Narceinone



Compound IDCDAMM00604
Common nameNarceinone
IUPAC name6-[2-[6-[2-(dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]-2-oxoacetyl]-2,3-dimethoxybenzoic acid
Molecular formulaC23H25NO9

Experimental data

Retention time13.31
Adduct[M+H]+
Actual mz460.156
Theoretical mz460.16
Error9.73
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.4085

Identifiers and class information

Inchi keyHXFMRYFLZVSZMP-UHFFFAOYSA-N
SmilesO=C(O)C1=C(OC)C(OC)=CC=C1C(=O)C(=O)C2=C(OC)C=3OCOC3C=C2CCN(C)C
SuperclassPhenylpropanoids and polyketides
ClassStilbenes

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)1
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)10
    Number of reactive functional groups (#rtvFG)3
    Predicted central nervous system activity (CNS)0
    Molecular weight (mol_MW)459.452
    Computed dipole moment(dipole)6.722
    Total solvent accessible surface area (SASA)701.17
    Hydrophobic component of SASA (FOSA)488.759
    Hydrophilic component of SASA (FISA)100.738
    Pie component of the SASA (PISA)111.672
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1330.19
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)11.75
    Free energy of solvation of dipole (dip^2/V)0.0339677
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0167577
    Globularity descriptor (glob)0.83423
    Predicted polarizability in cubic angstroms (QPpolrz)41.726
    Predicted hexadecane/gas partition coefficient (QPlogPC16)12.271
    Predicted octanol/gas partition coefficient (QPlogPoct)21.595
    Predicted water/gas partition coefficient (QPlogPw)13.684
    Predicted octanol/water partition coefficient (QPlogPo/w)0.243
    Predicted aqueous solubility (QPlogS)-2.443
    Conformation-independent predicted aqueous solubility (CIQPlogS)-3.588
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-3.666
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)69.359
    Predicted brain/blood partition coefficient (QPlogBB)-0.606
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)38.908
    Predicted skin permeability, log Kp (QPlogKp)-4.085
    PM3 calculated ionization potential (IP(ev))9.109
    PM3 calculated electron affinity (EA(eV))0.797
    Number of likely metabolic reactions (#metab)5
    Prediction of binding to human serum albumin (QPlogKhsa)-0.707
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)61.319
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)125.605
    Number of nitrogen and oxygen atoms (#NandO)10
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    Q12809KCNH2HERGT20251SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    P04818TYMSThymidylate synthase (by homology)T98397SwissTargetPrediction
    Q8TDS4HCAR2Hydroxycarboxylic acid receptor 2T88185SwissTargetPrediction
    P12821ACEAngiotensin-converting enzymeT98311SwissTargetPrediction
    P15144ANPEPAminopeptidase NT67272SwissTargetPrediction
    P09960LTA4HLeukotriene A4 hydrolaseT03691SwissTargetPrediction
    O75899GABBR2GABA-B receptorT42446SwissTargetPrediction
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P05067APPBeta amyloid A4 proteinT87024SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    P06239LCKTyrosine-protein kinase LCKT12499SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P27487DPP4Dipeptidyl peptidase IVT31391SwissTargetPrediction
    P98170XIAPInhibitor of apoptosis protein 3T16769SwissTargetPrediction
    P78352DLG4Disks large homolog 4T04507SwissTargetPrediction
    P55210CASP7Caspase-7T72252SwissTargetPrediction
    P08473MMENeprilysinT05409SwissTargetPrediction
    P39086GRIK1Glutamate receptor ionotropic kainate 1T73495SwissTargetPrediction
    Q13002GRIK2Glutamate receptor ionotropic kainate 2T58178SwissTargetPrediction
    Q13003GRIK3Glutamate receptor ionotropic kainate 3T68876SwissTargetPrediction
    P42262GRIA2Glutamate receptor ionotropic, AMPA 2T42392SwissTargetPrediction
    P35354PTGS2Cyclooxygenase-2T66665SwissTargetPrediction
    Q9H4A4RNPEPAminopeptidase BT57818SwissTargetPrediction
    Q96IY4CPB2Carboxypeptidase B2 isoform AT98022SwissTargetPrediction
    Q07075ENPEPAminopeptidase AT31956SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    P00338LDHAL-lactate dehydrogenase A chainT15053SwissTargetPrediction
    P04626ERBB2Receptor protein-tyrosine kinase erbB-2T14597SwissTargetPrediction
    P00519ABL1Tyrosine-protein kinase ABLT63505SwissTargetPrediction
    P56817BACE1Beta-secretase 1T79031SwissTargetPrediction
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SwissTargetPrediction
    P13497BMP1Bone morphogenetic protein 1T53350SwissTargetPrediction
    O43603GALR2Galanin receptor 2 (by homology)T13453SwissTargetPrediction
    P00742F10Thrombin and coagulation factor XT84631SwissTargetPrediction
    Q08499PDE4DPhosphodiesterase 4DT02001SEA
    P49356FNTBFarnesyl protein transferaseT13127SwissTargetPrediction
    P11387TOP1DNA topoisomerase IT09826SwissTargetPrediction
    P11388TOP2ADNA topoisomerase II alphaT17048SwissTargetPrediction
    Q9UHL4DPP7Dipeptidyl peptidase IIT50773SwissTargetPrediction
    O75116ROCK2Rho-associated protein kinase 2T06093SwissTargetPrediction
    P05771PRKCBProtein kinase C betaT40276SwissTargetPrediction
    O15111CHUKInhibitor of NF-kappa-B kinase (IKK)T78429SwissTargetPrediction
    Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2T65818SwissTargetPrediction
    P50579METAP2Methionine aminopeptidase 2T75596SwissTargetPrediction
    P06756ITGAVVitronectin receptor alphaT67103SwissTargetPrediction
    P05556ITGB1Integrin alpha2/beta1T01851SwissTargetPrediction
    P11362FGFR1Fibroblast growth factor receptor 1T47101SwissTargetPrediction
    P25101EDNRAEndothelin receptor ET-AT23499SEA
    P39900MMP12Matrix metalloproteinase 12T03500SwissTargetPrediction
    P06737PYGLLiver glycogen phosphorylaseT19184SwissTargetPrediction
    P25025CXCR2Interleukin-8 receptor BT56923SwissTargetPrediction
    P24557TBXAS1Thromboxane-A synthaseT78356SwissTargetPrediction
    O76074PDE5APhosphodiesterase 5AT07663SwissTargetPrediction
    P00749PLAUUrokinase-type plasminogen activatorT17758SwissTargetPrediction
    P14735IDEInsulin-degrading enzymeT81900SwissTargetPrediction
    Q06187BTKTyrosine-protein kinase BTKT97719SwissTargetPrediction
    P08709F7Coagulation factor VIIT43332SwissTargetPrediction
    P24530EDNRBEndothelin receptor ET-BT92828SEA
    P80192MAP3K9Mitogen-activated protein kinase kinase kinase 9T19760SwissTargetPrediction
    P29317EPHA2Ephrin type-A receptor 2T57278SwissTargetPrediction
    P00374DHFRDihydrofolate reductaseT17345SwissTargetPrediction
    P53609PGGT1BGeranylgeranyl transferase type IT76396SwissTargetPrediction
    P26010ITGB7Integrin alpha-4/beta-7T07403SwissTargetPrediction
    P09238MMP10Matrix metalloproteinase 10T40488SwissTargetPrediction
    Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SwissTargetPrediction
    Q92523CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform (by homology)T75888SEA
    P62937PPIACyclophilin AT47081SwissTargetPrediction
    P19438TNFRSF1ATumor necrosis factor receptor R1T86552SwissTargetPrediction
    P53582METAP1Methionine aminopeptidase 1T42337SwissTargetPrediction
    P13612ITGA4Integrin alpha-4T97587SwissTargetPrediction
    Q9NZ08ERAP1Endoplasmic reticulum aminopeptidase 1T72849SwissTargetPrediction
    Q9UBC3DNMT3BDNA (cytosine-5)-methyltransferase 3BT65501SwissTargetPrediction
    O43895XPNPEP2Xaa-Pro aminopeptidase 2T68320SwissTargetPrediction
    P16444DPEP1Renal dipeptidaseT41201SwissTargetPrediction
    Q02880TOP2BDNA topoisomerase II betaT85733SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T20251DI0175Heart failure[ICD-11: BD10-BD1Z]Q12809KCNH2
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
    T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
    T88185DI0203Inborn lipid metabolism error[ICD-11: 5C52]Q8TDS4HCAR2
    T98311DI0175Heart failure[ICD-11: BD10-BD1Z]P12821ACE
    T98311DI0190Hypertension[ICD-11: BA00-BA04]P12821ACE
    T67272DI0351Psoriasis[ICD-11: EA90]P15144ANPEP
    T03691DI0012Acute myeloid leukaemia[ICD-11: 2A60]P09960LTA4H
    T42446DI0117Depression[ICD-11: 6A70-6A7Z]O75899GABBR2
    T42446DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]O75899GABBR2
    T42446DI0275Multiple sclerosis[ICD-11: 8A40]O75899GABBR2
    T42446DI0290Narcolepsy[ICD-11: 7A20]O75899GABBR2
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T87024DI0025Alzheimer disease[ICD-11: 8A20]P05067APP
    T87024DI0122Diagnostic imaging[ICD-11: N.A.]P05067APP
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T31391DI0009Acute diabete complication[ICD-11: 5A2Y]P27487DPP4
    T31391DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P27487DPP4
    T16769DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]P98170XIAP
    T04507DI0073Cerebral ischaemia[ICD-11: 8B1Z]P78352DLG4
    T04507DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P78352DLG4
    T72252DI0110Cystic fibrosis[ICD-11: CA25]P55210CASP7
    T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
    T73495DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P39086GRIK1
    T73495DI0396Substance abuse[ICD-11: 6C40]P39086GRIK1
    T42392DI0298Neuropathy[ICD-11: 8C0Z]P42262GRIA2
    T66665DI0087Chronic pain[ICD-11: MG30]P35354PTGS2
    T66665DI0145Female pelvic pain[ICD-11: GA34]P35354PTGS2
    T66665DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P35354PTGS2
    T66665DI0207Indeterminate colitis[ICD-11: DD72]P35354PTGS2
    T66665DI0227Knee osteoarthritis[ICD-11: FA01]P35354PTGS2
    T66665DI0320Osteoarthritis[ICD-11: FA00-FA05]P35354PTGS2
    T66665DI0324Pain[ICD-11: MG30-MG3Z]P35354PTGS2
    T66665DI0366Rheumatoid arthritis[ICD-11: FA20]P35354PTGS2
    T66665DI0416Tuberculosis[ICD-11: 1B10-1B12]P35354PTGS2
    T98022DI0073Cerebral ischaemia[ICD-11: 8B1Z]Q96IY4CPB2
    T98022DI0074Cerebral ischaemic stroke[ICD-11: 8B11]Q96IY4CPB2
    T98022DI0405Thrombosis[ICD-11: DB61-GB90]Q96IY4CPB2
    T31956DI0190Hypertension[ICD-11: BA00-BA04]Q07075ENPEP
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T14597DI0062Breast cancer[ICD-11: 2C60-2C6Y]P04626ERBB2
    T14597DI0238Lung cancer[ICD-11: 2C25]P04626ERBB2
    T14597DI0346Prostate cancer[ICD-11: 2C82]P04626ERBB2
    T63505DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00519ABL1
    T63505DI0220Ischemia[ICD-11: 8B10-8B11]P00519ABL1
    T63505DI0250Mature B-cell lymphoma[ICD-11: 2A85]P00519ABL1
    T63505DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00519ABL1
    T79031DI0025Alzheimer disease[ICD-11: 8A20]P56817BACE1
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T84631DI0053Blood-forming organ disease[ICD-11: 3C0Z]P00742F10
    T84631DI0080Christmas disease[ICD-11: 3B11]P00742F10
    T84631DI0091Coagulation defect[ICD-11: 3B10]P00742F10
    T84631DI0103Coronary thrombosis[ICD-11: BA43]P00742F10
    T84631DI0114Deep vein thrombosis[ICD-11: BD71]P00742F10
    T84631DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P00742F10
    T84631DI0405Thrombosis[ICD-11: DB61-GB90]P00742F10
    T84631DI0433Venous thromboembolism[ICD-11: BD72]P00742F10
    T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
    T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
    T09826DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P11387TOP1
    T09826DI0095Colorectal cancer[ICD-11: 2B91]P11387TOP1
    T09826DI0238Lung cancer[ICD-11: 2C25]P11387TOP1
    T09826DI0321Ovarian cancer[ICD-11: 2C73]P11387TOP1
    T09826DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11387TOP1
    T17048DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11388TOP2A
    T17048DI0225Kaposi sarcoma[ICD-11: 2B57]P11388TOP2A
    T17048DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11388TOP2A
    T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
    T40276DI0123Diffuse large B-cell lymphoma[ICD-11: 2A81]P05771PRKCB
    T40276DI0241Lymphoma[ICD-11: 2A80-2A86]P05771PRKCB
    T40276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P05771PRKCB
    T78429DI0250Mature B-cell lymphoma[ICD-11: 2A85]O15111CHUK
    T75596DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50579METAP2
    T67103DI0095Colorectal cancer[ICD-11: 2B91]P06756ITGAV
    T67103DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06756ITGAV
    T01851DI0060Brain cancer[ICD-11: 2A00]P05556ITGB1
    T01851DI0238Lung cancer[ICD-11: 2C25]P05556ITGB1
    T01851DI0365Retinopathy[ICD-11: 9B71]P05556ITGB1
    T47101DI0095Colorectal cancer[ICD-11: 2B91]P11362FGFR1
    T47101DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P11362FGFR1
    T47101DI0235Liver cancer[ICD-11: 2C12]P11362FGFR1
    T47101DI0403Thrombocytopenia[ICD-11: 3B64]P11362FGFR1
    T23499DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25101EDNRA
    T23499DI0356Pulmonary hypertension[ICD-11: BB01]P25101EDNRA
    T23499DI0425Urinary system clinical symptom[ICD-11: MF8Y]P25101EDNRA
    T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
    T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
    T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
    T56923DI0155Fungal infection[ICD-11: 1F29-1F2F]P25025CXCR2
    T56923DI0324Pain[ICD-11: MG30-MG3Z]P25025CXCR2
    T78356DI0030Angina pectoris[ICD-11: BA40]P24557TBXAS1
    T07663DI0190Hypertension[ICD-11: BA00-BA04]O76074PDE5A
    T07663DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]O76074PDE5A
    T07663DI0378Sexual dysfunction[ICD-11: HA00-HA01]O76074PDE5A
    T07663DI0411Tonus and reflex abnormality[ICD-11: MB47]O76074PDE5A
    T17758DI0211Inherited coagulation factor deficiency[ICD-11: 3B14]P00749PLAU
    T17758DI0287Myocardial infarction[ICD-11: BA41-BA43]P00749PLAU
    T81900DI0383Skin and skin-structure infection[ICD-11: 1F28-1G0Z]P14735IDE
    T97719DI0231Leukaemia[ICD-11: 2A60-2B33]Q06187BTK
    T43332DI0091Coagulation defect[ICD-11: 3B10]P08709F7
    T92828DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P24530EDNRB
    T92828DI0356Pulmonary hypertension[ICD-11: BB01]P24530EDNRB
    T19760DI0037Asthma[ICD-11: CA23]P80192MAP3K9
    T57278DI0060Brain cancer[ICD-11: 2A00]P29317EPHA2
    T57278DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29317EPHA2
    T17345DI0207Indeterminate colitis[ICD-11: DD72]P00374DHFR
    T17345DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00374DHFR
    T17345DI0416Tuberculosis[ICD-11: 1B10-1B12]P00374DHFR
    T17345DI0427Urinary tract infection[ICD-11: GC08]P00374DHFR
    T76396DI0241Lymphoma[ICD-11: 2A80-2A86]P53609PGGT1B
    T07403DI0107Crohn disease[ICD-11: DD70]P26010ITGB7
    T75888DI0030Angina pectoris[ICD-11: BA40]Q92523CPT1B
    T75888DI0265Mild neurocognitive disorder[ICD-11: 6D71]Q92523CPT1B
    T75888DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q92523CPT1B
    T47081DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P62937PPIA
    T86552DI0060Brain cancer[ICD-11: 2A00]P19438TNFRSF1A
    T86552DI0321Ovarian cancer[ICD-11: 2C73]P19438TNFRSF1A
    T97587DI0107Crohn disease[ICD-11: DD70]P13612ITGA4
    T97587DI0275Multiple sclerosis[ICD-11: 8A40]P13612ITGA4
    T97587DI0419Ulcerative colitis[ICD-11: DD71]P13612ITGA4
    T65501DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UBC3DNMT3B
    T41201DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P16444DPEP1
    T85733DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q02880TOP2B
    T85733DI0076Chemoprotection[ICD-11: N.A.]Q02880TOP2B

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