Compound details

L-N-(1H-Indol-3-ylacetyl)glutamic acid

Compound ID	CDAMM01544
Common name	L-N-(1H-Indol-3-ylacetyl)glutamic acid
IUPAC name	2-[[2-(1H-indol-3-yl)acetyl]amino]pentanedioic acid
Molecular formula	C₁₅H₁₆N₂O₅

Experimental data

Retention time	9.31
Adduct	[2M+K]+
Actual mz	647.181
Theoretical mz	647.175
Error	8.56
Ionizaton mode	Positive
Instrument type	LC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score	6.1123

Identifiers and class information

Inchi key	YRKLGWOHYXIKSF-UHFFFAOYNA-N
Smiles	O=C(O)CCC(NC(=O)CC1=CNC=2C=CC=CC21)C(=O)O
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives

Plant source

Cinnamomum tamala (Buch.-Ham.) T.Nees & C.H.Eberm.

External sources

HMDB ID	HMDB0038665
KNApSAcK ID
FooDB ID	FDB018064
DrugBank ID
ChEBI ID	CHEBI:133516
Pubchem Compound ID	25200809
PlantCyc ID	INDOLE-3-ACETYL-GLU
UNPD ID	UNPD3249
Coconut ID	CNP0111070
LipidMAPS ID
NANPDB ID

Pharmacokinetic properties

Number of descriptor values(#stars)	0
Number of non-conjugated amine groups (#amine)	0
Number of amidine and guanidine groups (#amidine)	0
Number of carboxylic acid groups (#acid)	2
Number of non-conjugated amide groups (#amide)	1
Number of rotatable bonds (#rotor)	7
Number of reactive functional groups (#rtvFG)	0
Predicted central nervous system activity (CNS)	-2
Molecular weight (mol_MW)	304.302
Computed dipole moment(dipole)	12.149
Total solvent accessible surface area (SASA)	506.1
Hydrophobic component of SASA (FOSA)	104.667
Hydrophilic component of SASA (FISA)	231.378
Pie component of the SASA (PISA)	170.055
Weakly polar component of the SASA (WPSA)	0
Total solvent accesible volume (volume)	917.216
Number of hydrogen bond donors (donorHB)	3.25
Number of hydrogen bond acceptors (accptHB)	5.75
Free energy of solvation of dipole (dip^2/V)	0.160922
Index of cohesive interaction in solids (ACxDN^.5/SA)	0.020482
Globularity descriptor (glob)	0.902076
Predicted polarizability in cubic angstroms (QPpolrz)	27.682
Predicted hexadecane/gas partition coefficient (QPlogPC16)	10.521
Predicted octanol/gas partition coefficient (QPlogPoct)	19.372
Predicted water/gas partition coefficient (QPlogPw)	14.982
Predicted octanol/water partition coefficient (QPlogPo/w)	1.416
Predicted aqueous solubility (QPlogS)	-1.311
Conformation-independent predicted aqueous solubility (CIQPlogS)	-2.933
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)	1.062
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)	2.223
Predicted brain/blood partition coefficient (QPlogBB)	-1.754
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)	2.083
Predicted skin permeability, log Kp (QPlogKp)	-4.513
PM3 calculated ionization potential (IP(ev))	8.727
PM3 calculated electron affinity (EA(eV))	0.399
Number of likely metabolic reactions (#metab)	3
Prediction of binding to human serum albumin (QPlogKhsa)	-0.911
Predicted qualitative human oral absorption (HumanOralAbsorption)	1
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)	41.448
Solvent-accessible surface area of fluorine atoms (SAFluorine)	0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)	32.904
Van der Waals surface area (PSA)	144.733
Number of nitrogen and oxygen atoms (#NandO)	7
Number of violations of Lipinskiâ€™s rule of five (RuleOfFive)	0
Number of violations of Jorgensenâ€™s rule of three (RuleOfThree)	1

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID	Gene name	Target name	TTD_ID	Prediction source
P22303	ACHE	Acetylcholinesterase	T30082	SwissTargetPrediction and SEA
P20309	CHRM3	Muscarinic acetylcholine receptor M3	T67684	SwissTargetPrediction
P04818	TYMS	Thymidylate synthase (by homology)	T98397	SEA
Q99720	SIGMAR1	Sigma opioid receptor	T46360	SwissTargetPrediction
P34903	GABRA3	GABA A receptor alpha-3/beta-2/gamma-2	T62292	SwissTargetPrediction
P47869	GABRA2	GABA A receptor alpha-2/beta-2/gamma-2	T51452	SwissTargetPrediction
P12821	ACE	Angiotensin-converting enzyme	T98311	SwissTargetPrediction
Q96KS0	EIT6	HIF-prolyl hydroxylase 1	T53904	SwissTargetPrediction
P09960	LTA4H	Leukotriene A4 hydrolase	T03691	SwissTargetPrediction and SEA
O15379	HDAC3	Histone deacetylase 3	T05090	SEA
P21917	DRD4	Dopamine D4 receptor	T24983	SEA
P00918	CA2	Carbonic anhydrase II	T20401	SEA
P14416	DRD2	Dopamine D2 receptor	T67162	SEA
P08514	ITGA2B	Integrin alpha-IIb/beta-3	T50688	SEA
P98170	XIAP	Inhibitor of apoptosis protein 3	T16769	SwissTargetPrediction
P78352	DLG4	Disks large homolog 4	T04507	SEA
P08473	MME	Neprilysin	T05409	SwissTargetPrediction and SEA
P21554	CNR1	Cannabinoid receptor 1 (by homology)	T76685	SwissTargetPrediction
P31645	SLC6A4	Serotonin transporter (by homology)	T27812	SwissTargetPrediction
P28222	HTR1B	Serotonin 1b (5-HT1b) receptor	T07806	SEA
P28221	HTR1D	Serotonin 1d (5-HT1d) receptor	T11072	SEA
P08908	HTR1A	Serotonin 1a (5-HT1a) receptor	T78709	SEA
P28566	HTR1E	Serotonin 1e (5-HT1e) receptor	T84117	SEA
P14867	GABRA1	GABA-A receptor; alpha-1/beta-2/gamma-2	T51487	SwissTargetPrediction
Q9UQL6	HDAC5	Histone deacetylase 5	T07930	SEA
Q8WUI4	HDAC7	Histone deacetylase 7	T98698	SEA
P56524	HDAC4	Histone deacetylase 4	T63816	SEA
Q9UKV0	HDAC9	Histone deacetylase 9	T03687	SEA
Q92769	HDAC2	Histone deacetylase 2	T51191	SEA
O15229	KMO	Kynurenine 3-monooxygenase	T50973	SwissTargetPrediction
P53779	MAPK10	c-Jun N-terminal kinase 3	T85421	SEA
P08235	NR3C2	Mineralocorticoid receptor	T72168	SEA
P04150	NR3C1	Glucocorticoid receptor	T40016	SEA
P18031	PTPN1	Protein-tyrosine phosphatase 1B	T16347	SwissTargetPrediction and SEA
P17706	PTPN2	T-cell protein-tyrosine phosphatase	T49156	SwissTargetPrediction
P15090	FABP4	Fatty acid binding protein adipocyte	T07217	SEA
P28845	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	T65200	SwissTargetPrediction
P06746	POLB	DNA polymerase beta (by homology)	T06958	SEA
P08253	MMP2	Matrix metalloproteinase 2	T68251	SEA
P22894	MMP8	Matrix metalloproteinase 8	T08856	SwissTargetPrediction and SEA
P08254	MMP3	Matrix metalloproteinase 3	T86702	SEA
P14780	MMP9	Matrix metalloproteinase 9	T54156	SEA
P09467	FBP1	Fructose-1,6-bisphosphatase	T83391	SwissTargetPrediction
P09917	ALOX5	Arachidonate 5-lipoxygenase	T00140	SwissTargetPrediction
P03956	MMP1	Matrix metalloproteinase 1	T52450	SEA
Q9HC97	GPR35	G-protein coupled receptor 35	T56143	SwissTargetPrediction
P35462	DRD3	Dopamine D3 receptor	T02551	SEA
P35372	OPRM1	Mu opioid receptor	T47768	SEA
P10827	THRA	Thyroid hormone receptor alpha	T79591	SEA
P27695	APEX1	DNA-(apurinic or apyrimidinic site) lyase	T13348	SwissTargetPrediction
P54760	EPHB4	Ephrin receptor	T49507	SwissTargetPrediction
P06276	BCHE	Butyrylcholinesterase	T99799	SwissTargetPrediction and SEA
P45452	MMP13	Matrix metalloproteinase 13	T34296	SEA
P09237	MMP7	Matrix metalloproteinase 7	T73475	SwissTargetPrediction and SEA
P13497	BMP1	Bone morphogenetic protein 1	T53350	SEA
P35270	SPR	Substance-P receptor	T47094	SwissTargetPrediction and SEA
P07711	CTSL	Cathepsin L	T98691	SEA
P32245	MC4R	Melanocortin receptor 4	T72458	SwissTargetPrediction and SEA
P07858	CTSB	Cathepsin (B and K)	T61746	SwissTargetPrediction and SEA
Q92847	GHSR	Ghrelin receptor	T59604	SwissTargetPrediction and SEA
P41143	OPRD1	Delta opioid receptor	T58992	SEA
Q01726	MC1R	Melanocortin receptor 1	T35842	SwissTargetPrediction and SEA
P41968	MC3R	Melanocortin receptor 3	T76846	SwissTargetPrediction and SEA
P23946	CMA1	Chymase	T05114	SEA
Q13490	BIRC2	Baculoviral IAP repeat-containing protein 2	T84780	SwissTargetPrediction
P37231	PPARG	Peroxisome proliferator-activated receptor gamma	T58921	SwissTargetPrediction
P49356	FNTB	Farnesyl protein transferase	T13127	SEA
Q06124	PTPN11	Protein-tyrosine phosphatase 2C	T13057	SwissTargetPrediction
P13500	CCL2	C-C motif chemokine 2	T89988	SEA
Q13418	ILK	Serine/threonine-protein kinase ILK-1	T13616	SwissTargetPrediction
P31749	AKT1	Serine/threonine-protein kinase AKT	T67619	SEA
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	T18477	SwissTargetPrediction
P47871	GCGR	Glucagon receptor	T60182	SwissTargetPrediction
P49810	PSEN2	Gamma-secretase	T99204	SEA
P29466	CASP1	Caspase-1	T98269	SwissTargetPrediction and SEA
P12931	SRC	Tyrosine-protein kinase SRC	T85943	SEA
P09211	GSTP1	Glutathione S-transferase Pi	T21669	SwissTargetPrediction and SEA
Q6P179	ERAP2	Endoplasmic reticulum aminopeptidase 2	T65818	SEA
P48039	MTNR1A	Melatonin receptor 1A	T97613	SEA
P49286	MTNR1B	Melatonin receptor 1B	T48268	SEA
P47712	PLA2G4A	Cytosolic phospholipase A2	T14834	SEA
P04439	HLA-A	HLA class I histocompatibility antigen A-3	T08985	SwissTargetPrediction and SEA
P25090	FPR2	Lipoxin A4 receptor (by homology)	T97917	SEA
Q9BYF1	ACE2	Angiotensin-converting enzyme 2	T27889	SEA
P42892	ECE1	Endothelin-converting enzyme 1	T50970	SwissTargetPrediction and SEA
P30307	CDC25C	Dual specificity phosphatase Cdc25C	T40569	SEA
P05556	ITGB1	Integrin alpha2/beta1	T01851	SEA
P25101	EDNRA	Endothelin receptor ET-A	T23499	SwissTargetPrediction and SEA
P39900	MMP12	Matrix metalloproteinase 12	T03500	SEA
P49840	GSK3A	Glycogen synthase kinase-3 alpha	T76910	SEA
P06737	PYGL	Liver glycogen phosphorylase	T19184	SEA
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor	T15439	SEA
P35346	SSTR5	Somatostatin receptor 5	T64830	SwissTargetPrediction and SEA
P30874	SSTR2	Somatostatin receptor 2	T53024	SwissTargetPrediction and SEA
P31391	SSTR4	Somatostatin receptor 4	T62974	SwissTargetPrediction and SEA
P30872	SSTR1	Somatostatin receptor 1	T16633	SwissTargetPrediction and SEA
P32745	SSTR3	Somatostatin receptor 3	T13644	SwissTargetPrediction and SEA
P15085	CPA1	Carboxypeptidase A1	T33966	SEA
P32239	CCKBR	Cholecystokinin B receptor (by homology)	T05849	SwissTargetPrediction and SEA
P30989	NTSR1	Neurotensin receptor 1	T02728	SwissTargetPrediction and SEA
P50281	MMP14	Matrix metalloproteinase 14	T65019	SEA
P16109	SELP	P-selectin	T10965	SEA
Q9Y243	AKT3	Serine/threonine-protein kinase AKT	T71266	SEA
Q13976	PRKG1	cGMP-dependent protein kinase 1 beta	T78543	SEA
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	T40111	SEA
Q9H244	P2RY12	Purinergic receptor P2Y12 (by homology)	T46937	SEA
P32238	CCKAR	Cholecystokinin A receptor	T28330	SwissTargetPrediction and SEA
Q9UQM7	CAMK2A	CaM kinase II alpha	T18299	SEA
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	T30219	SEA
P28074	PSMB5	Proteasome Macropain subunit MB1	T49031	SEA
P24530	EDNRB	Endothelin receptor ET-B	T92828	SEA
P14679	TYR	Tyrosinase	T97035	SEA
Q9Y3Q0	NAALAD2	NAALADase II	T70036	SEA
Q92820	GGH	Gamma-glutamyl hydrolase	T71646	SEA
P29317	EPHA2	Ephrin type-A receptor 2	T57278	SwissTargetPrediction
P00374	DHFR	Dihydrofolate reductase	T17345	SEA
P21452	TACR2	Neurokinin 2 receptor	T52790	SwissTargetPrediction and SEA
P53609	PGGT1B	Geranylgeranyl transferase type I	T76396	SEA
P09238	MMP10	Matrix metalloproteinase 10	T40488	SEA
P13569	CFTR	Cystic fibrosis transmembrane conductance regulator	T55654	SEA
Q13526	PIN1	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	T16308	SEA
Q16549	PCSK7	Subtilisin/kexin type 7	T33211	SEA
P29371	TACR3	Neurokinin 3 receptor	T29683	SwissTargetPrediction and SEA
Q9UIQ6	LNPEP	Cystinyl aminopeptidase	T97537	SEA
P15735	PHKG2	Phosphorylase kinase gamma subunit 2	T69208	SEA
Q13237	PRKG2	cGMP-dependent protein kinase 2	T23606	SEA
P29323	EPHB2	Ephrin type-B receptor 2	T73756	SwissTargetPrediction
P22102	GART	GAR transformylase	T72042	SEA
P15328	FOLR1	Folate receptor alpha	T83386	SEA
P14207	FOLR2	Folate receptor beta	T82297	SEA
Q96NT5	SLC46A1	Proton-coupled folate transporter	T19229	SEA
Q04760	GLO1	Glyoxalase I	T88285	SEA
P98073	TMPRSS15	Enteropeptidase	T75772	SEA
P29320	EPHA3	Ephrin type-A receptor 3	T28413	SwissTargetPrediction
P28065	PSMB9	Proteasome subunit beta type-9	T06792	SEA
P28062	PSMB8	Proteasome subunit beta type-8	T77350	SEA
Q8IU80	TMPRSS6	Transmembrane protease serine 6	T13863	SEA
Q9Y5Y6	ST14	Matriptase	T31543	SEA
P40337	VHL	Von Hippel-Lindau disease tumor suppressor/Elongin B/Elongin C	T80423	SEA
P05129	PRKCG	Protein kinase C gamma	T47107	SEA
Q5VT25	CDC42BPA	Serine or threonine-protein kinase MRCK-A	T00075	SEA
P51511	MMP15	Matrix metalloproteinase 15	T81658	SEA
P62937	PPIA	Cyclophilin A	T47081	SwissTargetPrediction
P28336	NMBR	Neuromedin B receptor	T68887	SEA
P37840	SNCA	Alpha-synuclein	T03644	SEA
Q96DB2	HDAC11	Histone deacetylase 11	T97903	SEA
P33032	MC5R	Melanocortin receptor 5	T95302	SwissTargetPrediction and SEA
P53634	CTSC	Dipeptidyl peptidase I	T70490	SwissTargetPrediction
P49768	PSEN1	Presenilin 1	T93105	SEA
P28336	NMBR	Neuromedin B receptor	T68887	SEA
P06734	FCER2	Immunoglobulin epsilon Fc receptor	T67207	SEA
P30550	GRPR	Gastrin releasing peptide receptor	T99816	SEA
P54756	EPHA5	Ephrin type-A receptor 5	T18474	SwissTargetPrediction and SEA
P54764	EPHA4	Ephrin type-A receptor 4	T70234	SwissTargetPrediction and SEA
Q9UF33	EPHA6	Ephrin type-A receptor 6	T08647	SwissTargetPrediction
P54753	EPHB3	Ephrin type-B receptor 3	T56121	SwissTargetPrediction and SEA
Q969S8	HDAC10	Histone deacetylase 10	T94324	SEA
P13612	ITGA4	Integrin alpha-4	T97587	SEA
Q9H2K8	TAOK3	Serine/threonine-protein kinase TAO3	T63682	SEA
P18507	GABRG2	GABA-A receptor; alpha-6/beta-3/gamma-2	T08910	SwissTargetPrediction
Q16513	PKN2	Protein kinase N2	T94197	SEA
Q9UQM7	CAMK2A	CaM kinase II alpha	T18299	SEA
Q9NZ08	ERAP1	Endoplasmic reticulum aminopeptidase 1	T72849	SEA
Q96BI3	APH1A	Gamma-secretase	T99840	SEA
P21462	FPR1	Formyl peptide receptor 1	T87831	SEA
P21709	EPHA1	Ephrin type-A receptor 1	T28418	SwissTargetPrediction
P29322	EPHA8	Ephrin type-A receptor 8	T58266	SwissTargetPrediction and SEA
Q15375	EPHA7	Ephrin type-A receptor 7	T57006	SwissTargetPrediction and SEA
P54762	EPHB1	Ephrin type-B receptor 1	T02446	SwissTargetPrediction
O15197	EPHB6	Ephrin receptor	T72732	SwissTargetPrediction
Q9UBC3	DNMT3B	DNA (cytosine-5)-methyltransferase 3B	T65501	SwissTargetPrediction
O95931	CBX7	Chromobox protein homolog 7	T72319	SwissTargetPrediction and SEA
P23284	PPIB	Cyclophilin B	T25847	SEA
Q04756	HGFAC	Hepatocyte growth factor activator	T38584	SEA
Q9NQS5	GPR84	G-protein coupled receptor 84	T98091	SEA
Q14145	KEAP1	Kelch-like ECH-associated protein 1	T83198	SEA
O60235	TMPRSS11D	Transmembrane protease serine 11D	T00302	SEA
O43781	DYRK3	Dual-specificity tyrosine-phosphorylation regulated kinase 3	T97149	SEA
Q04609	FOLH1	Glutamate carboxypeptidase II	T97071	SEA
P09958	FUR	HUMAN dibasic-processing enzyme	T98945	SEA
P29120	PCSK1	Neuroendocrine convertase 1	T36445	SEA
Q92824	PCSK5	Proprotein convertase subtilisin/kexin type 5	T38581	SEA
Q9BY41	HDAC8	Histone deacetylase 8	T28887	SEA
Q06609	RAD51	DNA repair protein RAD51 homolog 1	T63083	SEA
Q9Y4G9	PCSK6	Proprotein convertase subtilisin/kexin type 6	T86503	SEA
P04632	CAPNS1	HUMAN calpain-1 or calpain small subunit 1 heterodimer	T00099	SEA
P51843	NR0B1	Orphan nuclear receptor DAX-1	T23191	SEA
P05106	ITGB3	Integrin beta-3	T26457	SEA
P42263	GRIA3	Glutamate receptor AMPA 3	T62391	SEA
P49356	FNTB	Farnesyl protein transferase	T13127	SEA
O95622	ADCY5	Adenylate cyclase type 5	T19531	SEA
P47870	GABRB2	GABA(A) receptor beta-2	T80387	SEA
Q9NXA8	SIRT5	NAD-dependent deacetylase sirtuin-5	T91940	SEA
Q9HAN5	TRP1	Cationic trypsinogen	T27602	SEA
P35270	SPR	Substance-P receptor	T47094	SEA
P24347	MMP11	Matrix metalloproteinase-11	T73180	SEA
P05981	HPN	Serine protease hepsin	T73471	SEA
Q9ULZ9	MMP17	Matrix metalloproteinase-17	T55616	SEA
Q96BR1	SGK3	Serum-and glucocorticoid-inducible kinase SGK	T64102	SEA
P55211	CASP9	Caspase-9	T93903	SEA
P14672	GLUT4	Glucose transporter type 4	T67658	SEA
Q96BI3	APH1A	Gamma-secretase	T99840	SEA
P16519	PCSK2	Neuroendocrine convertase 2	T97749	SEA
Q9GZT9	EGLN1	Egl nine homolog 1	T32880	SwissTargetPrediction

Target associated diseases

TTD_ID	Disease_ID	Disease name	ICD_11	Uniprot ID	Gene names
T30082	DI0025	Alzheimer disease	[ICD-11: 8A20]	P22303	ACHE
T30082	DI0166	Glaucoma	[ICD-11: 9C61]	P22303	ACHE
T30082	DI0282	Myasthenia gravis	[ICD-11: 8C6Y]	P22303	ACHE
T30082	DI0313	Oesophageal/gastroduodenal disorder	[ICD-11: DD90]	P22303	ACHE
T30082	DI0332	Pediculosis	[ICD-11: 1G00]	P22303	ACHE
T30082	DI0421	Unspecific substance harmful effect	[ICD-11: NE6Z]	P22303	ACHE
T67684	DI0037	Asthma	[ICD-11: CA23]	P20309	CHRM3
T67684	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P20309	CHRM3
T67684	DI0154	Functional bladder disorder	[ICD-11: GC50]	P20309	CHRM3
T67684	DI0166	Glaucoma	[ICD-11: 9C61]	P20309	CHRM3
T67684	DI0293	Nausea/vomiting	[ICD-11: MD90]	P20309	CHRM3
T67684	DI0333	Peptic ulcer	[ICD-11: DA61]	P20309	CHRM3
T67684	DI0362	Respiratory system disease	[ICD-11: CB40-CB7Z]	P20309	CHRM3
T67684	DI0371	Sebaceous gland disorder	[ICD-11: ED91]	P20309	CHRM3
T67684	DI0382	Sjogren syndrome	[ICD-11: 4A43]	P20309	CHRM3
T67684	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P20309	CHRM3
T98397	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P04818	TYMS
T98397	DI0395	Stomach cancer	[ICD-11: 2B72]	P04818	TYMS
T46360	DI0105	Cough	[ICD-11: MD12]	Q99720	SIGMAR1
T62292	DI0216	Intentional self-harm	[ICD-11: PC91]	P34903	GABRA3
T51452	DI0216	Intentional self-harm	[ICD-11: PC91]	P47869	GABRA2
T98311	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P12821	ACE
T98311	DI0190	Hypertension	[ICD-11: BA00-BA04]	P12821	ACE
T53904	DI0010	Acute disease anaemia	[ICD-11: 3A90]	Q96KS0	EIT6
T03691	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P09960	LTA4H
T05090	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O15379	HDAC3
T05090	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O15379	HDAC3
T24983	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	P21917	DRD4
T24983	DI0370	Schizophrenia	[ICD-11: 6A20]	P21917	DRD4
T20401	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P00918	CA2
T20401	DI0137	Essential hypertension	[ICD-11: BA00]	P00918	CA2
T20401	DI0166	Glaucoma	[ICD-11: 9C61]	P00918	CA2
T20401	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P00918	CA2
T20401	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P00918	CA2
T20401	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00918	CA2
T67162	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	P14416	DRD2
T67162	DI0025	Alzheimer disease	[ICD-11: 8A20]	P14416	DRD2
T67162	DI0037	Asthma	[ICD-11: CA23]	P14416	DRD2
T67162	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P14416	DRD2
T67162	DI0051	Bipolar disorder	[ICD-11: 6A60]	P14416	DRD2
T67162	DI0063	Breathing abnormality	[ICD-11: MD11]	P14416	DRD2
T67162	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P14416	DRD2
T67162	DI0073	Cerebral ischaemia	[ICD-11: 8B1Z]	P14416	DRD2
T67162	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P14416	DRD2
T67162	DI0124	Digestive system disease	[ICD-11: DE2Z]	P14416	DRD2
T67162	DI0137	Essential hypertension	[ICD-11: BA00]	P14416	DRD2
T67162	DI0142	Faecal incontinence	[ICD-11: ME07]	P14416	DRD2
T67162	DI0156	Gangrene	[ICD-11: MC85]	P14416	DRD2
T67162	DI0166	Glaucoma	[ICD-11: 9C61]	P14416	DRD2
T67162	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P14416	DRD2
T67162	DI0185	Hyperaemia	[ICD-11: 9A61-9B7Y]	P14416	DRD2
T67162	DI0190	Hypertension	[ICD-11: BA00-BA04]	P14416	DRD2
T67162	DI0196	Hypotension	[ICD-11: BA20-BA21]	P14416	DRD2
T67162	DI0205	Inborn porphyrin/heme metabolism error	[ICD-11: 5C58]	P14416	DRD2
T67162	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P14416	DRD2
T67162	DI0222	Itching	[ICD-11: 1F28-1G07]	P14416	DRD2
T67162	DI0264	Migraine	[ICD-11: 8A80]	P14416	DRD2
T67162	DI0293	Nausea/vomiting	[ICD-11: MD90]	P14416	DRD2
T67162	DI0324	Pain	[ICD-11: MG30-MG3Z]	P14416	DRD2
T67162	DI0331	Parkinsonism	[ICD-11: 8A00]	P14416	DRD2
T67162	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P14416	DRD2
T67162	DI0340	Postpartum haemorrhage	[ICD-11: JA43]	P14416	DRD2
T67162	DI0354	Psychotic disorder	[ICD-11: 6A20-6A25]	P14416	DRD2
T67162	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P14416	DRD2
T67162	DI0370	Schizophrenia	[ICD-11: 6A20]	P14416	DRD2
T67162	DI0396	Substance abuse	[ICD-11: 6C40]	P14416	DRD2
T67162	DI0408	Thyrotoxicosis	[ICD-11: 5A02]	P14416	DRD2
T67162	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P14416	DRD2
T50688	DI0007	Acquired hypermelanosis	[ICD-11: ED60]	P08514	ITGA2B
T50688	DI0030	Angina pectoris	[ICD-11: BA40]	P08514	ITGA2B
T50688	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P08514	ITGA2B
T16769	DI0259	Metastatic lymph node neoplasm	[ICD-11: 2D60]	P98170	XIAP
T04507	DI0073	Cerebral ischaemia	[ICD-11: 8B1Z]	P78352	DLG4
T04507	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P78352	DLG4
T05409	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P08473	MME
T76685	DI0031	Anorexia nervosa	[ICD-11: 6B80]	P21554	CNR1
T76685	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P21554	CNR1
T76685	DI0308	Obesity	[ICD-11: 5B80-5B81]	P21554	CNR1
T27812	DI0033	Anxiety disorder	[ICD-11: 6B00-6B0Z]	P31645	SLC6A4
T27812	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P31645	SLC6A4
T27812	DI0087	Chronic pain	[ICD-11: MG30]	P31645	SLC6A4
T27812	DI0096	concerning food/fluid intake symptom	[ICD-11: MG43]	P31645	SLC6A4
T27812	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P31645	SLC6A4
T27812	DI0105	Cough	[ICD-11: MD12]	P31645	SLC6A4
T27812	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P31645	SLC6A4
T27812	DI0264	Migraine	[ICD-11: 8A80]	P31645	SLC6A4
T27812	DI0301	Nicotine use disorder	[ICD-11: 6C4A]	P31645	SLC6A4
T27812	DI0308	Obesity	[ICD-11: 5B80-5B81]	P31645	SLC6A4
T27812	DI0324	Pain	[ICD-11: MG30-MG3Z]	P31645	SLC6A4
T07806	DI0264	Migraine	[ICD-11: 8A80]	P28222	HTR1B
T07806	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P28222	HTR1B
T07806	DI0354	Psychotic disorder	[ICD-11: 6A20-6A25]	P28222	HTR1B
T07806	DI0370	Schizophrenia	[ICD-11: 6A20]	P28222	HTR1B
T11072	DI0264	Migraine	[ICD-11: 8A80]	P28221	HTR1D
T11072	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P28221	HTR1D
T78709	DI0033	Anxiety disorder	[ICD-11: 6B00-6B0Z]	P08908	HTR1A
T78709	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P08908	HTR1A
T78709	DI0190	Hypertension	[ICD-11: BA00-BA04]	P08908	HTR1A
T78709	DI0264	Migraine	[ICD-11: 8A80]	P08908	HTR1A
T78709	DI0270	Mood disorder	[ICD-11: 6A60-6E23]	P08908	HTR1A
T84117	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P28566	HTR1E
T51487	DI0014	Acute respiratory distress syndrome	[ICD-11: CB00]	P14867	GABRA1
T51487	DI0033	Anxiety disorder	[ICD-11: 6B00-6B0Z]	P14867	GABRA1
T51487	DI0082	Chronic insomnia	[ICD-11: 7A00]	P14867	GABRA1
T51487	DI0087	Chronic pain	[ICD-11: MG30]	P14867	GABRA1
T51487	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P14867	GABRA1
T51487	DI0112	Cystitis	[ICD-11: GC00]	P14867	GABRA1
T51487	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P14867	GABRA1
T51487	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P14867	GABRA1
T51487	DI0173	Headache	[ICD-11: 8A80-8A84]	P14867	GABRA1
T51487	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P14867	GABRA1
T51487	DI0243	Malaria	[ICD-11: 1F40-1F45]	P14867	GABRA1
T51487	DI0256	Mental/behavioural/neurodevelopmental disorder	[ICD-11: 6E20-6E8Z]	P14867	GABRA1
T51487	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P14867	GABRA1
T63816	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P56524	HDAC4
T51191	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q92769	HDAC2
T51191	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q92769	HDAC2
T85421	DI0125	Dissociative neurological symptom disorder	[ICD-11: 6B60]	P53779	MAPK10
T72168	DI0018	Adrenocortical insufficiency	[ICD-11: 5A74]	P08235	NR3C2
T72168	DI0083	Chronic kidney disease	[ICD-11: GB61]	P08235	NR3C2
T72168	DI0100	Contraceptive management	[ICD-11: QA21]	P08235	NR3C2
T72168	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P08235	NR3C2
T72168	DI0190	Hypertension	[ICD-11: BA00-BA04]	P08235	NR3C2
T72168	DI0194	Hypo-osmolality/hyponatraemia	[ICD-11: 5C72]	P08235	NR3C2
T40016	DI0016	Adaptive immunity immunodeficiency	[ICD-11: 4A01]	P04150	NR3C1
T40016	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	P04150	NR3C1
T40016	DI0037	Asthma	[ICD-11: CA23]	P04150	NR3C1
T40016	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P04150	NR3C1
T40016	DI0108	Cushing syndrome	[ICD-11: 5A70]	P04150	NR3C1
T40016	DI0280	Muscular dystrophy	[ICD-11: 8C70]	P04150	NR3C1
T40016	DI0314	Oesophagitis	[ICD-11: DA24]	P04150	NR3C1
T40016	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	P04150	NR3C1
T40016	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P04150	NR3C1
T40016	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P04150	NR3C1
T40016	DI0432	Vasomotor/allergic rhinitis	[ICD-11: CA08]	P04150	NR3C1
T16347	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P18031	PTPN1
T16347	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P18031	PTPN1
T16347	DI0308	Obesity	[ICD-11: 5B80-5B81]	P18031	PTPN1
T16347	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P18031	PTPN1
T49156	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P17706	PTPN2
T65200	DI0210	Influenza	[ICD-11: 1E30-1E32]	P28845	HSD11B1
T65200	DI0239	Lupus erythematosus	[ICD-11: 4A40]	P28845	HSD11B1
T65200	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P28845	HSD11B1
T06958	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P06746	POLB
T68251	DI0238	Lung cancer	[ICD-11: 2C25]	P08253	MMP2
T08856	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P22894	MMP8
T86702	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P08254	MMP3
T86702	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P08254	MMP3
T86702	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P08254	MMP3
T86702	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P08254	MMP3
T86702	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P08254	MMP3
T86702	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P08254	MMP3
T86702	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P08254	MMP3
T54156	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P14780	MMP9
T54156	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P14780	MMP9
T54156	DI0395	Stomach cancer	[ICD-11: 2B72]	P14780	MMP9
T54156	DI0419	Ulcerative colitis	[ICD-11: DD71]	P14780	MMP9
T83391	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P09467	FBP1
T00140	DI0037	Asthma	[ICD-11: CA23]	P09917	ALOX5
T00140	DI0147	Filariasis	[ICD-11: 1F66]	P09917	ALOX5
T00140	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P09917	ALOX5
T52450	DI0238	Lung cancer	[ICD-11: 2C25]	P03956	MMP1
T02551	DI0051	Bipolar disorder	[ICD-11: 6A60]	P35462	DRD3
T02551	DI0331	Parkinsonism	[ICD-11: 8A00]	P35462	DRD3
T47768	DI0013	Acute pain	[ICD-11: MG31]	P35372	OPRM1
T47768	DI0059	Bowel habit change	[ICD-11: ME05]	P35372	OPRM1
T47768	DI0087	Chronic pain	[ICD-11: MG30]	P35372	OPRM1
T47768	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P35372	OPRM1
T47768	DI0105	Cough	[ICD-11: MD12]	P35372	OPRM1
T47768	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P35372	OPRM1
T47768	DI0124	Digestive system disease	[ICD-11: DE2Z]	P35372	OPRM1
T47768	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P35372	OPRM1
T47768	DI0228	Large intestine motility disorder	[ICD-11: DB32]	P35372	OPRM1
T47768	DI0317	Opioid use disorder	[ICD-11: 6C43]	P35372	OPRM1
T47768	DI0324	Pain	[ICD-11: MG30-MG3Z]	P35372	OPRM1
T47768	DI0349	Pruritus	[ICD-11: EC90]	P35372	OPRM1
T47768	DI0374	Sensation disturbance	[ICD-11: MB40]	P35372	OPRM1
T79591	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P10827	THRA
T79591	DI0197	Hypo-thyroidism	[ICD-11: 5A00]	P10827	THRA
T13348	DI0365	Retinopathy	[ICD-11: 9B71]	P27695	APEX1
T13348	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P27695	APEX1
T49507	DI0060	Brain cancer	[ICD-11: 2A00]	P54760	EPHB4
T49507	DI0111	Cystic/dysplastic kidney disease	[ICD-11: GB8Y]	P54760	EPHB4
T49507	DI0238	Lung cancer	[ICD-11: 2C25]	P54760	EPHB4
T49507	DI0261	Metastatic meninges neoplasm	[ICD-11: 2D51]	P54760	EPHB4
T49507	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	P54760	EPHB4
T99799	DI0324	Pain	[ICD-11: MG30-MG3Z]	P06276	BCHE
T99799	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P06276	BCHE
T34296	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P45452	MMP13
T73475	DI0238	Lung cancer	[ICD-11: 2C25]	P09237	MMP7
T47094	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P35270	SPR
T47094	DI0293	Nausea/vomiting	[ICD-11: MD90]	P35270	SPR
T98691	DI0263	Middle East Respiratory Syndrome	[ICD-11: 1D64]	P07711	CTSL
T98691	DI0376	Severe acute respiratory syndrome	[ICD-11: 1D65]	P07711	CTSL
T72458	DI0192	Hypoactive sexual desire dysfunction	[ICD-11: HA00]	P32245	MC4R
T72458	DI0228	Large intestine motility disorder	[ICD-11: DB32]	P32245	MC4R
T72458	DI0308	Obesity	[ICD-11: 5B80-5B81]	P32245	MC4R
T61746	DI0023	Alopecia	[ICD-11: ED70]	P07858	CTSB
T61746	DI0025	Alzheimer disease	[ICD-11: 8A20]	P07858	CTSB
T61746	DI0037	Asthma	[ICD-11: CA23]	P07858	CTSB
T61746	DI0055	Bone cancer	[ICD-11: 2B5Z]	P07858	CTSB
T61746	DI0060	Brain cancer	[ICD-11: 2A00]	P07858	CTSB
T61746	DI0067	Cardiac arrest	[ICD-11: MC82]	P07858	CTSB
T61746	DI0074	Cerebral ischaemic stroke	[ICD-11: 8B11]	P07858	CTSB
T61746	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P07858	CTSB
T61746	DI0087	Chronic pain	[ICD-11: MG30]	P07858	CTSB
T61746	DI0110	Cystic fibrosis	[ICD-11: CA25]	P07858	CTSB
T61746	DI0124	Digestive system disease	[ICD-11: DE2Z]	P07858	CTSB
T61746	DI0178	Hepatic fibrosis/cirrhosis	[ICD-11: DB93]	P07858	CTSB
T61746	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P07858	CTSB
T61746	DI0253	Meningioma	[ICD-11: 2A01]	P07858	CTSB
T61746	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	P07858	CTSB
T61746	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P07858	CTSB
T61746	DI0296	Neurodegenerative disorder	[ICD-11: 8A20-8A23]	P07858	CTSB
T61746	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P07858	CTSB
T61746	DI0351	Psoriasis	[ICD-11: EA90]	P07858	CTSB
T61746	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P07858	CTSB
T59604	DI0087	Chronic pain	[ICD-11: MG30]	Q92847	GHSR
T59604	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	Q92847	GHSR
T58992	DI0059	Bowel habit change	[ICD-11: ME05]	P41143	OPRD1
T58992	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P41143	OPRD1
T58992	DI0324	Pain	[ICD-11: MG30-MG3Z]	P41143	OPRD1
T35842	DI0192	Hypoactive sexual desire dysfunction	[ICD-11: HA00]	Q01726	MC1R
T35842	DI0205	Inborn porphyrin/heme metabolism error	[ICD-11: 5C58]	Q01726	MC1R
T76846	DI0308	Obesity	[ICD-11: 5B80-5B81]	P41968	MC3R
T76846	DI0378	Sexual dysfunction	[ICD-11: HA00-HA01]	P41968	MC3R
T76846	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P41968	MC3R
T05114	DI0039	Atopic eczema	[ICD-11: EA80]	P23946	CMA1
T05114	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P23946	CMA1
T05114	DI0169	Gram-positive bacterial infection	[ICD-11: 1B74-1F40]	P23946	CMA1
T05114	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P23946	CMA1
T05114	DI0229	Left ventricular failure	[ICD-11: BD11]	P23946	CMA1
T05114	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P23946	CMA1
T84780	DI0259	Metastatic lymph node neoplasm	[ICD-11: 2D60]	Q13490	BIRC2
T58921	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P37231	PPARG
T58921	DI0025	Alzheimer disease	[ICD-11: 8A20]	P37231	PPARG
T58921	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P37231	PPARG
T13127	DI0342	Premature ageing appearance	[ICD-11: LD2B]	P49356	FNTB
T13057	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q06124	PTPN11
T89988	DI0083	Chronic kidney disease	[ICD-11: GB61]	P13500	CCL2
T89988	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P13500	CCL2
T89988	DI0087	Chronic pain	[ICD-11: MG30]	P13500	CCL2
T89988	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	P13500	CCL2
T89988	DI0252	Melanoma	[ICD-11: 2C30]	P13500	CCL2
T89988	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	P13500	CCL2
T89988	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P13500	CCL2
T89988	DI0326	Pancreatic cancer	[ICD-11: 2C10]	P13500	CCL2
T89988	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P13500	CCL2
T89988	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P13500	CCL2
T13616	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q13418	ILK
T67619	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P31749	AKT1
T18477	DI0015	Acute upper respiratory infection	[ICD-11: CA07]	P07900	HSP90AA1
T18477	DI0037	Asthma	[ICD-11: CA23]	P07900	HSP90AA1
T60182	DI0193	Hypo-glycaemia	[ICD-11: 5A41]	P47871	GCGR
T99204	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P49810	PSEN2
T99204	DI0380	Shoulder lesion	[ICD-11: FB53]	P49810	PSEN2
T99204	DI0390	Soft tissue disorder	[ICD-11: FB56]	P49810	PSEN2
T98269	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P29466	CASP1
T98269	DI0146	Fibrosis	[ICD-11: GA14-GC01]	P29466	CASP1
T98269	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P29466	CASP1
T98269	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P29466	CASP1
T85943	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P12931	SRC
T85943	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P12931	SRC
T85943	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P12931	SRC
T85943	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P12931	SRC
T21669	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P09211	GSTP1
T97613	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P48039	MTNR1A
T48268	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P49286	MTNR1B
T14834	DI0039	Atopic eczema	[ICD-11: EA80]	P47712	PLA2G4A
T97917	DI0025	Alzheimer disease	[ICD-11: 8A20]	P25090	FPR2
T27889	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	Q9BYF1	ACE2
T27889	DI0217	Intrathoracic organs injury	[ICD-11: NB32]	Q9BYF1	ACE2
T27889	DI0356	Pulmonary hypertension	[ICD-11: BB01]	Q9BYF1	ACE2
T01851	DI0060	Brain cancer	[ICD-11: 2A00]	P05556	ITGB1
T01851	DI0238	Lung cancer	[ICD-11: 2C25]	P05556	ITGB1
T01851	DI0365	Retinopathy	[ICD-11: 9B71]	P05556	ITGB1
T23499	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P25101	EDNRA
T23499	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P25101	EDNRA
T23499	DI0425	Urinary system clinical symptom	[ICD-11: MF8Y]	P25101	EDNRA
T03500	DI0037	Asthma	[ICD-11: CA23]	P39900	MMP12
T03500	DI0238	Lung cancer	[ICD-11: 2C25]	P39900	MMP12
T03500	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P39900	MMP12
T76910	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P49840	GSK3A
T15439	DI0431	Vasculitis	[ICD-11: 4A44]	P21730	C5AR1
T64830	DI0108	Cushing syndrome	[ICD-11: 5A70]	P35346	SSTR5
T53024	DI0108	Cushing syndrome	[ICD-11: 5A70]	P30874	SSTR2
T53024	DI0122	Diagnostic imaging	[ICD-11: N.A.]	P30874	SSTR2
T53024	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P30874	SSTR2
T62974	DI0087	Chronic pain	[ICD-11: MG30]	P31391	SSTR4
T62974	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P31391	SSTR4
T16633	DI0108	Cushing syndrome	[ICD-11: 5A70]	P30872	SSTR1
T16633	DI0395	Stomach cancer	[ICD-11: 2B72]	P30872	SSTR1
T13644	DI0108	Cushing syndrome	[ICD-11: 5A70]	P32745	SSTR3
T05849	DI0122	Diagnostic imaging	[ICD-11: N.A.]	P32239	CCKBR
T05849	DI0327	Pancreatic internal secretion disorder	[ICD-11: 5A4Y]	P32239	CCKBR
T02728	DI0207	Indeterminate colitis	[ICD-11: DD72]	P30989	NTSR1
T65019	DI0178	Hepatic fibrosis/cirrhosis	[ICD-11: DB93]	P50281	MMP14
T10965	DI0088	Circulatory system disease	[ICD-11: BE2Z]	P16109	SELP
T10965	DI0381	Sickle-cell disorder	[ICD-11: 3A51]	P16109	SELP
T71266	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q9Y243	AKT3
T40111	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P20839	IMPDH1
T40111	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P20839	IMPDH1
T40111	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P20839	IMPDH1
T40111	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P20839	IMPDH1
T40111	DI0413	Transplant rejection	[ICD-11: NE84]	P20839	IMPDH1
T46937	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	Q9H244	P2RY12
T46937	DI0405	Thrombosis	[ICD-11: DB61-GB90]	Q9H244	P2RY12
T28330	DI0210	Influenza	[ICD-11: 1E30-1E32]	P32238	CCKAR
T28330	DI0328	Pancreatic malfunction	[ICD-11: DC30-DC3Z]	P32238	CCKAR
T18299	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9UQM7	CAMK2A
T92828	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P24530	EDNRB
T92828	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P24530	EDNRB
T97035	DI0007	Acquired hypermelanosis	[ICD-11: ED60]	P14679	TYR
T97035	DI0008	Acquired hypomelanotic disorder	[ICD-11: ED63]	P14679	TYR
T57278	DI0060	Brain cancer	[ICD-11: 2A00]	P29317	EPHA2
T57278	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P29317	EPHA2
T17345	DI0207	Indeterminate colitis	[ICD-11: DD72]	P00374	DHFR
T17345	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P00374	DHFR
T17345	DI0416	Tuberculosis	[ICD-11: 1B10-1B12]	P00374	DHFR
T17345	DI0427	Urinary tract infection	[ICD-11: GC08]	P00374	DHFR
T52790	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P21452	TACR2
T76396	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P53609	PGGT1B
T55654	DI0110	Cystic fibrosis	[ICD-11: CA25]	P13569	CFTR
T55654	DI0217	Intrathoracic organs injury	[ICD-11: NB32]	P13569	CFTR
T55654	DI0435	Viral intestinal infection	[ICD-11: 1A2Z]	P13569	CFTR
T16308	DI0238	Lung cancer	[ICD-11: 2C25]	Q13526	PIN1
T29683	DI0254	Menopausal disorder	[ICD-11: GA30]	P29371	TACR3
T73756	DI0225	Kaposi sarcoma	[ICD-11: 2B57]	P29323	EPHB2
T73756	DI0252	Melanoma	[ICD-11: 2C30]	P29323	EPHB2
T73756	DI0326	Pancreatic cancer	[ICD-11: 2C10]	P29323	EPHB2
T73756	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P29323	EPHB2
T72042	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P22102	GART
T83386	DI0243	Malaria	[ICD-11: 1F40-1F45]	P15328	FOLR1
T83386	DI0321	Ovarian cancer	[ICD-11: 2C73]	P15328	FOLR1
T19229	DI0150	Folate deficiency anaemia	[ICD-11: 3A02]	Q96NT5	SLC46A1
T19229	DI0231	Leukaemia	[ICD-11: 2A60-2B33]	Q96NT5	SLC46A1
T19229	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	Q96NT5	SLC46A1
T88285	DI0210	Influenza	[ICD-11: 1E30-1E32]	Q04760	GLO1
T28413	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P29320	EPHA3
T28413	DI0060	Brain cancer	[ICD-11: 2A00]	P29320	EPHA3
T28413	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P29320	EPHA3
T28413	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	P29320	EPHA3
T77350	DI0274	Multiple myeloma	[ICD-11: 2A83]	P28062	PSMB8
T47107	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P05129	PRKCG
T47107	DI0248	Mastocytosis	[ICD-11: 2A21]	P05129	PRKCG
T47081	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P62937	PPIA
T68887	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P28336	NMBR
T68887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P28336	NMBR
T03644	DI0025	Alzheimer disease	[ICD-11: 8A20]	P37840	SNCA
T03644	DI0044	Autonomic nervous system disorder	[ICD-11: 8D87]	P37840	SNCA
T03644	DI0331	Parkinsonism	[ICD-11: 8A00]	P37840	SNCA
T95302	DI0005	Acne vulgaris	[ICD-11: ED80]	P33032	MC5R
T95302	DI0371	Sebaceous gland disorder	[ICD-11: ED91]	P33032	MC5R
T70490	DI0064	Bronchiectasis	[ICD-11: CA24]	P53634	CTSC
T93105	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P49768	PSEN1
T93105	DI0380	Shoulder lesion	[ICD-11: FB53]	P49768	PSEN1
T93105	DI0390	Soft tissue disorder	[ICD-11: FB56]	P49768	PSEN1
T68887	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P28336	NMBR
T68887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P28336	NMBR
T67207	DI0231	Leukaemia	[ICD-11: 2A60-2B33]	P06734	FCER2
T99816	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P30550	GRPR
T99816	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P30550	GRPR
T99816	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P30550	GRPR
T70234	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P54764	EPHA4
T94324	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q969S8	HDAC10
T97587	DI0107	Crohn disease	[ICD-11: DD70]	P13612	ITGA4
T97587	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P13612	ITGA4
T97587	DI0419	Ulcerative colitis	[ICD-11: DD71]	P13612	ITGA4
T08910	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P18507	GABRG2
T08910	DI0256	Mental/behavioural/neurodevelopmental disorder	[ICD-11: 6E20-6E8Z]	P18507	GABRG2
T08910	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P18507	GABRG2
T18299	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9UQM7	CAMK2A
T99840	DI0119	Desmoid tumour	[ICD-11: 2F7C]	Q96BI3	APH1A
T87831	DI0333	Peptic ulcer	[ICD-11: DA61]	P21462	FPR1
T65501	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9UBC3	DNMT3B
T25847	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P23284	PPIB
T98091	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	Q9NQS5	GPR84
T98091	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	Q9NQS5	GPR84
T83198	DI0356	Pulmonary hypertension	[ICD-11: BB01]	Q14145	KEAP1
T83198	DI0425	Urinary system clinical symptom	[ICD-11: MF8Y]	Q14145	KEAP1
T97071	DI0122	Diagnostic imaging	[ICD-11: N.A.]	Q04609	FOLH1
T97071	DI0346	Prostate cancer	[ICD-11: 2C82]	Q04609	FOLH1
T98945	DI0263	Middle East Respiratory Syndrome	[ICD-11: 1D64]	P09958	FUR
T28887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9BY41	HDAC8
T63083	DI0048	B-cell lymphoma	[ICD-11: 2A86]	Q06609	RAD51
T63083	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q06609	RAD51
T00099	DI0106	COVID-19	[ICD-11: 1D6Y]	P04632	CAPNS1
T62391	DI0298	Neuropathy	[ICD-11: 8C0Z]	P42263	GRIA3
T13127	DI0342	Premature ageing appearance	[ICD-11: LD2B]	P49356	FNTB
T80387	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P47870	GABRB2
T80387	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P47870	GABRB2
T80387	DI0256	Mental/behavioural/neurodevelopmental disorder	[ICD-11: 6E20-6E8Z]	P47870	GABRB2
T80387	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P47870	GABRB2
T27602	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q9HAN5	TRP1
T27602	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q9HAN5	TRP1
T47094	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P35270	SPR
T47094	DI0293	Nausea/vomiting	[ICD-11: MD90]	P35270	SPR
T93903	DI0110	Cystic fibrosis	[ICD-11: CA25]	P55211	CASP9
T67658	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P14672	GLUT4
T99840	DI0119	Desmoid tumour	[ICD-11: 2F7C]	Q96BI3	APH1A