Compound details

Nantoamide

Compound ID	CDAMM00683
Common name	Nantoamide
IUPAC name	N-(2-phenylethyl)-1,3-benzodioxole-5-carboxamide
Molecular formula	C₁₆H₁₅NO₃

Experimental data

Retention time	7.68
Adduct	[M+Na]+
Actual mz	292.095
Theoretical mz	292.094
Error	1.31
Ionizaton mode	Positive
Instrument type	LC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score	7.4655

Identifiers and class information

Inchi key	KBJGLIJMWJNSKP-UHFFFAOYSA-N
Smiles	O=C(NCCC=1C=CC=CC1)C2=CC=C3OCOC3=C2
Superclass	Organoheterocyclic compounds
Class	Benzodioxoles

Plant source

Piper retrofractum Vahl

External sources

HMDB ID
KNApSAcK ID	C00032054
FooDB ID
DrugBank ID
ChEBI ID
Pubchem Compound ID	669595
PlantCyc ID
UNPD ID	UNPD96552
Coconut ID	CNP0257812
LipidMAPS ID
NANPDB ID

Pharmacokinetic properties

Number of descriptor values(#stars)	0
Number of non-conjugated amine groups (#amine)	0
Number of amidine and guanidine groups (#amidine)	0
Number of carboxylic acid groups (#acid)	0
Number of non-conjugated amide groups (#amide)	0
Number of rotatable bonds (#rotor)	4
Number of reactive functional groups (#rtvFG)	1
Predicted central nervous system activity (CNS)	1
Molecular weight (mol_MW)	269.299
Computed dipole moment(dipole)	4.012
Total solvent accessible surface area (SASA)	492.124
Hydrophobic component of SASA (FOSA)	161.431
Hydrophilic component of SASA (FISA)	32.867
Pie component of the SASA (PISA)	297.826
Weakly polar component of the SASA (WPSA)	0
Total solvent accesible volume (volume)	857.579
Number of hydrogen bond donors (donorHB)	1
Number of hydrogen bond acceptors (accptHB)	4
Free energy of solvation of dipole (dip^2/V)	0.018769
Index of cohesive interaction in solids (ACxDN^.5/SA)	0.008128
Globularity descriptor (glob)	0.887033
Predicted polarizability in cubic angstroms (QPpolrz)	28.442
Predicted hexadecane/gas partition coefficient (QPlogPC16)	8.854
Predicted octanol/gas partition coefficient (QPlogPoct)	12.736
Predicted water/gas partition coefficient (QPlogPw)	7.675
Predicted octanol/water partition coefficient (QPlogPo/w)	3.124
Predicted aqueous solubility (QPlogS)	-3.208
Conformation-independent predicted aqueous solubility (CIQPlogS)	-3.929
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)	-4.78
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)	4833.02
Predicted brain/blood partition coefficient (QPlogBB)	0.044
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)	2715.87
Predicted skin permeability, log Kp (QPlogKp)	-0.692
PM3 calculated ionization potential (IP(ev))	9.179
PM3 calculated electron affinity (EA(eV))	0.384
Number of likely metabolic reactions (#metab)	1
Prediction of binding to human serum albumin (QPlogKhsa)	0.035
Predicted qualitative human oral absorption (HumanOralAbsorption)	3
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)	100
Solvent-accessible surface area of fluorine atoms (SAFluorine)	0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)	0
Van der Waals surface area (PSA)	52.832
Number of nitrogen and oxygen atoms (#NandO)	4
Number of violations of Lipinski’s rule of five (RuleOfFive)	0
Number of violations of Jorgensen’s rule of three (RuleOfThree)	0

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID	Gene name	Target name	TTD_ID	Prediction source
Q9GZV3	SLC5A7	High-affinity choline transporter (by homology)	T83143	SEA
P08912	CHRM5	Muscarinic acetylcholine receptor M5	T79961	SEA
P11229	CHRM1	Muscarinic acetylcholine receptor M1	T28893	SEA
P22303	ACHE	Acetylcholinesterase	T30082	SEA
P20309	CHRM3	Muscarinic acetylcholine receptor M3	T67684	SEA
P30542	ADORA1	Adenosine A1 receptor	T92072	SEA
O43570	CA12	Carbonic anhydrase XII	T16987	SEA
Q16790	CA9	Carbonic anhydrase IX	T64567	SwissTargetPrediction and SEA
P29475	NOS1	Nitric-oxide synthase, brain	T16117	SwissTargetPrediction
P35228	NOS2	Nitric oxide synthase, inducible	T02703	SEA
P29474	NOS3	Nitric-oxide synthase, endothelial	T06046	SwissTargetPrediction
Q07820	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	T14912	SEA
Q99720	SIGMAR1	Sigma opioid receptor	T46360	SwissTargetPrediction and SEA
P34903	GABRA3	GABA A receptor alpha-3/beta-2/gamma-2	T62292	SwissTargetPrediction
P47869	GABRA2	GABA A receptor alpha-2/beta-2/gamma-2	T51452	SwissTargetPrediction
Q96KS0	EIT6	HIF-prolyl hydroxylase 1	T53904	SEA
P15144	ANPEP	Aminopeptidase N	T67272	SEA
P00734	F2	Thrombin	T94033	SwissTargetPrediction
O15379	HDAC3	Histone deacetylase 3	T05090	SEA
P21917	DRD4	Dopamine D4 receptor	T24983	SEA
P21397	MAOA	Monoamine oxidase A	T83875	SwissTargetPrediction
P00915	CA1	Carbonic anhydrase I	T13201	SwissTargetPrediction and SEA
P42336	PIK3CA	PI3-kinase p110-alpha subunit	T80276	SwissTargetPrediction
P00918	CA2	Carbonic anhydrase II	T20401	SwissTargetPrediction and SEA
P16083	NQO2	Quinone reductase 2	T75498	SwissTargetPrediction and SEA
P14416	DRD2	Dopamine D2 receptor	T67162	SEA
Q9NTG7	SIRT3	NAD-dependent deacetylase sirtuin 3	T91959	SwissTargetPrediction
Q8IXJ6	SIRT2	NAD-dependent deacetylase sirtuin 2	T83904	SwissTargetPrediction
Q4U2R8	SLC22A6	Solute carrier family 22 member 6 (by homology)	T70680	SEA
P08514	ITGA2B	Integrin alpha-IIb/beta-3	T50688	SEA
Q96RI1	NR1H4	Bile acid receptor FXR	T51426	SEA
P08473	MME	Neprilysin	T05409	SEA
P17612	PRKACA	cAMP-dependent protein kinase alpha-catalytic subunit	T12808	SwissTargetPrediction
P21554	CNR1	Cannabinoid receptor 1 (by homology)	T76685	SwissTargetPrediction and SEA
P34913	EPHX2	Epoxide hydratase	T35734	SEA
Q02083	NAAA	N-acylsphingosine-amidohydrolase (by homology)	T78326	SwissTargetPrediction
P43166	CA7	Carbonic anhydrase VII	T37541	SwissTargetPrediction and SEA
Q9ULX7	CA14	Carbonic anhydrase XIV	T31992	SEA
P22748	CA4	Carbonic anhydrase IV	T53378	SEA
P27338	MAOB	Monoamine oxidase B	T83011	SwissTargetPrediction and SEA
O60341	KDM1A	Lysine-specific histone demethylase 1	T16739	SwissTargetPrediction
P28223	HTR2A	Serotonin 2a (5-HT2a) receptor	T32060	SwissTargetPrediction and SEA
P28335	HTR2C	Serotonin 2c (5-HT2c) receptor	T83813	SwissTargetPrediction and SEA
Q96RJ0	TAAR1	Trace amine-associated receptor 1 (by homology)	T99524	SEA
P41595	HTR2B	Serotonin 2b (5-HT2b) receptor	T31204	SwissTargetPrediction and SEA
P08913	ADRA2A	Alpha-2a adrenergic receptor	T11448	SEA
P08908	HTR1A	Serotonin 1a (5-HT1a) receptor	T78709	SEA
Q01959	SLC6A3	Dopamine transporter	T55959	SwissTargetPrediction
P56524	HDAC4	Histone deacetylase 4	T63816	SEA
Q9UKV0	HDAC9	Histone deacetylase 9	T03687	SEA
Q92769	HDAC2	Histone deacetylase 2	T51191	SEA
Q99705	MCHR1	Melanin-concentrating hormone receptor 1	T09572	SwissTargetPrediction and SEA
Q9H3R0	KDM4C	Lysine-specific demethylase 4C	T73863	SwissTargetPrediction
P23141	CES1	Acyl coenzyme A:cholesterol acyltransferase	T76369	SwissTargetPrediction and SEA
Q6B0I6	KDM4D	Lysine-specific demethylase 4D	T17036	SwissTargetPrediction
O75164	KDM4A	Lysine-specific demethylase 4A	T18904	SwissTargetPrediction
Q6B0I6	KDM4D	Lysine-specific demethylase 4D	T17036	SwissTargetPrediction
O00519	FAAH	Anandamide amidohydrolase	T11754	SEA
Q8NER1	TRPV1	Vanilloid receptor	T83193	SEA
P06401	PGR	Progesterone receptor	T22939	SwissTargetPrediction
P25021	HRH2	Histamine H2 receptor	T30985	SEA
P08575	PTPRC	Leukocyte common antigen	T43115	SwissTargetPrediction and SEA
P49137	MAPKAPK2	MAP kinase-activated protein kinase 2	T21307	SwissTargetPrediction
P08253	MMP2	Matrix metalloproteinase 2	T68251	SEA
P22894	MMP8	Matrix metalloproteinase 8	T08856	SEA
P08254	MMP3	Matrix metalloproteinase 3	T86702	SEA
P14780	MMP9	Matrix metalloproteinase 9	T54156	SwissTargetPrediction
P09917	ALOX5	Arachidonate 5-lipoxygenase	T00140	SEA
P03956	MMP1	Matrix metalloproteinase 1	T52450	SwissTargetPrediction and SEA
P35462	DRD3	Dopamine D3 receptor	T02551	SEA
P21731	TBXA2R	Thromboxane A2 receptor	T76198	SEA
P18825	ADRA2C	Adrenergic receptor alpha-2	T01777	SEA
P08183	ABCB1	P-glycoprotein 1	T25258	SwissTargetPrediction
P35372	OPRM1	Mu opioid receptor	T47768	SwissTargetPrediction and SEA
P41145	OPRK1	Kappa Opioid receptor	T60693	SEA
P10827	THRA	Thyroid hormone receptor alpha	T79591	SEA
P10828	THRB	Thyroid hormone receptor beta-1	T98933	SEA
P52732	KIF11	Kinesin-like protein 1	T28484	SwissTargetPrediction
P11309	PIM1	Serine/threonine-protein kinase PIM1	T50594	SwissTargetPrediction
P04626	ERBB2	Receptor protein-tyrosine kinase erbB-2	T14597	SwissTargetPrediction
O14757	CHEK1	Serine/threonine-protein kinase Chk1	T62449	SwissTargetPrediction
P06276	BCHE	Butyrylcholinesterase	T99799	SEA
O60674	JAK2	Tyrosine-protein kinase JAK2	T08391	SwissTargetPrediction
P36888	FLT3	Tyrosine-protein kinase receptor FLT3	T74312	SwissTargetPrediction
Q9P1W9	PIM2	Serine/threonine-protein kinase PIM2	T07279	SwissTargetPrediction
Q86V86	PIM3	Serine/threonine-protein kinase PIM3	T16596	SwissTargetPrediction
P45452	MMP13	Matrix metalloproteinase 13	T34296	SwissTargetPrediction
Q9Y233	PDE10A	Phosphodiesterase 10A (by homology)	T84133	SwissTargetPrediction
P13497	BMP1	Bone morphogenetic protein 1	T53350	SEA
P25105	PTAFR	Platelet activating factor receptor	T87023	SEA
P07711	CTSL	Cathepsin L	T98691	SEA
P41143	OPRD1	Delta opioid receptor	T58992	SwissTargetPrediction and SEA
P23946	CMA1	Chymase	T05114	SEA
P00742	F10	Thrombin and coagulation factor X	T84631	SwissTargetPrediction
P62942	FKBP1A	FK506-binding protein 1A	T76059	SEA
O43193	MLNR	Motilin receptor	T62306	SEA
O14746	TERT	Telomerase reverse transcriptase	T86052	SEA
P43116	PTGER2	Prostanoid EP2 receptor	T38529	SEA
Q06124	PTPN11	Protein-tyrosine phosphatase 2C	T13057	SEA
Q15722	LTB4R	Leukotriene B4 receptor 1	T59626	SEA
P11137	MAP2	Microtubule-associated protein 2	T23276	SEA
P13500	CCL2	C-C motif chemokine 2	T89988	SEA
P35348	ADRA1A	Alpha-1a adrenergic receptor	T92609	SEA
O75116	ROCK2	Rho-associated protein kinase 2	T06093	SwissTargetPrediction and SEA
P23458	JAK1	Tyrosine-protein kinase JAK1	T62460	SwissTargetPrediction
P08238	HSP90AB1	Heat shock protein HSP 90-beta	T96623	SwissTargetPrediction
P47871	GCGR	Glucagon receptor	T60182	SEA
Q5S007	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2	T08123	SwissTargetPrediction
P41229	KDM5C	Lysine-specific demethylase 5C	T85540	SwissTargetPrediction
P36897	TGFBR1	TGF-beta receptor type I	T53389	SEA
O00329	PIK3CD	PI3-kinase p110-delta subunit	T67849	SwissTargetPrediction
P17948	FLT1	Vascular endothelial growth factor receptor 1	T63966	SwissTargetPrediction
Q15078	CDK5R1	Cyclin-dependent kinase 5/CDK5 activator 1	T09513	SwissTargetPrediction and SEA
Q9HBH9	MKNK2	MAP kinase signal-integrating kinase 2	T99160	SwissTargetPrediction
P25098	GRK2	G-protein coupled receptor kinase 2	T62548	SwissTargetPrediction and SEA
Q13627	DYRK1A	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	T92803	SwissTargetPrediction
P33981	TTK	Dual specificity protein kinase TTK	T74977	SwissTargetPrediction
P49759	CLK1	Dual specificty protein kinase CLK1	T46685	SwissTargetPrediction and SEA
P52333	JAK3	Tyrosine-protein kinase JAK3	T23172	SwissTargetPrediction
P29597	TYK2	Tyrosine-protein kinase TYK2	T78932	SwissTargetPrediction
Q6P179	ERAP2	Endoplasmic reticulum aminopeptidase 2	T65818	SEA
P20151	KLK2	Kallikrein 2	T01908	SEA
P47898	HTR5A	Serotonin 5a (5-HT5a) receptor	T15571	SwissTargetPrediction and SEA
P48039	MTNR1A	Melatonin receptor 1A	T97613	SEA
P49286	MTNR1B	Melatonin receptor 1B	T48268	SEA
P18089	ADRA2B	Alpha-2b adrenergic receptor	T41580	SEA
P34972	CNR2	Cannabinoid receptor 2	T37693	SwissTargetPrediction
P43115	PTGER3	Prostanoid EP3 receptor	T85467	SEA
P06756	ITGAV	Vitronectin receptor alpha	T67103	SEA
P17301	ITGA2	Integrin alpha-2	T55293	SEA
O00311	CDC7	CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)	T81358	SwissTargetPrediction
P42892	ECE1	Endothelin-converting enzyme 1	T50970	SEA
Q9ULW8	PADI3	Protein-arginine deiminase type-3	T36612	SEA
Q9UM07	PADI4	Protein-arginine deiminase type-4	T50429	SEA
Q9HAZ1	CLK4	Dual specificity protein kinase CLK4	T98225	SEA
P11362	FGFR1	Fibroblast growth factor receptor 1	T47101	SwissTargetPrediction
P25101	EDNRA	Endothelin receptor ET-A	T23499	SEA
P07333	CSF1R	Macrophage colony stimulating factor receptor	T20333	SwissTargetPrediction
P49840	GSK3A	Glycogen synthase kinase-3 alpha	T76910	SwissTargetPrediction
P50750	CDK9	Cyclin-dependent kinase 9	T44458	SwissTargetPrediction
P49761	CLK3	Dual specificity protein kinase CLK3	T21585	SwissTargetPrediction and SEA
P46098	HTR3A	Serotonin 3a (5-HT3a) receptor	T64591	SEA
Q13258	PTGDR	Prostanoid DP receptor	T68782	SEA
P17936	IGFBP3	Insulin-like growth factor binding protein 3	T33455	SEA
O76074	PDE5A	Phosphodiesterase 5A	T07663	SEA
Q13976	PRKG1	cGMP-dependent protein kinase 1 beta	T78543	SwissTargetPrediction
Q04759	PRKCQ	Protein kinase C theta	T23995	SwissTargetPrediction
P43119	PTGIR	Prostanoid IP receptor	T99954	SEA
P53350	PLK1	Serine/threonine-protein kinase PLK1	T40694	SEA
P00749	PLAU	Urokinase-type plasminogen activator	T17758	SEA
P04049	RAF1	Serine/threonine-protein kinase RAF	T51883	SwissTargetPrediction
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	T23787	SwissTargetPrediction
P15056	BRAF	Serine/threonine-protein kinase B-raf	T99089	SwissTargetPrediction
P24530	EDNRB	Endothelin receptor ET-B	T92828	SEA
Q9Y210	TRPC6	Short transient receptor potential channel 6	T80165	SwissTargetPrediction
P53671	LIMK2	LIM domain kinase 2	T09133	SEA
P50053	KHK	Ketohexokinase	T79326	SwissTargetPrediction
P43490	NAMPT	Nicotinamide phosphoribosyltransferase	T54582	SEA
Q14524	SCN5A	Sodium channel protein type V alpha subunit	T39716	SEA
P22460	KCNA5	Voltage-gated potassium channel subunit Kv1.5	T17569	SEA
Q9UKP6	UTS2R	Urotensin II receptor	T49072	SwissTargetPrediction
Q13526	PIN1	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	T16308	SEA
P22001	KCNA3	Voltage-gated potassium channel subunit Kv1.3	T76914	SEA
P01130	LDLR	LDL receptor	T94692	SEA
Q92630	DYRK2	Dual-specificity tyrosine-phosphorylation regulated kinase 2	T39486	SwissTargetPrediction and SEA
Q15746	MYLK	Myosin light chain kinase, smooth muscle	T97141	SwissTargetPrediction
Q13464	ROCK1	Rho-associated protein kinase 1	T51282	SwissTargetPrediction and SEA
P06730	EIF4E	Eukaryotic translation initation factor (by homology)	T31186	SEA
Q16548	BCL2A1	Bcl-2-related protein A1 (by homology)	T12797	SEA
Q15661	TPSAB1	Tryptase beta-1	T14558	SEA
Q13393	PLD1	Phospholipase D1	T38996	SEA
O14939	PLD2	Phospholipase D2	T10383	SEA
O43497	CACNA1G	Voltage-gated T-type calcium channel alpha-1G subunit	T64795	SEA
P05129	PRKCG	Protein kinase C gamma	T47107	SwissTargetPrediction
Q13224	GRIN2B	Glutamate [NMDA] receptor subunit epsilon 2	T76414	SEA
Q15303	ERBB4	Receptor protein-tyrosine kinase erbB-4	T92057	SwissTargetPrediction
P49682	CXCR3	C-X-C chemokine receptor type 3	T25315	SEA
P19438	TNFRSF1A	Tumor necrosis factor receptor R1	T86552	SEA
P28336	NMBR	Neuromedin B receptor	T68887	SEA
Q9NRG4	SMYD2	N-lysine methyltransferase SMYD2	T15797	SEA
P37840	SNCA	Alpha-synuclein	T03644	SEA
Q96DB2	HDAC11	Histone deacetylase 11	T97903	SEA
P33032	MC5R	Melanocortin receptor 5	T95302	SEA
Q9H1C0	LPAR5	Lysophosphatidic acid receptor 5	T18616	SEA
P09382	LGALS1	Galectin-1	T09544	SEA
Q969S8	HDAC10	Histone deacetylase 10	T94324	SEA
O95136	S1PR2	Sphingosine 1-phosphate receptor Edg-5	T47888	SEA
Q9Y271	CYSLTR1	Cysteinyl leukotriene receptor 1	T71192	SEA
Q9H2K8	TAOK3	Serine/threonine-protein kinase TAO3	T63682	SEA
P18507	GABRG2	GABA-A receptor; alpha-6/beta-3/gamma-2	T08910	SwissTargetPrediction
Q9UJ67	APAF1	Caterpiller protein 1.1	T08499	SEA
Q9Y345	SLC6A5	Glycine transporter 2	T58937	SwissTargetPrediction and SEA
Q92633	LPAR1	Lysophosphatidic acid receptor Edg-2	T92640	SEA
P16885	PLCG2	Phospholipase C-gamma-2	T93922	SEA
Q6DWJ6	GPR139	Probable G-protein coupled receptor 139	T84439	SEA
P40306	PSMB10	26S proteosome	T09022	SEA
P08311	CTSG	Cathepsin G	T86385	SEA
P04792	HSPB1	Heat shock protein beta-1	T39921	SEA
Q9UJM8	HAO1	Hydroxyacid oxidase 1	T63170	SEA
Q9P0U3	SENP1	Sentrin-specific protease 1	T96435	SEA
O95822	MLYCD	Malonyl-CoA decarboxylase	T98078	SEA
P01275	GCG	Glucagon	T44919	SEA
P48546	GIPR	Gastric inhibitory polypeptide receptor	T41750	SEA
Q8IWU9	TPH2	Tryptophan hydroxylase	T51593	SEA
P13500	CCL2	C-C motif chemokine 2	T89988	SEA
P24557	TBXAS1	Thromboxane-A synthase	T78356	SEA
Q4U2R8	SLC22A6	Solute carrier family 22 member 6 (by homology)	T70680	SEA
P09958	FUR	HUMAN dibasic-processing enzyme	T98945	SEA
Q9GZQ6	NPFFR1	Neuropeptide FF receptor 1	T79780	SEA
Q9Y5X5	NPFFR2	Neuropeptide FF receptor 2	T90818	SEA
O60259	KLK8	Neuropsin	T43289	SEA
Q9BY41	HDAC8	Histone deacetylase 8	T28887	SEA
Q9Y5K2	KLK4	Kallikrein-4	T79400	SEA
P51843	NR0B1	Orphan nuclear receptor DAX-1	T23191	SEA
Q7RTX1	TAS1R1	Taste receptor	T41263	SEA
P05106	ITGB3	Integrin beta-3	T26457	SEA
P55011	SLC12A2	Na-K-Cl cotransporter	T85581	SEA
Q9HAN5	TRP1	Cationic trypsinogen	T27602	SEA
P35270	SPR	Substance-P receptor	T47094	SEA
P25786	PSMA1	Core proteasome 20S complex	T61997	SEA
P28072	PSMB6	Proteasome beta-1	T54973	SEA
Q99436	PSMB7	Proteasome beta-2	T55986	SEA
P43354	NR4A2	Orphan nuclear receptor NURR1	T67163	SEA
Q4ZFZ2	FSHR	Follicle-stimulating hormone receptor	T68334	SEA
Q96LD8	SENP8	Deneddylase-1	T13928	SEA
P41587	VIPR2	Helodermin-preferring VIP receptor	T06182	SEA
P18564	ITGB6	Integrin beta-6	T23178	SEA
Q9GZT9	EGLN1	Egl nine homolog 1	T32880	SEA

Target associated diseases

TTD_ID	Disease_ID	Disease name	ICD_11	Uniprot ID	Gene names
T79961	DI0002	Abnormal micturition	[ICD-11: MF50]	P08912	CHRM5
T79961	DI0032	Anterior uveitis	[ICD-11: 9A96]	P08912	CHRM5
T79961	DI0034	Appearance/behaviour symptom	[ICD-11: MB23]	P08912	CHRM5
T79961	DI0037	Asthma	[ICD-11: CA23]	P08912	CHRM5
T79961	DI0061	Brain disease	[ICD-11: 8C70-8E61]	P08912	CHRM5
T79961	DI0071	Central and peripheral nervous disease	[ICD-11: 8A04-8E7Z]	P08912	CHRM5
T79961	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P08912	CHRM5
T79961	DI0093	Cognition symptoms/signs/clinical symptom	[ICD-11: MB21]	P08912	CHRM5
T79961	DI0105	Cough	[ICD-11: MD12]	P08912	CHRM5
T79961	DI0124	Digestive system disease	[ICD-11: DE2Z]	P08912	CHRM5
T79961	DI0145	Female pelvic pain	[ICD-11: GA34]	P08912	CHRM5
T79961	DI0154	Functional bladder disorder	[ICD-11: GC50]	P08912	CHRM5
T79961	DI0158	Gastritis	[ICD-11: DA42]	P08912	CHRM5
T79961	DI0162	General examination	[ICD-11: QA00]	P08912	CHRM5
T79961	DI0166	Glaucoma	[ICD-11: 9C61]	P08912	CHRM5
T79961	DI0190	Hypertension	[ICD-11: BA00-BA04]	P08912	CHRM5
T79961	DI0208	Infectious gastroenteritis/colitis	[ICD-11: 1A40]	P08912	CHRM5
T79961	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P08912	CHRM5
T79961	DI0307	Nystagmus	[ICD-11: 9C84]	P08912	CHRM5
T79961	DI0315	Oesophagus motility disorder	[ICD-11: DA21]	P08912	CHRM5
T79961	DI0324	Pain	[ICD-11: MG30-MG3Z]	P08912	CHRM5
T79961	DI0329	Pancreatitis	[ICD-11: DC31-DC34]	P08912	CHRM5
T79961	DI0331	Parkinsonism	[ICD-11: 8A00]	P08912	CHRM5
T79961	DI0333	Peptic ulcer	[ICD-11: DA61]	P08912	CHRM5
T79961	DI0338	Polyuria	[ICD-11: MF55]	P08912	CHRM5
T79961	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P08912	CHRM5
T79961	DI0421	Unspecific substance harmful effect	[ICD-11: NE6Z]	P08912	CHRM5
T79961	DI0424	Urgency	[ICD-11: N.A.]	P08912	CHRM5
T28893	DI0001	Abdominal pelvic pain	[ICD-11: MD81]	P11229	CHRM1
T28893	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P11229	CHRM1
T28893	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P11229	CHRM1
T28893	DI0129	Dystonic disorder	[ICD-11: 8A02]	P11229	CHRM1
T28893	DI0154	Functional bladder disorder	[ICD-11: GC50]	P11229	CHRM1
T28893	DI0157	Gastric ulcer	[ICD-11: DA60]	P11229	CHRM1
T28893	DI0166	Glaucoma	[ICD-11: 9C61]	P11229	CHRM1
T28893	DI0186	Hyperhidrosis	[ICD-11: EE00]	P11229	CHRM1
T28893	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P11229	CHRM1
T28893	DI0331	Parkinsonism	[ICD-11: 8A00]	P11229	CHRM1
T28893	DI0333	Peptic ulcer	[ICD-11: DA61]	P11229	CHRM1
T28893	DI0371	Sebaceous gland disorder	[ICD-11: ED91]	P11229	CHRM1
T30082	DI0025	Alzheimer disease	[ICD-11: 8A20]	P22303	ACHE
T30082	DI0166	Glaucoma	[ICD-11: 9C61]	P22303	ACHE
T30082	DI0282	Myasthenia gravis	[ICD-11: 8C6Y]	P22303	ACHE
T30082	DI0313	Oesophageal/gastroduodenal disorder	[ICD-11: DD90]	P22303	ACHE
T30082	DI0332	Pediculosis	[ICD-11: 1G00]	P22303	ACHE
T30082	DI0421	Unspecific substance harmful effect	[ICD-11: NE6Z]	P22303	ACHE
T67684	DI0037	Asthma	[ICD-11: CA23]	P20309	CHRM3
T67684	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P20309	CHRM3
T67684	DI0154	Functional bladder disorder	[ICD-11: GC50]	P20309	CHRM3
T67684	DI0166	Glaucoma	[ICD-11: 9C61]	P20309	CHRM3
T67684	DI0293	Nausea/vomiting	[ICD-11: MD90]	P20309	CHRM3
T67684	DI0333	Peptic ulcer	[ICD-11: DA61]	P20309	CHRM3
T67684	DI0362	Respiratory system disease	[ICD-11: CB40-CB7Z]	P20309	CHRM3
T67684	DI0371	Sebaceous gland disorder	[ICD-11: ED91]	P20309	CHRM3
T67684	DI0382	Sjogren syndrome	[ICD-11: 4A43]	P20309	CHRM3
T67684	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P20309	CHRM3
T92072	DI0319	Orthostatic hypotension	[ICD-11: BA21]	P30542	ADORA1
T16987	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	O43570	CA12
T16987	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	O43570	CA12
T64567	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q16790	CA9
T16117	DI0173	Headache	[ICD-11: 8A80-8A84]	P29475	NOS1
T16117	DI0264	Migraine	[ICD-11: 8A80]	P29475	NOS1
T02703	DI0083	Chronic kidney disease	[ICD-11: GB61]	P35228	NOS2
T02703	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P35228	NOS2
T02703	DI0375	Sepsis	[ICD-11: 1G40-1G41]	P35228	NOS2
T02703	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P35228	NOS2
T06046	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P29474	NOS3
T14912	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q07820	MCL1
T14912	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	Q07820	MCL1
T14912	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q07820	MCL1
T14912	DI0252	Melanoma	[ICD-11: 2C30]	Q07820	MCL1
T14912	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q07820	MCL1
T14912	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q07820	MCL1
T46360	DI0105	Cough	[ICD-11: MD12]	Q99720	SIGMAR1
T62292	DI0216	Intentional self-harm	[ICD-11: PC91]	P34903	GABRA3
T51452	DI0216	Intentional self-harm	[ICD-11: PC91]	P47869	GABRA2
T53904	DI0010	Acute disease anaemia	[ICD-11: 3A90]	Q96KS0	EIT6
T67272	DI0351	Psoriasis	[ICD-11: EA90]	P15144	ANPEP
T94033	DI0052	Bleeding disorder	[ICD-11: GA20-GA21]	P00734	F2
T94033	DI0091	Coagulation defect	[ICD-11: 3B10]	P00734	F2
T94033	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P00734	F2
T94033	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P00734	F2
T94033	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00734	F2
T94033	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P00734	F2
T94033	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P00734	F2
T94033	DI0405	Thrombosis	[ICD-11: DB61-GB90]	P00734	F2
T05090	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O15379	HDAC3
T05090	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O15379	HDAC3
T24983	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	P21917	DRD4
T24983	DI0370	Schizophrenia	[ICD-11: 6A20]	P21917	DRD4
T83875	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P21397	MAOA
T83875	DI0331	Parkinsonism	[ICD-11: 8A00]	P21397	MAOA
T13201	DI0166	Glaucoma	[ICD-11: 9C61]	P00915	CA1
T13201	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00915	CA1
T80276	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P42336	PIK3CA
T80276	DI0151	Follicular lymphoma	[ICD-11: 2A80]	P42336	PIK3CA
T80276	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P42336	PIK3CA
T20401	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P00918	CA2
T20401	DI0137	Essential hypertension	[ICD-11: BA00]	P00918	CA2
T20401	DI0166	Glaucoma	[ICD-11: 9C61]	P00918	CA2
T20401	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P00918	CA2
T20401	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P00918	CA2
T20401	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00918	CA2
T75498	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P16083	NQO2
T67162	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	P14416	DRD2
T67162	DI0025	Alzheimer disease	[ICD-11: 8A20]	P14416	DRD2
T67162	DI0037	Asthma	[ICD-11: CA23]	P14416	DRD2
T67162	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P14416	DRD2
T67162	DI0051	Bipolar disorder	[ICD-11: 6A60]	P14416	DRD2
T67162	DI0063	Breathing abnormality	[ICD-11: MD11]	P14416	DRD2
T67162	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P14416	DRD2
T67162	DI0073	Cerebral ischaemia	[ICD-11: 8B1Z]	P14416	DRD2
T67162	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P14416	DRD2
T67162	DI0124	Digestive system disease	[ICD-11: DE2Z]	P14416	DRD2
T67162	DI0137	Essential hypertension	[ICD-11: BA00]	P14416	DRD2
T67162	DI0142	Faecal incontinence	[ICD-11: ME07]	P14416	DRD2
T67162	DI0156	Gangrene	[ICD-11: MC85]	P14416	DRD2
T67162	DI0166	Glaucoma	[ICD-11: 9C61]	P14416	DRD2
T67162	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P14416	DRD2
T67162	DI0185	Hyperaemia	[ICD-11: 9A61-9B7Y]	P14416	DRD2
T67162	DI0190	Hypertension	[ICD-11: BA00-BA04]	P14416	DRD2
T67162	DI0196	Hypotension	[ICD-11: BA20-BA21]	P14416	DRD2
T67162	DI0205	Inborn porphyrin/heme metabolism error	[ICD-11: 5C58]	P14416	DRD2
T67162	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P14416	DRD2
T67162	DI0222	Itching	[ICD-11: 1F28-1G07]	P14416	DRD2
T67162	DI0264	Migraine	[ICD-11: 8A80]	P14416	DRD2
T67162	DI0293	Nausea/vomiting	[ICD-11: MD90]	P14416	DRD2
T67162	DI0324	Pain	[ICD-11: MG30-MG3Z]	P14416	DRD2
T67162	DI0331	Parkinsonism	[ICD-11: 8A00]	P14416	DRD2
T67162	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P14416	DRD2
T67162	DI0340	Postpartum haemorrhage	[ICD-11: JA43]	P14416	DRD2
T67162	DI0354	Psychotic disorder	[ICD-11: 6A20-6A25]	P14416	DRD2
T67162	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P14416	DRD2
T67162	DI0370	Schizophrenia	[ICD-11: 6A20]	P14416	DRD2
T67162	DI0396	Substance abuse	[ICD-11: 6C40]	P14416	DRD2
T67162	DI0408	Thyrotoxicosis	[ICD-11: 5A02]	P14416	DRD2
T67162	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P14416	DRD2
T83904	DI0365	Retinopathy	[ICD-11: 9B71]	Q8IXJ6	SIRT2
T70680	DI0167	Gout	[ICD-11: FA25]	Q4U2R8	SLC22A6
T70680	DI0206	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Q4U2R8	SLC22A6
T70680	DI0310	Ocular disease	[ICD-11: N.A.]	Q4U2R8	SLC22A6
T50688	DI0007	Acquired hypermelanosis	[ICD-11: ED60]	P08514	ITGA2B
T50688	DI0030	Angina pectoris	[ICD-11: BA40]	P08514	ITGA2B
T50688	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P08514	ITGA2B
T51426	DI0043	Autoimmune liver disease	[ICD-11: DB96]	Q96RI1	NR1H4
T51426	DI0077	Cholelithiasis	[ICD-11: DC11]	Q96RI1	NR1H4
T51426	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	Q96RI1	NR1H4
T05409	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P08473	MME
T12808	DI0279	Muscular atrophy	[ICD-11: 8B61]	P17612	PRKACA
T76685	DI0031	Anorexia nervosa	[ICD-11: 6B80]	P21554	CNR1
T76685	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P21554	CNR1
T76685	DI0308	Obesity	[ICD-11: 5B80-5B81]	P21554	CNR1
T35734	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P34913	EPHX2
T35734	DI0190	Hypertension	[ICD-11: BA00-BA04]	P34913	EPHX2
T31992	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q9ULX7	CA14
T31992	DI0204	Inborn metabolism deficiency	[ICD-11: 5C50-5C59]	Q9ULX7	CA14
T53378	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P22748	CA4
T53378	DI0166	Glaucoma	[ICD-11: 9C61]	P22748	CA4
T53378	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P22748	CA4
T83011	DI0115	Dementia	[ICD-11: 6D80-6D8Z]	P27338	MAOB
T83011	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P27338	MAOB
T83011	DI0190	Hypertension	[ICD-11: BA00-BA04]	P27338	MAOB
T83011	DI0243	Malaria	[ICD-11: 1F40-1F45]	P27338	MAOB
T83011	DI0264	Migraine	[ICD-11: 8A80]	P27338	MAOB
T83011	DI0331	Parkinsonism	[ICD-11: 8A00]	P27338	MAOB
T16739	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	O60341	KDM1A
T16739	DI0025	Alzheimer disease	[ICD-11: 8A20]	O60341	KDM1A
T16739	DI0138	Ewing sarcoma	[ICD-11: 2B52]	O60341	KDM1A
T16739	DI0238	Lung cancer	[ICD-11: 2C25]	O60341	KDM1A
T16739	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O60341	KDM1A
T16739	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	O60341	KDM1A
T16739	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	O60341	KDM1A
T16739	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	O60341	KDM1A
T16739	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O60341	KDM1A
T32060	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P28223	HTR2A
T32060	DI0033	Anxiety disorder	[ICD-11: 6B00-6B0Z]	P28223	HTR2A
T32060	DI0073	Cerebral ischaemia	[ICD-11: 8B1Z]	P28223	HTR2A
T32060	DI0270	Mood disorder	[ICD-11: 6A60-6E23]	P28223	HTR2A
T32060	DI0331	Parkinsonism	[ICD-11: 8A00]	P28223	HTR2A
T32060	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P28223	HTR2A
T32060	DI0370	Schizophrenia	[ICD-11: 6A20]	P28223	HTR2A
T83813	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P28335	HTR2C
T83813	DI0264	Migraine	[ICD-11: 8A80]	P28335	HTR2C
T83813	DI0308	Obesity	[ICD-11: 5B80-5B81]	P28335	HTR2C
T83813	DI0324	Pain	[ICD-11: MG30-MG3Z]	P28335	HTR2C
T83813	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P28335	HTR2C
T99524	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	Q96RJ0	TAAR1
T99524	DI0149	Focal/segmental autonomic disorder	[ICD-11: 8D8A]	Q96RJ0	TAAR1
T99524	DI0290	Narcolepsy	[ICD-11: 7A20]	Q96RJ0	TAAR1
T31204	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P41595	HTR2B
T31204	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P41595	HTR2B
T31204	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P41595	HTR2B
T31204	DI0354	Psychotic disorder	[ICD-11: 6A20-6A25]	P41595	HTR2B
T11448	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P08913	ADRA2A
T11448	DI0317	Opioid use disorder	[ICD-11: 6C43]	P08913	ADRA2A
T11448	DI0396	Substance abuse	[ICD-11: 6C40]	P08913	ADRA2A
T78709	DI0033	Anxiety disorder	[ICD-11: 6B00-6B0Z]	P08908	HTR1A
T78709	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P08908	HTR1A
T78709	DI0190	Hypertension	[ICD-11: BA00-BA04]	P08908	HTR1A
T78709	DI0264	Migraine	[ICD-11: 8A80]	P08908	HTR1A
T78709	DI0270	Mood disorder	[ICD-11: 6A60-6E23]	P08908	HTR1A
T55959	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	Q01959	SLC6A3
T55959	DI0051	Bipolar disorder	[ICD-11: 6A60]	Q01959	SLC6A3
T55959	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	Q01959	SLC6A3
T55959	DI0290	Narcolepsy	[ICD-11: 7A20]	Q01959	SLC6A3
T55959	DI0308	Obesity	[ICD-11: 5B80-5B81]	Q01959	SLC6A3
T55959	DI0331	Parkinsonism	[ICD-11: 8A00]	Q01959	SLC6A3
T63816	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P56524	HDAC4
T51191	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q92769	HDAC2
T51191	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q92769	HDAC2
T09572	DI0308	Obesity	[ICD-11: 5B80-5B81]	Q99705	MCHR1
T76369	DI0335	Peroxisomal disease	[ICD-11: 5C57]	P23141	CES1
T76369	DI0398	Synthesis disorder	[ICD-11: 5C52-5C59]	P23141	CES1
T11754	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	O00519	FAAH
T83193	DI0163	General pain disorder	[ICD-11: 8E43]	Q8NER1	TRPV1
T22939	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P06401	PGR
T22939	DI0100	Contraceptive management	[ICD-11: QA21]	P06401	PGR
T22939	DI0255	Menstrual cycle bleeding disorder	[ICD-11: GA20]	P06401	PGR
T22939	DI0344	Preterm labour/delivery	[ICD-11: JB00]	P06401	PGR
T22939	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P06401	PGR
T30985	DI0161	Gastro-oesophageal reflux disease	[ICD-11: DA22]	P25021	HRH2
T30985	DI0313	Oesophageal/gastroduodenal disorder	[ICD-11: DD90]	P25021	HRH2
T30985	DI0333	Peptic ulcer	[ICD-11: DA61]	P25021	HRH2
T43115	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P08575	PTPRC
T43115	DI0414	Transplanted organ/tissue	[ICD-11: QB63]	P08575	PTPRC
T21307	DI0011	Acute laryngitis/tracheitis	[ICD-11: CA05]	P49137	MAPKAPK2
T21307	DI0181	Hidradenitis suppurativa	[ICD-11: ED92]	P49137	MAPKAPK2
T21307	DI0269	Monogenic autoinflammatory syndrome	[ICD-11: 4A60]	P49137	MAPKAPK2
T21307	DI0334	Peritoneal cancer	[ICD-11: 2C51]	P49137	MAPKAPK2
T21307	DI0352	Psoriatic arthritis	[ICD-11: FA21]	P49137	MAPKAPK2
T21307	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P49137	MAPKAPK2
T21307	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P49137	MAPKAPK2
T68251	DI0238	Lung cancer	[ICD-11: 2C25]	P08253	MMP2
T08856	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P22894	MMP8
T86702	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P08254	MMP3
T86702	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P08254	MMP3
T86702	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P08254	MMP3
T86702	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P08254	MMP3
T86702	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P08254	MMP3
T86702	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P08254	MMP3
T86702	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P08254	MMP3
T54156	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P14780	MMP9
T54156	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P14780	MMP9
T54156	DI0395	Stomach cancer	[ICD-11: 2B72]	P14780	MMP9
T54156	DI0419	Ulcerative colitis	[ICD-11: DD71]	P14780	MMP9
T00140	DI0037	Asthma	[ICD-11: CA23]	P09917	ALOX5
T00140	DI0147	Filariasis	[ICD-11: 1F66]	P09917	ALOX5
T00140	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P09917	ALOX5
T52450	DI0238	Lung cancer	[ICD-11: 2C25]	P03956	MMP1
T02551	DI0051	Bipolar disorder	[ICD-11: 6A60]	P35462	DRD3
T02551	DI0331	Parkinsonism	[ICD-11: 8A00]	P35462	DRD3
T76198	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	P21731	TBXA2R
T76198	DI0121	Diabetic foot ulcer	[ICD-11: BD54]	P21731	TBXA2R
T76198	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P21731	TBXA2R
T76198	DI0378	Sexual dysfunction	[ICD-11: HA00-HA01]	P21731	TBXA2R
T01777	DI0166	Glaucoma	[ICD-11: 9C61]	P18825	ADRA2C
T01777	DI0190	Hypertension	[ICD-11: BA00-BA04]	P18825	ADRA2C
T01777	DI0196	Hypotension	[ICD-11: BA20-BA21]	P18825	ADRA2C
T01777	DI0308	Obesity	[ICD-11: 5B80-5B81]	P18825	ADRA2C
T01777	DI0310	Ocular disease	[ICD-11: N.A.]	P18825	ADRA2C
T01777	DI0396	Substance abuse	[ICD-11: 6C40]	P18825	ADRA2C
T25258	DI0238	Lung cancer	[ICD-11: 2C25]	P08183	ABCB1
T47768	DI0013	Acute pain	[ICD-11: MG31]	P35372	OPRM1
T47768	DI0059	Bowel habit change	[ICD-11: ME05]	P35372	OPRM1
T47768	DI0087	Chronic pain	[ICD-11: MG30]	P35372	OPRM1
T47768	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P35372	OPRM1
T47768	DI0105	Cough	[ICD-11: MD12]	P35372	OPRM1
T47768	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P35372	OPRM1
T47768	DI0124	Digestive system disease	[ICD-11: DE2Z]	P35372	OPRM1
T47768	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P35372	OPRM1
T47768	DI0228	Large intestine motility disorder	[ICD-11: DB32]	P35372	OPRM1
T47768	DI0317	Opioid use disorder	[ICD-11: 6C43]	P35372	OPRM1
T47768	DI0324	Pain	[ICD-11: MG30-MG3Z]	P35372	OPRM1
T47768	DI0349	Pruritus	[ICD-11: EC90]	P35372	OPRM1
T47768	DI0374	Sensation disturbance	[ICD-11: MB40]	P35372	OPRM1
T60693	DI0304	Non-specific cutaneous vascular symptom	[ICD-11: ME64]	P41145	OPRK1
T60693	DI0324	Pain	[ICD-11: MG30-MG3Z]	P41145	OPRK1
T60693	DI0349	Pruritus	[ICD-11: EC90]	P41145	OPRK1
T79591	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P10827	THRA
T79591	DI0197	Hypo-thyroidism	[ICD-11: 5A00]	P10827	THRA
T98933	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P10828	THRB
T28484	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P52732	KIF11
T28484	DI0172	Head and neck cancer	[ICD-11: 2D42]	P52732	KIF11
T28484	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P52732	KIF11
T28484	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P52732	KIF11
T28484	DI0274	Multiple myeloma	[ICD-11: 2A83]	P52732	KIF11
T28484	DI0321	Ovarian cancer	[ICD-11: 2C73]	P52732	KIF11
T28484	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P52732	KIF11
T28484	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P52732	KIF11
T50594	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P11309	PIM1
T50594	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P11309	PIM1
T14597	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P04626	ERBB2
T14597	DI0238	Lung cancer	[ICD-11: 2C25]	P04626	ERBB2
T14597	DI0346	Prostate cancer	[ICD-11: 2C82]	P04626	ERBB2
T62449	DI0027	Anal cancer	[ICD-11: 2C00]	O14757	CHEK1
T62449	DI0172	Head and neck cancer	[ICD-11: 2D42]	O14757	CHEK1
T62449	DI0183	Hodgkin lymphoma	[ICD-11: 2B30]	O14757	CHEK1
T62449	DI0238	Lung cancer	[ICD-11: 2C25]	O14757	CHEK1
T62449	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O14757	CHEK1
T62449	DI0321	Ovarian cancer	[ICD-11: 2C73]	O14757	CHEK1
T62449	DI0326	Pancreatic cancer	[ICD-11: 2C10]	O14757	CHEK1
T62449	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O14757	CHEK1
T99799	DI0324	Pain	[ICD-11: MG30-MG3Z]	P06276	BCHE
T99799	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P06276	BCHE
T08391	DI0039	Atopic eczema	[ICD-11: EA80]	O60674	JAK2
T08391	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	O60674	JAK2
T08391	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	O60674	JAK2
T08391	DI0404	Thrombocytosis	[ICD-11: 3B63]	O60674	JAK2
T74312	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P36888	FLT3
T74312	DI0058	Bone/articular cartilage neoplasm	[ICD-11: 2F7B]	P36888	FLT3
T74312	DI0095	Colorectal cancer	[ICD-11: 2B91]	P36888	FLT3
T74312	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	P36888	FLT3
T74312	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P36888	FLT3
T74312	DI0248	Mastocytosis	[ICD-11: 2A21]	P36888	FLT3
T74312	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P36888	FLT3
T74312	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P36888	FLT3
T07279	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q9P1W9	PIM2
T07279	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9P1W9	PIM2
T34296	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P45452	MMP13
T84133	DI0079	Choreiform disorder	[ICD-11: 8A01]	Q9Y233	PDE10A
T84133	DI0206	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Q9Y233	PDE10A
T84133	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	Q9Y233	PDE10A
T84133	DI0370	Schizophrenia	[ICD-11: 6A20]	Q9Y233	PDE10A
T84133	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9Y233	PDE10A
T87023	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P25105	PTAFR
T98691	DI0263	Middle East Respiratory Syndrome	[ICD-11: 1D64]	P07711	CTSL
T98691	DI0376	Severe acute respiratory syndrome	[ICD-11: 1D65]	P07711	CTSL
T58992	DI0059	Bowel habit change	[ICD-11: ME05]	P41143	OPRD1
T58992	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P41143	OPRD1
T58992	DI0324	Pain	[ICD-11: MG30-MG3Z]	P41143	OPRD1
T05114	DI0039	Atopic eczema	[ICD-11: EA80]	P23946	CMA1
T05114	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P23946	CMA1
T05114	DI0169	Gram-positive bacterial infection	[ICD-11: 1B74-1F40]	P23946	CMA1
T05114	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P23946	CMA1
T05114	DI0229	Left ventricular failure	[ICD-11: BD11]	P23946	CMA1
T05114	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P23946	CMA1
T84631	DI0053	Blood-forming organ disease	[ICD-11: 3C0Z]	P00742	F10
T84631	DI0080	Christmas disease	[ICD-11: 3B11]	P00742	F10
T84631	DI0091	Coagulation defect	[ICD-11: 3B10]	P00742	F10
T84631	DI0103	Coronary thrombosis	[ICD-11: BA43]	P00742	F10
T84631	DI0114	Deep vein thrombosis	[ICD-11: BD71]	P00742	F10
T84631	DI0397	Supraventricular tachyarrhythmia	[ICD-11: BC81]	P00742	F10
T84631	DI0405	Thrombosis	[ICD-11: DB61-GB90]	P00742	F10
T84631	DI0433	Venous thromboembolism	[ICD-11: BD72]	P00742	F10
T76059	DI0331	Parkinsonism	[ICD-11: 8A00]	P62942	FKBP1A
T76059	DI0349	Pruritus	[ICD-11: EC90]	P62942	FKBP1A
T76059	DI0413	Transplant rejection	[ICD-11: NE84]	P62942	FKBP1A
T62306	DI0124	Digestive system disease	[ICD-11: DE2Z]	O43193	MLNR
T62306	DI0159	Gastroduodenal motor/secretory disorder	[ICD-11: DA41]	O43193	MLNR
T62306	DI0161	Gastro-oesophageal reflux disease	[ICD-11: DA22]	O43193	MLNR
T62306	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	O43193	MLNR
T62306	DI0324	Pain	[ICD-11: MG30-MG3Z]	O43193	MLNR
T86052	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	O14746	TERT
T86052	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	O14746	TERT
T86052	DI0326	Pancreatic cancer	[ICD-11: 2C10]	O14746	TERT
T38529	DI0003	Abortion	[ICD-11: JA00]	P43116	PTGER2
T38529	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	P43116	PTGER2
T38529	DI0121	Diabetic foot ulcer	[ICD-11: BD54]	P43116	PTGER2
T38529	DI0166	Glaucoma	[ICD-11: 9C61]	P43116	PTGER2
T38529	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P43116	PTGER2
T38529	DI0378	Sexual dysfunction	[ICD-11: HA00-HA01]	P43116	PTGER2
T38529	DI0413	Transplant rejection	[ICD-11: NE84]	P43116	PTGER2
T13057	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q06124	PTPN11
T59626	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	Q15722	LTB4R
T59626	DI0355	Pulmonary disease	[ICD-11: 1B10-1F85]	Q15722	LTB4R
T59626	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	Q15722	LTB4R
T23276	DI0036	Arteries/arterioles disorder	[ICD-11: BD52]	P11137	MAP2
T23276	DI0252	Melanoma	[ICD-11: 2C30]	P11137	MAP2
T23276	DI0326	Pancreatic cancer	[ICD-11: 2C10]	P11137	MAP2
T23276	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P11137	MAP2
T89988	DI0083	Chronic kidney disease	[ICD-11: GB61]	P13500	CCL2
T89988	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P13500	CCL2
T89988	DI0087	Chronic pain	[ICD-11: MG30]	P13500	CCL2
T89988	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	P13500	CCL2
T89988	DI0252	Melanoma	[ICD-11: 2C30]	P13500	CCL2
T89988	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	P13500	CCL2
T89988	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P13500	CCL2
T89988	DI0326	Pancreatic cancer	[ICD-11: 2C10]	P13500	CCL2
T89988	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P13500	CCL2
T89988	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P13500	CCL2
T92609	DI0190	Hypertension	[ICD-11: BA00-BA04]	P35348	ADRA1A
T92609	DI0348	Prostate hyperplasia	[ICD-11: GA90]	P35348	ADRA1A
T06093	DI0168	Graft-versus-host disease	[ICD-11: 4B24]	O75116	ROCK2
T62460	DI0039	Atopic eczema	[ICD-11: EA80]	P23458	JAK1
T62460	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P23458	JAK1
T62460	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P23458	JAK1
T62460	DI0404	Thrombocytosis	[ICD-11: 3B63]	P23458	JAK1
T96623	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P08238	HSP90AB1
T96623	DI0238	Lung cancer	[ICD-11: 2C25]	P08238	HSP90AB1
T96623	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P08238	HSP90AB1
T96623	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	P08238	HSP90AB1
T96623	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P08238	HSP90AB1
T96623	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P08238	HSP90AB1
T96623	DI0395	Stomach cancer	[ICD-11: 2B72]	P08238	HSP90AB1
T60182	DI0193	Hypo-glycaemia	[ICD-11: 5A41]	P47871	GCGR
T08123	DI0331	Parkinsonism	[ICD-11: 8A00]	Q5S007	LRRK2
T53389	DI0035	Arterial occlusive disease	[ICD-11: BD40]	P36897	TGFBR1
T53389	DI0238	Lung cancer	[ICD-11: 2C25]	P36897	TGFBR1
T67849	DI0151	Follicular lymphoma	[ICD-11: 2A80]	O00329	PIK3CD
T67849	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	O00329	PIK3CD
T67849	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	O00329	PIK3CD
T67849	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	O00329	PIK3CD
T67849	DI0395	Stomach cancer	[ICD-11: 2B72]	O00329	PIK3CD
T63966	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P17948	FLT1
T99160	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q9HBH9	MKNK2
T99160	DI0095	Colorectal cancer	[ICD-11: 2B91]	Q9HBH9	MKNK2
T99160	DI0235	Liver cancer	[ICD-11: 2C12]	Q9HBH9	MKNK2
T99160	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q9HBH9	MKNK2
T99160	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9HBH9	MKNK2
T92803	DI0113	Cytomegaloviral disease	[ICD-11: 1D82]	Q13627	DYRK1A
T74977	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P33981	TTK
T23172	DI0023	Alopecia	[ICD-11: ED70]	P52333	JAK3
T23172	DI0039	Atopic eczema	[ICD-11: EA80]	P52333	JAK3
T23172	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P52333	JAK3
T23172	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P52333	JAK3
T78932	DI0351	Psoriasis	[ICD-11: EA90]	P29597	TYK2
T01908	DI0213	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	P20151	KLK2
T15571	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P47898	HTR5A
T97613	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P48039	MTNR1A
T48268	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P49286	MTNR1B
T41580	DI0396	Substance abuse	[ICD-11: 6C40]	P18089	ADRA2B
T37693	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P34972	CNR2
T37693	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P34972	CNR2
T85467	DI0166	Glaucoma	[ICD-11: 9C61]	P43115	PTGER3
T85467	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P43115	PTGER3
T85467	DI0414	Transplanted organ/tissue	[ICD-11: QB63]	P43115	PTGER3
T67103	DI0095	Colorectal cancer	[ICD-11: 2B91]	P06756	ITGAV
T67103	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P06756	ITGAV
T55293	DI0095	Colorectal cancer	[ICD-11: 2B91]	P17301	ITGA2
T55293	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P17301	ITGA2
T81358	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	O00311	CDC7
T81358	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O00311	CDC7
T47101	DI0095	Colorectal cancer	[ICD-11: 2B91]	P11362	FGFR1
T47101	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P11362	FGFR1
T47101	DI0235	Liver cancer	[ICD-11: 2C12]	P11362	FGFR1
T47101	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P11362	FGFR1
T23499	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P25101	EDNRA
T23499	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P25101	EDNRA
T23499	DI0425	Urinary system clinical symptom	[ICD-11: MF8Y]	P25101	EDNRA
T20333	DI0058	Bone/articular cartilage neoplasm	[ICD-11: 2F7B]	P07333	CSF1R
T76910	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P49840	GSK3A
T44458	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P50750	CDK9
T44458	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P50750	CDK9
T44458	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P50750	CDK9
T44458	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	P50750	CDK9
T44458	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P50750	CDK9
T44458	DI0302	Non-alcoholic fatty liver disease	[ICD-11: DB92]	P50750	CDK9
T44458	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P50750	CDK9
T64591	DI0087	Chronic pain	[ICD-11: MG30]	P46098	HTR3A
T64591	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P46098	HTR3A
T64591	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P46098	HTR3A
T64591	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P46098	HTR3A
T64591	DI0293	Nausea/vomiting	[ICD-11: MD90]	P46098	HTR3A
T68782	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	Q13258	PTGDR
T33455	DI0115	Dementia	[ICD-11: 6D80-6D8Z]	P17936	IGFBP3
T07663	DI0190	Hypertension	[ICD-11: BA00-BA04]	O76074	PDE5A
T07663	DI0213	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	O76074	PDE5A
T07663	DI0378	Sexual dysfunction	[ICD-11: HA00-HA01]	O76074	PDE5A
T07663	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	O76074	PDE5A
T23995	DI0413	Transplant rejection	[ICD-11: NE84]	Q04759	PRKCQ
T99954	DI0003	Abortion	[ICD-11: JA00]	P43119	PTGIR
T99954	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	P43119	PTGIR
T99954	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P43119	PTGIR
T40694	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P53350	PLK1
T40694	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	P53350	PLK1
T40694	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P53350	PLK1
T17758	DI0211	Inherited coagulation factor deficiency	[ICD-11: 3B14]	P00749	PLAU
T17758	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00749	PLAU
T51883	DI0252	Melanoma	[ICD-11: 2C30]	P04049	RAF1
T51883	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P04049	RAF1
T51883	DI0321	Ovarian cancer	[ICD-11: 2C73]	P04049	RAF1
T51883	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P04049	RAF1
T23787	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q16875	PFKFB3
T99089	DI0252	Melanoma	[ICD-11: 2C30]	P15056	BRAF
T92828	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P24530	EDNRB
T92828	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P24530	EDNRB
T54582	DI0231	Leukaemia	[ICD-11: 2A60-2B33]	P43490	NAMPT
T54582	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P43490	NAMPT
T54582	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P43490	NAMPT
T39716	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q14524	SCN5A
T39716	DI0068	Cardiac arrhythmia	[ICD-11: BC9Z]	Q14524	SCN5A
T39716	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	Q14524	SCN5A
T39716	DI0105	Cough	[ICD-11: MD12]	Q14524	SCN5A
T39716	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	Q14524	SCN5A
T39716	DI0264	Migraine	[ICD-11: 8A80]	Q14524	SCN5A
T39716	DI0324	Pain	[ICD-11: MG30-MG3Z]	Q14524	SCN5A
T39716	DI0434	Ventricular tachyarrhythmia	[ICD-11: BC71]	Q14524	SCN5A
T17569	DI0030	Angina pectoris	[ICD-11: BA40]	P22460	KCNA5
T49072	DI0037	Asthma	[ICD-11: CA23]	Q9UKP6	UTS2R
T16308	DI0238	Lung cancer	[ICD-11: 2C25]	Q13526	PIN1
T76914	DI0198	Idiopathic inflammatory myopathy	[ICD-11: 4A41]	P22001	KCNA3
T76914	DI0351	Psoriasis	[ICD-11: EA90]	P22001	KCNA3
T76914	DI0352	Psoriatic arthritis	[ICD-11: FA21]	P22001	KCNA3
T94692	DI0238	Lung cancer	[ICD-11: 2C25]	P01130	LDLR
T97141	DI0127	Duodenal ulcer	[ICD-11: DA63]	Q15746	MYLK
T51282	DI0166	Glaucoma	[ICD-11: 9C61]	Q13464	ROCK1
T14558	DI0155	Fungal infection	[ICD-11: 1F29-1F2F]	Q15661	TPSAB1
T14558	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q15661	TPSAB1
T10383	DI0091	Coagulation defect	[ICD-11: 3B10]	O14939	PLD2
T64795	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	O43497	CACNA1G
T64795	DI0190	Hypertension	[ICD-11: BA00-BA04]	O43497	CACNA1G
T64795	DI0276	Multiple structural anomalies syndrome	[ICD-11: LD2F]	O43497	CACNA1G
T64795	DI0326	Pancreatic cancer	[ICD-11: 2C10]	O43497	CACNA1G
T64795	DI0370	Schizophrenia	[ICD-11: 6A20]	O43497	CACNA1G
T47107	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P05129	PRKCG
T47107	DI0248	Mastocytosis	[ICD-11: 2A21]	P05129	PRKCG
T76414	DI0024	Alpha-1-antitrypsin deficiency	[ICD-11: 5C5A]	Q13224	GRIN2B
T92057	DI0238	Lung cancer	[ICD-11: 2C25]	Q15303	ERBB4
T25315	DI0178	Hepatic fibrosis/cirrhosis	[ICD-11: DB93]	P49682	CXCR3
T25315	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	P49682	CXCR3
T25315	DI0351	Psoriasis	[ICD-11: EA90]	P49682	CXCR3
T25315	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P49682	CXCR3
T86552	DI0060	Brain cancer	[ICD-11: 2A00]	P19438	TNFRSF1A
T86552	DI0321	Ovarian cancer	[ICD-11: 2C73]	P19438	TNFRSF1A
T68887	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P28336	NMBR
T68887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P28336	NMBR
T15797	DI0238	Lung cancer	[ICD-11: 2C25]	Q9NRG4	SMYD2
T15797	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9NRG4	SMYD2
T03644	DI0025	Alzheimer disease	[ICD-11: 8A20]	P37840	SNCA
T03644	DI0044	Autonomic nervous system disorder	[ICD-11: 8D87]	P37840	SNCA
T03644	DI0331	Parkinsonism	[ICD-11: 8A00]	P37840	SNCA
T95302	DI0005	Acne vulgaris	[ICD-11: ED80]	P33032	MC5R
T95302	DI0371	Sebaceous gland disorder	[ICD-11: ED91]	P33032	MC5R
T94324	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q969S8	HDAC10
T47888	DI0419	Ulcerative colitis	[ICD-11: DD71]	O95136	S1PR2
T71192	DI0037	Asthma	[ICD-11: CA23]	Q9Y271	CYSLTR1
T08910	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P18507	GABRG2
T08910	DI0256	Mental/behavioural/neurodevelopmental disorder	[ICD-11: 6E20-6E8Z]	P18507	GABRG2
T08910	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P18507	GABRG2
T08499	DI0087	Chronic pain	[ICD-11: MG30]	Q9UJ67	APAF1
T08499	DI0167	Gout	[ICD-11: FA25]	Q9UJ67	APAF1
T08499	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	Q9UJ67	APAF1
T08499	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9UJ67	APAF1
T92640	DI0146	Fibrosis	[ICD-11: GA14-GC01]	Q92633	LPAR1
T92640	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	Q92633	LPAR1
T92640	DI0351	Psoriasis	[ICD-11: EA90]	Q92633	LPAR1
T92640	DI0399	Systemic sclerosis	[ICD-11: 4A42]	Q92633	LPAR1
T84439	DI0377	Sex development malformative disorder	[ICD-11: LD2A]	Q6DWJ6	GPR139
T86385	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P08311	CTSG
T39921	DI0037	Asthma	[ICD-11: CA23]	P04792	HSPB1
T63170	DI0201	Inborn carbohydrate metabolism error	[ICD-11: 5C51]	Q9UJM8	HAO1
T44919	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P01275	GCG
T44919	DI0120	Diabetes mellitus	[ICD-11: 5A10]	P01275	GCG
T44919	DI0308	Obesity	[ICD-11: 5B80-5B81]	P01275	GCG
T44919	DI0331	Parkinsonism	[ICD-11: 8A00]	P01275	GCG
T44919	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P01275	GCG
T41750	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P48546	GIPR
T51593	DI0066	Carcinoid syndrome	[ICD-11: 5B10]	Q8IWU9	TPH2
T51593	DI0389	Small intestine developmental anomaly	[ICD-11: DA90]	Q8IWU9	TPH2
T89988	DI0083	Chronic kidney disease	[ICD-11: GB61]	P13500	CCL2
T89988	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P13500	CCL2
T89988	DI0087	Chronic pain	[ICD-11: MG30]	P13500	CCL2
T89988	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	P13500	CCL2
T89988	DI0252	Melanoma	[ICD-11: 2C30]	P13500	CCL2
T89988	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	P13500	CCL2
T89988	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P13500	CCL2
T89988	DI0326	Pancreatic cancer	[ICD-11: 2C10]	P13500	CCL2
T89988	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P13500	CCL2
T89988	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P13500	CCL2
T78356	DI0030	Angina pectoris	[ICD-11: BA40]	P24557	TBXAS1
T70680	DI0167	Gout	[ICD-11: FA25]	Q4U2R8	SLC22A6
T70680	DI0206	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Q4U2R8	SLC22A6
T70680	DI0310	Ocular disease	[ICD-11: N.A.]	Q4U2R8	SLC22A6
T98945	DI0263	Middle East Respiratory Syndrome	[ICD-11: 1D64]	P09958	FUR
T28887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9BY41	HDAC8
T41263	DI0078	Cholera	[ICD-11: 1A00]	Q7RTX1	TAS1R1
T85581	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P55011	SLC12A2
T27602	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q9HAN5	TRP1
T27602	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q9HAN5	TRP1
T47094	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P35270	SPR
T47094	DI0293	Nausea/vomiting	[ICD-11: MD90]	P35270	SPR
T68334	DI0144	Female infertility	[ICD-11: GA31]	Q4ZFZ2	FSHR
T06182	DI0069	Cardiomyopathy	[ICD-11: BC43]	P41587	VIPR2
T06182	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P41587	VIPR2
T06182	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P41587	VIPR2
T06182	DI0190	Hypertension	[ICD-11: BA00-BA04]	P41587	VIPR2
T06182	DI0280	Muscular dystrophy	[ICD-11: 8C70]	P41587	VIPR2
T06182	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P41587	VIPR2
T23178	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P18564	ITGB6