(9S,10S)-9,10-dihydroxyoctadecanoate



Compound IDCDAMM00588
Common name(9S,10S)-9,10-dihydroxyoctadecanoate
IUPAC name9,10-dihydroxyoctadecanoic acid
Molecular formulaC18H36O4

Experimental data

Retention time13.5
Adduct[M+Na]+
Actual mz339.246
Theoretical mz339.25
Error11.55
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.4586

Identifiers and class information

Inchi keyVACHUYIREGFMSP-RXQGYGPJNA-N
SmilesO=C(O)CCCCCCCC(O)C(O)CCCCCCCC
SuperclassLipids and lipid-like molecules
ClassFatty Acyls

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)3
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)1
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)18
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)316.48
    Computed dipole moment(dipole)6.007
    Total solvent accessible surface area (SASA)748.961
    Hydrophobic component of SASA (FOSA)572.141
    Hydrophilic component of SASA (FISA)176.82
    Pie component of the SASA (PISA)0
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1278.52
    Number of hydrogen bond donors (donorHB)3
    Number of hydrogen bond acceptors (accptHB)5.4
    Free energy of solvation of dipole (dip^2/V)0.028226
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0124881
    Globularity descriptor (glob)0.760637
    Predicted polarizability in cubic angstroms (QPpolrz)33.455
    Predicted hexadecane/gas partition coefficient (QPlogPC16)12.211
    Predicted octanol/gas partition coefficient (QPlogPoct)17.68
    Predicted water/gas partition coefficient (QPlogPw)8.466
    Predicted octanol/water partition coefficient (QPlogPo/w)3.953
    Predicted aqueous solubility (QPlogS)-4.696
    Conformation-independent predicted aqueous solubility (CIQPlogS)-3.396
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-3.598
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)52.81
    Predicted brain/blood partition coefficient (QPlogBB)-2.559
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)26.194
    Predicted skin permeability, log Kp (QPlogKp)-3.05
    PM3 calculated ionization potential (IP(ev))10.893
    PM3 calculated electron affinity (EA(eV))-1.08
    Number of likely metabolic reactions (#metab)3
    Prediction of binding to human serum albumin (QPlogKhsa)-0.053
    Predicted qualitative human oral absorption (HumanOralAbsorption)1
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)80.922
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)91.421
    Number of nitrogen and oxygen atoms (#NandO)4
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P36544CHRNA7Neuronal acetylcholine receptor protein alpha-7 subunitT34429SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    P07327ADH1AAlcohol dehydrogenase alpha chainT65570SEA
    P47869GABRA2GABA A receptor alpha-2/beta-2/gamma-2T51452SwissTargetPrediction
    P24046GABRR1GABA receptor rho-1 subunitT99665SEA
    O75899GABBR2GABA-B receptorT42446SEA
    P09960LTA4HLeukotriene A4 hydrolaseT03691SwissTargetPrediction
    P48066SLC6A11GABA transporter 3T38200SEA
    O75899GABBR2GABA-B receptorT42446SwissTargetPrediction and SEA
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SwissTargetPrediction and SEA
    P14555PLA2G2APhospholipase A2 group IIAT19160SEA
    Q96RI1NR1H4Bile acid receptor FXRT51426SwissTargetPrediction
    P34913EPHX2Epoxide hydrataseT35734SwissTargetPrediction and SEA
    Q9H3R0KDM4CLysine-specific demethylase 4CT73863SEA
    P23141CES1Acyl coenzyme A:cholesterol acyltransferaseT76369SEA
    O75164KDM4ALysine-specific demethylase 4AT18904SEA
    P10275ARAndrogen ReceptorT11211SwissTargetPrediction
    O00519FAAHAnandamide amidohydrolaseT11754SEA
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P06401PGRProgesterone receptorT22939SwissTargetPrediction
    P08185SERPINA6Corticosteroid binding globulinT88452SwissTargetPrediction
    P11511CYP19A1Cytochrome P450 19A1T13260SwissTargetPrediction
    P51681CCR5C-C chemokine receptor type 5T09960SwissTargetPrediction
    Q9UHC9NPC1L1Niemann-Pick C1-like protein 1T33901SwissTargetPrediction
    P18031PTPN1Protein-tyrosine phosphatase 1BT16347SwissTargetPrediction
    Q07075ENPEPAminopeptidase AT31956SEA
    P15090FABP4Fatty acid binding protein adipocyteT07217SwissTargetPrediction
    Q07869PPARAPeroxisome proliferator-activated receptor alphaT86591SwissTargetPrediction and SEA
    Q01469FABP5Fatty acid binding protein epidermalT21507SwissTargetPrediction
    Q03181PPARDPeroxisome proliferator-activated receptor deltaT36557SwissTargetPrediction and SEA
    O14842FFAR1Free fatty acid receptor 1T25608SwissTargetPrediction
    P08575PTPRCLeukocyte common antigenT43115SwissTargetPrediction
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SwissTargetPrediction and SEA
    P28845HSD11B111-beta-hydroxysteroid dehydrogenase 1T65200SwissTargetPrediction
    P11473VDRVitamin D receptorT34234SwissTargetPrediction
    Q8TDU6GPBAR1G-protein coupled bile acid receptor 1T86273SwissTargetPrediction
    P06746POLBDNA polymerase beta (by homology)T06958SwissTargetPrediction and SEA
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction and SEA
    P16662UGT2B7UDP-glucuronosyltransferase 2B7T62815SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    P21731TBXA2RThromboxane A2 receptorT76198SwissTargetPrediction and SEA
    P10827THRAThyroid hormone receptor alphaT79591SwissTargetPrediction
    P10828THRBThyroid hormone receptor beta-1T98933SwissTargetPrediction
    P62993GRB2Growth factor receptor-bound protein 2T30926SwissTargetPrediction
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    Q16539MAPK14MAP kinase p38 alphaT65864SwissTargetPrediction
    P06213INSRInsulin receptorT85435SwissTargetPrediction
    P55072VCPTransitional endoplasmic reticulum ATPaseT12646SwissTargetPrediction
    P24941CDK2Cyclin-dependent kinase 2T70176SwissTargetPrediction
    P36888FLT3Tyrosine-protein kinase receptor FLT3T74312SwissTargetPrediction
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SwissTargetPrediction
    P08172CHRM2Muscarinic acetylcholine receptor M2T46185SwissTargetPrediction
    P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SwissTargetPrediction and SEA
    P43116PTGER2Prostanoid EP2 receptorT38529SwissTargetPrediction and SEA
    P49356FNTBFarnesyl protein transferaseT13127SwissTargetPrediction
    P80365HSD11B211-beta-hydroxysteroid dehydrogenase 2T43721SwissTargetPrediction
    P04035HMGCRHMG-CoA reductaseT53585SwissTargetPrediction and SEA
    P11413G6PDGlucose-6-phosphate 1-dehydrogenaseT63484SwissTargetPrediction
    Q15722LTB4RLeukotriene B4 receptor 1T59626SEA
    P11137MAP2Microtubule-associated protein 2T23276SwissTargetPrediction
    P20701ITGALIntercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2T35640SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    P32246CCR1C-C chemokine receptor type 1T16016SwissTargetPrediction
    P01375TNFTNF-alphaT20178SwissTargetPrediction
    P47871GCGRGlucagon receptorT60182SwissTargetPrediction
    P30556AGTR1Type-1 angiotensin II receptorT74456SwissTargetPrediction
    P41229KDM5CLysine-specific demethylase 5CT85540SwissTargetPrediction
    P53779MAPK10c-Jun N-terminal kinase 3T85421SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    P08263GSTA1Glutathione S-transferase A1T17221SEA
    P47712PLA2G4ACytosolic phospholipase A2T14834SwissTargetPrediction
    P35408PTGER4Prostanoid EP4 receptorT18876SwissTargetPrediction and SEA
    P43115PTGER3Prostanoid EP3 receptorT85467SwissTargetPrediction and SEA
    P0DJD9PGA5Pepsin AT17863SEA
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SEA
    Q9Y2K7KDM2ALysine-specific demethylase 2AT71949SwissTargetPrediction
    P34995PTGER1Prostanoid EP1 receptorT15497SwissTargetPrediction and SEA
    P06493CDK1Cyclin-dependent kinase 1/cyclin B1T49898SwissTargetPrediction
    P25101EDNRAEndothelin receptor ET-AT23499SwissTargetPrediction
    P04629NTRK1Nerve growth factor receptor Trk-AT07173SwissTargetPrediction
    P49840GSK3AGlycogen synthase kinase-3 alphaT76910SwissTargetPrediction
    Q00535CDK5Cyclin-dependent kinase 5/CDK5 activator 1T20973SwissTargetPrediction
    Q16620NTRK2Neurotrophic tyrosine kinase receptor type 2T84703SwissTargetPrediction
    Q13258PTGDRProstanoid DP receptorT68782SwissTargetPrediction
    P10619CTSALysosomal protective proteinT37154SwissTargetPrediction
    Q8TDS5OXER1Oxoeicosanoid receptor 1T68834SEA
    P43088PTGFRProstanoid FP receptorT75797SwissTargetPrediction and SEA
    P16109SELPP-selectinT10965SEA
    P14151SELLLeukocyte adhesion molecule-1T60526SEA
    O76074PDE5APhosphodiesterase 5AT07663SwissTargetPrediction
    P43119PTGIRProstanoid IP receptorT99954SEA
    P20839IMPDH1Inosine-5'-monophosphate dehydrogenase 1T40111SwissTargetPrediction
    P12268IMPDH2Inosine-5'-monophosphate dehydrogenase 2T89360SwissTargetPrediction
    Q6ZMT4KDM7ALysine-specific demethylase 7A/7BT18784SEA
    P00390GSRGlutathione reductaseT30803SEA
    Q96GD4AURKBSerine/threonine-protein kinase Aurora-BT46781SwissTargetPrediction
    P24530EDNRBEndothelin receptor ET-BT92828SwissTargetPrediction
    Q9Y3Q0NAALAD2NAALADase IIT70036SEA
    Q92820GGHGamma-glutamyl hydrolaseT71646SEA
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SEA
    O00408PDE2APhosphodiesterase 2AT77400SwissTargetPrediction
    P40189IL6STInterleukin-6 receptor subunit betaT93440SEA
    O75907DGAT1Diacylglycerol O-acyltransferase 1T16688SwissTargetPrediction
    Q13822ENPP2AutotaxinT63512SEA
    Q9HBW0LPAR2Lysophosphatidic acid receptor Edg-4T39380SEA
    Q9UPP1PHF8Histone lysine demethylase PHF8T00933SwissTargetPrediction
    Q99500S1PR3Sphingosine 1-phosphate receptor Edg-3T11241SEA
    P13631RARGRetinoic acid receptor gammaT82146SwissTargetPrediction
    P10826RARBRetinoic acid receptor betaT61657SwissTargetPrediction
    P43657LPAR6Lysophosphatidic acid receptor 6T13484SEA
    Q9H1C0LPAR5Lysophosphatidic acid receptor 5T18616SEA
    O95136S1PR2Sphingosine 1-phosphate receptor Edg-5T47888SEA
    P18507GABRG2GABA-A receptor; alpha-6/beta-3/gamma-2T08910SwissTargetPrediction
    O95977S1PR4Sphingosine 1-phosphate receptor Edg-6T17523SEA
    O60906SMPD2Neutral sphingomyelinaseT57316SEA
    Q9UPC5GPR34Probable G-protein coupled receptor 34T73859SEA
    O00398P2RY10Putative P2Y purinoceptor 10T00488SEA
    Q9BXC1GPR174Probable G-protein coupled receptor 174T87661SEA
    Q9UBY5LPAR3Lysophosphatidic acid receptor Edg-7T95923SEA
    Q92633LPAR1Lysophosphatidic acid receptor Edg-2T92640SEA
    Q99677LPAR4Lysophosphatidic acid receptor 4T58130SEA
    P08311CTSGCathepsin GT86385SEA
    Q9UJM8HAO1Hydroxyacid oxidase 1T63170SwissTargetPrediction and SEA
    P48546GIPRGastric inhibitory polypeptide receptorT41750SwissTargetPrediction
    P43220GLP1RGlucagon-like peptide 1 receptorT36075SwissTargetPrediction
    O95749GGPS1GeranyltranstransferaseT86528SEA
    P24557TBXAS1Thromboxane-A synthaseT78356SEA
    Q04609FOLH1Glutamate carboxypeptidase IIT97071SEA
    Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
    Q9UN88GABRQGABA(A) receptor thetaT15161SEA
    P78329CYP4F2Cytochrome P450 4fT82604SEA
    O60603TLR2Toll-like receptor 2T82078SEA
    O95749GGPS1GeranyltranstransferaseT86528SEA
    P47870GABRB2GABA(A) receptor beta-2T80387SwissTargetPrediction
    Q92887CMOATMultidrug resistance-associated protein 2T61792SEA
    Q92959SLCO2A1Prostaglandin transporterT15518SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T34429DI0101Corneal disease[ICD-11: 9A76-9A78]P36544CHRNA7
    T34429DI0370Schizophrenia[ICD-11: 6A20]P36544CHRNA7
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T65570DI0139Exposure to noxious substances harmful effect[ICD-11: NE61]P07327ADH1A
    T51452DI0216Intentional self-harm[ICD-11: PC91]P47869GABRA2
    T42446DI0117Depression[ICD-11: 6A70-6A7Z]O75899GABBR2
    T42446DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]O75899GABBR2
    T42446DI0275Multiple sclerosis[ICD-11: 8A40]O75899GABBR2
    T42446DI0290Narcolepsy[ICD-11: 7A20]O75899GABBR2
    T03691DI0012Acute myeloid leukaemia[ICD-11: 2A60]P09960LTA4H
    T38200DI0207Indeterminate colitis[ICD-11: DD72]P48066SLC6A11
    T42446DI0117Depression[ICD-11: 6A70-6A7Z]O75899GABBR2
    T42446DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]O75899GABBR2
    T42446DI0275Multiple sclerosis[ICD-11: 8A40]O75899GABBR2
    T42446DI0290Narcolepsy[ICD-11: 7A20]O75899GABBR2
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
    T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
    T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
    T19160DI0062Breast cancer[ICD-11: 2C60-2C6Y]P14555PLA2G2A
    T51426DI0043Autoimmune liver disease[ICD-11: DB96]Q96RI1NR1H4
    T51426DI0077Cholelithiasis[ICD-11: DC11]Q96RI1NR1H4
    T51426DI0320Osteoarthritis[ICD-11: FA00-FA05]Q96RI1NR1H4
    T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
    T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
    T76369DI0335Peroxisomal disease[ICD-11: 5C57]P23141CES1
    T76369DI0398Synthesis disorder[ICD-11: 5C52-5C59]P23141CES1
    T11211DI0005Acne vulgaris[ICD-11: ED80]P10275AR
    T11211DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10275AR
    T11211DI0021Alcoholic liver disease[ICD-11: DB94]P10275AR
    T11211DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10275AR
    T11211DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P10275AR
    T11211DI0145Female pelvic pain[ICD-11: GA34]P10275AR
    T11211DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P10275AR
    T11211DI0237Low bone mass disorder[ICD-11: FB83]P10275AR
    T11211DI0247Mammary tumour[ICD-11: 2C60-2C6Z]P10275AR
    T11211DI0346Prostate cancer[ICD-11: 2C82]P10275AR
    T11211DI0401Testicular dysfunction[ICD-11: 5A81]P10275AR
    T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T22939DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06401PGR
    T22939DI0100Contraceptive management[ICD-11: QA21]P06401PGR
    T22939DI0255Menstrual cycle bleeding disorder[ICD-11: GA20]P06401PGR
    T22939DI0344Preterm labour/delivery[ICD-11: JB00]P06401PGR
    T22939DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06401PGR
    T88452DI0037Asthma[ICD-11: CA23]P08185SERPINA6
    T88452DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P08185SERPINA6
    T88452DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08185SERPINA6
    T13260DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11511CYP19A1
    T13260DI0108Cushing syndrome[ICD-11: 5A70]P11511CYP19A1
    T09960DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P51681CCR5
    T33901DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q9UHC9NPC1L1
    T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
    T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
    T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
    T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
    T31956DI0190Hypertension[ICD-11: BA00-BA04]Q07075ENPEP
    T86591DI0187Hyperlipidemia[ICD-11: 5C80]Q07869PPARA
    T86591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q07869PPARA
    T86591DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q07869PPARA
    T36557DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]Q03181PPARD
    T36557DI0308Obesity[ICD-11: 5B80-5B81]Q03181PPARD
    T25608DI0417Type 2 diabetes mellitus[ICD-11: 5A11]O14842FFAR1
    T43115DI0012Acute myeloid leukaemia[ICD-11: 2A60]P08575PTPRC
    T43115DI0414Transplanted organ/tissue[ICD-11: QB63]P08575PTPRC
    T65200DI0210Influenza[ICD-11: 1E30-1E32]P28845HSD11B1
    T65200DI0239Lupus erythematosus[ICD-11: 4A40]P28845HSD11B1
    T65200DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P28845HSD11B1
    T34234DI0083Chronic kidney disease[ICD-11: GB61]P11473VDR
    T34234DI0171Hair/hair growth developmental defect[ICD-11: LC30]P11473VDR
    T34234DI0189Hyper-parathyroidism[ICD-11: 5A51]P11473VDR
    T34234DI0195Hypo-parathyroidism[ICD-11: 5A50]P11473VDR
    T34234DI0266Mineral deficiency[ICD-11: 5B5K]P11473VDR
    T34234DI0351Psoriasis[ICD-11: EA90]P11473VDR
    T34234DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]P11473VDR
    T86273DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q8TDU6GPBAR1
    T06958DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06746POLB
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T76198DI0102Coronary atherosclerosis[ICD-11: BA52]P21731TBXA2R
    T76198DI0121Diabetic foot ulcer[ICD-11: BD54]P21731TBXA2R
    T76198DI0287Myocardial infarction[ICD-11: BA41-BA43]P21731TBXA2R
    T76198DI0378Sexual dysfunction[ICD-11: HA00-HA01]P21731TBXA2R
    T79591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10827THRA
    T79591DI0197Hypo-thyroidism[ICD-11: 5A00]P10827THRA
    T98933DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10828THRB
    T30926DI0012Acute myeloid leukaemia[ICD-11: 2A60]P62993GRB2
    T30926DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P62993GRB2
    T30926DI0250Mature B-cell lymphoma[ICD-11: 2A85]P62993GRB2
    T30926DI0284Myelodysplastic syndrome[ICD-11: 2A37]P62993GRB2
    T30926DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P62993GRB2
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T65864DI0102Coronary atherosclerosis[ICD-11: BA52]Q16539MAPK14
    T65864DI0287Myocardial infarction[ICD-11: BA41-BA43]Q16539MAPK14
    T65864DI0366Rheumatoid arthritis[ICD-11: FA20]Q16539MAPK14
    T65864DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]Q16539MAPK14
    T85435DI0009Acute diabete complication[ICD-11: 5A2Y]P06213INSR
    T85435DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P06213INSR
    T12646DI0012Acute myeloid leukaemia[ICD-11: 2A60]P55072VCP
    T12646DI0274Multiple myeloma[ICD-11: 2A83]P55072VCP
    T12646DI0284Myelodysplastic syndrome[ICD-11: 2A37]P55072VCP
    T12646DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P55072VCP
    T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
    T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
    T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
    T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
    T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
    T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
    T74312DI0012Acute myeloid leukaemia[ICD-11: 2A60]P36888FLT3
    T74312DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P36888FLT3
    T74312DI0095Colorectal cancer[ICD-11: 2B91]P36888FLT3
    T74312DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P36888FLT3
    T74312DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P36888FLT3
    T74312DI0248Mastocytosis[ICD-11: 2A21]P36888FLT3
    T74312DI0250Mature B-cell lymphoma[ICD-11: 2A85]P36888FLT3
    T74312DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P36888FLT3
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T46185DI0037Asthma[ICD-11: CA23]P08172CHRM2
    T46185DI0166Glaucoma[ICD-11: 9C61]P08172CHRM2
    T46185DI0278Muscle disorder[ICD-11: FB32-FB3Z]P08172CHRM2
    T46185DI0333Peptic ulcer[ICD-11: DA61]P08172CHRM2
    T46185DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08172CHRM2
    T46185DI0371Sebaceous gland disorder[ICD-11: ED91]P08172CHRM2
    T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
    T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
    T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
    T38529DI0003Abortion[ICD-11: JA00]P43116PTGER2
    T38529DI0102Coronary atherosclerosis[ICD-11: BA52]P43116PTGER2
    T38529DI0121Diabetic foot ulcer[ICD-11: BD54]P43116PTGER2
    T38529DI0166Glaucoma[ICD-11: 9C61]P43116PTGER2
    T38529DI0356Pulmonary hypertension[ICD-11: BB01]P43116PTGER2
    T38529DI0378Sexual dysfunction[ICD-11: HA00-HA01]P43116PTGER2
    T38529DI0413Transplant rejection[ICD-11: NE84]P43116PTGER2
    T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
    T43721DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P80365HSD11B2
    T53585DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P04035HMGCR
    T53585DI0102Coronary atherosclerosis[ICD-11: BA52]P04035HMGCR
    T53585DI0128Dyslipidemia[ICD-11: 5C80-5C81]P04035HMGCR
    T53585DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P04035HMGCR
    T53585DI0275Multiple sclerosis[ICD-11: 8A40]P04035HMGCR
    T53585DI0287Myocardial infarction[ICD-11: BA41-BA43]P04035HMGCR
    T53585DI0324Pain[ICD-11: MG30-MG3Z]P04035HMGCR
    T63484DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P11413G6PD
    T59626DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]Q15722LTB4R
    T59626DI0355Pulmonary disease[ICD-11: 1B10-1F85]Q15722LTB4R
    T59626DI0361Renal cell carcinoma[ICD-11: 2C90]Q15722LTB4R
    T23276DI0036Arteries/arterioles disorder[ICD-11: BD52]P11137MAP2
    T23276DI0252Melanoma[ICD-11: 2C30]P11137MAP2
    T23276DI0326Pancreatic cancer[ICD-11: 2C10]P11137MAP2
    T23276DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11137MAP2
    T35640DI0351Psoriasis[ICD-11: EA90]P20701ITGAL
    T35640DI0436Visual system disease[ICD-11: 9E1Z]P20701ITGAL
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T16016DI0120Diabetes mellitus[ICD-11: 5A10]P32246CCR1
    T16016DI0366Rheumatoid arthritis[ICD-11: FA20]P32246CCR1
    T20178DI0035Arterial occlusive disease[ICD-11: BD40]P01375TNF
    T20178DI0274Multiple myeloma[ICD-11: 2A83]P01375TNF
    T20178DI0351Psoriasis[ICD-11: EA90]P01375TNF
    T20178DI0366Rheumatoid arthritis[ICD-11: FA20]P01375TNF
    T60182DI0193Hypo-glycaemia[ICD-11: 5A41]P47871GCGR
    T74456DI0137Essential hypertension[ICD-11: BA00]P30556AGTR1
    T74456DI0190Hypertension[ICD-11: BA00-BA04]P30556AGTR1
    T74456DI0373Secondary hypertension[ICD-11: BA04]P30556AGTR1
    T74456DI0425Urinary system clinical symptom[ICD-11: MF8Y]P30556AGTR1
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T14834DI0039Atopic eczema[ICD-11: EA80]P47712PLA2G4A
    T18876DI0037Asthma[ICD-11: CA23]P35408PTGER4
    T18876DI0175Heart failure[ICD-11: BD10-BD1Z]P35408PTGER4
    T18876DI0264Migraine[ICD-11: 8A80]P35408PTGER4
    T18876DI0303Non-small-cell lung cancer[ICD-11: 2C25]P35408PTGER4
    T18876DI0324Pain[ICD-11: MG30-MG3Z]P35408PTGER4
    T18876DI0360Rectum cancer[ICD-11: 2B92]P35408PTGER4
    T18876DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35408PTGER4
    T18876DI0414Transplanted organ/tissue[ICD-11: QB63]P35408PTGER4
    T85467DI0166Glaucoma[ICD-11: 9C61]P43115PTGER3
    T85467DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43115PTGER3
    T85467DI0414Transplanted organ/tissue[ICD-11: QB63]P43115PTGER3
    T15497DI0405Thrombosis[ICD-11: DB61-GB90]P34995PTGER1
    T49898DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06493CDK1
    T49898DI0238Lung cancer[ICD-11: 2C25]P06493CDK1
    T49898DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P06493CDK1
    T49898DI0250Mature B-cell lymphoma[ICD-11: 2A85]P06493CDK1
    T49898DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06493CDK1
    T23499DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25101EDNRA
    T23499DI0356Pulmonary hypertension[ICD-11: BB01]P25101EDNRA
    T23499DI0425Urinary system clinical symptom[ICD-11: MF8Y]P25101EDNRA
    T07173DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04629NTRK1
    T07173DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04629NTRK1
    T76910DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P49840GSK3A
    T20973DI0308Obesity[ICD-11: 5B80-5B81]Q00535CDK5
    T84703DI0303Non-small-cell lung cancer[ICD-11: 2C25]Q16620NTRK2
    T84703DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16620NTRK2
    T68782DI0102Coronary atherosclerosis[ICD-11: BA52]Q13258PTGDR
    T37154DI0009Acute diabete complication[ICD-11: 5A2Y]P10619CTSA
    T75797DI0003Abortion[ICD-11: JA00]P43088PTGFR
    T75797DI0102Coronary atherosclerosis[ICD-11: BA52]P43088PTGFR
    T75797DI0166Glaucoma[ICD-11: 9C61]P43088PTGFR
    T10965DI0088Circulatory system disease[ICD-11: BE2Z]P16109SELP
    T10965DI0381Sickle-cell disorder[ICD-11: 3A51]P16109SELP
    T60526DI0037Asthma[ICD-11: CA23]P14151SELL
    T60526DI0088Circulatory system disease[ICD-11: BE2Z]P14151SELL
    T07663DI0190Hypertension[ICD-11: BA00-BA04]O76074PDE5A
    T07663DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]O76074PDE5A
    T07663DI0378Sexual dysfunction[ICD-11: HA00-HA01]O76074PDE5A
    T07663DI0411Tonus and reflex abnormality[ICD-11: MB47]O76074PDE5A
    T99954DI0003Abortion[ICD-11: JA00]P43119PTGIR
    T99954DI0102Coronary atherosclerosis[ICD-11: BA52]P43119PTGIR
    T99954DI0356Pulmonary hypertension[ICD-11: BB01]P43119PTGIR
    T40111DI0062Breast cancer[ICD-11: 2C60-2C6Y]P20839IMPDH1
    T40111DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P20839IMPDH1
    T40111DI0250Mature B-cell lymphoma[ICD-11: 2A85]P20839IMPDH1
    T40111DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P20839IMPDH1
    T40111DI0413Transplant rejection[ICD-11: NE84]P20839IMPDH1
    T89360DI0413Transplant rejection[ICD-11: NE84]P12268IMPDH2
    T30803DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00390GSR
    T46781DI0009Acute diabete complication[ICD-11: 5A2Y]Q96GD4AURKB
    T46781DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q96GD4AURKB
    T92828DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P24530EDNRB
    T92828DI0356Pulmonary hypertension[ICD-11: BB01]P24530EDNRB
    T77400DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]O00408PDE2A
    T77400DI0207Indeterminate colitis[ICD-11: DD72]O00408PDE2A
    T77400DI0218Irritable bowel syndrome[ICD-11: DD91]O00408PDE2A
    T77400DI0270Mood disorder[ICD-11: 6A60-6E23]O00408PDE2A
    T93440DI0366Rheumatoid arthritis[ICD-11: FA20]P40189IL6ST
    T16688DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]O75907DGAT1
    T63512DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q13822ENPP2
    T11241DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q99500S1PR3
    T82146DI0005Acne vulgaris[ICD-11: ED80]P13631RARG
    T82146DI0012Acute myeloid leukaemia[ICD-11: 2A60]P13631RARG
    T82146DI0225Kaposi sarcoma[ICD-11: 2B57]P13631RARG
    T82146DI0277Muscle calcification/ossification[ICD-11: FB31]P13631RARG
    T82146DI0351Psoriasis[ICD-11: EA90]P13631RARG
    T61657DI0225Kaposi sarcoma[ICD-11: 2B57]P10826RARB
    T47888DI0419Ulcerative colitis[ICD-11: DD71]O95136S1PR2
    T08910DI0117Depression[ICD-11: 6A70-6A7Z]P18507GABRG2
    T08910DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P18507GABRG2
    T08910DI0411Tonus and reflex abnormality[ICD-11: MB47]P18507GABRG2
    T95923DI0146Fibrosis[ICD-11: GA14-GC01]Q9UBY5LPAR3
    T95923DI0399Systemic sclerosis[ICD-11: 4A42]Q9UBY5LPAR3
    T92640DI0146Fibrosis[ICD-11: GA14-GC01]Q92633LPAR1
    T92640DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q92633LPAR1
    T92640DI0351Psoriasis[ICD-11: EA90]Q92633LPAR1
    T92640DI0399Systemic sclerosis[ICD-11: 4A42]Q92633LPAR1
    T86385DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P08311CTSG
    T63170DI0201Inborn carbohydrate metabolism error[ICD-11: 5C51]Q9UJM8HAO1
    T41750DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P48546GIPR
    T36075DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P43220GLP1R
    T36075DI0418Type-1/2 diabete[ICD-11: 5A10-5A11]P43220GLP1R
    T86528DI0057Bone paget disease[ICD-11: FB85]O95749GGPS1
    T86528DI0237Low bone mass disorder[ICD-11: FB83]O95749GGPS1
    T86528DI0267Mineral excesses[ICD-11: 5B91]O95749GGPS1
    T86528DI0281Musculoskeletal disorder[ICD-11: FA00-FC0Z]O95749GGPS1
    T78356DI0030Angina pectoris[ICD-11: BA40]P24557TBXAS1
    T97071DI0122Diagnostic imaging[ICD-11: N.A.]Q04609FOLH1
    T97071DI0346Prostate cancer[ICD-11: 2C82]Q04609FOLH1
    T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
    T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
    T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
    T82078DI0346Prostate cancer[ICD-11: 2C82]O60603TLR2
    T86528DI0057Bone paget disease[ICD-11: FB85]O95749GGPS1
    T86528DI0237Low bone mass disorder[ICD-11: FB83]O95749GGPS1
    T86528DI0267Mineral excesses[ICD-11: 5B91]O95749GGPS1
    T86528DI0281Musculoskeletal disorder[ICD-11: FA00-FC0Z]O95749GGPS1
    T80387DI0117Depression[ICD-11: 6A70-6A7Z]P47870GABRB2
    T80387DI0214Insomnia[ICD-11: 7A00-7A0Z]P47870GABRB2
    T80387DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P47870GABRB2
    T80387DI0411Tonus and reflex abnormality[ICD-11: MB47]P47870GABRB2

    Copyright © 2025