Stephalonine C



Compound IDCDAMM00630
Common nameStephalonine C
IUPAC name(3-hydroxy-4,11,12-trimethoxy-18-oxa-17-azapentacyclo[8.4.3.18,11.01,10.02,7]octadeca-2(7),3,5-trien-13-yl) 3-phenylprop-2-enoate
Molecular formulaC28H31NO7

Experimental data

Retention time12.35
Adduct[M+K]+
Actual mz532.17
Theoretical mz532.173
Error5.93
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score5.2629

Identifiers and class information

Inchi keyOKJXULSSFGSEHT-AENVTGLYNA-N
SmilesO=C(OC1CC23C4=C(O)C(OC)=CC=C4C5OC(OC)(C1OC)C3(NCC2)C5)C=CC=6C=CC=CC6
SuperclassAlkaloids and derivatives
ClassHasubanan alkaloids

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)8
    Number of reactive functional groups (#rtvFG)2
    Predicted central nervous system activity (CNS)1
    Molecular weight (mol_MW)493.555
    Computed dipole moment(dipole)6.208
    Total solvent accessible surface area (SASA)763.854
    Hydrophobic component of SASA (FOSA)394.45
    Hydrophilic component of SASA (FISA)87.918
    Pie component of the SASA (PISA)281.486
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1448.68
    Number of hydrogen bond donors (donorHB)2
    Number of hydrogen bond acceptors (accptHB)7.7
    Free energy of solvation of dipole (dip^2/V)0.0266053
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0142559
    Globularity descriptor (glob)0.810594
    Predicted polarizability in cubic angstroms (QPpolrz)49.374
    Predicted hexadecane/gas partition coefficient (QPlogPC16)14.723
    Predicted octanol/gas partition coefficient (QPlogPoct)23.663
    Predicted water/gas partition coefficient (QPlogPw)12.819
    Predicted octanol/water partition coefficient (QPlogPo/w)4.223
    Predicted aqueous solubility (QPlogS)-4.76
    Conformation-independent predicted aqueous solubility (CIQPlogS)-5.855
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-6.665
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)362.303
    Predicted brain/blood partition coefficient (QPlogBB)-0.412
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)182.658
    Predicted skin permeability, log Kp (QPlogKp)-3.443
    PM3 calculated ionization potential (IP(ev))8.94
    PM3 calculated electron affinity (EA(eV))0.544
    Number of likely metabolic reactions (#metab)4
    Prediction of binding to human serum albumin (QPlogKhsa)0.673
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)100
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)85.121
    Number of nitrogen and oxygen atoms (#NandO)8
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P20309CHRM3Muscarinic acetylcholine receptor M3T67684SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P35228NOS2Nitric oxide synthase, inducibleT02703SwissTargetPrediction
    P00734F2ThrombinT94033SwissTargetPrediction
    P21917DRD4Dopamine D4 receptorT24983SwissTargetPrediction
    P06239LCKTyrosine-protein kinase LCKT12499SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P27487DPP4Dipeptidyl peptidase IVT31391SwissTargetPrediction
    P98170XIAPInhibitor of apoptosis protein 3T16769SwissTargetPrediction
    P55210CASP7Caspase-7T72252SwissTargetPrediction
    P28335HTR2CSerotonin 2c (5-HT2c) receptorT83813SwissTargetPrediction
    P08913ADRA2AAlpha-2a adrenergic receptorT11448SwissTargetPrediction
    P28222HTR1BSerotonin 1b (5-HT1b) receptorT07806SwissTargetPrediction
    P28221HTR1DSerotonin 1d (5-HT1d) receptorT11072SwissTargetPrediction
    P08588ADRB1Beta-1 adrenergic receptorT44068SwissTargetPrediction
    P34969HTR7Serotonin 7 (5-HT7) receptorT79062SwissTargetPrediction
    P50406HTR6Serotonin 6 (5-HT6) receptorT16691SwissTargetPrediction
    P12955PEPDXaa-Pro dipeptidaseT94823SwissTargetPrediction
    P35968KDRVascular endothelial growth factor receptor 2T80975SwissTargetPrediction
    O60885BRD4Bromodomain-containing protein 4T00407SwissTargetPrediction
    Q9H3N8HRH4Histamine H4 receptorT26500SwissTargetPrediction
    P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    P07550ADRB2Adrenergic receptor betaT52522SwissTargetPrediction
    P13945ADRB3Beta-3 adrenergic receptorT51408SwissTargetPrediction
    P18825ADRA2CAdrenergic receptor alpha-2T01777SwissTargetPrediction
    P08183ABCB1P-glycoprotein 1T25258SEA
    P35372OPRM1Mu opioid receptorT47768SwissTargetPrediction
    P41145OPRK1Kappa Opioid receptorT60693SwissTargetPrediction
    P52732KIF11Kinesin-like protein 1T28484SwissTargetPrediction
    P11309PIM1Serine/threonine-protein kinase PIM1T50594SwissTargetPrediction
    O60674JAK2Tyrosine-protein kinase JAK2T08391SwissTargetPrediction
    P24941CDK2Cyclin-dependent kinase 2T70176SwissTargetPrediction
    P36888FLT3Tyrosine-protein kinase receptor FLT3T74312SwissTargetPrediction
    Q9Y233PDE10APhosphodiesterase 10A (by homology)T84133SwissTargetPrediction
    P08172CHRM2Muscarinic acetylcholine receptor M2T46185SwissTargetPrediction
    Q92847GHSRGhrelin receptorT59604SwissTargetPrediction
    P41143OPRD1Delta opioid receptorT58992SwissTargetPrediction
    P00742F10Thrombin and coagulation factor XT84631SwissTargetPrediction
    Q9HAN5TRP1Cationic trypsinogenT27602SwissTargetPrediction
    Q13490BIRC2Baculoviral IAP repeat-containing protein 2T84780SwissTargetPrediction
    P13500CCL2C-C motif chemokine 2T89988SwissTargetPrediction
    P23458JAK1Tyrosine-protein kinase JAK1T62460SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    P08238HSP90AB1Heat shock protein HSP 90-betaT96623SwissTargetPrediction
    P29466CASP1Caspase-1T98269SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    P29597TYK2Tyrosine-protein kinase TYK2T78932SwissTargetPrediction
    P18089ADRA2BAlpha-2b adrenergic receptorT41580SwissTargetPrediction
    P50579METAP2Methionine aminopeptidase 2T75596SwissTargetPrediction
    Q9NWZ3IRAK4Interleukin-1 receptor-associated kinase 4T55398SwissTargetPrediction
    Q9UQ81MCH5Caspase-8T15700SwissTargetPrediction
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SwissTargetPrediction
    Q13976PRKG1cGMP-dependent protein kinase 1 betaT78543SwissTargetPrediction
    Q04759PRKCQProtein kinase C thetaT23995SwissTargetPrediction
    P12268IMPDH2Inosine-5'-monophosphate dehydrogenase 2T89360SwissTargetPrediction
    Q96GD4AURKBSerine/threonine-protein kinase Aurora-BT46781SwissTargetPrediction
    P24530EDNRBEndothelin receptor ET-BT92828SwissTargetPrediction
    P29317EPHA2Ephrin type-A receptor 2T57278SwissTargetPrediction
    Q9NPH5NOX4NADPH oxidase 4T29741SwissTargetPrediction
    P30939HTR1FSerotonin 1f (5-HT1f) receptorT78656SwissTargetPrediction
    Q6PL18ATAD2ATPase family AAA domain-containing protein 2T82467SwissTargetPrediction
    O43826SLC37A4Glucose-6-phosphate translocaseT47306SEA
    O43895XPNPEP2Xaa-Pro aminopeptidase 2T68320SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T67684DI0037Asthma[ICD-11: CA23]P20309CHRM3
    T67684DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P20309CHRM3
    T67684DI0154Functional bladder disorder[ICD-11: GC50]P20309CHRM3
    T67684DI0166Glaucoma[ICD-11: 9C61]P20309CHRM3
    T67684DI0293Nausea/vomiting[ICD-11: MD90]P20309CHRM3
    T67684DI0333Peptic ulcer[ICD-11: DA61]P20309CHRM3
    T67684DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P20309CHRM3
    T67684DI0371Sebaceous gland disorder[ICD-11: ED91]P20309CHRM3
    T67684DI0382Sjogren syndrome[ICD-11: 4A43]P20309CHRM3
    T67684DI0411Tonus and reflex abnormality[ICD-11: MB47]P20309CHRM3
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T02703DI0083Chronic kidney disease[ICD-11: GB61]P35228NOS2
    T02703DI0320Osteoarthritis[ICD-11: FA00-FA05]P35228NOS2
    T02703DI0375Sepsis[ICD-11: 1G40-1G41]P35228NOS2
    T02703DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35228NOS2
    T94033DI0052Bleeding disorder[ICD-11: GA20-GA21]P00734F2
    T94033DI0091Coagulation defect[ICD-11: 3B10]P00734F2
    T94033DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P00734F2
    T94033DI0275Multiple sclerosis[ICD-11: 8A40]P00734F2
    T94033DI0287Myocardial infarction[ICD-11: BA41-BA43]P00734F2
    T94033DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00734F2
    T94033DI0403Thrombocytopenia[ICD-11: 3B64]P00734F2
    T94033DI0405Thrombosis[ICD-11: DB61-GB90]P00734F2
    T24983DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21917DRD4
    T24983DI0370Schizophrenia[ICD-11: 6A20]P21917DRD4
    T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T31391DI0009Acute diabete complication[ICD-11: 5A2Y]P27487DPP4
    T31391DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P27487DPP4
    T16769DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]P98170XIAP
    T72252DI0110Cystic fibrosis[ICD-11: CA25]P55210CASP7
    T83813DI0117Depression[ICD-11: 6A70-6A7Z]P28335HTR2C
    T83813DI0264Migraine[ICD-11: 8A80]P28335HTR2C
    T83813DI0308Obesity[ICD-11: 5B80-5B81]P28335HTR2C
    T83813DI0324Pain[ICD-11: MG30-MG3Z]P28335HTR2C
    T83813DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28335HTR2C
    T11448DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P08913ADRA2A
    T11448DI0317Opioid use disorder[ICD-11: 6C43]P08913ADRA2A
    T11448DI0396Substance abuse[ICD-11: 6C40]P08913ADRA2A
    T07806DI0264Migraine[ICD-11: 8A80]P28222HTR1B
    T07806DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28222HTR1B
    T07806DI0354Psychotic disorder[ICD-11: 6A20-6A25]P28222HTR1B
    T07806DI0370Schizophrenia[ICD-11: 6A20]P28222HTR1B
    T11072DI0264Migraine[ICD-11: 8A80]P28221HTR1D
    T11072DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28221HTR1D
    T44068DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P08588ADRB1
    T44068DI0037Asthma[ICD-11: CA23]P08588ADRB1
    T44068DI0068Cardiac arrhythmia[ICD-11: BC9Z]P08588ADRB1
    T44068DI0071Central and peripheral nervous disease[ICD-11: 8A04-8E7Z]P08588ADRB1
    T44068DI0088Circulatory system disease[ICD-11: BE2Z]P08588ADRB1
    T44068DI0097Conduction disorder[ICD-11: BC63]P08588ADRB1
    T44068DI0102Coronary atherosclerosis[ICD-11: BA52]P08588ADRB1
    T44068DI0137Essential hypertension[ICD-11: BA00]P08588ADRB1
    T44068DI0166Glaucoma[ICD-11: 9C61]P08588ADRB1
    T44068DI0175Heart failure[ICD-11: BD10-BD1Z]P08588ADRB1
    T44068DI0190Hypertension[ICD-11: BA00-BA04]P08588ADRB1
    T44068DI0264Migraine[ICD-11: 8A80]P08588ADRB1
    T44068DI0375Sepsis[ICD-11: 1G40-1G41]P08588ADRB1
    T44068DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P08588ADRB1
    T44068DI0434Ventricular tachyarrhythmia[ICD-11: BC71]P08588ADRB1
    T79062DI0025Alzheimer disease[ICD-11: 8A20]P34969HTR7
    T79062DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34969HTR7
    T79062DI0051Bipolar disorder[ICD-11: 6A60]P34969HTR7
    T79062DI0117Depression[ICD-11: 6A70-6A7Z]P34969HTR7
    T79062DI0265Mild neurocognitive disorder[ICD-11: 6D71]P34969HTR7
    T79062DI0331Parkinsonism[ICD-11: 8A00]P34969HTR7
    T79062DI0370Schizophrenia[ICD-11: 6A20]P34969HTR7
    T16691DI0025Alzheimer disease[ICD-11: 8A20]P50406HTR6
    T16691DI0370Schizophrenia[ICD-11: 6A20]P50406HTR6
    T80975DI0062Breast cancer[ICD-11: 2C60-2C6Y]P35968KDR
    T80975DI0095Colorectal cancer[ICD-11: 2B91]P35968KDR
    T80975DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P35968KDR
    T80975DI0244Malignant digestive organ neoplasm[ICD-11: 2C11]P35968KDR
    T80975DI0361Renal cell carcinoma[ICD-11: 2C90]P35968KDR
    T80975DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35968KDR
    T80975DI0395Stomach cancer[ICD-11: 2B72]P35968KDR
    T80975DI0403Thrombocytopenia[ICD-11: 3B64]P35968KDR
    T80975DI0407Thyroid cancer[ICD-11: 2D10]P35968KDR
    T26500DI0037Asthma[ICD-11: CA23]Q9H3N8HRH4
    T26500DI0039Atopic eczema[ICD-11: EA80]Q9H3N8HRH4
    T26500DI0351Psoriasis[ICD-11: EA90]Q9H3N8HRH4
    T26500DI0366Rheumatoid arthritis[ICD-11: FA20]Q9H3N8HRH4
    T26500DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q9H3N8HRH4
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T52522DI0037Asthma[ICD-11: CA23]P07550ADRB2
    T52522DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07550ADRB2
    T52522DI0097Conduction disorder[ICD-11: BC63]P07550ADRB2
    T52522DI0344Preterm labour/delivery[ICD-11: JB00]P07550ADRB2
    T52522DI0387Sleep-related breathing disorder[ICD-11: 7A4Z]P07550ADRB2
    T51408DI0030Angina pectoris[ICD-11: BA40]P13945ADRB3
    T51408DI0037Asthma[ICD-11: CA23]P13945ADRB3
    T51408DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P13945ADRB3
    T51408DI0129Dystonic disorder[ICD-11: 8A02]P13945ADRB3
    T51408DI0154Functional bladder disorder[ICD-11: GC50]P13945ADRB3
    T51408DI0190Hypertension[ICD-11: BA00-BA04]P13945ADRB3
    T51408DI0331Parkinsonism[ICD-11: 8A00]P13945ADRB3
    T01777DI0166Glaucoma[ICD-11: 9C61]P18825ADRA2C
    T01777DI0190Hypertension[ICD-11: BA00-BA04]P18825ADRA2C
    T01777DI0196Hypotension[ICD-11: BA20-BA21]P18825ADRA2C
    T01777DI0308Obesity[ICD-11: 5B80-5B81]P18825ADRA2C
    T01777DI0310Ocular disease[ICD-11: N.A.]P18825ADRA2C
    T01777DI0396Substance abuse[ICD-11: 6C40]P18825ADRA2C
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
    T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
    T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
    T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
    T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
    T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
    T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
    T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
    T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
    T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
    T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
    T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
    T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
    T60693DI0304Non-specific cutaneous vascular symptom[ICD-11: ME64]P41145OPRK1
    T60693DI0324Pain[ICD-11: MG30-MG3Z]P41145OPRK1
    T60693DI0349Pruritus[ICD-11: EC90]P41145OPRK1
    T28484DI0012Acute myeloid leukaemia[ICD-11: 2A60]P52732KIF11
    T28484DI0172Head and neck cancer[ICD-11: 2D42]P52732KIF11
    T28484DI0241Lymphoma[ICD-11: 2A80-2A86]P52732KIF11
    T28484DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P52732KIF11
    T28484DI0274Multiple myeloma[ICD-11: 2A83]P52732KIF11
    T28484DI0321Ovarian cancer[ICD-11: 2C73]P52732KIF11
    T28484DI0361Renal cell carcinoma[ICD-11: 2C90]P52732KIF11
    T28484DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P52732KIF11
    T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
    T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
    T08391DI0039Atopic eczema[ICD-11: EA80]O60674JAK2
    T08391DI0286Myeloproliferative neoplasm[ICD-11: 2A20]O60674JAK2
    T08391DI0366Rheumatoid arthritis[ICD-11: FA20]O60674JAK2
    T08391DI0404Thrombocytosis[ICD-11: 3B63]O60674JAK2
    T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
    T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
    T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
    T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
    T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
    T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
    T74312DI0012Acute myeloid leukaemia[ICD-11: 2A60]P36888FLT3
    T74312DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P36888FLT3
    T74312DI0095Colorectal cancer[ICD-11: 2B91]P36888FLT3
    T74312DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P36888FLT3
    T74312DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P36888FLT3
    T74312DI0248Mastocytosis[ICD-11: 2A21]P36888FLT3
    T74312DI0250Mature B-cell lymphoma[ICD-11: 2A85]P36888FLT3
    T74312DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P36888FLT3
    T84133DI0079Choreiform disorder[ICD-11: 8A01]Q9Y233PDE10A
    T84133DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q9Y233PDE10A
    T84133DI0218Irritable bowel syndrome[ICD-11: DD91]Q9Y233PDE10A
    T84133DI0370Schizophrenia[ICD-11: 6A20]Q9Y233PDE10A
    T84133DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9Y233PDE10A
    T46185DI0037Asthma[ICD-11: CA23]P08172CHRM2
    T46185DI0166Glaucoma[ICD-11: 9C61]P08172CHRM2
    T46185DI0278Muscle disorder[ICD-11: FB32-FB3Z]P08172CHRM2
    T46185DI0333Peptic ulcer[ICD-11: DA61]P08172CHRM2
    T46185DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08172CHRM2
    T46185DI0371Sebaceous gland disorder[ICD-11: ED91]P08172CHRM2
    T59604DI0087Chronic pain[ICD-11: MG30]Q92847GHSR
    T59604DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]Q92847GHSR
    T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
    T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
    T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
    T84631DI0053Blood-forming organ disease[ICD-11: 3C0Z]P00742F10
    T84631DI0080Christmas disease[ICD-11: 3B11]P00742F10
    T84631DI0091Coagulation defect[ICD-11: 3B10]P00742F10
    T84631DI0103Coronary thrombosis[ICD-11: BA43]P00742F10
    T84631DI0114Deep vein thrombosis[ICD-11: BD71]P00742F10
    T84631DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P00742F10
    T84631DI0405Thrombosis[ICD-11: DB61-GB90]P00742F10
    T84631DI0433Venous thromboembolism[ICD-11: BD72]P00742F10
    T27602DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q9HAN5TRP1
    T27602DI0274Multiple myeloma[ICD-11: 2A83]Q9HAN5TRP1
    T84780DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]Q13490BIRC2
    T89988DI0083Chronic kidney disease[ICD-11: GB61]P13500CCL2
    T89988DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P13500CCL2
    T89988DI0087Chronic pain[ICD-11: MG30]P13500CCL2
    T89988DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P13500CCL2
    T89988DI0252Melanoma[ICD-11: 2C30]P13500CCL2
    T89988DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P13500CCL2
    T89988DI0275Multiple sclerosis[ICD-11: 8A40]P13500CCL2
    T89988DI0326Pancreatic cancer[ICD-11: 2C10]P13500CCL2
    T89988DI0366Rheumatoid arthritis[ICD-11: FA20]P13500CCL2
    T89988DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P13500CCL2
    T62460DI0039Atopic eczema[ICD-11: EA80]P23458JAK1
    T62460DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P23458JAK1
    T62460DI0366Rheumatoid arthritis[ICD-11: FA20]P23458JAK1
    T62460DI0404Thrombocytosis[ICD-11: 3B63]P23458JAK1
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T96623DI0062Breast cancer[ICD-11: 2C60-2C6Y]P08238HSP90AB1
    T96623DI0238Lung cancer[ICD-11: 2C25]P08238HSP90AB1
    T96623DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P08238HSP90AB1
    T96623DI0249Mature B-cell leukaemia[ICD-11: 2A82]P08238HSP90AB1
    T96623DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P08238HSP90AB1
    T96623DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P08238HSP90AB1
    T96623DI0395Stomach cancer[ICD-11: 2B72]P08238HSP90AB1
    T98269DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P29466CASP1
    T98269DI0146Fibrosis[ICD-11: GA14-GC01]P29466CASP1
    T98269DI0366Rheumatoid arthritis[ICD-11: FA20]P29466CASP1
    T98269DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P29466CASP1
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T78932DI0351Psoriasis[ICD-11: EA90]P29597TYK2
    T41580DI0396Substance abuse[ICD-11: 6C40]P18089ADRA2B
    T75596DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50579METAP2
    T55398DI0039Atopic eczema[ICD-11: EA80]Q9NWZ3IRAK4
    T55398DI0109Cutaneous lupus erythematosus[ICD-11: EB50-EB5Z]Q9NWZ3IRAK4
    T55398DI0241Lymphoma[ICD-11: 2A80-2A86]Q9NWZ3IRAK4
    T55398DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q9NWZ3IRAK4
    T55398DI0351Psoriasis[ICD-11: EA90]Q9NWZ3IRAK4
    T55398DI0366Rheumatoid arthritis[ICD-11: FA20]Q9NWZ3IRAK4
    T15700DI0120Diabetes mellitus[ICD-11: 5A10]Q9UQ81MCH5
    T15700DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UQ81MCH5
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T23995DI0413Transplant rejection[ICD-11: NE84]Q04759PRKCQ
    T89360DI0413Transplant rejection[ICD-11: NE84]P12268IMPDH2
    T46781DI0009Acute diabete complication[ICD-11: 5A2Y]Q96GD4AURKB
    T46781DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q96GD4AURKB
    T92828DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P24530EDNRB
    T92828DI0356Pulmonary hypertension[ICD-11: BB01]P24530EDNRB
    T57278DI0060Brain cancer[ICD-11: 2A00]P29317EPHA2
    T57278DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29317EPHA2
    T29741DI0146Fibrosis[ICD-11: GA14-GC01]Q9NPH5NOX4
    T78656DI0264Migraine[ICD-11: 8A80]P30939HTR1F
    T78656DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30939HTR1F

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