(-)-Argemonine



Compound IDCDAMM00655
Common name(-)-Argemonine
IUPAC name4,5,12,13-tetramethoxy-17-methyl-17-azatetracyclo[7.7.1.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaene
Molecular formulaC21H25NO4

Experimental data

Retention time10.05
Adduct[2M+Na]+
Actual mz733.336
Theoretical mz733.345
Error12.43
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.9539

Identifiers and class information

Inchi keyQEOWCPFWLCIQSL-RXQGYGPJNA-N
SmilesO(C=1C=C2C(=CC1OC)C3N(C)C(C4=CC(OC)=C(OC)C=C4C3)C2)C
SuperclassAlkaloids and derivatives
ClassPavine alkaloids

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)2
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)4
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)2
    Molecular weight (mol_MW)355.433
    Computed dipole moment(dipole)1.959
    Total solvent accessible surface area (SASA)630.942
    Hydrophobic component of SASA (FOSA)533.692
    Hydrophilic component of SASA (FISA)5.077
    Pie component of the SASA (PISA)92.172
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1137.26
    Number of hydrogen bond donors (donorHB)0
    Number of hydrogen bond acceptors (accptHB)5
    Free energy of solvation of dipole (dip^2/V)0.0033737
    Index of cohesive interaction in solids (ACxDN^.5/SA)0
    Globularity descriptor (glob)0.83512
    Predicted polarizability in cubic angstroms (QPpolrz)37.671
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.466
    Predicted octanol/gas partition coefficient (QPlogPoct)14.285
    Predicted water/gas partition coefficient (QPlogPw)5.942
    Predicted octanol/water partition coefficient (QPlogPo/w)3.825
    Predicted aqueous solubility (QPlogS)-3.685
    Conformation-independent predicted aqueous solubility (CIQPlogS)-4.014
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.366
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)2211.31
    Predicted brain/blood partition coefficient (QPlogBB)0.672
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)1290.49
    Predicted skin permeability, log Kp (QPlogKp)-2.967
    PM3 calculated ionization potential (IP(ev))8.503
    PM3 calculated electron affinity (EA(eV))-0.217
    Number of likely metabolic reactions (#metab)9
    Prediction of binding to human serum albumin (QPlogKhsa)0.412
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)100
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)37.021
    Number of nitrogen and oxygen atoms (#NandO)5
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P43681CHRNA4Neuronal acetylcholine receptor; alpha4/beta2T70967SwissTargetPrediction
    P08173CHRM4Muscarinic acetylcholine receptor M4T20709SwissTargetPrediction
    P22303ACHEAcetylcholinesteraseT30082SwissTargetPrediction and SEA
    Q12809KCNH2HERGT20251SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    Q07820MCL1Induced myeloid leukemia cell differentiation protein Mcl-1T14912SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    Q99720SIGMAR1Sigma opioid receptorT46360SwissTargetPrediction
    P21917DRD4Dopamine D4 receptorT24983SwissTargetPrediction
    P21397MAOAMonoamine oxidase AT83875SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P14416DRD2Dopamine D2 receptorT67162SwissTargetPrediction and SEA
    P27487DPP4Dipeptidyl peptidase IVT31391SwissTargetPrediction and SEA
    Q96FL8SLC47A1Multidrug and toxin extrusion protein 1T39676SwissTargetPrediction
    Q9ULX7CA14Carbonic anhydrase XIVT31992SEA
    P28223HTR2ASerotonin 2a (5-HT2a) receptorT32060SwissTargetPrediction and SEA
    P28335HTR2CSerotonin 2c (5-HT2c) receptorT83813SwissTargetPrediction
    P31645SLC6A4Serotonin transporter (by homology)T27812SwissTargetPrediction
    Q05940SLC18A2Synaptic vesicular amine transporter (by homology)T48873SwissTargetPrediction and SEA
    P41595HTR2BSerotonin 2b (5-HT2b) receptorT31204SwissTargetPrediction and SEA
    P32297CHRNA3Neuronal acetylcholine receptor; alpha3/beta4T74166SwissTargetPrediction
    P08913ADRA2AAlpha-2a adrenergic receptorT11448SwissTargetPrediction
    P08588ADRB1Beta-1 adrenergic receptorT44068SwissTargetPrediction
    P08908HTR1ASerotonin 1a (5-HT1a) receptorT78709SwissTargetPrediction and SEA
    P34969HTR7Serotonin 7 (5-HT7) receptorT79062SwissTargetPrediction and SEA
    P50406HTR6Serotonin 6 (5-HT6) receptorT16691SwissTargetPrediction
    Q01959SLC6A3Dopamine transporterT55959SwissTargetPrediction
    P15538CYP11B1Cytochrome P450 11B1T84621SwissTargetPrediction
    P19099CYP11B2Cytochrome P450 11B2T59056SwissTargetPrediction
    Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
    P35354PTGS2Cyclooxygenase-2T66665SwissTargetPrediction
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    O60885BRD4Bromodomain-containing protein 4T00407SwissTargetPrediction
    P25440BRD2Bromodomain-containing protein 2T86597SwissTargetPrediction
    Q15059BRD3Bromodomain-containing protein 3T42048SwissTargetPrediction
    P03372ESR1Estrogen receptor alphaT02506SwissTargetPrediction
    Q13547HDAC1Histone deacetylase 1T68547SwissTargetPrediction
    P13726F3Coagulation factor VII/tissue factorT72702SwissTargetPrediction and SEA
    P35869AHRAryl hydrocarbon receptorT23666SwissTargetPrediction
    Q9UM73ALKALK tyrosine kinase receptorT56418SwissTargetPrediction
    P35462DRD3Dopamine D3 receptorT02551SwissTargetPrediction
    P21728DRD1Dopamine D1 receptorT22118SwissTargetPrediction and SEA
    P21918DRD5Dopamine D5 receptorT46828SwissTargetPrediction and SEA
    P21731TBXA2RThromboxane A2 receptorT76198SwissTargetPrediction
    P07550ADRB2Adrenergic receptor betaT52522SwissTargetPrediction
    P13945ADRB3Beta-3 adrenergic receptorT51408SwissTargetPrediction
    P18825ADRA2CAdrenergic receptor alpha-2T01777SwissTargetPrediction
    P33527ABCC1Multidrug resistance-associated protein 1T11288SwissTargetPrediction
    P08183ABCB1P-glycoprotein 1T25258SwissTargetPrediction
    P35372OPRM1Mu opioid receptorT47768SwissTargetPrediction
    P25100ADRA1DAlpha-1d adrenergic receptorT53381SwissTargetPrediction
    P35368ADRA1BAlpha-1b adrenergic receptorT29500SwissTargetPrediction
    P41145OPRK1Kappa Opioid receptorT60693SwissTargetPrediction
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    O95271TNKSTankyrase-1T83059SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    Q16539MAPK14MAP kinase p38 alphaT65864SwissTargetPrediction
    Q13535ATRSerine-protein kinase ATRT97155SwissTargetPrediction
    Q9Y233PDE10APhosphodiesterase 10A (by homology)T84133SwissTargetPrediction
    P41143OPRD1Delta opioid receptorT58992SwissTargetPrediction
    P62942FKBP1AFK506-binding protein 1AT76059SEA
    P43116PTGER2Prostanoid EP2 receptorT38529SwissTargetPrediction
    P35348ADRA1AAlpha-1a adrenergic receptorT92609SwissTargetPrediction
    Q5S007LRRK2Leucine-rich repeat serine/threonine-protein kinase 2T08123SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    P36897TGFBR1TGF-beta receptor type IT53389SwissTargetPrediction
    Q14432PDE3APhosphodiesterase 3T88975SwissTargetPrediction
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    P30411BDKRB2Bradykinin B2 receptorT23714SwissTargetPrediction
    P48039MTNR1AMelatonin receptor 1AT97613SwissTargetPrediction
    P49286MTNR1BMelatonin receptor 1BT48268SwissTargetPrediction and SEA
    P09619PDGFRBPlatelet-derived growth factor receptor betaT59102SwissTargetPrediction
    P07333CSF1RMacrophage colony stimulating factor receptorT20333SwissTargetPrediction
    P04629NTRK1Nerve growth factor receptor Trk-AT07173SwissTargetPrediction
    P49840GSK3AGlycogen synthase kinase-3 alphaT76910SwissTargetPrediction
    P78527PRKDCDNA-dependent protein kinaseT81735SwissTargetPrediction
    Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SwissTargetPrediction
    O43614HCRTR2Orexin receptor 2T69485SwissTargetPrediction
    O43613HCRTR1Orexin receptor 1T73482SwissTargetPrediction
    P16234PDGFRAPlatelet-derived growth factor receptorT53524SwissTargetPrediction
    Q13370PDE3BPhosphodiesterase 3BT21357SwissTargetPrediction
    O00408PDE2APhosphodiesterase 2AT77400SwissTargetPrediction
    Q92952KCNN1Small conductance calcium-activated potassium channel protein 1T11911SwissTargetPrediction and SEA
    Q9UGI6KCNN3Small conductance calcium-activated potassium channel protein 3T04388SwissTargetPrediction and SEA
    Q9Y3Q4HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4T30286SEA
    P30926CHRNB4Neuronal acetylcholine receptor; alpha2/beta4T73724SwissTargetPrediction
    Q9UIF9BAZ2ABromodomain adjacent to zinc finger domain protein 2AT95682SwissTargetPrediction
    O75884RBBP9Putative hydrolase RBBP9T12084SwissTargetPrediction and SEA
    Q9H2S1KCNN2Small conductance calcium-activated potassium channel protein 2T86271SwissTargetPrediction and SEA
    Q9H4B7TUBB1Tubulin beta-1 chainT84397SwissTargetPrediction
    Q9UIF8BAZ2BBromodomain adjacent to zinc finger domain protein 2BT15745SwissTargetPrediction
    P49862KLK7Kallikrein-7T79155SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T70967DI0029Aneurysm/dissection[ICD-11: BD50]P43681CHRNA4
    T70967DI0191Hypertensive crisis[ICD-11: BA03]P43681CHRNA4
    T70967DI0196Hypotension[ICD-11: BA20-BA21]P43681CHRNA4
    T20709DI0037Asthma[ICD-11: CA23]P08173CHRM4
    T20709DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]P08173CHRM4
    T20709DI0166Glaucoma[ICD-11: 9C61]P08173CHRM4
    T20709DI0293Nausea/vomiting[ICD-11: MD90]P08173CHRM4
    T20709DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08173CHRM4
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T20251DI0175Heart failure[ICD-11: BD10-BD1Z]Q12809KCNH2
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T14912DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q07820MCL1
    T14912DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]Q07820MCL1
    T14912DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q07820MCL1
    T14912DI0252Melanoma[ICD-11: 2C30]Q07820MCL1
    T14912DI0274Multiple myeloma[ICD-11: 2A83]Q07820MCL1
    T14912DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q07820MCL1
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T24983DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21917DRD4
    T24983DI0370Schizophrenia[ICD-11: 6A20]P21917DRD4
    T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
    T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T67162DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P14416DRD2
    T67162DI0025Alzheimer disease[ICD-11: 8A20]P14416DRD2
    T67162DI0037Asthma[ICD-11: CA23]P14416DRD2
    T67162DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P14416DRD2
    T67162DI0051Bipolar disorder[ICD-11: 6A60]P14416DRD2
    T67162DI0063Breathing abnormality[ICD-11: MD11]P14416DRD2
    T67162DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P14416DRD2
    T67162DI0073Cerebral ischaemia[ICD-11: 8B1Z]P14416DRD2
    T67162DI0117Depression[ICD-11: 6A70-6A7Z]P14416DRD2
    T67162DI0124Digestive system disease[ICD-11: DE2Z]P14416DRD2
    T67162DI0137Essential hypertension[ICD-11: BA00]P14416DRD2
    T67162DI0142Faecal incontinence[ICD-11: ME07]P14416DRD2
    T67162DI0156Gangrene[ICD-11: MC85]P14416DRD2
    T67162DI0166Glaucoma[ICD-11: 9C61]P14416DRD2
    T67162DI0175Heart failure[ICD-11: BD10-BD1Z]P14416DRD2
    T67162DI0185Hyperaemia[ICD-11: 9A61-9B7Y]P14416DRD2
    T67162DI0190Hypertension[ICD-11: BA00-BA04]P14416DRD2
    T67162DI0196Hypotension[ICD-11: BA20-BA21]P14416DRD2
    T67162DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]P14416DRD2
    T67162DI0214Insomnia[ICD-11: 7A00-7A0Z]P14416DRD2
    T67162DI0222Itching[ICD-11: 1F28-1G07]P14416DRD2
    T67162DI0264Migraine[ICD-11: 8A80]P14416DRD2
    T67162DI0293Nausea/vomiting[ICD-11: MD90]P14416DRD2
    T67162DI0324Pain[ICD-11: MG30-MG3Z]P14416DRD2
    T67162DI0331Parkinsonism[ICD-11: 8A00]P14416DRD2
    T67162DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P14416DRD2
    T67162DI0340Postpartum haemorrhage[ICD-11: JA43]P14416DRD2
    T67162DI0354Psychotic disorder[ICD-11: 6A20-6A25]P14416DRD2
    T67162DI0356Pulmonary hypertension[ICD-11: BB01]P14416DRD2
    T67162DI0370Schizophrenia[ICD-11: 6A20]P14416DRD2
    T67162DI0396Substance abuse[ICD-11: 6C40]P14416DRD2
    T67162DI0408Thyrotoxicosis[ICD-11: 5A02]P14416DRD2
    T67162DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14416DRD2
    T31391DI0009Acute diabete complication[ICD-11: 5A2Y]P27487DPP4
    T31391DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P27487DPP4
    T39676DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q96FL8SLC47A1
    T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
    T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
    T32060DI0009Acute diabete complication[ICD-11: 5A2Y]P28223HTR2A
    T32060DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P28223HTR2A
    T32060DI0073Cerebral ischaemia[ICD-11: 8B1Z]P28223HTR2A
    T32060DI0270Mood disorder[ICD-11: 6A60-6E23]P28223HTR2A
    T32060DI0331Parkinsonism[ICD-11: 8A00]P28223HTR2A
    T32060DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28223HTR2A
    T32060DI0370Schizophrenia[ICD-11: 6A20]P28223HTR2A
    T83813DI0117Depression[ICD-11: 6A70-6A7Z]P28335HTR2C
    T83813DI0264Migraine[ICD-11: 8A80]P28335HTR2C
    T83813DI0308Obesity[ICD-11: 5B80-5B81]P28335HTR2C
    T83813DI0324Pain[ICD-11: MG30-MG3Z]P28335HTR2C
    T83813DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28335HTR2C
    T27812DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P31645SLC6A4
    T27812DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P31645SLC6A4
    T27812DI0087Chronic pain[ICD-11: MG30]P31645SLC6A4
    T27812DI0096concerning food/fluid intake symptom[ICD-11: MG43]P31645SLC6A4
    T27812DI0101Corneal disease[ICD-11: 9A76-9A78]P31645SLC6A4
    T27812DI0105Cough[ICD-11: MD12]P31645SLC6A4
    T27812DI0117Depression[ICD-11: 6A70-6A7Z]P31645SLC6A4
    T27812DI0264Migraine[ICD-11: 8A80]P31645SLC6A4
    T27812DI0301Nicotine use disorder[ICD-11: 6C4A]P31645SLC6A4
    T27812DI0308Obesity[ICD-11: 5B80-5B81]P31645SLC6A4
    T27812DI0324Pain[ICD-11: MG30-MG3Z]P31645SLC6A4
    T48873DI0079Choreiform disorder[ICD-11: 8A01]Q05940SLC18A2
    T48873DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]Q05940SLC18A2
    T48873DI0129Dystonic disorder[ICD-11: 8A02]Q05940SLC18A2
    T48873DI0137Essential hypertension[ICD-11: BA00]Q05940SLC18A2
    T48873DI0190Hypertension[ICD-11: BA00-BA04]Q05940SLC18A2
    T31204DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P41595HTR2B
    T31204DI0117Depression[ICD-11: 6A70-6A7Z]P41595HTR2B
    T31204DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P41595HTR2B
    T31204DI0354Psychotic disorder[ICD-11: 6A20-6A25]P41595HTR2B
    T74166DI0105Cough[ICD-11: MD12]P32297CHRNA3
    T11448DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P08913ADRA2A
    T11448DI0317Opioid use disorder[ICD-11: 6C43]P08913ADRA2A
    T11448DI0396Substance abuse[ICD-11: 6C40]P08913ADRA2A
    T44068DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P08588ADRB1
    T44068DI0037Asthma[ICD-11: CA23]P08588ADRB1
    T44068DI0068Cardiac arrhythmia[ICD-11: BC9Z]P08588ADRB1
    T44068DI0071Central and peripheral nervous disease[ICD-11: 8A04-8E7Z]P08588ADRB1
    T44068DI0088Circulatory system disease[ICD-11: BE2Z]P08588ADRB1
    T44068DI0097Conduction disorder[ICD-11: BC63]P08588ADRB1
    T44068DI0102Coronary atherosclerosis[ICD-11: BA52]P08588ADRB1
    T44068DI0137Essential hypertension[ICD-11: BA00]P08588ADRB1
    T44068DI0166Glaucoma[ICD-11: 9C61]P08588ADRB1
    T44068DI0175Heart failure[ICD-11: BD10-BD1Z]P08588ADRB1
    T44068DI0190Hypertension[ICD-11: BA00-BA04]P08588ADRB1
    T44068DI0264Migraine[ICD-11: 8A80]P08588ADRB1
    T44068DI0375Sepsis[ICD-11: 1G40-1G41]P08588ADRB1
    T44068DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P08588ADRB1
    T44068DI0434Ventricular tachyarrhythmia[ICD-11: BC71]P08588ADRB1
    T78709DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P08908HTR1A
    T78709DI0117Depression[ICD-11: 6A70-6A7Z]P08908HTR1A
    T78709DI0190Hypertension[ICD-11: BA00-BA04]P08908HTR1A
    T78709DI0264Migraine[ICD-11: 8A80]P08908HTR1A
    T78709DI0270Mood disorder[ICD-11: 6A60-6E23]P08908HTR1A
    T79062DI0025Alzheimer disease[ICD-11: 8A20]P34969HTR7
    T79062DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34969HTR7
    T79062DI0051Bipolar disorder[ICD-11: 6A60]P34969HTR7
    T79062DI0117Depression[ICD-11: 6A70-6A7Z]P34969HTR7
    T79062DI0265Mild neurocognitive disorder[ICD-11: 6D71]P34969HTR7
    T79062DI0331Parkinsonism[ICD-11: 8A00]P34969HTR7
    T79062DI0370Schizophrenia[ICD-11: 6A20]P34969HTR7
    T16691DI0025Alzheimer disease[ICD-11: 8A20]P50406HTR6
    T16691DI0370Schizophrenia[ICD-11: 6A20]P50406HTR6
    T55959DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q01959SLC6A3
    T55959DI0051Bipolar disorder[ICD-11: 6A60]Q01959SLC6A3
    T55959DI0101Corneal disease[ICD-11: 9A76-9A78]Q01959SLC6A3
    T55959DI0290Narcolepsy[ICD-11: 7A20]Q01959SLC6A3
    T55959DI0308Obesity[ICD-11: 5B80-5B81]Q01959SLC6A3
    T55959DI0331Parkinsonism[ICD-11: 8A00]Q01959SLC6A3
    T84621DI0062Breast cancer[ICD-11: 2C60-2C6Y]P15538CYP11B1
    T84621DI0108Cushing syndrome[ICD-11: 5A70]P15538CYP11B1
    T59056DI0190Hypertension[ICD-11: BA00-BA04]P19099CYP11B2
    T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
    T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
    T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
    T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
    T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
    T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
    T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
    T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
    T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
    T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
    T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
    T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
    T66665DI0087Chronic pain[ICD-11: MG30]P35354PTGS2
    T66665DI0145Female pelvic pain[ICD-11: GA34]P35354PTGS2
    T66665DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P35354PTGS2
    T66665DI0207Indeterminate colitis[ICD-11: DD72]P35354PTGS2
    T66665DI0227Knee osteoarthritis[ICD-11: FA01]P35354PTGS2
    T66665DI0320Osteoarthritis[ICD-11: FA00-FA05]P35354PTGS2
    T66665DI0324Pain[ICD-11: MG30-MG3Z]P35354PTGS2
    T66665DI0366Rheumatoid arthritis[ICD-11: FA20]P35354PTGS2
    T66665DI0416Tuberculosis[ICD-11: 1B10-1B12]P35354PTGS2
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T86597DI0106COVID-19[ICD-11: 1D6Y]P25440BRD2
    T42048DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q15059BRD3
    T42048DI0346Prostate cancer[ICD-11: 2C82]Q15059BRD3
    T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
    T68547DI0274Multiple myeloma[ICD-11: 2A83]Q13547HDAC1
    T68547DI0283Mycosis fungoides[ICD-11: 2B01]Q13547HDAC1
    T72702DI0075Cervical cancer[ICD-11: 2C77]P13726F3
    T23666DI0351Psoriasis[ICD-11: EA90]P35869AHR
    T23666DI0403Thrombocytopenia[ICD-11: 3B64]P35869AHR
    T56418DI0238Lung cancer[ICD-11: 2C25]Q9UM73ALK
    T56418DI0251Mature T-cell lymphoma[ICD-11: 2A90]Q9UM73ALK
    T56418DI0303Non-small-cell lung cancer[ICD-11: 2C25]Q9UM73ALK
    T02551DI0051Bipolar disorder[ICD-11: 6A60]P35462DRD3
    T02551DI0331Parkinsonism[ICD-11: 8A00]P35462DRD3
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T46828DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21918DRD5
    T76198DI0102Coronary atherosclerosis[ICD-11: BA52]P21731TBXA2R
    T76198DI0121Diabetic foot ulcer[ICD-11: BD54]P21731TBXA2R
    T76198DI0287Myocardial infarction[ICD-11: BA41-BA43]P21731TBXA2R
    T76198DI0378Sexual dysfunction[ICD-11: HA00-HA01]P21731TBXA2R
    T52522DI0037Asthma[ICD-11: CA23]P07550ADRB2
    T52522DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07550ADRB2
    T52522DI0097Conduction disorder[ICD-11: BC63]P07550ADRB2
    T52522DI0344Preterm labour/delivery[ICD-11: JB00]P07550ADRB2
    T52522DI0387Sleep-related breathing disorder[ICD-11: 7A4Z]P07550ADRB2
    T51408DI0030Angina pectoris[ICD-11: BA40]P13945ADRB3
    T51408DI0037Asthma[ICD-11: CA23]P13945ADRB3
    T51408DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P13945ADRB3
    T51408DI0129Dystonic disorder[ICD-11: 8A02]P13945ADRB3
    T51408DI0154Functional bladder disorder[ICD-11: GC50]P13945ADRB3
    T51408DI0190Hypertension[ICD-11: BA00-BA04]P13945ADRB3
    T51408DI0331Parkinsonism[ICD-11: 8A00]P13945ADRB3
    T01777DI0166Glaucoma[ICD-11: 9C61]P18825ADRA2C
    T01777DI0190Hypertension[ICD-11: BA00-BA04]P18825ADRA2C
    T01777DI0196Hypotension[ICD-11: BA20-BA21]P18825ADRA2C
    T01777DI0308Obesity[ICD-11: 5B80-5B81]P18825ADRA2C
    T01777DI0310Ocular disease[ICD-11: N.A.]P18825ADRA2C
    T01777DI0396Substance abuse[ICD-11: 6C40]P18825ADRA2C
    T11288DI0167Gout[ICD-11: FA25]P33527ABCC1
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
    T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
    T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
    T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
    T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
    T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
    T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
    T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
    T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
    T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
    T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
    T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
    T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
    T53381DI0166Glaucoma[ICD-11: 9C61]P25100ADRA1D
    T53381DI0175Heart failure[ICD-11: BD10-BD1Z]P25100ADRA1D
    T53381DI0190Hypertension[ICD-11: BA00-BA04]P25100ADRA1D
    T53381DI0348Prostate hyperplasia[ICD-11: GA90]P25100ADRA1D
    T53381DI0378Sexual dysfunction[ICD-11: HA00-HA01]P25100ADRA1D
    T53381DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P25100ADRA1D
    T29500DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P35368ADRA1B
    T29500DI0190Hypertension[ICD-11: BA00-BA04]P35368ADRA1B
    T29500DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P35368ADRA1B
    T29500DI0308Obesity[ICD-11: 5B80-5B81]P35368ADRA1B
    T29500DI0324Pain[ICD-11: MG30-MG3Z]P35368ADRA1B
    T60693DI0304Non-specific cutaneous vascular symptom[ICD-11: ME64]P41145OPRK1
    T60693DI0324Pain[ICD-11: MG30-MG3Z]P41145OPRK1
    T60693DI0349Pruritus[ICD-11: EC90]P41145OPRK1
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T83059DI0060Brain cancer[ICD-11: 2A00]O95271TNKS
    T83059DI0062Breast cancer[ICD-11: 2C60-2C6Y]O95271TNKS
    T83059DI0321Ovarian cancer[ICD-11: 2C73]O95271TNKS
    T83059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O95271TNKS
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T65864DI0102Coronary atherosclerosis[ICD-11: BA52]Q16539MAPK14
    T65864DI0287Myocardial infarction[ICD-11: BA41-BA43]Q16539MAPK14
    T65864DI0366Rheumatoid arthritis[ICD-11: FA20]Q16539MAPK14
    T65864DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]Q16539MAPK14
    T97155DI0238Lung cancer[ICD-11: 2C25]Q13535ATR
    T97155DI0241Lymphoma[ICD-11: 2A80-2A86]Q13535ATR
    T97155DI0249Mature B-cell leukaemia[ICD-11: 2A82]Q13535ATR
    T97155DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q13535ATR
    T84133DI0079Choreiform disorder[ICD-11: 8A01]Q9Y233PDE10A
    T84133DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q9Y233PDE10A
    T84133DI0218Irritable bowel syndrome[ICD-11: DD91]Q9Y233PDE10A
    T84133DI0370Schizophrenia[ICD-11: 6A20]Q9Y233PDE10A
    T84133DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9Y233PDE10A
    T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
    T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
    T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
    T76059DI0331Parkinsonism[ICD-11: 8A00]P62942FKBP1A
    T76059DI0349Pruritus[ICD-11: EC90]P62942FKBP1A
    T76059DI0413Transplant rejection[ICD-11: NE84]P62942FKBP1A
    T38529DI0003Abortion[ICD-11: JA00]P43116PTGER2
    T38529DI0102Coronary atherosclerosis[ICD-11: BA52]P43116PTGER2
    T38529DI0121Diabetic foot ulcer[ICD-11: BD54]P43116PTGER2
    T38529DI0166Glaucoma[ICD-11: 9C61]P43116PTGER2
    T38529DI0356Pulmonary hypertension[ICD-11: BB01]P43116PTGER2
    T38529DI0378Sexual dysfunction[ICD-11: HA00-HA01]P43116PTGER2
    T38529DI0413Transplant rejection[ICD-11: NE84]P43116PTGER2
    T92609DI0190Hypertension[ICD-11: BA00-BA04]P35348ADRA1A
    T92609DI0348Prostate hyperplasia[ICD-11: GA90]P35348ADRA1A
    T08123DI0331Parkinsonism[ICD-11: 8A00]Q5S007LRRK2
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T53389DI0035Arterial occlusive disease[ICD-11: BD40]P36897TGFBR1
    T53389DI0238Lung cancer[ICD-11: 2C25]P36897TGFBR1
    T88975DI0035Arterial occlusive disease[ICD-11: BD40]Q14432PDE3A
    T88975DI0037Asthma[ICD-11: CA23]Q14432PDE3A
    T88975DI0175Heart failure[ICD-11: BD10-BD1Z]Q14432PDE3A
    T88975DI0404Thrombocytosis[ICD-11: 3B63]Q14432PDE3A
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T23714DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P30411BDKRB2
    T97613DI0214Insomnia[ICD-11: 7A00-7A0Z]P48039MTNR1A
    T48268DI0214Insomnia[ICD-11: 7A00-7A0Z]P49286MTNR1B
    T59102DI0009Acute diabete complication[ICD-11: 5A2Y]P09619PDGFRB
    T59102DI0361Renal cell carcinoma[ICD-11: 2C90]P09619PDGFRB
    T59102DI0403Thrombocytopenia[ICD-11: 3B64]P09619PDGFRB
    T20333DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P07333CSF1R
    T07173DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04629NTRK1
    T07173DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04629NTRK1
    T76910DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P49840GSK3A
    T81735DI0360Rectum cancer[ICD-11: 2B92]P78527PRKDC
    T81735DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P78527PRKDC
    T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
    T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
    T69485DI0214Insomnia[ICD-11: 7A00-7A0Z]O43614HCRTR2
    T73482DI0117Depression[ICD-11: 6A70-6A7Z]O43613HCRTR1
    T73482DI0214Insomnia[ICD-11: 7A00-7A0Z]O43613HCRTR1
    T73482DI0317Opioid use disorder[ICD-11: 6C43]O43613HCRTR1
    T53524DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P16234PDGFRA
    T53524DI0225Kaposi sarcoma[ICD-11: 2B57]P16234PDGFRA
    T53524DI0403Thrombocytopenia[ICD-11: 3B64]P16234PDGFRA
    T77400DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]O00408PDE2A
    T77400DI0207Indeterminate colitis[ICD-11: DD72]O00408PDE2A
    T77400DI0218Irritable bowel syndrome[ICD-11: DD91]O00408PDE2A
    T77400DI0270Mood disorder[ICD-11: 6A60-6E23]O00408PDE2A
    T11911DI0285Myelopathy[ICD-11: 8B42]Q92952KCNN1
    T04388DI0285Myelopathy[ICD-11: 8B42]Q9UGI6KCNN3
    T73724DI0301Nicotine use disorder[ICD-11: 6C4A]P30926CHRNB4
    T86271DI0285Myelopathy[ICD-11: 8B42]Q9H2S1KCNN2
    T84397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9H4B7TUBB1

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