(+)-Sterculinine II



Compound IDCDAMM01491
Common name(+)-Sterculinine II
IUPAC name4-methoxy-4-oxo-2-[(2-oxo-1H-quinoline-4-carbonyl)amino]butanoic acid
Molecular formulaC15H14N2O6

Experimental data

Retention time3.93
Adduct[M+H]+
Actual mz319.09
Theoretical mz319.092
Error7.45
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.9481

Identifiers and class information

Inchi keyDTWJLKCBGPJKQZ-LDGXTIHJNA-N
SmilesO=C1C=C(C(=O)NC(C(=O)O)CC(=O)OC)C=2C=CC=CC2N1
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives

Pharmacokinetic properties

Number of descriptor values(#stars)0
Number of non-conjugated amine groups (#amine)0
Number of amidine and guanidine groups (#amidine)0
Number of carboxylic acid groups (#acid)1
Number of non-conjugated amide groups (#amide)0
Number of rotatable bonds (#rotor)5
Number of reactive functional groups (#rtvFG)1
Predicted central nervous system activity (CNS)-2
Molecular weight (mol_MW)318.285
Computed dipole moment(dipole)10.393
Total solvent accessible surface area (SASA)571.833
Hydrophobic component of SASA (FOSA)141.803
Hydrophilic component of SASA (FISA)254.712
Pie component of the SASA (PISA)175.318
Weakly polar component of the SASA (WPSA)0
Total solvent accesible volume (volume)977.042
Number of hydrogen bond donors (donorHB)2
Number of hydrogen bond acceptors (accptHB)8
Free energy of solvation of dipole (dip^2/V)0.110561
Index of cohesive interaction in solids (ACxDN^.5/SA)0.019785
Globularity descriptor (glob)0.832731
Predicted polarizability in cubic angstroms (QPpolrz)31.411
Predicted hexadecane/gas partition coefficient (QPlogPC16)10.717
Predicted octanol/gas partition coefficient (QPlogPoct)19.378
Predicted water/gas partition coefficient (QPlogPw)13.727
Predicted octanol/water partition coefficient (QPlogPo/w)1.009
Predicted aqueous solubility (QPlogS)-3.225
Conformation-independent predicted aqueous solubility (CIQPlogS)-3.181
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-3.267
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)9.64
Predicted brain/blood partition coefficient (QPlogBB)-2.187
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)4.167
Predicted skin permeability, log Kp (QPlogKp)-5.116
PM3 calculated ionization potential (IP(ev))9.355
PM3 calculated electron affinity (EA(eV))1.4
Number of likely metabolic reactions (#metab)2
Prediction of binding to human serum albumin (QPlogKhsa)-0.57
Predicted qualitative human oral absorption (HumanOralAbsorption)2
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)50.468
Solvent-accessible surface area of fluorine atoms (SAFluorine)0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
Van der Waals surface area (PSA)159.743
Number of nitrogen and oxygen atoms (#NandO)8
Number of violations of Lipinski’s rule of five (RuleOfFive)0
Number of violations of Jorgensen’s rule of three (RuleOfThree)1

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID Gene name Target name TTD_ID Prediction source
P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
P04818TYMSThymidylate synthase (by homology)T98397SEA
P34903GABRA3GABA A receptor alpha-3/beta-2/gamma-2T62292SEA
P47869GABRA2GABA A receptor alpha-2/beta-2/gamma-2T51452SEA
P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
Q14833GRM4Metabotropic glutamate receptor 4T99402SwissTargetPrediction
Q8IXJ6SIRT2NAD-dependent deacetylase sirtuin 2T83904SwissTargetPrediction
P08473MMENeprilysinT05409SEA
P43166CA7Carbonic anhydrase VIIT37541SwissTargetPrediction
P23280CA6Carbonic anhydrase VIT06569SwissTargetPrediction
Q9ULX7CA14Carbonic anhydrase XIVT31992SwissTargetPrediction
P22748CA4Carbonic anhydrase IVT53378SwissTargetPrediction
P14867GABRA1GABA-A receptor; alpha-1/beta-2/gamma-2T51487SEA
Q9H3R0KDM4CLysine-specific demethylase 4CT73863SwissTargetPrediction
Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
P35354PTGS2Cyclooxygenase-2T66665SwissTargetPrediction
Q6B0I6KDM4DLysine-specific demethylase 4DT17036SwissTargetPrediction
O75164KDM4ALysine-specific demethylase 4AT18904SwissTargetPrediction
Q6B0I6KDM4DLysine-specific demethylase 4DT17036SwissTargetPrediction
Q96IY4CPB2Carboxypeptidase B2 isoform AT98022SwissTargetPrediction
Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction
P53779MAPK10c-Jun N-terminal kinase 3T85421SwissTargetPrediction
P07148FABP1Fatty acid-binding protein, liver (by homology)T73712SwissTargetPrediction
O14684PTGESProstaglandin E synthaseT02562SwissTargetPrediction
P15090FABP4Fatty acid binding protein adipocyteT07217SwissTargetPrediction
Q01469FABP5Fatty acid binding protein epidermalT21507SwissTargetPrediction
O14842FFAR1Free fatty acid receptor 1T25608SwissTargetPrediction
Q04609FOLH1Glutamate carboxypeptidase IIT97071SwissTargetPrediction
P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
P14780MMP9Matrix metalloproteinase 9T54156SEA
P14174MIFMacrophage migration inhibitory factorT39977SwissTargetPrediction
Q9Y4C1KDM3ALysine-specific demethylase 3AT25362SwissTargetPrediction
O15054KDM6BLysine-specific demethylase 6BT56057SwissTargetPrediction
Q9HC97GPR35G-protein coupled receptor 35T56143SwissTargetPrediction
P27695APEX1DNA-(apurinic or apyrimidinic site) lyaseT13348SwissTargetPrediction
P15086CPB1Carboxypeptidase BT36725SwissTargetPrediction
P11309PIM1Serine/threonine-protein kinase PIM1T50594SwissTargetPrediction
P07711CTSLCathepsin LT98691SEA
Q08499PDE4DPhosphodiesterase 4DT02001SwissTargetPrediction
Q96S37SLC22A12Solute carrier family 22 member 12T86057SwissTargetPrediction
Q9Y5Y4PTGDR2G protein-coupled receptor 44T61722SwissTargetPrediction
P49356FNTBFarnesyl protein transferaseT13127SEA
Q13418ILKSerine/threonine-protein kinase ILK-1T13616SwissTargetPrediction
P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
P41229KDM5CLysine-specific demethylase 5CT85540SwissTargetPrediction
Q99572P2RX7P2X purinoceptor 7T63414SwissTargetPrediction
P17948FLT1Vascular endothelial growth factor receptor 1T63966SwissTargetPrediction
Q15078CDK5R1Cyclin-dependent kinase 5/CDK5 activator 1T09513SwissTargetPrediction
Q9HBH9MKNK2MAP kinase signal-integrating kinase 2T99160SwissTargetPrediction
P29466CASP1Caspase-1T98269SEA
P29375KDM5ALysine-specific demethylase 5AT28052SwissTargetPrediction
Q9UNA0ADAMTS5ADAMTS5T98896SwissTargetPrediction
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2T65818SEA
P06756ITGAVVitronectin receptor alphaT67103SwissTargetPrediction
Q9BYF1ACE2Angiotensin-converting enzyme 2T27889SwissTargetPrediction and SEA
Q14289PTK2BProtein tyrosine kinase 2 betaT07087SwissTargetPrediction
P17301ITGA2Integrin alpha-2T55293SwissTargetPrediction
O15382BCAT2Branched-chain-amino-acid aminotransferase, mitochondrialT94788SwissTargetPrediction
O00311CDC7CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)T81358SwissTargetPrediction
P42892ECE1Endothelin-converting enzyme 1T50970SwissTargetPrediction and SEA
P30307CDC25CDual specificity phosphatase Cdc25CT40569SwissTargetPrediction
Q9NWZ3IRAK4Interleukin-1 receptor-associated kinase 4T55398SwissTargetPrediction
P28482MAPK1MAP kinase ERK2T58970SwissTargetPrediction
P14384CPMCarboxypeptidase MT65483SwissTargetPrediction
P41279MAP3K8Mitogen-activated protein kinase kinase kinase 8T00852SwissTargetPrediction
Q9UGL1KDM5BLysine-specific demethylase 5BT56871SwissTargetPrediction
P05556ITGB1Integrin alpha2/beta1T01851SwissTargetPrediction and SEA
Q9Y2K7KDM2ALysine-specific demethylase 2AT71949SwissTargetPrediction
P23443RPS6KB1Ribosomal protein S6 kinase 1T94479SwissTargetPrediction
Q99523SORT1Neurotensin receptor 3T63233SwissTargetPrediction
P23109AMPD1AMP deaminase 1T84553SwissTargetPrediction
Q9BPW0PPP5CSerine/threonine-protein phosphataseT04123SwissTargetPrediction
P62136PPP1CASerine/threonine protein phosphatase PP1-alpha catalytic subunitT59845SwissTargetPrediction
Q9ULW8PADI3Protein-arginine deiminase type-3T36612SwissTargetPrediction and SEA
Q9UM07PADI4Protein-arginine deiminase type-4T50429SwissTargetPrediction and SEA
Q9HAZ1CLK4Dual specificity protein kinase CLK4T98225SwissTargetPrediction
P09619PDGFRBPlatelet-derived growth factor receptor betaT59102SwissTargetPrediction
P11362FGFR1Fibroblast growth factor receptor 1T47101SwissTargetPrediction
P34995PTGER1Prostanoid EP1 receptorT15497SwissTargetPrediction
P25101EDNRAEndothelin receptor ET-AT23499SEA
P06737PYGLLiver glycogen phosphorylaseT19184SEA
P42574CASP3Caspase-3T57943SEA
P15085CPA1Carboxypeptidase A1T33966SEA
P32239CCKBRCholecystokinin B receptor (by homology)T05849SEA
P30989NTSR1Neurotensin receptor 1T02728SEA
P12268IMPDH2Inosine-5'-monophosphate dehydrogenase 2T89360SEA
P32238CCKARCholecystokinin A receptorT28330SEA
Q16581C3AR1C3a anaphylatoxin chemotactic receptorT30219SEA
Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SEA
P14679TYRTyrosinaseT97035SEA
P53609PGGT1BGeranylgeranyl transferase type IT76396SEA
P26010ITGB7Integrin alpha-4/beta-7T07403SEA
P13569CFTRCystic fibrosis transmembrane conductance regulatorT55654SEA
Q13526PIN1Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1T16308SEA
P29371TACR3Neurokinin 3 receptorT29683SEA
Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SEA
P55786NPEPPSPuromycin-sensitive aminopeptidaseT15610SEA
P15328FOLR1Folate receptor alphaT83386SEA
P14207FOLR2Folate receptor betaT82297SEA
Q96NT5SLC46A1Proton-coupled folate transporterT19229SEA
P98073TMPRSS15EnteropeptidaseT75772SEA
O60911CTSVCathepsin (V and K)T93653SEA
P28336NMBRNeuromedin B receptorT68887SEA
P13612ITGA4Integrin alpha-4T97587SEA
Q9NZ08ERAP1Endoplasmic reticulum aminopeptidase 1T72849SEA
P21462FPR1Formyl peptide receptor 1T87831SEA
Q6DWJ6GPR139Probable G-protein coupled receptor 139T84439SEA
O60235TMPRSS11DTransmembrane protease serine 11DT00302SEA
Q06609RAD51DNA repair protein RAD51 homolog 1T63083SEA
P04632CAPNS1HUMAN calpain-1 or calpain small subunit 1 heterodimerT00099SEA
Q7RTX1TAS1R1Taste receptorT41263SEA
P09936UCHL1Ubiquitin thioesterase L1T56051SEA
Q9NYN9PTPN13FAP-1 messenger RNAT09672SEA
P49356FNTBFarnesyl protein transferaseT13127SEA
O95622ADCY5Adenylate cyclase type 5T19531SEA
Q9HAN5TRP1Cationic trypsinogenT27602SEA
P55211CASP9Caspase-9T93903SEA
Q9UQ81MCH5Caspase-8T15700SEA

Target associated diseases

TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
T62292DI0216Intentional self-harm[ICD-11: PC91]P34903GABRA3
T51452DI0216Intentional self-harm[ICD-11: PC91]P47869GABRA2
T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
T99402DI0331Parkinsonism[ICD-11: 8A00]Q14833GRM4
T83904DI0365Retinopathy[ICD-11: 9B71]Q8IXJ6SIRT2
T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
T06569DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P23280CA6
T06569DI0372Seborrhoeic dermatitis[ICD-11: EA81]P23280CA6
T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
T53378DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P22748CA4
T53378DI0166Glaucoma[ICD-11: 9C61]P22748CA4
T53378DI0372Seborrhoeic dermatitis[ICD-11: EA81]P22748CA4
T51487DI0014Acute respiratory distress syndrome[ICD-11: CB00]P14867GABRA1
T51487DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P14867GABRA1
T51487DI0082Chronic insomnia[ICD-11: 7A00]P14867GABRA1
T51487DI0087Chronic pain[ICD-11: MG30]P14867GABRA1
T51487DI0101Corneal disease[ICD-11: 9A76-9A78]P14867GABRA1
T51487DI0112Cystitis[ICD-11: GC00]P14867GABRA1
T51487DI0117Depression[ICD-11: 6A70-6A7Z]P14867GABRA1
T51487DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P14867GABRA1
T51487DI0173Headache[ICD-11: 8A80-8A84]P14867GABRA1
T51487DI0214Insomnia[ICD-11: 7A00-7A0Z]P14867GABRA1
T51487DI0243Malaria[ICD-11: 1F40-1F45]P14867GABRA1
T51487DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P14867GABRA1
T51487DI0411Tonus and reflex abnormality[ICD-11: MB47]P14867GABRA1
T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
T66665DI0087Chronic pain[ICD-11: MG30]P35354PTGS2
T66665DI0145Female pelvic pain[ICD-11: GA34]P35354PTGS2
T66665DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P35354PTGS2
T66665DI0207Indeterminate colitis[ICD-11: DD72]P35354PTGS2
T66665DI0227Knee osteoarthritis[ICD-11: FA01]P35354PTGS2
T66665DI0320Osteoarthritis[ICD-11: FA00-FA05]P35354PTGS2
T66665DI0324Pain[ICD-11: MG30-MG3Z]P35354PTGS2
T66665DI0366Rheumatoid arthritis[ICD-11: FA20]P35354PTGS2
T66665DI0416Tuberculosis[ICD-11: 1B10-1B12]P35354PTGS2
T98022DI0073Cerebral ischaemia[ICD-11: 8B1Z]Q96IY4CPB2
T98022DI0074Cerebral ischaemic stroke[ICD-11: 8B11]Q96IY4CPB2
T98022DI0405Thrombosis[ICD-11: DB61-GB90]Q96IY4CPB2
T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
T73712DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P07148FABP1
T02562DI0025Alzheimer disease[ICD-11: 8A20]O14684PTGES
T25608DI0417Type 2 diabetes mellitus[ICD-11: 5A11]O14842FFAR1
T97071DI0122Diagnostic imaging[ICD-11: N.A.]Q04609FOLH1
T97071DI0346Prostate cancer[ICD-11: 2C82]Q04609FOLH1
T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
T39977DI0403Thrombocytopenia[ICD-11: 3B64]P14174MIF
T13348DI0365Retinopathy[ICD-11: 9B71]P27695APEX1
T13348DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P27695APEX1
T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
T86057DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q96S37SLC22A12
T61722DI0102Coronary atherosclerosis[ICD-11: BA52]Q9Y5Y4PTGDR2
T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
T13616DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q13418ILK
T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
T63414DI0224Joint pain[ICD-11: ME82]Q99572P2RX7
T63966DI0361Renal cell carcinoma[ICD-11: 2C90]P17948FLT1
T99160DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9HBH9MKNK2
T99160DI0095Colorectal cancer[ICD-11: 2B91]Q9HBH9MKNK2
T99160DI0235Liver cancer[ICD-11: 2C12]Q9HBH9MKNK2
T99160DI0241Lymphoma[ICD-11: 2A80-2A86]Q9HBH9MKNK2
T99160DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9HBH9MKNK2
T98269DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P29466CASP1
T98269DI0146Fibrosis[ICD-11: GA14-GC01]P29466CASP1
T98269DI0366Rheumatoid arthritis[ICD-11: FA20]P29466CASP1
T98269DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P29466CASP1
T98896DI0320Osteoarthritis[ICD-11: FA00-FA05]Q9UNA0ADAMTS5
T67103DI0095Colorectal cancer[ICD-11: 2B91]P06756ITGAV
T67103DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06756ITGAV
T27889DI0009Acute diabete complication[ICD-11: 5A2Y]Q9BYF1ACE2
T27889DI0217Intrathoracic organs injury[ICD-11: NB32]Q9BYF1ACE2
T27889DI0356Pulmonary hypertension[ICD-11: BB01]Q9BYF1ACE2
T55293DI0095Colorectal cancer[ICD-11: 2B91]P17301ITGA2
T55293DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P17301ITGA2
T81358DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00311CDC7
T81358DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O00311CDC7
T55398DI0039Atopic eczema[ICD-11: EA80]Q9NWZ3IRAK4
T55398DI0109Cutaneous lupus erythematosus[ICD-11: EB50-EB5Z]Q9NWZ3IRAK4
T55398DI0241Lymphoma[ICD-11: 2A80-2A86]Q9NWZ3IRAK4
T55398DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q9NWZ3IRAK4
T55398DI0351Psoriasis[ICD-11: EA90]Q9NWZ3IRAK4
T55398DI0366Rheumatoid arthritis[ICD-11: FA20]Q9NWZ3IRAK4
T58970DI0036Arteries/arterioles disorder[ICD-11: BD52]P28482MAPK1
T58970DI0252Melanoma[ICD-11: 2C30]P28482MAPK1
T58970DI0326Pancreatic cancer[ICD-11: 2C10]P28482MAPK1
T58970DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28482MAPK1
T00852DI0207Indeterminate colitis[ICD-11: DD72]P41279MAP3K8
T01851DI0060Brain cancer[ICD-11: 2A00]P05556ITGB1
T01851DI0238Lung cancer[ICD-11: 2C25]P05556ITGB1
T01851DI0365Retinopathy[ICD-11: 9B71]P05556ITGB1
T94479DI0025Alzheimer disease[ICD-11: 8A20]P23443RPS6KB1
T94479DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P23443RPS6KB1
T94479DI0419Ulcerative colitis[ICD-11: DD71]P23443RPS6KB1
T63233DI0153Frontotemporal dementia[ICD-11: 6D83]Q99523SORT1
T59845DI0268Molluscum contagiosum[ICD-11: 1E76]P62136PPP1CA
T59102DI0009Acute diabete complication[ICD-11: 5A2Y]P09619PDGFRB
T59102DI0361Renal cell carcinoma[ICD-11: 2C90]P09619PDGFRB
T59102DI0403Thrombocytopenia[ICD-11: 3B64]P09619PDGFRB
T47101DI0095Colorectal cancer[ICD-11: 2B91]P11362FGFR1
T47101DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P11362FGFR1
T47101DI0235Liver cancer[ICD-11: 2C12]P11362FGFR1
T47101DI0403Thrombocytopenia[ICD-11: 3B64]P11362FGFR1
T15497DI0405Thrombosis[ICD-11: DB61-GB90]P34995PTGER1
T23499DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25101EDNRA
T23499DI0356Pulmonary hypertension[ICD-11: BB01]P25101EDNRA
T23499DI0425Urinary system clinical symptom[ICD-11: MF8Y]P25101EDNRA
T57943DI0060Brain cancer[ICD-11: 2A00]P42574CASP3
T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
T02728DI0207Indeterminate colitis[ICD-11: DD72]P30989NTSR1
T89360DI0413Transplant rejection[ICD-11: NE84]P12268IMPDH2
T28330DI0210Influenza[ICD-11: 1E30-1E32]P32238CCKAR
T28330DI0328Pancreatic malfunction[ICD-11: DC30-DC3Z]P32238CCKAR
T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
T97035DI0007Acquired hypermelanosis[ICD-11: ED60]P14679TYR
T97035DI0008Acquired hypomelanotic disorder[ICD-11: ED63]P14679TYR
T76396DI0241Lymphoma[ICD-11: 2A80-2A86]P53609PGGT1B
T07403DI0107Crohn disease[ICD-11: DD70]P26010ITGB7
T55654DI0110Cystic fibrosis[ICD-11: CA25]P13569CFTR
T55654DI0217Intrathoracic organs injury[ICD-11: NB32]P13569CFTR
T55654DI0435Viral intestinal infection[ICD-11: 1A2Z]P13569CFTR
T16308DI0238Lung cancer[ICD-11: 2C25]Q13526PIN1
T29683DI0254Menopausal disorder[ICD-11: GA30]P29371TACR3
T15610DI0012Acute myeloid leukaemia[ICD-11: 2A60]P55786NPEPPS
T15610DI0284Myelodysplastic syndrome[ICD-11: 2A37]P55786NPEPPS
T83386DI0243Malaria[ICD-11: 1F40-1F45]P15328FOLR1
T83386DI0321Ovarian cancer[ICD-11: 2C73]P15328FOLR1
T19229DI0150Folate deficiency anaemia[ICD-11: 3A02]Q96NT5SLC46A1
T19229DI0231Leukaemia[ICD-11: 2A60-2B33]Q96NT5SLC46A1
T19229DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q96NT5SLC46A1
T93653DI0055Bone cancer[ICD-11: 2B5Z]O60911CTSV
T93653DI0087Chronic pain[ICD-11: MG30]O60911CTSV
T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
T97587DI0107Crohn disease[ICD-11: DD70]P13612ITGA4
T97587DI0275Multiple sclerosis[ICD-11: 8A40]P13612ITGA4
T97587DI0419Ulcerative colitis[ICD-11: DD71]P13612ITGA4
T87831DI0333Peptic ulcer[ICD-11: DA61]P21462FPR1
T84439DI0377Sex development malformative disorder[ICD-11: LD2A]Q6DWJ6GPR139
T63083DI0048B-cell lymphoma[ICD-11: 2A86]Q06609RAD51
T63083DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06609RAD51
T00099DI0106COVID-19[ICD-11: 1D6Y]P04632CAPNS1
T41263DI0078Cholera[ICD-11: 1A00]Q7RTX1TAS1R1
T56051DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P09936UCHL1
T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
T27602DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q9HAN5TRP1
T27602DI0274Multiple myeloma[ICD-11: 2A83]Q9HAN5TRP1
T93903DI0110Cystic fibrosis[ICD-11: CA25]P55211CASP9
T15700DI0120Diabetes mellitus[ICD-11: 5A10]Q9UQ81MCH5
T15700DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UQ81MCH5

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