Compound details

Phaitanthrin C

Compound ID	CDAMM01121
Common name	Phaitanthrin C
IUPAC name	7-hydroxyindolo[2,1-b]quinazoline-6,12-dione
Molecular formula	C₁₅H₈N₂O₃

Experimental data

Retention time	0.29
Adduct	[M+H]+
Actual mz	265.061
Theoretical mz	265.06
Error	1.98
Ionizaton mode	Positive
Instrument type	LC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score	6.7681

Identifiers and class information

Inchi key	WOQXYBJCORZEEE-UHFFFAOYSA-N
Smiles	O=C1C2=NC=3C=CC=CC3C(=O)N2C=4C=CC=C(O)C14
Superclass	Organoheterocyclic compounds
Class	Diazanaphthalenes

Plant source

Cinnamomum verum J. Presl

External sources

HMDB ID
KNApSAcK ID	C00039983
FooDB ID
DrugBank ID
ChEBI ID
Pubchem Compound ID	24970644
PlantCyc ID
UNPD ID	UNPD98477
Coconut ID	CNP0153714
LipidMAPS ID
NANPDB ID

Pharmacokinetic properties

Number of descriptor values(#stars)	0
Number of non-conjugated amine groups (#amine)	0
Number of amidine and guanidine groups (#amidine)	0
Number of carboxylic acid groups (#acid)	0
Number of non-conjugated amide groups (#amide)	0
Number of rotatable bonds (#rotor)	1
Number of reactive functional groups (#rtvFG)	0
Predicted central nervous system activity (CNS)	-1
Molecular weight (mol_MW)	264.24
Computed dipole moment(dipole)	2.739
Total solvent accessible surface area (SASA)	469.973
Hydrophobic component of SASA (FOSA)	0
Hydrophilic component of SASA (FISA)	158.231
Pie component of the SASA (PISA)	311.742
Weakly polar component of the SASA (WPSA)	0
Total solvent accesible volume (volume)	788.911
Number of hydrogen bond donors (donorHB)	0
Number of hydrogen bond acceptors (accptHB)	5.75
Free energy of solvation of dipole (dip^2/V)	0.0095061
Index of cohesive interaction in solids (ACxDN^.5/SA)	0
Globularity descriptor (glob)	0.878573
Predicted polarizability in cubic angstroms (QPpolrz)	27.753
Predicted hexadecane/gas partition coefficient (QPlogPC16)	8.877
Predicted octanol/gas partition coefficient (QPlogPoct)	12.566
Predicted water/gas partition coefficient (QPlogPw)	9.49
Predicted octanol/water partition coefficient (QPlogPo/w)	0.912
Predicted aqueous solubility (QPlogS)	-1.95
Conformation-independent predicted aqueous solubility (CIQPlogS)	-3.036
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)	-4.984
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)	312.894
Predicted brain/blood partition coefficient (QPlogBB)	-0.863
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)	140.908
Predicted skin permeability, log Kp (QPlogKp)	-3.242
PM3 calculated ionization potential (IP(ev))	9.091
PM3 calculated electron affinity (EA(eV))	1.555
Number of likely metabolic reactions (#metab)	1
Prediction of binding to human serum albumin (QPlogKhsa)	-0.672
Predicted qualitative human oral absorption (HumanOralAbsorption)	3
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)	76.946
Solvent-accessible surface area of fluorine atoms (SAFluorine)	0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)	0
Van der Waals surface area (PSA)	93.024
Number of nitrogen and oxygen atoms (#NandO)	5
Number of violations of Lipinski’s rule of five (RuleOfFive)	0
Number of violations of Jorgensen’s rule of three (RuleOfThree)	0

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID	Gene name	Target name	TTD_ID	Prediction source
Q9Y5N1	HRH3	Histamine H3 receptor	T64765	SEA
P00533	EGFR	Epidermal growth factor receptor erbB1	T59328	SwissTargetPrediction
P29474	NOS3	Nitric-oxide synthase, endothelial	T06046	SwissTargetPrediction
P00734	F2	Thrombin	T94033	SwissTargetPrediction
Q14833	GRM4	Metabotropic glutamate receptor 4	T99402	SwissTargetPrediction
P21397	MAOA	Monoamine oxidase A	T83875	SwissTargetPrediction
P04054	PLA2G1B	Phospholipase A2 group 1B	T31479	SEA
P08473	MME	Neprilysin	T05409	SwissTargetPrediction
P34913	EPHX2	Epoxide hydratase	T35734	SwissTargetPrediction
O60341	KDM1A	Lysine-specific histone demethylase 1	T16739	SwissTargetPrediction
P41595	HTR2B	Serotonin 2b (5-HT2b) receptor	T31204	SwissTargetPrediction
P07949	RET	Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET	T60631	SwissTargetPrediction
P34969	HTR7	Serotonin 7 (5-HT7) receptor	T79062	SEA
P50406	HTR6	Serotonin 6 (5-HT6) receptor	T16691	SwissTargetPrediction
P24864	CCNE1	Cyclin-dependent kinase 2/cyclin E1	T10052	SwissTargetPrediction
P19099	CYP11B2	Cytochrome P450 11B2	T59056	SwissTargetPrediction
P05164	MPO	Myeloperoxidase	T23471	SEA
Q9H3R0	KDM4C	Lysine-specific demethylase 4C	T73863	SwissTargetPrediction
P35354	PTGS2	Cyclooxygenase-2	T66665	SwissTargetPrediction
P14920	DAO	D-amino-acid oxidase	T33124	SwissTargetPrediction
P10275	AR	Androgen Receptor	T11211	SwissTargetPrediction
P11511	CYP19A1	Cytochrome P450 19A1	T13260	SwissTargetPrediction
P14902	IDO1	Indoleamine 2,3-dioxygenase	T89697	SwissTargetPrediction and SEA
P14174	MIF	Macrophage migration inhibitory factor	T39977	SwissTargetPrediction
P09917	ALOX5	Arachidonate 5-lipoxygenase	T00140	SwissTargetPrediction
O00206	TLR4	Toll-like receptor 4 (by homology)	T81443	SwissTargetPrediction
P21964	COMT	Catechol O-methyltransferase (by homology)	T76904	SEA
P33527	ABCC1	Multidrug resistance-associated protein 1	T11288	SEA
P25100	ADRA1D	Alpha-1d adrenergic receptor	T53381	SwissTargetPrediction
O14757	CHEK1	Serine/threonine-protein kinase Chk1	T62449	SwissTargetPrediction
P14061	HSD17B1	Estradiol 17-beta-dehydrogenase 1	T44011	SwissTargetPrediction
P00519	ABL1	Tyrosine-protein kinase ABL	T63505	SwissTargetPrediction
P06276	BCHE	Butyrylcholinesterase	T99799	SwissTargetPrediction
P24941	CDK2	Cyclin-dependent kinase 2	T70176	SwissTargetPrediction
Q9Y233	PDE10A	Phosphodiesterase 10A (by homology)	T84133	SwissTargetPrediction and SEA
P16050	ALOX15	Arachidonate 15-lipoxygenase	T16042	SwissTargetPrediction
Q13418	ILK	Serine/threonine-protein kinase ILK-1	T13616	SwissTargetPrediction
P23458	JAK1	Tyrosine-protein kinase JAK1	T62460	SwissTargetPrediction
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	T18477	SwissTargetPrediction
Q12884	FAP	Fibroblast activation protein alpha (by homology)	T53764	SwissTargetPrediction
P09211	GSTP1	Glutathione S-transferase Pi	T21669	SwissTargetPrediction
Q96EB6	SIRT1	NAD-dependent deacetylase sirtuin 1	T14731	SwissTargetPrediction
O15382	BCAT2	Branched-chain-amino-acid aminotransferase, mitochondrial	T94788	SwissTargetPrediction
P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase liver	T39321	SwissTargetPrediction
P25025	CXCR2	Interleukin-8 receptor B	T56923	SwissTargetPrediction
P42574	CASP3	Caspase-3	T57943	SwissTargetPrediction
P55212	CASP6	Caspase-6	T20600	SwissTargetPrediction
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	T40111	SwissTargetPrediction
P12268	IMPDH2	Inosine-5'-monophosphate dehydrogenase 2	T89360	SwissTargetPrediction
P00749	PLAU	Urokinase-type plasminogen activator	T17758	SwissTargetPrediction
P00390	GSR	Glutathione reductase	T30803	SEA
Q9UNQ0	ABCG2	ATP-binding cassette sub-family G member 2	T56556	SwissTargetPrediction
P08236	GUSB	Beta-glucuronidase	T96413	SEA
O75582	RPS6KA5	Ribosomal protein S6 kinase alpha 5	T50224	SwissTargetPrediction
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha 3	T03279	SwissTargetPrediction
P08631	HCK	Tyrosine-protein kinase HCK	T31406	SwissTargetPrediction
Q9UIQ6	LNPEP	Cystinyl aminopeptidase	T97537	SwissTargetPrediction
Q9UBF8	PI4KB	PI4-kinase beta subunit	T12541	SwissTargetPrediction
P55786	NPEPPS	Puromycin-sensitive aminopeptidase	T15610	SEA
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	T64205	SEA
Q16678	CYP1B1	Cytochrome P450 1B1	T92521	SwissTargetPrediction and SEA
Q16548	BCL2A1	Bcl-2-related protein A1 (by homology)	T12797	SwissTargetPrediction
P30281	CCND3	Cyclin-dependent kinase 4/cyclin D	T72507	SwissTargetPrediction
Q9BUB5	MKNK1	MAP kinase-interacting serine/threonine-protein kinase MNK1	T97136	SwissTargetPrediction
P32754	HPD	4-hydroxyphenylpyruvate dioxygenase	T07137	SEA
P49281	SLC11A2	Natural resistance-associated macrophage protein 2	T22717	SEA
Q9H4B7	TUBB1	Tubulin beta-1 chain	T84397	SwissTargetPrediction
Q15349	RPS6KA2	Ribosomal protein S6 kinase alpha 2	T28043	SwissTargetPrediction
O95602	POLR1A	DNA-directed RNA polymerase I subunit RPA1	T89530	SEA
P00748	F12	Coagulation factor XII	T38509	SwissTargetPrediction
P50454	SERPINH1	Collagen-binding protein 1	T56104	SwissTargetPrediction
Q9UPY5	SLC7A11	Cystine/glutamate transporter	T11615	SEA
Q06609	RAD51	DNA repair protein RAD51 homolog 1	T63083	SEA
P09172	DBH	Dopamine beta hydroxylase	T74937	SEA
Q9NXA8	SIRT5	NAD-dependent deacetylase sirtuin-5	T91940	SEA
Q6ZQW0	INDOL1	Indoleamine 2,3-dioxygenase 2	T62266	SEA
Q9BXC0	HCAR1	G protein coupled receptor 81	T56272	SEA
P45880	VDAC2	Voltage-dependent anion-selective channel 2	T35158	SEA

Target associated diseases

TTD_ID	Disease_ID	Disease name	ICD_11	Uniprot ID	Gene names
T64765	DI0392	Somnolence	[ICD-11: MG42]	Q9Y5N1	HRH3
T59328	DI0030	Angina pectoris	[ICD-11: BA40]	P00533	EGFR
T59328	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P00533	EGFR
T59328	DI0095	Colorectal cancer	[ICD-11: 2B91]	P00533	EGFR
T59328	DI0121	Diabetic foot ulcer	[ICD-11: BD54]	P00533	EGFR
T59328	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P00533	EGFR
T59328	DI0238	Lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P00533	EGFR
T59328	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P00533	EGFR
T59328	DI0420	Unspecific body region injury	[ICD-11: ND56]	P00533	EGFR
T06046	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P29474	NOS3
T94033	DI0052	Bleeding disorder	[ICD-11: GA20-GA21]	P00734	F2
T94033	DI0091	Coagulation defect	[ICD-11: 3B10]	P00734	F2
T94033	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P00734	F2
T94033	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P00734	F2
T94033	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00734	F2
T94033	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P00734	F2
T94033	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P00734	F2
T94033	DI0405	Thrombosis	[ICD-11: DB61-GB90]	P00734	F2
T99402	DI0331	Parkinsonism	[ICD-11: 8A00]	Q14833	GRM4
T83875	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P21397	MAOA
T83875	DI0331	Parkinsonism	[ICD-11: 8A00]	P21397	MAOA
T31479	DI0230	Leishmaniasis	[ICD-11: 1F54]	P04054	PLA2G1B
T31479	DI0335	Peroxisomal disease	[ICD-11: 5C57]	P04054	PLA2G1B
T31479	DI0367	Rosacea	[ICD-11: ED90]	P04054	PLA2G1B
T31479	DI0398	Synthesis disorder	[ICD-11: 5C52-5C59]	P04054	PLA2G1B
T05409	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P08473	MME
T35734	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P34913	EPHX2
T35734	DI0190	Hypertension	[ICD-11: BA00-BA04]	P34913	EPHX2
T16739	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	O60341	KDM1A
T16739	DI0025	Alzheimer disease	[ICD-11: 8A20]	O60341	KDM1A
T16739	DI0138	Ewing sarcoma	[ICD-11: 2B52]	O60341	KDM1A
T16739	DI0238	Lung cancer	[ICD-11: 2C25]	O60341	KDM1A
T16739	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O60341	KDM1A
T16739	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	O60341	KDM1A
T16739	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	O60341	KDM1A
T16739	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	O60341	KDM1A
T16739	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O60341	KDM1A
T31204	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P41595	HTR2B
T31204	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P41595	HTR2B
T31204	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P41595	HTR2B
T31204	DI0354	Psychotic disorder	[ICD-11: 6A20-6A25]	P41595	HTR2B
T60631	DI0095	Colorectal cancer	[ICD-11: 2B91]	P07949	RET
T60631	DI0238	Lung cancer	[ICD-11: 2C25]	P07949	RET
T60631	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P07949	RET
T60631	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P07949	RET
T60631	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P07949	RET
T60631	DI0407	Thyroid cancer	[ICD-11: 2D10]	P07949	RET
T79062	DI0025	Alzheimer disease	[ICD-11: 8A20]	P34969	HTR7
T79062	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P34969	HTR7
T79062	DI0051	Bipolar disorder	[ICD-11: 6A60]	P34969	HTR7
T79062	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P34969	HTR7
T79062	DI0265	Mild neurocognitive disorder	[ICD-11: 6D71]	P34969	HTR7
T79062	DI0331	Parkinsonism	[ICD-11: 8A00]	P34969	HTR7
T79062	DI0370	Schizophrenia	[ICD-11: 6A20]	P34969	HTR7
T16691	DI0025	Alzheimer disease	[ICD-11: 8A20]	P50406	HTR6
T16691	DI0370	Schizophrenia	[ICD-11: 6A20]	P50406	HTR6
T59056	DI0190	Hypertension	[ICD-11: BA00-BA04]	P19099	CYP11B2
T23471	DI0229	Left ventricular failure	[ICD-11: BD11]	P05164	MPO
T23471	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	P05164	MPO
T66665	DI0087	Chronic pain	[ICD-11: MG30]	P35354	PTGS2
T66665	DI0145	Female pelvic pain	[ICD-11: GA34]	P35354	PTGS2
T66665	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P35354	PTGS2
T66665	DI0207	Indeterminate colitis	[ICD-11: DD72]	P35354	PTGS2
T66665	DI0227	Knee osteoarthritis	[ICD-11: FA01]	P35354	PTGS2
T66665	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P35354	PTGS2
T66665	DI0324	Pain	[ICD-11: MG30-MG3Z]	P35354	PTGS2
T66665	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P35354	PTGS2
T66665	DI0416	Tuberculosis	[ICD-11: 1B10-1B12]	P35354	PTGS2
T33124	DI0038	Ataxic disorder	[ICD-11: 8A03]	P14920	DAO
T33124	DI0370	Schizophrenia	[ICD-11: 6A20]	P14920	DAO
T11211	DI0005	Acne vulgaris	[ICD-11: ED80]	P10275	AR
T11211	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P10275	AR
T11211	DI0021	Alcoholic liver disease	[ICD-11: DB94]	P10275	AR
T11211	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P10275	AR
T11211	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P10275	AR
T11211	DI0145	Female pelvic pain	[ICD-11: GA34]	P10275	AR
T11211	DI0194	Hypo-osmolality/hyponatraemia	[ICD-11: 5C72]	P10275	AR
T11211	DI0237	Low bone mass disorder	[ICD-11: FB83]	P10275	AR
T11211	DI0247	Mammary tumour	[ICD-11: 2C60-2C6Z]	P10275	AR
T11211	DI0346	Prostate cancer	[ICD-11: 2C82]	P10275	AR
T11211	DI0401	Testicular dysfunction	[ICD-11: 5A81]	P10275	AR
T13260	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P11511	CYP19A1
T13260	DI0108	Cushing syndrome	[ICD-11: 5A70]	P11511	CYP19A1
T89697	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P14902	IDO1
T39977	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P14174	MIF
T00140	DI0037	Asthma	[ICD-11: CA23]	P09917	ALOX5
T00140	DI0147	Filariasis	[ICD-11: 1F66]	P09917	ALOX5
T00140	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P09917	ALOX5
T81443	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	O00206	TLR4
T81443	DI0346	Prostate cancer	[ICD-11: 2C82]	O00206	TLR4
T81443	DI0375	Sepsis	[ICD-11: 1G40-1G41]	O00206	TLR4
T76904	DI0331	Parkinsonism	[ICD-11: 8A00]	P21964	COMT
T11288	DI0167	Gout	[ICD-11: FA25]	P33527	ABCC1
T53381	DI0166	Glaucoma	[ICD-11: 9C61]	P25100	ADRA1D
T53381	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P25100	ADRA1D
T53381	DI0190	Hypertension	[ICD-11: BA00-BA04]	P25100	ADRA1D
T53381	DI0348	Prostate hyperplasia	[ICD-11: GA90]	P25100	ADRA1D
T53381	DI0378	Sexual dysfunction	[ICD-11: HA00-HA01]	P25100	ADRA1D
T53381	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P25100	ADRA1D
T62449	DI0027	Anal cancer	[ICD-11: 2C00]	O14757	CHEK1
T62449	DI0172	Head and neck cancer	[ICD-11: 2D42]	O14757	CHEK1
T62449	DI0183	Hodgkin lymphoma	[ICD-11: 2B30]	O14757	CHEK1
T62449	DI0238	Lung cancer	[ICD-11: 2C25]	O14757	CHEK1
T62449	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O14757	CHEK1
T62449	DI0321	Ovarian cancer	[ICD-11: 2C73]	O14757	CHEK1
T62449	DI0326	Pancreatic cancer	[ICD-11: 2C10]	O14757	CHEK1
T62449	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O14757	CHEK1
T63505	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P00519	ABL1
T63505	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P00519	ABL1
T63505	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P00519	ABL1
T63505	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P00519	ABL1
T99799	DI0324	Pain	[ICD-11: MG30-MG3Z]	P06276	BCHE
T99799	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P06276	BCHE
T70176	DI0060	Brain cancer	[ICD-11: 2A00]	P24941	CDK2
T70176	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P24941	CDK2
T70176	DI0238	Lung cancer	[ICD-11: 2C25]	P24941	CDK2
T70176	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P24941	CDK2
T70176	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P24941	CDK2
T70176	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P24941	CDK2
T70176	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P24941	CDK2
T70176	DI0406	Thymoma	[ICD-11: 2C27]	P24941	CDK2
T84133	DI0079	Choreiform disorder	[ICD-11: 8A01]	Q9Y233	PDE10A
T84133	DI0206	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Q9Y233	PDE10A
T84133	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	Q9Y233	PDE10A
T84133	DI0370	Schizophrenia	[ICD-11: 6A20]	Q9Y233	PDE10A
T84133	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9Y233	PDE10A
T13616	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q13418	ILK
T62460	DI0039	Atopic eczema	[ICD-11: EA80]	P23458	JAK1
T62460	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P23458	JAK1
T62460	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P23458	JAK1
T62460	DI0404	Thrombocytosis	[ICD-11: 3B63]	P23458	JAK1
T18477	DI0015	Acute upper respiratory infection	[ICD-11: CA07]	P07900	HSP90AA1
T18477	DI0037	Asthma	[ICD-11: CA23]	P07900	HSP90AA1
T53764	DI0300	Neutropenia	[ICD-11: 4B00]	Q12884	FAP
T21669	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P09211	GSTP1
T14731	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q96EB6	SIRT1
T14731	DI0399	Systemic sclerosis	[ICD-11: 4A42]	Q96EB6	SIRT1
T14731	DI0431	Vasculitis	[ICD-11: 4A44]	Q96EB6	SIRT1
T39321	DI0279	Muscular atrophy	[ICD-11: 8B61]	P04406	GAPDH
T39321	DI0280	Muscular dystrophy	[ICD-11: 8C70]	P04406	GAPDH
T56923	DI0155	Fungal infection	[ICD-11: 1F29-1F2F]	P25025	CXCR2
T56923	DI0324	Pain	[ICD-11: MG30-MG3Z]	P25025	CXCR2
T57943	DI0060	Brain cancer	[ICD-11: 2A00]	P42574	CASP3
T40111	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P20839	IMPDH1
T40111	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P20839	IMPDH1
T40111	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P20839	IMPDH1
T40111	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P20839	IMPDH1
T40111	DI0413	Transplant rejection	[ICD-11: NE84]	P20839	IMPDH1
T89360	DI0413	Transplant rejection	[ICD-11: NE84]	P12268	IMPDH2
T17758	DI0211	Inherited coagulation factor deficiency	[ICD-11: 3B14]	P00749	PLAU
T17758	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00749	PLAU
T30803	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P00390	GSR
T56556	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	Q9UNQ0	ABCG2
T56556	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9UNQ0	ABCG2
T96413	DI0242	Lysosomal disease	[ICD-11: 5C56]	P08236	GUSB
T03279	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	P51812	RPS6KA3
T31406	DI0207	Indeterminate colitis	[ICD-11: DD72]	P08631	HCK
T12541	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	Q9UBF8	PI4KB
T12541	DI0440	Zoonotic viral disease	ICD-11: 1D6Y	Q9UBF8	PI4KB
T15610	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P55786	NPEPPS
T15610	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	P55786	NPEPPS
T64205	DI0383	Skin and skin-structure infection	[ICD-11: 1F28-1G0Z]	P42224	STAT1
T97136	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q9BUB5	MKNK1
T97136	DI0095	Colorectal cancer	[ICD-11: 2B91]	Q9BUB5	MKNK1
T97136	DI0235	Liver cancer	[ICD-11: 2C12]	Q9BUB5	MKNK1
T97136	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q9BUB5	MKNK1
T97136	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9BUB5	MKNK1
T07137	DI0258	Metabolism inborn error	[ICD-11: 5C50]	P32754	HPD
T84397	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9H4B7	TUBB1
T28043	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	Q15349	RPS6KA2
T38509	DI0213	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	P00748	F12
T11615	DI0054	Body-focused behaviour disorder	[ICD-11: 6B25]	Q9UPY5	SLC7A11
T63083	DI0048	B-cell lymphoma	[ICD-11: 2A86]	Q06609	RAD51
T63083	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q06609	RAD51
T74937	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P09172	DBH
T74937	DI0341	Post-traumatic stress disorder	[ICD-11: 6B40]	P09172	DBH