-cell lymphoma[ICD-11: 2A85]P10721KIT
    T57700DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P10721KIT
    T57700DI0361Renal cell carcinoma[ICD-11: 2C90]P10721KIT
    T57700DI0403Thrombocytopenia[ICD-11: 3B64]P10721KIT
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T49898DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06493CDK1
    T49898DI0238Lung cancer[ICD-11: 2C25]P06493CDK1
    T49898DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P06493CDK1
    T49898DI0250Mature B-cell lymphoma[ICD-11: 2A85]P06493CDK1
    T49898DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06493CDK1
    T00884DI0324Pain[ICD-11: MG30-MG3Z]P25024CXCR1
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T61698DI0275Multiple sclerosis[ICD-11: 8A40]P60568IL2
    T61698DI0361Renal cell carcinoma[ICD-11: 2C90]P60568IL2
    T40694DI0012Acute myeloid leukaemia[ICD-11: 2A60]P53350PLK1
    T40694DI0284Myelodysplastic syndrome[ICD-11: 2A37]P53350PLK1
    T40694DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P53350PLK1
    T51565DI0104Coronavirus infection[ICD-11: 1D92]P68400CSNK2A1
    T51565DI0235Liver cancer[ICD-11: 2C12]P68400CSNK2A1
    T51565DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P68400CSNK2A1
    T23787DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16875PFKFB3
    T46781DI0009Acute diabete complication[ICD-11: 5A2Y]Q96GD4AURKB
    T46781DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q96GD4AURKB
    T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
    T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
    T29741DI0146Fibrosis[ICD-11: GA14-GC01]Q9NPH5NOX4
    T40954DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]P47989XDH
    T40954DI0266Mineral deficiency[ICD-11: 5B5K]P47989XDH
    T97141DI0127Duodenal ulcer[ICD-11: DA63]Q15746MYLK
    T45593DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10636MAPT
    T45593DI0025Alzheimer disease[ICD-11: 8A20]P10636MAPT
    T45593DI0265Mild neurocognitive disorder[ICD-11: 6D71]P10636MAPT
    T88285DI0210Influenza[ICD-11: 1E30-1E32]Q04760GLO1
    T82383DI0012Acute myeloid leukaemia[ICD-11: 2A60]P30530AXL
    T22839DI0024Alpha-1-antitrypsin deficiency[ICD-11: 5C5A]Q9UNI1CELA1
    T22839DI0065Bronchitis[ICD-11: CA20]Q9UNI1CELA1
    T93653DI0055Bone cancer[ICD-11: 2B5Z]O60911CTSV
    T93653DI0087Chronic pain[ICD-11: MG30]O60911CTSV
    T03644DI0025Alzheimer disease[ICD-11: 8A20]P37840SNCA
    T03644DI0044Autonomic nervous system disorder[ICD-11: 8D87]P37840SNCA
    T03644DI0331Parkinsonism[ICD-11: 8A00]P37840SNCA
    T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
    T70518DI0037Asthma[ICD-11: CA23]P16152CBR1
    T10147DI0057Bone paget disease[ICD-11: FB85]Q13332PTPRS
    T63224DI0258Metabolism inborn error[ICD-11: 5C50]P05089ARG1
    T35445DI0226Kidney fibrosis[ICD-11: GC01]O35273SMAD3
    T74500DI0004Acidosis[ICD-11: 5C73]Q9UK17KCND3

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