Tryptamine



Compound IDCDAMM01844
Common nameTryptamine
IUPAC name2-(1H-indol-3-yl)ethanamine
Molecular formulaC10H12N2

Experimental data

Retention time5.6
Adduct[M+H]+
Actual mz161.107
Theoretical mz161.107
Error4.82
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.5035

Identifiers and class information

Inchi keyAPJYDQYYACXCRM-UHFFFAOYSA-N
SmilesNCCC1=CNC=2C=CC=CC21
SuperclassOrganoheterocyclic compounds
ClassIndoles and derivatives

Plant source

  • Curcuma longa L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)1
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)3
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)1
    Molecular weight (mol_MW)160.218
    Computed dipole moment(dipole)3.382
    Total solvent accessible surface area (SASA)383.423
    Hydrophobic component of SASA (FOSA)79.395
    Hydrophilic component of SASA (FISA)93.145
    Pie component of the SASA (PISA)210.883
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)611.397
    Number of hydrogen bond donors (donorHB)3
    Number of hydrogen bond acceptors (accptHB)1
    Free energy of solvation of dipole (dip^2/V)0.0187045
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0045173
    Globularity descriptor (glob)0.908592
    Predicted polarizability in cubic angstroms (QPpolrz)18.402
    Predicted hexadecane/gas partition coefficient (QPlogPC16)6.792
    Predicted octanol/gas partition coefficient (QPlogPoct)10.708
    Predicted water/gas partition coefficient (QPlogPw)7.427
    Predicted octanol/water partition coefficient (QPlogPo/w)1.173
    Predicted aqueous solubility (QPlogS)-0.498
    Conformation-independent predicted aqueous solubility (CIQPlogS)-1.15
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.743
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)323.222
    Predicted brain/blood partition coefficient (QPlogBB)0.029
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)161.458
    Predicted skin permeability, log Kp (QPlogKp)-4.268
    PM3 calculated ionization potential (IP(ev))8.246
    PM3 calculated electron affinity (EA(eV))-0.045
    Number of likely metabolic reactions (#metab)3
    Prediction of binding to human serum albumin (QPlogKhsa)-0.361
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)78.728
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)41.773
    Number of nitrogen and oxygen atoms (#NandO)2
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P22303ACHEAcetylcholinesteraseT30082SEA
    Q99720SIGMAR1Sigma opioid receptorT46360SwissTargetPrediction
    P09960LTA4HLeukotriene A4 hydrolaseT03691SwissTargetPrediction
    O15379HDAC3Histone deacetylase 3T05090SEA
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P21917DRD4Dopamine D4 receptorT24983SEA
    P14416DRD2Dopamine D2 receptorT67162SwissTargetPrediction and SEA
    P27487DPP4Dipeptidyl peptidase IVT31391SwissTargetPrediction
    Q9Y2I1NISCHNischarinT65689SwissTargetPrediction
    P23280CA6Carbonic anhydrase VIT06569SwissTargetPrediction
    P28223HTR2ASerotonin 2a (5-HT2a) receptorT32060SwissTargetPrediction and SEA
    P28335HTR2CSerotonin 2c (5-HT2c) receptorT83813SwissTargetPrediction and SEA
    P31645SLC6A4Serotonin transporter (by homology)T27812SwissTargetPrediction and SEA
    Q96RJ0TAAR1Trace amine-associated receptor 1 (by homology)T99524SEA
    P41595HTR2BSerotonin 2b (5-HT2b) receptorT31204SwissTargetPrediction and SEA
    P08913ADRA2AAlpha-2a adrenergic receptorT11448SwissTargetPrediction
    P28222HTR1BSerotonin 1b (5-HT1b) receptorT07806SwissTargetPrediction and SEA
    P28221HTR1DSerotonin 1d (5-HT1d) receptorT11072SwissTargetPrediction and SEA
    P08588ADRB1Beta-1 adrenergic receptorT44068SwissTargetPrediction
    P08908HTR1ASerotonin 1a (5-HT1a) receptorT78709SwissTargetPrediction and SEA
    P28566HTR1ESerotonin 1e (5-HT1e) receptorT84117SwissTargetPrediction and SEA
    P34969HTR7Serotonin 7 (5-HT7) receptorT79062SwissTargetPrediction and SEA
    P50406HTR6Serotonin 6 (5-HT6) receptorT16691SwissTargetPrediction and SEA
    Q01959SLC6A3Dopamine transporterT55959SwissTargetPrediction
    P05164MPOMyeloperoxidaseT23471SwissTargetPrediction and SEA
    Q92769HDAC2Histone deacetylase 2T51191SEA
    P35968KDRVascular endothelial growth factor receptor 2T80975SwissTargetPrediction
    P08235NR3C2Mineralocorticoid receptorT72168SEA
    P04150NR3C1Glucocorticoid receptorT40016SEA
    P35367HRH1Histamine H1 receptorT77913SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SEA
    P22894MMP8Matrix metalloproteinase 8T08856SEA
    P14780MMP9Matrix metalloproteinase 9T54156SEA
    Q7Z2W7TRPM8Transient receptor potential cation channel subfamily M member 8T41955SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SEA
    P08069IGF1RInsulin-like growth factor I receptorT48069SwissTargetPrediction
    P35462DRD3Dopamine D3 receptorT02551SwissTargetPrediction and SEA
    P21728DRD1Dopamine D1 receptorT22118SwissTargetPrediction
    P23975SLC6A2Norepinephrine transporterT21945SwissTargetPrediction
    Q13639HTR4Serotonin 4 (5-HT4) receptorT59679SwissTargetPrediction
    P18825ADRA2CAdrenergic receptor alpha-2T01777SwissTargetPrediction
    P35368ADRA1BAlpha-1b adrenergic receptorT29500SwissTargetPrediction
    P41145OPRK1Kappa Opioid receptorT60693SwissTargetPrediction
    P52732KIF11Kinesin-like protein 1T28484SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SEA
    P35270SPRSubstance-P receptorT47094SEA
    P07711CTSLCathepsin LT98691SEA
    P32245MC4RMelanocortin receptor 4T72458SEA
    P07858CTSBCathepsin (B and K)T61746SEA
    Q92847GHSRGhrelin receptorT59604SEA
    Q01726MC1RMelanocortin receptor 1T35842SEA
    P41968MC3RMelanocortin receptor 3T76846SEA
    Q9UHL4DPP7Dipeptidyl peptidase IIT50773SwissTargetPrediction
    P35348ADRA1AAlpha-1a adrenergic receptorT92609SwissTargetPrediction
    P31749AKT1Serine/threonine-protein kinase AKTT67619SEA
    P35916FLT4Vascular endothelial growth factor receptor 3T07303SwissTargetPrediction
    Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2T65818SEA
    P47898HTR5ASerotonin 5a (5-HT5a) receptorT15571SwissTargetPrediction and SEA
    P48039MTNR1AMelatonin receptor 1AT97613SwissTargetPrediction and SEA
    P49286MTNR1BMelatonin receptor 1BT48268SwissTargetPrediction and SEA
    P26358DNMT1DNA (cytosine-5)-methyltransferase 1 (by homology)T88304SwissTargetPrediction
    P18089ADRA2BAlpha-2b adrenergic receptorT41580SwissTargetPrediction and SEA
    P42892ECE1Endothelin-converting enzyme 1T50970SEA
    P49840GSK3AGlycogen synthase kinase-3 alphaT76910SEA
    P35346SSTR5Somatostatin receptor 5T64830SEA
    P30874SSTR2Somatostatin receptor 2T53024SEA
    P31391SSTR4Somatostatin receptor 4T62974SEA
    P30872SSTR1Somatostatin receptor 1T16633SEA
    P32745SSTR3Somatostatin receptor 3T13644SEA
    P32239CCKBRCholecystokinin B receptor (by homology)T05849SEA
    P50281MMP14Matrix metalloproteinase 14T65019SEA
    P31751AKT2Serine/threonine-protein kinase AKT2T94621SEA
    Q9Y243AKT3Serine/threonine-protein kinase AKTT71266SEA
    Q13976PRKG1cGMP-dependent protein kinase 1 betaT78543SEA
    Q9UQM7CAMK2ACaM kinase II alphaT18299SEA
    P14679TYRTyrosinaseT97035SEA
    P21452TACR2Neurokinin 2 receptorT52790SEA
    P13569CFTRCystic fibrosis transmembrane conductance regulatorT55654SEA
    P51812RPS6KA3Ribosomal protein S6 kinase alpha 3T03279SEA
    Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SEA
    P15735PHKG2Phosphorylase kinase gamma subunit 2T69208SEA
    Q13237PRKG2cGMP-dependent protein kinase 2T23606SEA
    Q7KZI7MARK2MAP/microtubule affinity-regulating kinase 2T01396SEA
    P17612PRKACAcAMP-dependent protein kinase alpha-catalytic subunitT12808SEA
    P30939HTR1FSerotonin 1f (5-HT1f) receptorT78656SEA
    Q05513PRKCZProtein kinase C (PKC)T59190SEA
    P05129PRKCGProtein kinase C gammaT47107SEA
    Q5VT25CDC42BPASerine or threonine-protein kinase MRCK-AT00075SEA
    O96013PAK4Serine/threonine-protein kinase PAK 4T98293SEA
    P51511MMP15Matrix metalloproteinase 15T81658SEA
    P28336NMBRNeuromedin B receptorT68887SEA
    P37840SNCAAlpha-synucleinT03644SEA
    Q96DB2HDAC11Histone deacetylase 11T97903SEA
    P33032MC5RMelanocortin receptor 5T95302SEA
    P28336NMBRNeuromedin B receptorT68887SEA
    Q16513PKN2Protein kinase N2T94197SEA
    Q9UQM7CAMK2ACaM kinase II alphaT18299SEA
    Q9NZ08ERAP1Endoplasmic reticulum aminopeptidase 1T72849SEA
    Q9NQS5GPR84G-protein coupled receptor 84T98091SEA
    O43781DYRK3Dual-specificity tyrosine-phosphorylation regulated kinase 3T97149SEA
    Q06609RAD51DNA repair protein RAD51 homolog 1T63083SEA
    P35270SPRSubstance-P receptorT47094SEA
    P24347MMP11Matrix metalloproteinase-11T73180SEA
    Q9ULZ9MMP17Matrix metalloproteinase-17T55616SEA
    Q96BR1SGK3Serum-and glucocorticoid-inducible kinase SGKT64102SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T03691DI0012Acute myeloid leukaemia[ICD-11: 2A60]P09960LTA4H
    T05090DI0241Lymphoma[ICD-11: 2A80-2A86]O15379HDAC3
    T05090DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15379HDAC3
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T24983DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21917DRD4
    T24983DI0370Schizophrenia[ICD-11: 6A20]P21917DRD4
    T67162DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P14416DRD2
    T67162DI0025Alzheimer disease[ICD-11: 8A20]P14416DRD2
    T67162DI0037Asthma[ICD-11: CA23]P14416DRD2
    T67162DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P14416DRD2
    T67162DI0051Bipolar disorder[ICD-11: 6A60]P14416DRD2
    T67162DI0063Breathing abnormality[ICD-11: MD11]P14416DRD2
    T67162DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P14416DRD2
    T67162DI0073Cerebral ischaemia[ICD-11: 8B1Z]P14416DRD2
    T67162DI0117Depression[ICD-11: 6A70-6A7Z]P14416DRD2
    T67162DI0124Digestive system disease[ICD-11: DE2Z]P14416DRD2
    T67162DI0137Essential hypertension[ICD-11: BA00]P14416DRD2
    T67162DI0142Faecal incontinence[ICD-11: ME07]P14416DRD2
    T67162DI0156Gangrene[ICD-11: MC85]P14416DRD2
    T67162DI0166Glaucoma[ICD-11: 9C61]P14416DRD2
    T67162DI0175Heart failure[ICD-11: BD10-BD1Z]P14416DRD2
    T67162DI0185Hyperaemia[ICD-11: 9A61-9B7Y]P14416DRD2
    T67162DI0190Hypertension[ICD-11: BA00-BA04]P14416DRD2
    T67162DI0196Hypotension[ICD-11: BA20-BA21]P14416DRD2
    T67162DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]P14416DRD2
    T67162DI0214Insomnia[ICD-11: 7A00-7A0Z]P14416DRD2
    T67162DI0222Itching[ICD-11: 1F28-1G07]P14416DRD2
    T67162DI0264Migraine[ICD-11: 8A80]P14416DRD2
    T67162DI0293Nausea/vomiting[ICD-11: MD90]P14416DRD2
    T67162DI0324Pain[ICD-11: MG30-MG3Z]P14416DRD2
    T67162DI0331Parkinsonism[ICD-11: 8A00]P14416DRD2
    T67162DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P14416DRD2
    T67162DI0340Postpartum haemorrhage[ICD-11: JA43]P14416DRD2
    T67162DI0354Psychotic disorder[ICD-11: 6A20-6A25]P14416DRD2
    T67162DI0356Pulmonary hypertension[ICD-11: BB01]P14416DRD2
    T67162DI0370Schizophrenia[ICD-11: 6A20]P14416DRD2
    T67162DI0396Substance abuse[ICD-11: 6C40]P14416DRD2
    T67162DI0408Thyrotoxicosis[ICD-11: 5A02]P14416DRD2
    T67162DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14416DRD2
    T31391DI0009Acute diabete complication[ICD-11: 5A2Y]P27487DPP4
    T31391DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P27487DPP4
    T06569DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P23280CA6
    T06569DI0372Seborrhoeic dermatitis[ICD-11: EA81]P23280CA6
    T32060DI0009Acute diabete complication[ICD-11: 5A2Y]P28223HTR2A
    T32060DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P28223HTR2A
    T32060DI0073Cerebral ischaemia[ICD-11: 8B1Z]P28223HTR2A
    T32060DI0270Mood disorder[ICD-11: 6A60-6E23]P28223HTR2A
    T32060DI0331Parkinsonism[ICD-11: 8A00]P28223HTR2A
    T32060DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28223HTR2A
    T32060DI0370Schizophrenia[ICD-11: 6A20]P28223HTR2A
    T83813DI0117Depression[ICD-11: 6A70-6A7Z]P28335HTR2C
    T83813DI0264Migraine[ICD-11: 8A80]P28335HTR2C
    T83813DI0308Obesity[ICD-11: 5B80-5B81]P28335HTR2C
    T83813DI0324Pain[ICD-11: MG30-MG3Z]P28335HTR2C
    T83813DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28335HTR2C
    T27812DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P31645SLC6A4
    T27812DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P31645SLC6A4
    T27812DI0087Chronic pain[ICD-11: MG30]P31645SLC6A4
    T27812DI0096concerning food/fluid intake symptom[ICD-11: MG43]P31645SLC6A4
    T27812DI0101Corneal disease[ICD-11: 9A76-9A78]P31645SLC6A4
    T27812DI0105Cough[ICD-11: MD12]P31645SLC6A4
    T27812DI0117Depression[ICD-11: 6A70-6A7Z]P31645SLC6A4
    T27812DI0264Migraine[ICD-11: 8A80]P31645SLC6A4
    T27812DI0301Nicotine use disorder[ICD-11: 6C4A]P31645SLC6A4
    T27812DI0308Obesity[ICD-11: 5B80-5B81]P31645SLC6A4
    T27812DI0324Pain[ICD-11: MG30-MG3Z]P31645SLC6A4
    T99524DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q96RJ0TAAR1
    T99524DI0149Focal/segmental autonomic disorder[ICD-11: 8D8A]Q96RJ0TAAR1
    T99524DI0290Narcolepsy[ICD-11: 7A20]Q96RJ0TAAR1
    T31204DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P41595HTR2B
    T31204DI0117Depression[ICD-11: 6A70-6A7Z]P41595HTR2B
    T31204DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P41595HTR2B
    T31204DI0354Psychotic disorder[ICD-11: 6A20-6A25]P41595HTR2B
    T11448DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P08913ADRA2A
    T11448DI0317Opioid use disorder[ICD-11: 6C43]P08913ADRA2A
    T11448DI0396Substance abuse[ICD-11: 6C40]P08913ADRA2A
    T07806DI0264Migraine[ICD-11: 8A80]P28222HTR1B
    T07806DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28222HTR1B
    T07806DI0354Psychotic disorder[ICD-11: 6A20-6A25]P28222HTR1B
    T07806DI0370Schizophrenia[ICD-11: 6A20]P28222HTR1B
    T11072DI0264Migraine[ICD-11: 8A80]P28221HTR1D
    T11072DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28221HTR1D
    T44068DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P08588ADRB1
    T44068DI0037Asthma[ICD-11: CA23]P08588ADRB1
    T44068DI0068Cardiac arrhythmia[ICD-11: BC9Z]P08588ADRB1
    T44068DI0071Central and peripheral nervous disease[ICD-11: 8A04-8E7Z]P08588ADRB1
    T44068DI0088Circulatory system disease[ICD-11: BE2Z]P08588ADRB1
    T44068DI0097Conduction disorder[ICD-11: BC63]P08588ADRB1
    T44068DI0102Coronary atherosclerosis[ICD-11: BA52]P08588ADRB1
    T44068DI0137Essential hypertension[ICD-11: BA00]P08588ADRB1
    T44068DI0166Glaucoma[ICD-11: 9C61]P08588ADRB1
    T44068DI0175Heart failure[ICD-11: BD10-BD1Z]P08588ADRB1
    T44068DI0190Hypertension[ICD-11: BA00-BA04]P08588ADRB1
    T44068DI0264Migraine[ICD-11: 8A80]P08588ADRB1
    T44068DI0375Sepsis[ICD-11: 1G40-1G41]P08588ADRB1
    T44068DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P08588ADRB1
    T44068DI0434Ventricular tachyarrhythmia[ICD-11: BC71]P08588ADRB1
    T78709DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P08908HTR1A
    T78709DI0117Depression[ICD-11: 6A70-6A7Z]P08908HTR1A
    T78709DI0190Hypertension[ICD-11: BA00-BA04]P08908HTR1A
    T78709DI0264Migraine[ICD-11: 8A80]P08908HTR1A
    T78709DI0270Mood disorder[ICD-11: 6A60-6E23]P08908HTR1A
    T84117DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28566HTR1E
    T79062DI0025Alzheimer disease[ICD-11: 8A20]P34969HTR7
    T79062DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34969HTR7
    T79062DI0051Bipolar disorder[ICD-11: 6A60]P34969HTR7
    T79062DI0117Depression[ICD-11: 6A70-6A7Z]P34969HTR7
    T79062DI0265Mild neurocognitive disorder[ICD-11: 6D71]P34969HTR7
    T79062DI0331Parkinsonism[ICD-11: 8A00]P34969HTR7
    T79062DI0370Schizophrenia[ICD-11: 6A20]P34969HTR7
    T16691DI0025Alzheimer disease[ICD-11: 8A20]P50406HTR6
    T16691DI0370Schizophrenia[ICD-11: 6A20]P50406HTR6
    T55959DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q01959SLC6A3
    T55959DI0051Bipolar disorder[ICD-11: 6A60]Q01959SLC6A3
    T55959DI0101Corneal disease[ICD-11: 9A76-9A78]Q01959SLC6A3
    T55959DI0290Narcolepsy[ICD-11: 7A20]Q01959SLC6A3
    T55959DI0308Obesity[ICD-11: 5B80-5B81]Q01959SLC6A3
    T55959DI0331Parkinsonism[ICD-11: 8A00]Q01959SLC6A3
    T23471DI0229Left ventricular failure[ICD-11: BD11]P05164MPO
    T23471DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P05164MPO
    T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
    T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
    T80975DI0062Breast cancer[ICD-11: 2C60-2C6Y]P35968KDR
    T80975DI0095Colorectal cancer[ICD-11: 2B91]P35968KDR
    T80975DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P35968KDR
    T80975DI0244Malignant digestive organ neoplasm[ICD-11: 2C11]P35968KDR
    T80975DI0361Renal cell carcinoma[ICD-11: 2C90]P35968KDR
    T80975DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35968KDR
    T80975DI0395Stomach cancer[ICD-11: 2B72]P35968KDR
    T80975DI0403Thrombocytopenia[ICD-11: 3B64]P35968KDR
    T80975DI0407Thyroid cancer[ICD-11: 2D10]P35968KDR
    T72168DI0018Adrenocortical insufficiency[ICD-11: 5A74]P08235NR3C2
    T72168DI0083Chronic kidney disease[ICD-11: GB61]P08235NR3C2
    T72168DI0100Contraceptive management[ICD-11: QA21]P08235NR3C2
    T72168DI0175Heart failure[ICD-11: BD10-BD1Z]P08235NR3C2
    T72168DI0190Hypertension[ICD-11: BA00-BA04]P08235NR3C2
    T72168DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P08235NR3C2
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T77913DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P35367HRH1
    T77913DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P35367HRH1
    T77913DI0063Breathing abnormality[ICD-11: MD11]P35367HRH1
    T77913DI0099Conjunctiva disorder[ICD-11: 9A60]P35367HRH1
    T77913DI0105Cough[ICD-11: MD12]P35367HRH1
    T77913DI0117Depression[ICD-11: 6A70-6A7Z]P35367HRH1
    T77913DI0136Episodic vestibular syndrome[ICD-11: AB31]P35367HRH1
    T77913DI0173Headache[ICD-11: 8A80-8A84]P35367HRH1
    T77913DI0214Insomnia[ICD-11: 7A00-7A0Z]P35367HRH1
    T77913DI0272Morning sickness disorder[ICD-11: SC00]P35367HRH1
    T77913DI0292Nasopharyngitis[ICD-11: CA00]P35367HRH1
    T77913DI0293Nausea/vomiting[ICD-11: MD90]P35367HRH1
    T77913DI0331Parkinsonism[ICD-11: 8A00]P35367HRH1
    T77913DI0349Pruritus[ICD-11: EC90]P35367HRH1
    T77913DI0366Rheumatoid arthritis[ICD-11: FA20]P35367HRH1
    T77913DI0388Sleep-wake disorder[ICD-11: 7A00-7B2Z]P35367HRH1
    T77913DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P35367HRH1
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T41955DI0422Upper respiratory tract disorder[ICD-11: CA0Z]Q7Z2W7TRPM8
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T48069DI0276Multiple structural anomalies syndrome[ICD-11: LD2F]P08069IGF1R
    T48069DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P08069IGF1R
    T48069DI0408Thyrotoxicosis[ICD-11: 5A02]P08069IGF1R
    T02551DI0051Bipolar disorder[ICD-11: 6A60]P35462DRD3
    T02551DI0331Parkinsonism[ICD-11: 8A00]P35462DRD3
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T21945DI0013Acute pain[ICD-11: MG31]P23975SLC6A2
    T21945DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P23975SLC6A2
    T21945DI0087Chronic pain[ICD-11: MG30]P23975SLC6A2
    T21945DI0101Corneal disease[ICD-11: 9A76-9A78]P23975SLC6A2
    T21945DI0117Depression[ICD-11: 6A70-6A7Z]P23975SLC6A2
    T21945DI0166Glaucoma[ICD-11: 9C61]P23975SLC6A2
    T21945DI0264Migraine[ICD-11: 8A80]P23975SLC6A2
    T21945DI0301Nicotine use disorder[ICD-11: 6C4A]P23975SLC6A2
    T21945DI0308Obesity[ICD-11: 5B80-5B81]P23975SLC6A2
    T21945DI0324Pain[ICD-11: MG30-MG3Z]P23975SLC6A2
    T21945DI0395Stomach cancer[ICD-11: 2B72]P23975SLC6A2
    T59679DI0161Gastro-oesophageal reflux disease[ICD-11: DA22]Q13639HTR4
    T59679DI0218Irritable bowel syndrome[ICD-11: DD91]Q13639HTR4
    T01777DI0166Glaucoma[ICD-11: 9C61]P18825ADRA2C
    T01777DI0190Hypertension[ICD-11: BA00-BA04]P18825ADRA2C
    T01777DI0196Hypotension[ICD-11: BA20-BA21]P18825ADRA2C
    T01777DI0308Obesity[ICD-11: 5B80-5B81]P18825ADRA2C
    T01777DI0310Ocular disease[ICD-11: N.A.]P18825ADRA2C
    T01777DI0396Substance abuse[ICD-11: 6C40]P18825ADRA2C
    T29500DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P35368ADRA1B
    T29500DI0190Hypertension[ICD-11: BA00-BA04]P35368ADRA1B
    T29500DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P35368ADRA1B
    T29500DI0308Obesity[ICD-11: 5B80-5B81]P35368ADRA1B
    T29500DI0324Pain[ICD-11: MG30-MG3Z]P35368ADRA1B
    T60693DI0304Non-specific cutaneous vascular symptom[ICD-11: ME64]P41145OPRK1
    T60693DI0324Pain[ICD-11: MG30-MG3Z]P41145OPRK1
    T60693DI0349Pruritus[ICD-11: EC90]P41145OPRK1
    T28484DI0012Acute myeloid leukaemia[ICD-11: 2A60]P52732KIF11
    T28484DI0172Head and neck cancer[ICD-11: 2D42]P52732KIF11
    T28484DI0241Lymphoma[ICD-11: 2A80-2A86]P52732KIF11
    T28484DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P52732KIF11
    T28484DI0274Multiple myeloma[ICD-11: 2A83]P52732KIF11
    T28484DI0321Ovarian cancer[ICD-11: 2C73]P52732KIF11
    T28484DI0361Renal cell carcinoma[ICD-11: 2C90]P52732KIF11
    T28484DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P52732KIF11
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T47094DI0117Depression[ICD-11: 6A70-6A7Z]P35270SPR
    T47094DI0293Nausea/vomiting[ICD-11: MD90]P35270SPR
    T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
    T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
    T72458DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]P32245MC4R
    T72458DI0228Large intestine motility disorder[ICD-11: DB32]P32245MC4R
    T72458DI0308Obesity[ICD-11: 5B80-5B81]P32245MC4R
    T61746DI0023Alopecia[ICD-11: ED70]P07858CTSB
    T61746DI0025Alzheimer disease[ICD-11: 8A20]P07858CTSB
    T61746DI0037Asthma[ICD-11: CA23]P07858CTSB
    T61746DI0055Bone cancer[ICD-11: 2B5Z]P07858CTSB
    T61746DI0060Brain cancer[ICD-11: 2A00]P07858CTSB
    T61746DI0067Cardiac arrest[ICD-11: MC82]P07858CTSB
    T61746DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P07858CTSB
    T61746DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07858CTSB
    T61746DI0087Chronic pain[ICD-11: MG30]P07858CTSB
    T61746DI0110Cystic fibrosis[ICD-11: CA25]P07858CTSB
    T61746DI0124Digestive system disease[ICD-11: DE2Z]P07858CTSB
    T61746DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P07858CTSB
    T61746DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P07858CTSB
    T61746DI0253Meningioma[ICD-11: 2A01]P07858CTSB
    T61746DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P07858CTSB
    T61746DI0275Multiple sclerosis[ICD-11: 8A40]P07858CTSB
    T61746DI0296Neurodegenerative disorder[ICD-11: 8A20-8A23]P07858CTSB
    T61746DI0320Osteoarthritis[ICD-11: FA00-FA05]P07858CTSB
    T61746DI0351Psoriasis[ICD-11: EA90]P07858CTSB
    T61746DI0366Rheumatoid arthritis[ICD-11: FA20]P07858CTSB
    T59604DI0087Chronic pain[ICD-11: MG30]Q92847GHSR
    T59604DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]Q92847GHSR
    T35842DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]Q01726MC1R
    T35842DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]Q01726MC1R
    T76846DI0308Obesity[ICD-11: 5B80-5B81]P41968MC3R
    T76846DI0378Sexual dysfunction[ICD-11: HA00-HA01]P41968MC3R
    T76846DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P41968MC3R
    T92609DI0190Hypertension[ICD-11: BA00-BA04]P35348ADRA1A
    T92609DI0348Prostate hyperplasia[ICD-11: GA90]P35348ADRA1A
    T67619DI0062Breast cancer[ICD-11: 2C60-2C6Y]P31749AKT1
    T07303DI0361Renal cell carcinoma[ICD-11: 2C90]P35916FLT4
    T15571DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P47898HTR5A
    T97613DI0214Insomnia[ICD-11: 7A00-7A0Z]P48039MTNR1A
    T48268DI0214Insomnia[ICD-11: 7A00-7A0Z]P49286MTNR1B
    T88304DI0012Acute myeloid leukaemia[ICD-11: 2A60]P26358DNMT1
    T88304DI0284Myelodysplastic syndrome[ICD-11: 2A37]P26358DNMT1
    T88304DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P26358DNMT1
    T41580DI0396Substance abuse[ICD-11: 6C40]P18089ADRA2B
    T76910DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P49840GSK3A
    T64830DI0108Cushing syndrome[ICD-11: 5A70]P35346SSTR5
    T53024DI0108Cushing syndrome[ICD-11: 5A70]P30874SSTR2
    T53024DI0122Diagnostic imaging[ICD-11: N.A.]P30874SSTR2
    T53024DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30874SSTR2
    T62974DI0087Chronic pain[ICD-11: MG30]P31391SSTR4
    T62974DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P31391SSTR4
    T16633DI0108Cushing syndrome[ICD-11: 5A70]P30872SSTR1
    T16633DI0395Stomach cancer[ICD-11: 2B72]P30872SSTR1
    T13644DI0108Cushing syndrome[ICD-11: 5A70]P32745SSTR3
    T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
    T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
    T65019DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P50281MMP14
    T71266DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9Y243AKT3
    T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
    T97035DI0007Acquired hypermelanosis[ICD-11: ED60]P14679TYR
    T97035DI0008Acquired hypomelanotic disorder[ICD-11: ED63]P14679TYR
    T52790DI0218Irritable bowel syndrome[ICD-11: DD91]P21452TACR2
    T55654DI0110Cystic fibrosis[ICD-11: CA25]P13569CFTR
    T55654DI0217Intrathoracic organs injury[ICD-11: NB32]P13569CFTR
    T55654DI0435Viral intestinal infection[ICD-11: 1A2Z]P13569CFTR
    T03279DI0249Mature B-cell leukaemia[ICD-11: 2A82]P51812RPS6KA3
    T12808DI0279Muscular atrophy[ICD-11: 8B61]P17612PRKACA
    T78656DI0264Migraine[ICD-11: 8A80]P30939HTR1F
    T78656DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30939HTR1F
    T59190DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q05513PRKCZ
    T47107DI0012Acute myeloid leukaemia[ICD-11: 2A60]P05129PRKCG
    T47107DI0248Mastocytosis[ICD-11: 2A21]P05129PRKCG
    T98293DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O96013PAK4
    T98293DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O96013PAK4
    T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
    T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
    T03644DI0025Alzheimer disease[ICD-11: 8A20]P37840SNCA
    T03644DI0044Autonomic nervous system disorder[ICD-11: 8D87]P37840SNCA
    T03644DI0331Parkinsonism[ICD-11: 8A00]P37840SNCA
    T95302DI0005Acne vulgaris[ICD-11: ED80]P33032MC5R
    T95302DI0371Sebaceous gland disorder[ICD-11: ED91]P33032MC5R
    T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
    T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
    T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
    T98091DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q9NQS5GPR84
    T98091DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q9NQS5GPR84
    T63083DI0048B-cell lymphoma[ICD-11: 2A86]Q06609RAD51
    T63083DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06609RAD51
    T47094DI0117Depression[ICD-11: 6A70-6A7Z]P35270SPR
    T47094DI0293Nausea/vomiting[ICD-11: MD90]P35270SPR

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