Compound details

Acetovanillone

Compound ID	CDAMM00784
Common name	Acetovanillone
IUPAC name	1-(4-hydroxy-3-methoxyphenyl)ethanone
Molecular formula	C₉H₁₀O₃

Experimental data

Retention time	12.15
Adduct	[M+H]+
Actual mz	167.072
Theoretical mz	167.07
Error	10.92
Ionizaton mode	Positive
Instrument type	LC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score	7.5781

Identifiers and class information

Inchi key	DFYRUELUNQRZTB-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C(O)C(OC)=C1)C
Superclass	Organic oxygen compounds
Class	Organooxygen compounds

Plant source

Cinnamomum verum J. Presl

External sources

HMDB ID
KNApSAcK ID	C00002689
FooDB ID	FDB012055
DrugBank ID
ChEBI ID	CHEBI:2781
Pubchem Compound ID	2214
PlantCyc ID
UNPD ID	UNPD157048
Coconut ID	CNP0219031
LipidMAPS ID
NANPDB ID	NANPDB_1493

Pharmacokinetic properties

Number of descriptor values(#stars)	0
Number of non-conjugated amine groups (#amine)	0
Number of amidine and guanidine groups (#amidine)	0
Number of carboxylic acid groups (#acid)	0
Number of non-conjugated amide groups (#amide)	0
Number of rotatable bonds (#rotor)	3
Number of reactive functional groups (#rtvFG)	0
Predicted central nervous system activity (CNS)	0
Molecular weight (mol_MW)	166.176
Computed dipole moment(dipole)	2.472
Total solvent accessible surface area (SASA)	381.141
Hydrophobic component of SASA (FOSA)	172.859
Hydrophilic component of SASA (FISA)	105.062
Pie component of the SASA (PISA)	103.219
Weakly polar component of the SASA (WPSA)	0
Total solvent accesible volume (volume)	603.26
Number of hydrogen bond donors (donorHB)	1
Number of hydrogen bond acceptors (accptHB)	3.5
Free energy of solvation of dipole (dip^2/V)	0.0101337
Index of cohesive interaction in solids (ACxDN^.5/SA)	0.009183
Globularity descriptor (glob)	0.905905
Predicted polarizability in cubic angstroms (QPpolrz)	17.048
Predicted hexadecane/gas partition coefficient (QPlogPC16)	5.551
Predicted octanol/gas partition coefficient (QPlogPoct)	8.437
Predicted water/gas partition coefficient (QPlogPw)	6.303
Predicted octanol/water partition coefficient (QPlogPo/w)	1.502
Predicted aqueous solubility (QPlogS)	-1.965
Conformation-independent predicted aqueous solubility (CIQPlogS)	-1.649
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)	-3.547
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)	999.072
Predicted brain/blood partition coefficient (QPlogBB)	-0.471
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)	494.213
Predicted skin permeability, log Kp (QPlogKp)	-2.804
PM3 calculated ionization potential (IP(ev))	9.078
PM3 calculated electron affinity (EA(eV))	0.469
Number of likely metabolic reactions (#metab)	2
Prediction of binding to human serum albumin (QPlogKhsa)	-0.481
Predicted qualitative human oral absorption (HumanOralAbsorption)	3
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)	89.428
Solvent-accessible surface area of fluorine atoms (SAFluorine)	0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)	0
Van der Waals surface area (PSA)	58.713
Number of nitrogen and oxygen atoms (#NandO)	3
Number of violations of Lipinski’s rule of five (RuleOfFive)	0
Number of violations of Jorgensen’s rule of three (RuleOfThree)	0

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID	Gene name	Target name	TTD_ID	Prediction source
P22303	ACHE	Acetylcholinesterase	T30082	SwissTargetPrediction and SEA
O43570	CA12	Carbonic anhydrase XII	T16987	SwissTargetPrediction and SEA
Q16790	CA9	Carbonic anhydrase IX	T64567	SwissTargetPrediction and SEA
Q07820	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	T14912	SEA
P12821	ACE	Angiotensin-converting enzyme	T98311	SwissTargetPrediction
P41594	GRM5	Metabotropic glutamate receptor 5	T99347	SwissTargetPrediction
P21397	MAOA	Monoamine oxidase A	T83875	SEA
P00915	CA1	Carbonic anhydrase I	T13201	SwissTargetPrediction and SEA
P02766	TTR	Transthyretin	T86462	SwissTargetPrediction and SEA
P05067	APP	Beta amyloid A4 protein	T87024	SEA
P00918	CA2	Carbonic anhydrase II	T20401	SwissTargetPrediction and SEA
Q15125	EBP	Anti-estrogen binding site (AEBS)	T25317	SEA
P31213	SRD5A2	Steroid 5-alpha-reductase 2	T71390	SwissTargetPrediction
P43166	CA7	Carbonic anhydrase VII	T37541	SwissTargetPrediction and SEA
P23280	CA6	Carbonic anhydrase VI	T06569	SEA
Q9ULX7	CA14	Carbonic anhydrase XIV	T31992	SwissTargetPrediction and SEA
P27338	MAOB	Monoamine oxidase B	T83011	SwissTargetPrediction and SEA
P05164	MPO	Myeloperoxidase	T23471	SEA
Q9H3R0	KDM4C	Lysine-specific demethylase 4C	T73863	SEA
P23141	CES1	Acyl coenzyme A:cholesterol acyltransferase	T76369	SEA
P42330	AKR1C3	Aldo-keto-reductase family 1 member C3	T60857	SEA
Q6B0I6	KDM4D	Lysine-specific demethylase 4D	T17036	SEA
P11926	ODC1	Ornithine decarboxylase	T60366	SEA
P80404	ABAT	Gamma-amino-N-butyrate transaminase	T59045	SwissTargetPrediction
Q8NER1	TRPV1	Vanilloid receptor	T83193	SEA
O14684	PTGES	Prostaglandin E synthase	T02562	SEA
P18031	PTPN1	Protein-tyrosine phosphatase 1B	T16347	SEA
Q7Z2W7	TRPM8	Transient receptor potential cation channel subfamily M member 8	T41955	SEA
P09917	ALOX5	Arachidonate 5-lipoxygenase	T00140	SEA
Q9Y4C1	KDM3A	Lysine-specific demethylase 3A	T25362	SEA
P13726	F3	Coagulation factor VII/tissue factor	T72702	SEA
P21964	COMT	Catechol O-methyltransferase (by homology)	T76904	SwissTargetPrediction
P21728	DRD1	Dopamine D1 receptor	T22118	SEA
P33527	ABCC1	Multidrug resistance-associated protein 1	T11288	SEA
P08183	ABCB1	P-glycoprotein 1	T25258	SEA
O14757	CHEK1	Serine/threonine-protein kinase Chk1	T62449	SEA
P19838	NFKB1	Nuclear factor NF-kappa-B p105 subunit	T83145	SEA
P16050	ALOX15	Arachidonate 15-lipoxygenase	T16042	SEA
Q08499	PDE4D	Phosphodiesterase 4D	T02001	SEA
P04035	HMGCR	HMG-CoA reductase	T53585	SwissTargetPrediction
O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	T01003	SwissTargetPrediction
Q09472	EP300	Histone acetyltransferase p300	T25956	SwissTargetPrediction and SEA
P10276	RARA	Retinoic acid receptor alpha	T94085	SEA
O96017	CHEK2	Serine/threonine-protein kinase Chk2	T28713	SEA
P47871	GCGR	Glucagon receptor	T60182	SEA
P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	T09538	SwissTargetPrediction and SEA
Q9NR96	TLR9	Toll-like receptor (TLR7/TLR9)	T11451	SEA
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	T98225	SEA
Q92793	CREBBP	CREB-binding protein/p53	T03634	SEA
P17936	IGFBP3	Insulin-like growth factor binding protein 3	T33455	SEA
P04049	RAF1	Serine/threonine-protein kinase RAF	T51883	SEA
Q9UQM7	CAMK2A	CaM kinase II alpha	T18299	SEA
P15056	BRAF	Serine/threonine-protein kinase B-raf	T99089	SEA
Q9UNQ0	ABCG2	ATP-binding cassette sub-family G member 2	T56556	SEA
Q12791	KCNMA1	Calcium-activated potassium channel subunit alpha-1	T66538	SEA
O14649	KCNK3	Potassium channel subfamily K member 3	T15795	SEA
Q9NPC2	KCNK9	Potassium channel subfamily K member 9	T57613	SEA
P16234	PDGFRA	Platelet-derived growth factor receptor	T53524	SEA
Q9NPH5	NOX4	NADPH oxidase 4	T29741	SEA
O95819	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4	T71367	SEA
P15735	PHKG2	Phosphorylase kinase gamma subunit 2	T69208	SEA
O43293	DAPK3	Death-associated protein kinase 3	T81623	SEA
P78368	CSNK1G2	Casein kinase I gamma 2	T82773	SEA
P48729	CSNK1A1	Casein kinase I alpha	T13075	SwissTargetPrediction
P48730	CSNK1D	Casein kinase I delta	T87109	SwissTargetPrediction
Q13464	ROCK1	Rho-associated protein kinase 1	T51282	SEA
Q16678	CYP1B1	Cytochrome P450 1B1	T92521	SEA
P10636	MAPT	Microtubule-associated protein tau	T45593	SEA
Q04760	GLO1	Glyoxalase I	T88285	SEA
Q96KB5	PBK	PDZ-binding kinase	T98642	SEA
P30281	CCND3	Cyclin-dependent kinase 4/cyclin D	T72507	SEA
Q08493	PDE4C	Phosphodiesterase 4C	T12081	SEA
P10696	ALPG	Alkaline phosphatase placental-like	T35565	SEA
P19438	TNFRSF1A	Tumor necrosis factor receptor R1	T86552	SEA
Q16236	NFE2L2	Nuclear factor erythroid 2-related factor 2	T88505	SEA
P13631	RARG	Retinoic acid receptor gamma	T82146	SEA
P10826	RARB	Retinoic acid receptor beta	T61657	SEA
Q9UQM7	CAMK2A	CaM kinase II alpha	T18299	SEA
Q15120	PDK3	Pyruvate dehydrogenase kinase isoform 3	T99029	SEA
Q9UQM7	CAMK2A	CaM kinase II alpha	T18299	SEA
Q9Y337	KLK5	Kallikrein 5	T11808	SEA
O75884	RBBP9	Putative hydrolase RBBP9	T12084	SEA
Q9H4B7	TUBB1	Tubulin beta-1 chain	T84397	SEA
P30837	ALDH1B1	Acetaldehyde dehydrogenase	T99641	SwissTargetPrediction
P24593	IGFBP5	Insulin-like growth factor binding protein 5	T17008	SEA
Q14721	KCNB1	Potassium voltage-gated channel subfamily B member 1	T44516	SEA
P41586	ADCYAP1R1	Pituitary adenylate cyclase-activating polypeptide type I receptor	T92185	SEA
Q96PF2	TSSK2	Testis-specific serine/threonine-protein kinase 2	T04413	SEA
P24592	IGFBP6	Insulin-like growth factor binding protein 6	T61800	SEA
P18065	IGFBP2	Insulin-like growth factor binding protein 2	T64268	SEA
P08833	IGFBP1	Insulin-like growth factor binding protein 1	T15048	SEA
O43781	DYRK3	Dual-specificity tyrosine-phosphorylation regulated kinase 3	T97149	SEA
Q9UEE5	STK17A	Serine/threonine-protein kinase 17A	T91323	SEA
P11717	IGF2R	Insulin-like growth factor II receptor	T59550	SEA
P49862	KLK7	Kallikrein-7	T79155	SEA
Q9BY41	HDAC8	Histone deacetylase 8	T28887	SEA
Q7RTX1	TAS1R1	Taste receptor	T41263	SEA
P01100	FOS	Proto-oncogene c-Fos	T28025	SEA
Q9NXA8	SIRT5	NAD-dependent deacetylase sirtuin-5	T91940	SEA
Q9NR20	DYRK4	Dual-specificity tyrosine-phosphorylation regulated kinase 4	T20542	SEA
Q8N183	NDUFAF2	HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2	T01453	SEA
Q9P0J0	NDUFA13	Mitochondrial complex I	T82391	SEA
Q9Y6M9	NDUFB9	HUMAN NADH:ubiquinone oxidoreductase subunit B9	T01465	SEA
Q8N183	NDUFAF2	HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2	T01453	SEA
P03897	MT-ND3	NADH dehydrogenase	T77195	SEA
O75751	EMTH	Organic cation transporter 3	T55948	SEA
Q8TDC3	BRSK1	BR serine/threonine kinase 1	T20053	SEA
Q9Y6M4	CSNK1G3	Casein kinase I gamma-3	T29728	SEA

Target associated diseases

TTD_ID	Disease_ID	Disease name	ICD_11	Uniprot ID	Gene names
T30082	DI0025	Alzheimer disease	[ICD-11: 8A20]	P22303	ACHE
T30082	DI0166	Glaucoma	[ICD-11: 9C61]	P22303	ACHE
T30082	DI0282	Myasthenia gravis	[ICD-11: 8C6Y]	P22303	ACHE
T30082	DI0313	Oesophageal/gastroduodenal disorder	[ICD-11: DD90]	P22303	ACHE
T30082	DI0332	Pediculosis	[ICD-11: 1G00]	P22303	ACHE
T30082	DI0421	Unspecific substance harmful effect	[ICD-11: NE6Z]	P22303	ACHE
T16987	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	O43570	CA12
T16987	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	O43570	CA12
T64567	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q16790	CA9
T14912	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q07820	MCL1
T14912	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	Q07820	MCL1
T14912	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q07820	MCL1
T14912	DI0252	Melanoma	[ICD-11: 2C30]	Q07820	MCL1
T14912	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q07820	MCL1
T14912	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q07820	MCL1
T98311	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P12821	ACE
T98311	DI0190	Hypertension	[ICD-11: BA00-BA04]	P12821	ACE
T99347	DI0152	Fragile X chromosome	[ICD-11: LD55]	P41594	GRM5
T99347	DI0331	Parkinsonism	[ICD-11: 8A00]	P41594	GRM5
T83875	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P21397	MAOA
T83875	DI0331	Parkinsonism	[ICD-11: 8A00]	P21397	MAOA
T13201	DI0166	Glaucoma	[ICD-11: 9C61]	P00915	CA1
T13201	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00915	CA1
T86462	DI0026	Amyloidosis	[ICD-11: 5D00]	P02766	TTR
T87024	DI0025	Alzheimer disease	[ICD-11: 8A20]	P05067	APP
T87024	DI0122	Diagnostic imaging	[ICD-11: N.A.]	P05067	APP
T20401	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P00918	CA2
T20401	DI0137	Essential hypertension	[ICD-11: BA00]	P00918	CA2
T20401	DI0166	Glaucoma	[ICD-11: 9C61]	P00918	CA2
T20401	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P00918	CA2
T20401	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P00918	CA2
T20401	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00918	CA2
T25317	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q15125	EBP
T71390	DI0348	Prostate hyperplasia	[ICD-11: GA90]	P31213	SRD5A2
T06569	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P23280	CA6
T06569	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P23280	CA6
T31992	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q9ULX7	CA14
T31992	DI0204	Inborn metabolism deficiency	[ICD-11: 5C50-5C59]	Q9ULX7	CA14
T83011	DI0115	Dementia	[ICD-11: 6D80-6D8Z]	P27338	MAOB
T83011	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P27338	MAOB
T83011	DI0190	Hypertension	[ICD-11: BA00-BA04]	P27338	MAOB
T83011	DI0243	Malaria	[ICD-11: 1F40-1F45]	P27338	MAOB
T83011	DI0264	Migraine	[ICD-11: 8A80]	P27338	MAOB
T83011	DI0331	Parkinsonism	[ICD-11: 8A00]	P27338	MAOB
T23471	DI0229	Left ventricular failure	[ICD-11: BD11]	P05164	MPO
T23471	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	P05164	MPO
T76369	DI0335	Peroxisomal disease	[ICD-11: 5C57]	P23141	CES1
T76369	DI0398	Synthesis disorder	[ICD-11: 5C52-5C59]	P23141	CES1
T60857	DI0145	Female pelvic pain	[ICD-11: GA34]	P42330	AKR1C3
T60366	DI0020	African trypanosomiasis	[ICD-11: 1F51]	P11926	ODC1
T59045	DI0060	Brain cancer	[ICD-11: 2A00]	P80404	ABAT
T59045	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P80404	ABAT
T59045	DI0135	Epileptic encephalopathy	[ICD-11: 8A62]	P80404	ABAT
T59045	DI0266	Mineral deficiency	[ICD-11: 5B5K]	P80404	ABAT
T59045	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P80404	ABAT
T83193	DI0163	General pain disorder	[ICD-11: 8E43]	Q8NER1	TRPV1
T02562	DI0025	Alzheimer disease	[ICD-11: 8A20]	O14684	PTGES
T16347	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P18031	PTPN1
T16347	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P18031	PTPN1
T16347	DI0308	Obesity	[ICD-11: 5B80-5B81]	P18031	PTPN1
T16347	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P18031	PTPN1
T41955	DI0422	Upper respiratory tract disorder	[ICD-11: CA0Z]	Q7Z2W7	TRPM8
T00140	DI0037	Asthma	[ICD-11: CA23]	P09917	ALOX5
T00140	DI0147	Filariasis	[ICD-11: 1F66]	P09917	ALOX5
T00140	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P09917	ALOX5
T72702	DI0075	Cervical cancer	[ICD-11: 2C77]	P13726	F3
T76904	DI0331	Parkinsonism	[ICD-11: 8A00]	P21964	COMT
T22118	DI0003	Abortion	[ICD-11: JA00]	P21728	DRD1
T22118	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	P21728	DRD1
T22118	DI0190	Hypertension	[ICD-11: BA00-BA04]	P21728	DRD1
T22118	DI0331	Parkinsonism	[ICD-11: 8A00]	P21728	DRD1
T11288	DI0167	Gout	[ICD-11: FA25]	P33527	ABCC1
T25258	DI0238	Lung cancer	[ICD-11: 2C25]	P08183	ABCB1
T62449	DI0027	Anal cancer	[ICD-11: 2C00]	O14757	CHEK1
T62449	DI0172	Head and neck cancer	[ICD-11: 2D42]	O14757	CHEK1
T62449	DI0183	Hodgkin lymphoma	[ICD-11: 2B30]	O14757	CHEK1
T62449	DI0238	Lung cancer	[ICD-11: 2C25]	O14757	CHEK1
T62449	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O14757	CHEK1
T62449	DI0321	Ovarian cancer	[ICD-11: 2C73]	O14757	CHEK1
T62449	DI0326	Pancreatic cancer	[ICD-11: 2C10]	O14757	CHEK1
T62449	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O14757	CHEK1
T83145	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P19838	NFKB1
T83145	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P19838	NFKB1
T02001	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	Q08499	PDE4D
T53585	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P04035	HMGCR
T53585	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	P04035	HMGCR
T53585	DI0128	Dyslipidemia	[ICD-11: 5C80-5C81]	P04035	HMGCR
T53585	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P04035	HMGCR
T53585	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P04035	HMGCR
T53585	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P04035	HMGCR
T53585	DI0324	Pain	[ICD-11: MG30-MG3Z]	P04035	HMGCR
T01003	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	O75460	ERN1
T25956	DI0346	Prostate cancer	[ICD-11: 2C82]	Q09472	EP300
T25956	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q09472	EP300
T94085	DI0025	Alzheimer disease	[ICD-11: 8A20]	P10276	RARA
T94085	DI0251	Mature T-cell lymphoma	[ICD-11: 2A90]	P10276	RARA
T28713	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O96017	CHEK2
T60182	DI0193	Hypo-glycaemia	[ICD-11: 5A41]	P47871	GCGR
T09538	DI0164	Genetic prion disease	[ICD-11: 8E02]	P05186	ALPL
T09538	DI0330	Parasitic infection	[ICD-11: 1D0Y-1G2Z]	P05186	ALPL
T11451	DI0095	Colorectal cancer	[ICD-11: 2B91]	Q9NR96	TLR9
T11451	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	Q9NR96	TLR9
T11451	DI0252	Melanoma	[ICD-11: 2C30]	Q9NR96	TLR9
T11451	DI0346	Prostate cancer	[ICD-11: 2C82]	Q9NR96	TLR9
T03634	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q92793	CREBBP
T03634	DI0346	Prostate cancer	[ICD-11: 2C82]	Q92793	CREBBP
T03634	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q92793	CREBBP
T03634	DI0399	Systemic sclerosis	[ICD-11: 4A42]	Q92793	CREBBP
T33455	DI0115	Dementia	[ICD-11: 6D80-6D8Z]	P17936	IGFBP3
T51883	DI0252	Melanoma	[ICD-11: 2C30]	P04049	RAF1
T51883	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P04049	RAF1
T51883	DI0321	Ovarian cancer	[ICD-11: 2C73]	P04049	RAF1
T51883	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P04049	RAF1
T18299	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9UQM7	CAMK2A
T99089	DI0252	Melanoma	[ICD-11: 2C30]	P15056	BRAF
T56556	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	Q9UNQ0	ABCG2
T56556	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9UNQ0	ABCG2
T66538	DI0037	Asthma	[ICD-11: CA23]	Q12791	KCNMA1
T66538	DI0154	Functional bladder disorder	[ICD-11: GC50]	Q12791	KCNMA1
T15795	DI0309	Obstructive sleep apnoea	[ICD-11: 7A41]	O14649	KCNK3
T53524	DI0160	Gastrointestinal stromal tumour	[ICD-11: 2B5B]	P16234	PDGFRA
T53524	DI0225	Kaposi sarcoma	[ICD-11: 2B57]	P16234	PDGFRA
T53524	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P16234	PDGFRA
T29741	DI0146	Fibrosis	[ICD-11: GA14-GC01]	Q9NPH5	NOX4
T13075	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P48729	CSNK1A1
T13075	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P48729	CSNK1A1
T87109	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	P48730	CSNK1D
T87109	DI0326	Pancreatic cancer	[ICD-11: 2C10]	P48730	CSNK1D
T51282	DI0166	Glaucoma	[ICD-11: 9C61]	Q13464	ROCK1
T45593	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P10636	MAPT
T45593	DI0025	Alzheimer disease	[ICD-11: 8A20]	P10636	MAPT
T45593	DI0265	Mild neurocognitive disorder	[ICD-11: 6D71]	P10636	MAPT
T88285	DI0210	Influenza	[ICD-11: 1E30-1E32]	Q04760	GLO1
T98642	DI0291	Nasopharyngeal cancer	[ICD-11: 2B6B]	Q96KB5	PBK
T86552	DI0060	Brain cancer	[ICD-11: 2A00]	P19438	TNFRSF1A
T86552	DI0321	Ovarian cancer	[ICD-11: 2C73]	P19438	TNFRSF1A
T88505	DI0038	Ataxic disorder	[ICD-11: 8A03]	Q16236	NFE2L2
T82146	DI0005	Acne vulgaris	[ICD-11: ED80]	P13631	RARG
T82146	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P13631	RARG
T82146	DI0225	Kaposi sarcoma	[ICD-11: 2B57]	P13631	RARG
T82146	DI0277	Muscle calcification/ossification	[ICD-11: FB31]	P13631	RARG
T82146	DI0351	Psoriasis	[ICD-11: EA90]	P13631	RARG
T61657	DI0225	Kaposi sarcoma	[ICD-11: 2B57]	P10826	RARB
T18299	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9UQM7	CAMK2A
T18299	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9UQM7	CAMK2A
T84397	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9H4B7	TUBB1
T99641	DI0396	Substance abuse	[ICD-11: 6C40]	P30837	ALDH1B1
T92185	DI0264	Migraine	[ICD-11: 8A80]	P41586	ADCYAP1R1
T59550	DI0146	Fibrosis	[ICD-11: GA14-GC01]	P11717	IGF2R
T59550	DI0368	Sarcoidosis	[ICD-11: 4B20]	P11717	IGF2R
T28887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9BY41	HDAC8
T41263	DI0078	Cholera	[ICD-11: 1A00]	Q7RTX1	TAS1R1
T82391	DI0069	Cardiomyopathy	[ICD-11: BC43]	Q9P0J0	NDUFA13
T77195	DI0331	Parkinsonism	[ICD-11: 8A00]	P03897	MT-ND3