[8]-Paradol



Compound IDCDAMM00582
Common name[8]-Paradol
IUPAC name1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one
Molecular formulaC19H30O3

Experimental data

Retention time12.69
Adduct[M+H]+
Actual mz307.225
Theoretical mz307.226
Error3.5
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.9532

Identifiers and class information

Inchi keyTYQRTQZWHUXDLG-UHFFFAOYSA-N
SmilesO=C(CCC1=CC=C(O)C(OC)=C1)CCCCCCCCC
SuperclassBenzenoids
ClassPhenols

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)13
    Number of reactive functional groups (#rtvFG)1
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)306.444
    Computed dipole moment(dipole)5.215
    Total solvent accessible surface area (SASA)711.421
    Hydrophobic component of SASA (FOSA)511.938
    Hydrophilic component of SASA (FISA)96.833
    Pie component of the SASA (PISA)102.65
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1212.8
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)3.5
    Free energy of solvation of dipole (dip^2/V)0.0224252
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0049197
    Globularity descriptor (glob)0.773094
    Predicted polarizability in cubic angstroms (QPpolrz)35.015
    Predicted hexadecane/gas partition coefficient (QPlogPC16)11.213
    Predicted octanol/gas partition coefficient (QPlogPoct)14.195
    Predicted water/gas partition coefficient (QPlogPw)4.833
    Predicted octanol/water partition coefficient (QPlogPo/w)4.871
    Predicted aqueous solubility (QPlogS)-5.84
    Conformation-independent predicted aqueous solubility (CIQPlogS)-4.391
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.693
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)1195.73
    Predicted brain/blood partition coefficient (QPlogBB)-1.3
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)600.152
    Predicted skin permeability, log Kp (QPlogKp)-1.694
    PM3 calculated ionization potential (IP(ev))8.93
    PM3 calculated electron affinity (EA(eV))-0.141
    Number of likely metabolic reactions (#metab)5
    Prediction of binding to human serum albumin (QPlogKhsa)0.679
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)100
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)57.289
    Number of nitrogen and oxygen atoms (#NandO)3
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P22303ACHEAcetylcholinesteraseT30082SwissTargetPrediction and SEA
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    P04818TYMSThymidylate synthase (by homology)T98397SwissTargetPrediction
    Q99720SIGMAR1Sigma opioid receptorT46360SEA
    Q96KS0EIT6HIF-prolyl hydroxylase 1T53904SwissTargetPrediction
    P54289CACNA2D1Voltage-gated calcium channel alpha2/delta subunit 1 (by homology)T84316SwissTargetPrediction
    P21397MAOAMonoamine oxidase AT83875SwissTargetPrediction
    P02766TTRTransthyretinT86462SwissTargetPrediction and SEA
    P05067APPBeta amyloid A4 proteinT87024SwissTargetPrediction and SEA
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    Q15125EBPAnti-estrogen binding site (AEBS)T25317SEA
    P14555PLA2G2APhospholipase A2 group IIAT19160SEA
    P98170XIAPInhibitor of apoptosis protein 3T16769SwissTargetPrediction
    P21554CNR1Cannabinoid receptor 1 (by homology)T76685SwissTargetPrediction and SEA
    Q05586GRIN1Glutamate NMDA receptor; GRIN1/GRIN2BT62276SwissTargetPrediction
    P43166CA7Carbonic anhydrase VIIT37541SEA
    P23280CA6Carbonic anhydrase VIT06569SwissTargetPrediction and SEA
    Q9ULX7CA14Carbonic anhydrase XIVT31992SEA
    P22748CA4Carbonic anhydrase IVT53378SwissTargetPrediction
    P31645SLC6A4Serotonin transporter (by homology)T27812SwissTargetPrediction
    P41595HTR2BSerotonin 2b (5-HT2b) receptorT31204SwissTargetPrediction
    P07949RETKinesin-1 heavy chain/ Tyrosine-protein kinase receptor RETT60631SwissTargetPrediction
    P08908HTR1ASerotonin 1a (5-HT1a) receptorT78709SwissTargetPrediction
    P14867GABRA1GABA-A receptor; alpha-1/beta-2/gamma-2T51487SwissTargetPrediction
    P29275ADORA2BAdenosine A2b receptorT86679SwissTargetPrediction
    P23141CES1Acyl coenzyme A:cholesterol acyltransferaseT76369SEA
    Q6B0I6KDM4DLysine-specific demethylase 4DT17036SEA
    P10275ARAndrogen ReceptorT11211SwissTargetPrediction
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    P35968KDRVascular endothelial growth factor receptor 2T80975SwissTargetPrediction
    O60885BRD4Bromodomain-containing protein 4T00407SwissTargetPrediction
    Q15059BRD3Bromodomain-containing protein 3T42048SwissTargetPrediction
    O00519FAAHAnandamide amidohydrolaseT11754SEA
    Q8NER1TRPV1Vanilloid receptorT83193SwissTargetPrediction and SEA
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P11511CYP19A1Cytochrome P450 19A1T13260SwissTargetPrediction
    O14684PTGESProstaglandin E synthaseT02562SwissTargetPrediction and SEA
    P28845HSD11B111-beta-hydroxysteroid dehydrogenase 1T65200SwissTargetPrediction
    P49137MAPKAPK2MAP kinase-activated protein kinase 2T21307SwissTargetPrediction
    P06746POLBDNA polymerase beta (by homology)T06958SEA
    Q7Z2W7TRPM8Transient receptor potential cation channel subfamily M member 8T41955SEA
    P03372ESR1Estrogen receptor alphaT02506SwissTargetPrediction
    P14174MIFMacrophage migration inhibitory factorT39977SwissTargetPrediction
    P09917ALOX5Arachidonate 5-lipoxygenaseT00140SwissTargetPrediction and SEA
    P08069IGF1RInsulin-like growth factor I receptorT48069SwissTargetPrediction
    Q9UM73ALKALK tyrosine kinase receptorT56418SwissTargetPrediction
    P21728DRD1Dopamine D1 receptorT22118SEA
    P23975SLC6A2Norepinephrine transporterT21945SwissTargetPrediction
    P35372OPRM1Mu opioid receptorT47768SwissTargetPrediction
    P10827THRAThyroid hormone receptor alphaT79591SEA
    P10828THRBThyroid hormone receptor beta-1T98933SEA
    P11309PIM1Serine/threonine-protein kinase PIM1T50594SwissTargetPrediction
    Q15118PDK1Pyruvate dehydrogenase kinase isoform 1T20891SwissTargetPrediction
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    P14061HSD17B1Estradiol 17-beta-dehydrogenase 1T44011SwissTargetPrediction
    P00519ABL1Tyrosine-protein kinase ABLT63505SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SEA
    P55072VCPTransitional endoplasmic reticulum ATPaseT12646SwissTargetPrediction
    P09237MMP7Matrix metalloproteinase 7T73475SwissTargetPrediction
    P13497BMP1Bone morphogenetic protein 1T53350SwissTargetPrediction
    P19838NFKB1Nuclear factor NF-kappa-B p105 subunitT83145SEA
    P16050ALOX15Arachidonate 15-lipoxygenaseT16042SwissTargetPrediction and SEA
    P18054ALOX12Arachidonate 12-lipoxygenaseT35527SwissTargetPrediction
    P41143OPRD1Delta opioid receptorT58992SwissTargetPrediction
    P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SwissTargetPrediction
    O00767SCDAcyl-CoA desaturaseT10897SwissTargetPrediction
    P49356FNTBFarnesyl protein transferaseT13127SwissTargetPrediction
    Q15722LTB4RLeukotriene B4 receptor 1T59626SwissTargetPrediction and SEA
    P11388TOP2ADNA topoisomerase II alphaT17048SEA
    O75116ROCK2Rho-associated protein kinase 2T06093SwissTargetPrediction
    Q09472EP300Histone acetyltransferase p300T25956SEA
    P08238HSP90AB1Heat shock protein HSP 90-betaT96623SwissTargetPrediction
    P07900HSP90AA1Heat shock protein HSP 90-alphaT18477SwissTargetPrediction
    Q05397PTK2Focal adhesion kinase 1T15068SwissTargetPrediction
    Q02750MAP2K1Dual specificity mitogen-activated protein kinase kinase 1T99057SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SEA
    P17948FLT1Vascular endothelial growth factor receptor 1T63966SwissTargetPrediction
    Q15078CDK5R1Cyclin-dependent kinase 5/CDK5 activator 1T09513SwissTargetPrediction
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    Q13627DYRK1ADual-specificity tyrosine-phosphorylation regulated kinase 1AT92803SwissTargetPrediction
    P08842STSSteryl-sulfataseT33489SwissTargetPrediction and SEA
    P48039MTNR1AMelatonin receptor 1AT97613SEA
    P49286MTNR1BMelatonin receptor 1BT48268SEA
    P34972CNR2Cannabinoid receptor 2T37693SwissTargetPrediction and SEA
    P47712PLA2G4ACytosolic phospholipase A2T14834SwissTargetPrediction and SEA
    Q13443ADAM9ADAM9T03672SwissTargetPrediction
    O00311CDC7CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)T81358SwissTargetPrediction
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SEA
    P31644GABRA5GABA receptor alpha-5 subunitT26368SwissTargetPrediction
    Q99835SMOSmoothened homologT66505SwissTargetPrediction
    O00763ACACBAcetyl-CoA carboxylase 2T08922SwissTargetPrediction
    Q8TDS5OXER1Oxoeicosanoid receptor 1T68834SEA
    P43088PTGFRProstanoid FP receptorT75797SwissTargetPrediction
    P50281MMP14Matrix metalloproteinase 14T65019SwissTargetPrediction
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SwissTargetPrediction
    Q9Y4D2DAGLASn1-specific diacylglycerol lipase alphaT03150SEA
    Q9H228S1PR5Sphingosine 1-phosphate receptor Edg-8T50089SEA
    P21453S1PR1Sphingosine 1-phosphate receptor Edg-1T13852SEA
    P04049RAF1Serine/threonine-protein kinase RAFT51883SwissTargetPrediction
    Q16875PFKFB36-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3T23787SwissTargetPrediction
    P15056BRAFSerine/threonine-protein kinase B-rafT99089SwissTargetPrediction
    Q07973CYP24A1Cytochrome P450 24A1T92458SwissTargetPrediction
    P55201BRPF1PeregrinT41145SwissTargetPrediction
    Q9NPH5NOX4NADPH oxidase 4T29741SwissTargetPrediction
    P01130LDLRLDL receptorT94692SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SwissTargetPrediction
    P63000RAC1Ras-related C3 botulinum toxin substrate 1T88752SwissTargetPrediction
    P10636MAPTMicrotubule-associated protein tauT45593SEA
    Q04760GLO1Glyoxalase IT88285SEA
    Q15910EZH2EZH2/SUZ12/EED/RBBP7/RBBP4T25265SwissTargetPrediction
    P51512MMP16Matrix metalloproteinase 16T35824SwissTargetPrediction
    Q13822ENPP2AutotaxinT63512SEA
    Q9HBW0LPAR2Lysophosphatidic acid receptor Edg-4T39380SEA
    Q99500S1PR3Sphingosine 1-phosphate receptor Edg-3T11241SEA
    Q16236NFE2L2Nuclear factor erythroid 2-related factor 2T88505SEA
    P10826RARBRetinoic acid receptor betaT61657SEA
    Q96DB2HDAC11Histone deacetylase 11T97903SwissTargetPrediction
    Q9H1C0LPAR5Lysophosphatidic acid receptor 5T18616SEA
    Q969S8HDAC10Histone deacetylase 10T94324SwissTargetPrediction
    O95136S1PR2Sphingosine 1-phosphate receptor Edg-5T47888SEA
    O95977S1PR4Sphingosine 1-phosphate receptor Edg-6T17523SEA
    Q9UPC5GPR34Probable G-protein coupled receptor 34T73859SEA
    O00398P2RY10Putative P2Y purinoceptor 10T00488SEA
    Q9BXC1GPR174Probable G-protein coupled receptor 174T87661SEA
    Q9UBY5LPAR3Lysophosphatidic acid receptor Edg-7T95923SEA
    Q92633LPAR1Lysophosphatidic acid receptor Edg-2T92640SEA
    Q12772SREBF2Sterol regulatory element-binding protein 2T03385SwissTargetPrediction
    Q9H4B7TUBB1Tubulin beta-1 chainT84397SEA
    Q9NQS5GPR84G-protein coupled receptor 84T98091SEA
    Q9UJM8HAO1Hydroxyacid oxidase 1T63170SEA
    P24593IGFBP5Insulin-like growth factor binding protein 5T17008SEA
    Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
    Q7RTX1TAS1R1Taste receptorT41263SEA
    O60603TLR2Toll-like receptor 2T82078SEA
    P01100FOSProto-oncogene c-FosT28025SEA
    O15269SPTLC1Serine palmitoyltransferaseT30817SEA
    Q8N183NDUFAF2HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2T01453SEA
    Q9P0J0NDUFA13Mitochondrial complex IT82391SEA
    Q9Y6M9NDUFB9HUMAN NADH:ubiquinone oxidoreductase subunit B9T01465SEA
    Q8N183NDUFAF2HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2T01453SEA
    P03897MT-ND3NADH dehydrogenaseT77195SEA
    Q4ZFZ2FSHRFollicle-stimulating hormone receptorT68334SEA
    O75751EMTHOrganic cation transporter 3T55948SEA
    Q9H6Q9KIF20BKinesin-like protein KIF20BT92865SEA
    Q9GZT9EGLN1Egl nine homolog 1T32880SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
    T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T53904DI0010Acute disease anaemia[ICD-11: 3A90]Q96KS0EIT6
    T84316DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P54289CACNA2D1
    T84316DI0190Hypertension[ICD-11: BA00-BA04]P54289CACNA2D1
    T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
    T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
    T86462DI0026Amyloidosis[ICD-11: 5D00]P02766TTR
    T87024DI0025Alzheimer disease[ICD-11: 8A20]P05067APP
    T87024DI0122Diagnostic imaging[ICD-11: N.A.]P05067APP
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T25317DI0366Rheumatoid arthritis[ICD-11: FA20]Q15125EBP
    T19160DI0062Breast cancer[ICD-11: 2C60-2C6Y]P14555PLA2G2A
    T16769DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]P98170XIAP
    T76685DI0031Anorexia nervosa[ICD-11: 6B80]P21554CNR1
    T76685DI0214Insomnia[ICD-11: 7A00-7A0Z]P21554CNR1
    T76685DI0308Obesity[ICD-11: 5B80-5B81]P21554CNR1
    T62276DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q05586GRIN1
    T62276DI0182HIV-infected patients with tuberculosis[ICD-11: 1B10-1B14]Q05586GRIN1
    T06569DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P23280CA6
    T06569DI0372Seborrhoeic dermatitis[ICD-11: EA81]P23280CA6
    T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
    T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
    T53378DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P22748CA4
    T53378DI0166Glaucoma[ICD-11: 9C61]P22748CA4
    T53378DI0372Seborrhoeic dermatitis[ICD-11: EA81]P22748CA4
    T27812DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P31645SLC6A4
    T27812DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P31645SLC6A4
    T27812DI0087Chronic pain[ICD-11: MG30]P31645SLC6A4
    T27812DI0096concerning food/fluid intake symptom[ICD-11: MG43]P31645SLC6A4
    T27812DI0101Corneal disease[ICD-11: 9A76-9A78]P31645SLC6A4
    T27812DI0105Cough[ICD-11: MD12]P31645SLC6A4
    T27812DI0117Depression[ICD-11: 6A70-6A7Z]P31645SLC6A4
    T27812DI0264Migraine[ICD-11: 8A80]P31645SLC6A4
    T27812DI0301Nicotine use disorder[ICD-11: 6C4A]P31645SLC6A4
    T27812DI0308Obesity[ICD-11: 5B80-5B81]P31645SLC6A4
    T27812DI0324Pain[ICD-11: MG30-MG3Z]P31645SLC6A4
    T31204DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P41595HTR2B
    T31204DI0117Depression[ICD-11: 6A70-6A7Z]P41595HTR2B
    T31204DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P41595HTR2B
    T31204DI0354Psychotic disorder[ICD-11: 6A20-6A25]P41595HTR2B
    T60631DI0095Colorectal cancer[ICD-11: 2B91]P07949RET
    T60631DI0238Lung cancer[ICD-11: 2C25]P07949RET
    T60631DI0250Mature B-cell lymphoma[ICD-11: 2A85]P07949RET
    T60631DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P07949RET
    T60631DI0403Thrombocytopenia[ICD-11: 3B64]P07949RET
    T60631DI0407Thyroid cancer[ICD-11: 2D10]P07949RET
    T78709DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P08908HTR1A
    T78709DI0117Depression[ICD-11: 6A70-6A7Z]P08908HTR1A
    T78709DI0190Hypertension[ICD-11: BA00-BA04]P08908HTR1A
    T78709DI0264Migraine[ICD-11: 8A80]P08908HTR1A
    T78709DI0270Mood disorder[ICD-11: 6A60-6E23]P08908HTR1A
    T51487DI0014Acute respiratory distress syndrome[ICD-11: CB00]P14867GABRA1
    T51487DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P14867GABRA1
    T51487DI0082Chronic insomnia[ICD-11: 7A00]P14867GABRA1
    T51487DI0087Chronic pain[ICD-11: MG30]P14867GABRA1
    T51487DI0101Corneal disease[ICD-11: 9A76-9A78]P14867GABRA1
    T51487DI0112Cystitis[ICD-11: GC00]P14867GABRA1
    T51487DI0117Depression[ICD-11: 6A70-6A7Z]P14867GABRA1
    T51487DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P14867GABRA1
    T51487DI0173Headache[ICD-11: 8A80-8A84]P14867GABRA1
    T51487DI0214Insomnia[ICD-11: 7A00-7A0Z]P14867GABRA1
    T51487DI0243Malaria[ICD-11: 1F40-1F45]P14867GABRA1
    T51487DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P14867GABRA1
    T51487DI0411Tonus and reflex abnormality[ICD-11: MB47]P14867GABRA1
    T86679DI0180Herpes simplex infection[ICD-11: 1F00]P29275ADORA2B
    T86679DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P29275ADORA2B
    T76369DI0335Peroxisomal disease[ICD-11: 5C57]P23141CES1
    T76369DI0398Synthesis disorder[ICD-11: 5C52-5C59]P23141CES1
    T11211DI0005Acne vulgaris[ICD-11: ED80]P10275AR
    T11211DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10275AR
    T11211DI0021Alcoholic liver disease[ICD-11: DB94]P10275AR
    T11211DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10275AR
    T11211DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P10275AR
    T11211DI0145Female pelvic pain[ICD-11: GA34]P10275AR
    T11211DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P10275AR
    T11211DI0237Low bone mass disorder[ICD-11: FB83]P10275AR
    T11211DI0247Mammary tumour[ICD-11: 2C60-2C6Z]P10275AR
    T11211DI0346Prostate cancer[ICD-11: 2C82]P10275AR
    T11211DI0401Testicular dysfunction[ICD-11: 5A81]P10275AR
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T80975DI0062Breast cancer[ICD-11: 2C60-2C6Y]P35968KDR
    T80975DI0095Colorectal cancer[ICD-11: 2B91]P35968KDR
    T80975DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P35968KDR
    T80975DI0244Malignant digestive organ neoplasm[ICD-11: 2C11]P35968KDR
    T80975DI0361Renal cell carcinoma[ICD-11: 2C90]P35968KDR
    T80975DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35968KDR
    T80975DI0395Stomach cancer[ICD-11: 2B72]P35968KDR
    T80975DI0403Thrombocytopenia[ICD-11: 3B64]P35968KDR
    T80975DI0407Thyroid cancer[ICD-11: 2D10]P35968KDR
    T42048DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q15059BRD3
    T42048DI0346Prostate cancer[ICD-11: 2C82]Q15059BRD3
    T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
    T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T13260DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11511CYP19A1
    T13260DI0108Cushing syndrome[ICD-11: 5A70]P11511CYP19A1
    T02562DI0025Alzheimer disease[ICD-11: 8A20]O14684PTGES
    T65200DI0210Influenza[ICD-11: 1E30-1E32]P28845HSD11B1
    T65200DI0239Lupus erythematosus[ICD-11: 4A40]P28845HSD11B1
    T65200DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P28845HSD11B1
    T21307DI0011Acute laryngitis/tracheitis[ICD-11: CA05]P49137MAPKAPK2
    T21307DI0181Hidradenitis suppurativa[ICD-11: ED92]P49137MAPKAPK2
    T21307DI0269Monogenic autoinflammatory syndrome[ICD-11: 4A60]P49137MAPKAPK2
    T21307DI0334Peritoneal cancer[ICD-11: 2C51]P49137MAPKAPK2
    T21307DI0352Psoriatic arthritis[ICD-11: FA21]P49137MAPKAPK2
    T21307DI0366Rheumatoid arthritis[ICD-11: FA20]P49137MAPKAPK2
    T21307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49137MAPKAPK2
    T06958DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06746POLB
    T41955DI0422Upper respiratory tract disorder[ICD-11: CA0Z]Q7Z2W7TRPM8
    T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
    T39977DI0403Thrombocytopenia[ICD-11: 3B64]P14174MIF
    T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
    T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
    T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
    T48069DI0276Multiple structural anomalies syndrome[ICD-11: LD2F]P08069IGF1R
    T48069DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P08069IGF1R
    T48069DI0408Thyrotoxicosis[ICD-11: 5A02]P08069IGF1R
    T56418DI0238Lung cancer[ICD-11: 2C25]Q9UM73ALK
    T56418DI0251Mature T-cell lymphoma[ICD-11: 2A90]Q9UM73ALK
    T56418DI0303Non-small-cell lung cancer[ICD-11: 2C25]Q9UM73ALK
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T21945DI0013Acute pain[ICD-11: MG31]P23975SLC6A2
    T21945DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P23975SLC6A2
    T21945DI0087Chronic pain[ICD-11: MG30]P23975SLC6A2
    T21945DI0101Corneal disease[ICD-11: 9A76-9A78]P23975SLC6A2
    T21945DI0117Depression[ICD-11: 6A70-6A7Z]P23975SLC6A2
    T21945DI0166Glaucoma[ICD-11: 9C61]P23975SLC6A2
    T21945DI0264Migraine[ICD-11: 8A80]P23975SLC6A2
    T21945DI0301Nicotine use disorder[ICD-11: 6C4A]P23975SLC6A2
    T21945DI0308Obesity[ICD-11: 5B80-5B81]P23975SLC6A2
    T21945DI0324Pain[ICD-11: MG30-MG3Z]P23975SLC6A2
    T21945DI0395Stomach cancer[ICD-11: 2B72]P23975SLC6A2
    T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
    T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
    T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
    T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
    T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
    T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
    T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
    T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
    T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
    T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
    T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
    T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
    T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
    T79591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10827THRA
    T79591DI0197Hypo-thyroidism[ICD-11: 5A00]P10827THRA
    T98933DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10828THRB
    T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
    T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
    T20891DI0241Lymphoma[ICD-11: 2A80-2A86]Q15118PDK1
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T63505DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00519ABL1
    T63505DI0220Ischemia[ICD-11: 8B10-8B11]P00519ABL1
    T63505DI0250Mature B-cell lymphoma[ICD-11: 2A85]P00519ABL1
    T63505DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00519ABL1
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T12646DI0012Acute myeloid leukaemia[ICD-11: 2A60]P55072VCP
    T12646DI0274Multiple myeloma[ICD-11: 2A83]P55072VCP
    T12646DI0284Myelodysplastic syndrome[ICD-11: 2A37]P55072VCP
    T12646DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P55072VCP
    T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
    T83145DI0218Irritable bowel syndrome[ICD-11: DD91]P19838NFKB1
    T83145DI0366Rheumatoid arthritis[ICD-11: FA20]P19838NFKB1
    T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
    T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
    T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
    T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
    T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
    T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
    T10897DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O00767SCD
    T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
    T59626DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]Q15722LTB4R
    T59626DI0355Pulmonary disease[ICD-11: 1B10-1F85]Q15722LTB4R
    T59626DI0361Renal cell carcinoma[ICD-11: 2C90]Q15722LTB4R
    T17048DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11388TOP2A
    T17048DI0225Kaposi sarcoma[ICD-11: 2B57]P11388TOP2A
    T17048DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11388TOP2A
    T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
    T25956DI0346Prostate cancer[ICD-11: 2C82]Q09472EP300
    T25956DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q09472EP300
    T96623DI0062Breast cancer[ICD-11: 2C60-2C6Y]P08238HSP90AB1
    T96623DI0238Lung cancer[ICD-11: 2C25]P08238HSP90AB1
    T96623DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P08238HSP90AB1
    T96623DI0249Mature B-cell leukaemia[ICD-11: 2A82]P08238HSP90AB1
    T96623DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P08238HSP90AB1
    T96623DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P08238HSP90AB1
    T96623DI0395Stomach cancer[ICD-11: 2B72]P08238HSP90AB1
    T18477DI0015Acute upper respiratory infection[ICD-11: CA07]P07900HSP90AA1
    T18477DI0037Asthma[ICD-11: CA23]P07900HSP90AA1
    T15068DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q05397PTK2
    T15068DI0321Ovarian cancer[ICD-11: 2C73]Q05397PTK2
    T15068DI0326Pancreatic cancer[ICD-11: 2C10]Q05397PTK2
    T15068DI0334Peritoneal cancer[ICD-11: 2C51]Q05397PTK2
    T15068DI0356Pulmonary hypertension[ICD-11: BB01]Q05397PTK2
    T15068DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q05397PTK2
    T99057DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q02750MAP2K1
    T99057DI0336Phakomatoses/hamartoneoplastic syndrome[ICD-11: LD2D]Q02750MAP2K1
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T63966DI0361Renal cell carcinoma[ICD-11: 2C90]P17948FLT1
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T92803DI0113Cytomegaloviral disease[ICD-11: 1D82]Q13627DYRK1A
    T33489DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P08842STS
    T97613DI0214Insomnia[ICD-11: 7A00-7A0Z]P48039MTNR1A
    T48268DI0214Insomnia[ICD-11: 7A00-7A0Z]P49286MTNR1B
    T37693DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34972CNR2
    T37693DI0214Insomnia[ICD-11: 7A00-7A0Z]P34972CNR2
    T14834DI0039Atopic eczema[ICD-11: EA80]P47712PLA2G4A
    T03672DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q13443ADAM9
    T81358DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00311CDC7
    T81358DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O00311CDC7
    T26368DI0216Intentional self-harm[ICD-11: PC91]P31644GABRA5
    T66505DI0047Basal cell carcinoma[ICD-11: 2C32]Q99835SMO
    T66505DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]Q99835SMO
    T66505DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q99835SMO
    T08922DI0417Type 2 diabetes mellitus[ICD-11: 5A11]O00763ACACB
    T75797DI0003Abortion[ICD-11: JA00]P43088PTGFR
    T75797DI0102Coronary atherosclerosis[ICD-11: BA52]P43088PTGFR
    T75797DI0166Glaucoma[ICD-11: 9C61]P43088PTGFR
    T65019DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P50281MMP14
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T50089DI0275Multiple sclerosis[ICD-11: 8A40]Q9H228S1PR5
    T13852DI0275Multiple sclerosis[ICD-11: 8A40]P21453S1PR1
    T13852DI0419Ulcerative colitis[ICD-11: DD71]P21453S1PR1
    T51883DI0252Melanoma[ICD-11: 2C30]P04049RAF1
    T51883DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04049RAF1
    T51883DI0321Ovarian cancer[ICD-11: 2C73]P04049RAF1
    T51883DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04049RAF1
    T23787DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16875PFKFB3
    T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
    T92458DI0351Psoriasis[ICD-11: EA90]Q07973CYP24A1
    T29741DI0146Fibrosis[ICD-11: GA14-GC01]Q9NPH5NOX4
    T94692DI0238Lung cancer[ICD-11: 2C25]P01130LDLR
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T88752DI0025Alzheimer disease[ICD-11: 8A20]P63000RAC1
    T45593DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10636MAPT
    T45593DI0025Alzheimer disease[ICD-11: 8A20]P10636MAPT
    T45593DI0265Mild neurocognitive disorder[ICD-11: 6D71]P10636MAPT
    T88285DI0210Influenza[ICD-11: 1E30-1E32]Q04760GLO1
    T25265DI0151Follicular lymphoma[ICD-11: 2A80]Q15910EZH2
    T63512DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q13822ENPP2
    T11241DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q99500S1PR3
    T88505DI0038Ataxic disorder[ICD-11: 8A03]Q16236NFE2L2
    T61657DI0225Kaposi sarcoma[ICD-11: 2B57]P10826RARB
    T94324DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q969S8HDAC10
    T47888DI0419Ulcerative colitis[ICD-11: DD71]O95136S1PR2
    T95923DI0146Fibrosis[ICD-11: GA14-GC01]Q9UBY5LPAR3
    T95923DI0399Systemic sclerosis[ICD-11: 4A42]Q9UBY5LPAR3
    T92640DI0146Fibrosis[ICD-11: GA14-GC01]Q92633LPAR1
    T92640DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q92633LPAR1
    T92640DI0351Psoriasis[ICD-11: EA90]Q92633LPAR1
    T92640DI0399Systemic sclerosis[ICD-11: 4A42]Q92633LPAR1
    T84397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9H4B7TUBB1
    T98091DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q9NQS5GPR84
    T98091DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q9NQS5GPR84
    T63170DI0201Inborn carbohydrate metabolism error[ICD-11: 5C51]Q9UJM8HAO1
    T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
    T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
    T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
    T41263DI0078Cholera[ICD-11: 1A00]Q7RTX1TAS1R1
    T82078DI0346Prostate cancer[ICD-11: 2C82]O60603TLR2
    T30817DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]O15269SPTLC1
    T82391DI0069Cardiomyopathy[ICD-11: BC43]Q9P0J0NDUFA13
    T77195DI0331Parkinsonism[ICD-11: 8A00]P03897MT-ND3
    T68334DI0144Female infertility[ICD-11: GA31]Q4ZFZ2FSHR

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