(R)-3\',7-Dihydroxy-2\',4\'-dimethoxyisoflavan



Compound IDCDAMM00581
Common name(R)-3\',7-Dihydroxy-2\',4\'-dimethoxyisoflavan
IUPAC name3-(3-hydroxy-2,4-dimethoxyphenyl)-3,4-dihydro-2H-chromen-7-ol
Molecular formulaC17H18O5

Experimental data

Retention time7.91
Adduct[M+H]+
Actual mz303.122
Theoretical mz303.122
Error0.41
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.7153

Identifiers and class information

Inchi keyNUNFZNIXYWTZMW-UHFFFAOYNA-N
SmilesOC1=CC=C2C(OCC(C3=CC=C(OC)C(O)=C3OC)C2)=C1
SuperclassPhenylpropanoids and polyketides
ClassIsoflavonoids

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)4
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)0
    Molecular weight (mol_MW)302.326
    Computed dipole moment(dipole)5.958
    Total solvent accessible surface area (SASA)535.08
    Hydrophobic component of SASA (FOSA)239.192
    Hydrophilic component of SASA (FISA)95.348
    Pie component of the SASA (PISA)200.54
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)936.757
    Number of hydrogen bond donors (donorHB)2
    Number of hydrogen bond acceptors (accptHB)3.75
    Free energy of solvation of dipole (dip^2/V)0.0378994
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0099112
    Globularity descriptor (glob)0.865295
    Predicted polarizability in cubic angstroms (QPpolrz)30.682
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.491
    Predicted octanol/gas partition coefficient (QPlogPoct)15.211
    Predicted water/gas partition coefficient (QPlogPw)8.76
    Predicted octanol/water partition coefficient (QPlogPo/w)2.995
    Predicted aqueous solubility (QPlogS)-3.93
    Conformation-independent predicted aqueous solubility (CIQPlogS)-4.537
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.668
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)1235.14
    Predicted brain/blood partition coefficient (QPlogBB)-0.527
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)621.564
    Predicted skin permeability, log Kp (QPlogKp)-2.186
    PM3 calculated ionization potential (IP(ev))8.886
    PM3 calculated electron affinity (EA(eV))0.063
    Number of likely metabolic reactions (#metab)6
    Prediction of binding to human serum albumin (QPlogKhsa)0.225
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)100
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)66.89
    Number of nitrogen and oxygen atoms (#NandO)5
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P36544CHRNA7Neuronal acetylcholine receptor protein alpha-7 subunitT34429SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction
    P04818TYMSThymidylate synthase (by homology)T98397SwissTargetPrediction
    P42338PIK3CBPI3-kinase p110-beta subunitT05031SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    P06239LCKTyrosine-protein kinase LCKT12499SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    Q9ULX7CA14Carbonic anhydrase XIVT31992SwissTargetPrediction
    P27338MAOBMonoamine oxidase BT83011SwissTargetPrediction
    P07949RETKinesin-1 heavy chain/ Tyrosine-protein kinase receptor RETT60631SwissTargetPrediction
    P24864CCNE1Cyclin-dependent kinase 2/cyclin E1T10052SwissTargetPrediction
    Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    P35968KDRVascular endothelial growth factor receptor 2T80975SwissTargetPrediction
    P11511CYP19A1Cytochrome P450 19A1T13260SwissTargetPrediction
    P49137MAPKAPK2MAP kinase-activated protein kinase 2T21307SwissTargetPrediction
    P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
    P03372ESR1Estrogen receptor alphaT02506SwissTargetPrediction
    P14174MIFMacrophage migration inhibitory factorT39977SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    P13726F3Coagulation factor VII/tissue factorT72702SwissTargetPrediction and SEA
    Q9UM73ALKALK tyrosine kinase receptorT56418SwissTargetPrediction
    P21964COMTCatechol O-methyltransferase (by homology)T76904SwissTargetPrediction
    P21728DRD1Dopamine D1 receptorT22118SEA
    P21918DRD5Dopamine D5 receptorT46828SEA
    P08183ABCB1P-glycoprotein 1T25258SwissTargetPrediction
    P52732KIF11Kinesin-like protein 1T28484SwissTargetPrediction
    P11309PIM1Serine/threonine-protein kinase PIM1T50594SwissTargetPrediction
    P11474ESRRAEstrogen-related receptor alphaT72841SwissTargetPrediction
    O95718ESRRBEstrogen-related receptor betaT42025SwissTargetPrediction and SEA
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    Q9H2K2TNKS2Tankyrase-2T38087SwissTargetPrediction
    O95271TNKSTankyrase-1T83059SwissTargetPrediction
    P42858HTTHuntingtinT22496SwissTargetPrediction
    P30291WEE1Serine/threonine-protein kinase WEE1T69991SwissTargetPrediction
    P55072VCPTransitional endoplasmic reticulum ATPaseT12646SwissTargetPrediction
    P24941CDK2Cyclin-dependent kinase 2T70176SwissTargetPrediction
    P11802CDK4Cyclin-dependent kinase 4T85799SwissTargetPrediction
    Q9P1W9PIM2Serine/threonine-protein kinase PIM2T07279SwissTargetPrediction
    Q86V86PIM3Serine/threonine-protein kinase PIM3T16596SwissTargetPrediction
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SwissTargetPrediction
    P78536ADAM17ADAM17T82393SwissTargetPrediction
    P09237MMP7Matrix metalloproteinase 7T73475SwissTargetPrediction
    P13497BMP1Bone morphogenetic protein 1T53350SwissTargetPrediction
    P16050ALOX15Arachidonate 15-lipoxygenaseT16042SwissTargetPrediction and SEA
    P18054ALOX12Arachidonate 12-lipoxygenaseT35527SwissTargetPrediction
    P11387TOP1DNA topoisomerase IT09826SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    P07900HSP90AA1Heat shock protein HSP 90-alphaT18477SwissTargetPrediction
    Q02750MAP2K1Dual specificity mitogen-activated protein kinase kinase 1T99057SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    O00329PIK3CDPI3-kinase p110-delta subunitT67849SwissTargetPrediction
    P05186ALPLAlkaline phosphatase, tissue-nonspecific isozymeT09538SwissTargetPrediction
    P10721KITStem cell growth factor receptorT57700SwissTargetPrediction
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    P25098GRK2G-protein coupled receptor kinase 2T62548SwissTargetPrediction
    Q9UGN5PARP2Poly [ADP-ribose] polymerase 2T40812SwissTargetPrediction
    P24385CCND1Cyclin-dependent kinase 4/cyclin D1T12355SwissTargetPrediction
    P49759CLK1Dual specificty protein kinase CLK1T46685SwissTargetPrediction
    Q9Y463DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1BT82720SwissTargetPrediction
    P25774CTSSCathepsin ST68290SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    P23443RPS6KB1Ribosomal protein S6 kinase 1T94479SwissTargetPrediction
    P11362FGFR1Fibroblast growth factor receptor 1T47101SwissTargetPrediction
    P06493CDK1Cyclin-dependent kinase 1/cyclin B1T49898SwissTargetPrediction
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SwissTargetPrediction
    P53350PLK1Serine/threonine-protein kinase PLK1T40694SwissTargetPrediction
    P04049RAF1Serine/threonine-protein kinase RAFT51883SwissTargetPrediction
    P15056BRAFSerine/threonine-protein kinase B-rafT99089SwissTargetPrediction
    Q96GD4AURKBSerine/threonine-protein kinase Aurora-BT46781SwissTargetPrediction
    P14679TYRTyrosinaseT97035SwissTargetPrediction and SEA
    Q9NPH5NOX4NADPH oxidase 4T29741SwissTargetPrediction
    Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SwissTargetPrediction
    Q9HCP0CSNK1G1Casein kinase I gamma 1T41702SwissTargetPrediction
    Q15418RPS6KA1Ribosomal protein S6 kinase alpha 1T83202SwissTargetPrediction
    O14672ADAM10ADAM10T31902SwissTargetPrediction
    P30281CCND3Cyclin-dependent kinase 4/cyclin DT72507SwissTargetPrediction
    Q9BUB5MKNK1MAP kinase-interacting serine/threonine-protein kinase MNK1T97136SwissTargetPrediction
    O96013PAK4Serine/threonine-protein kinase PAK 4T98293SwissTargetPrediction
    P51512MMP16Matrix metalloproteinase 16T35824SwissTargetPrediction
    P10696ALPGAlkaline phosphatase placental-likeT35565SwissTargetPrediction
    P22736NR4A1Nuclear receptor subfamily 4 group A member 1T41119SwissTargetPrediction
    O00141SGK1Serine/threonine-protein kinase Sgk1T64682SwissTargetPrediction
    Q9H4B7TUBB1Tubulin beta-1 chainT84397SEA
    Q15349RPS6KA2Ribosomal protein S6 kinase alpha 2T28043SwissTargetPrediction
    O75751EMTHOrganic cation transporter 3T55948SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T34429DI0101Corneal disease[ICD-11: 9A76-9A78]P36544CHRNA7
    T34429DI0370Schizophrenia[ICD-11: 6A20]P36544CHRNA7
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
    T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
    T05031DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42338PIK3CB
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
    T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
    T83011DI0115Dementia[ICD-11: 6D80-6D8Z]P27338MAOB
    T83011DI0117Depression[ICD-11: 6A70-6A7Z]P27338MAOB
    T83011DI0190Hypertension[ICD-11: BA00-BA04]P27338MAOB
    T83011DI0243Malaria[ICD-11: 1F40-1F45]P27338MAOB
    T83011DI0264Migraine[ICD-11: 8A80]P27338MAOB
    T83011DI0331Parkinsonism[ICD-11: 8A00]P27338MAOB
    T60631DI0095Colorectal cancer[ICD-11: 2B91]P07949RET
    T60631DI0238Lung cancer[ICD-11: 2C25]P07949RET
    T60631DI0250Mature B-cell lymphoma[ICD-11: 2A85]P07949RET
    T60631DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P07949RET
    T60631DI0403Thrombocytopenia[ICD-11: 3B64]P07949RET
    T60631DI0407Thyroid cancer[ICD-11: 2D10]P07949RET
    T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
    T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
    T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
    T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
    T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
    T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
    T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
    T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
    T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
    T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
    T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
    T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T80975DI0062Breast cancer[ICD-11: 2C60-2C6Y]P35968KDR
    T80975DI0095Colorectal cancer[ICD-11: 2B91]P35968KDR
    T80975DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P35968KDR
    T80975DI0244Malignant digestive organ neoplasm[ICD-11: 2C11]P35968KDR
    T80975DI0361Renal cell carcinoma[ICD-11: 2C90]P35968KDR
    T80975DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35968KDR
    T80975DI0395Stomach cancer[ICD-11: 2B72]P35968KDR
    T80975DI0403Thrombocytopenia[ICD-11: 3B64]P35968KDR
    T80975DI0407Thyroid cancer[ICD-11: 2D10]P35968KDR
    T13260DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11511CYP19A1
    T13260DI0108Cushing syndrome[ICD-11: 5A70]P11511CYP19A1
    T21307DI0011Acute laryngitis/tracheitis[ICD-11: CA05]P49137MAPKAPK2
    T21307DI0181Hidradenitis suppurativa[ICD-11: ED92]P49137MAPKAPK2
    T21307DI0269Monogenic autoinflammatory syndrome[ICD-11: 4A60]P49137MAPKAPK2
    T21307DI0334Peritoneal cancer[ICD-11: 2C51]P49137MAPKAPK2
    T21307DI0352Psoriatic arthritis[ICD-11: FA21]P49137MAPKAPK2
    T21307DI0366Rheumatoid arthritis[ICD-11: FA20]P49137MAPKAPK2
    T21307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49137MAPKAPK2
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
    T39977DI0403Thrombocytopenia[ICD-11: 3B64]P14174MIF
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T72702DI0075Cervical cancer[ICD-11: 2C77]P13726F3
    T56418DI0238Lung cancer[ICD-11: 2C25]Q9UM73ALK
    T56418DI0251Mature T-cell lymphoma[ICD-11: 2A90]Q9UM73ALK
    T56418DI0303Non-small-cell lung cancer[ICD-11: 2C25]Q9UM73ALK
    T76904DI0331Parkinsonism[ICD-11: 8A00]P21964COMT
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T46828DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21918DRD5
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T28484DI0012Acute myeloid leukaemia[ICD-11: 2A60]P52732KIF11
    T28484DI0172Head and neck cancer[ICD-11: 2D42]P52732KIF11
    T28484DI0241Lymphoma[ICD-11: 2A80-2A86]P52732KIF11
    T28484DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P52732KIF11
    T28484DI0274Multiple myeloma[ICD-11: 2A83]P52732KIF11
    T28484DI0321Ovarian cancer[ICD-11: 2C73]P52732KIF11
    T28484DI0361Renal cell carcinoma[ICD-11: 2C90]P52732KIF11
    T28484DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P52732KIF11
    T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
    T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
    T72841DI0366Rheumatoid arthritis[ICD-11: FA20]P11474ESRRA
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T38087DI0321Ovarian cancer[ICD-11: 2C73]Q9H2K2TNKS2
    T83059DI0060Brain cancer[ICD-11: 2A00]O95271TNKS
    T83059DI0062Breast cancer[ICD-11: 2C60-2C6Y]O95271TNKS
    T83059DI0321Ovarian cancer[ICD-11: 2C73]O95271TNKS
    T83059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O95271TNKS
    T22496DI0079Choreiform disorder[ICD-11: 8A01]P42858HTT
    T69991DI0321Ovarian cancer[ICD-11: 2C73]P30291WEE1
    T69991DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P30291WEE1
    T69991DI0429Uterine ligament/parametrium/uterine adnexa neoplasm[ICD-11: 2C72]P30291WEE1
    T12646DI0012Acute myeloid leukaemia[ICD-11: 2A60]P55072VCP
    T12646DI0274Multiple myeloma[ICD-11: 2A83]P55072VCP
    T12646DI0284Myelodysplastic syndrome[ICD-11: 2A37]P55072VCP
    T12646DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P55072VCP
    T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
    T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
    T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
    T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
    T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
    T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
    T85799DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11802CDK4
    T85799DI0238Lung cancer[ICD-11: 2C25]P11802CDK4
    T85799DI0351Psoriasis[ICD-11: EA90]P11802CDK4
    T07279DI0274Multiple myeloma[ICD-11: 2A83]Q9P1W9PIM2
    T07279DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9P1W9PIM2
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T82393DI0062Breast cancer[ICD-11: 2C60-2C6Y]P78536ADAM17
    T82393DI0366Rheumatoid arthritis[ICD-11: FA20]P78536ADAM17
    T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
    T09826DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P11387TOP1
    T09826DI0095Colorectal cancer[ICD-11: 2B91]P11387TOP1
    T09826DI0238Lung cancer[ICD-11: 2C25]P11387TOP1
    T09826DI0321Ovarian cancer[ICD-11: 2C73]P11387TOP1
    T09826DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11387TOP1
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T18477DI0015Acute upper respiratory infection[ICD-11: CA07]P07900HSP90AA1
    T18477DI0037Asthma[ICD-11: CA23]P07900HSP90AA1
    T99057DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q02750MAP2K1
    T99057DI0336Phakomatoses/hamartoneoplastic syndrome[ICD-11: LD2D]Q02750MAP2K1
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T67849DI0151Follicular lymphoma[ICD-11: 2A80]O00329PIK3CD
    T67849DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00329PIK3CD
    T67849DI0249Mature B-cell leukaemia[ICD-11: 2A82]O00329PIK3CD
    T67849DI0250Mature B-cell lymphoma[ICD-11: 2A85]O00329PIK3CD
    T67849DI0395Stomach cancer[ICD-11: 2B72]O00329PIK3CD
    T09538DI0164Genetic prion disease[ICD-11: 8E02]P05186ALPL
    T09538DI0330Parasitic infection[ICD-11: 1D0Y-1G2Z]P05186ALPL
    T57700DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P10721KIT
    T57700DI0095Colorectal cancer[ICD-11: 2B91]P10721KIT
    T57700DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P10721KIT
    T57700DI0250Mature B-cell lymphoma[ICD-11: 2A85]P10721KIT
    T57700DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P10721KIT
    T57700DI0361Renal cell carcinoma[ICD-11: 2C90]P10721KIT
    T57700DI0403Thrombocytopenia[ICD-11: 3B64]P10721KIT
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T40812DI0321Ovarian cancer[ICD-11: 2C73]Q9UGN5PARP2
    T40812DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UGN5PARP2
    T12355DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P24385CCND1
    T68290DI0042Autoimmune disease[ICD-11: 4A40-4A45]P25774CTSS
    T68290DI0092Coeliac disease[ICD-11: DA95]P25774CTSS
    T68290DI0107Crohn disease[ICD-11: DD70]P25774CTSS
    T68290DI0120Diabetes mellitus[ICD-11: 5A10]P25774CTSS
    T68290DI0163General pain disorder[ICD-11: 8E43]P25774CTSS
    T68290DI0324Pain[ICD-11: MG30-MG3Z]P25774CTSS
    T68290DI0382Sjogren syndrome[ICD-11: 4A43]P25774CTSS
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T94479DI0025Alzheimer disease[ICD-11: 8A20]P23443RPS6KB1
    T94479DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P23443RPS6KB1
    T94479DI0419Ulcerative colitis[ICD-11: DD71]P23443RPS6KB1
    T47101DI0095Colorectal cancer[ICD-11: 2B91]P11362FGFR1
    T47101DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P11362FGFR1
    T47101DI0235Liver cancer[ICD-11: 2C12]P11362FGFR1
    T47101DI0403Thrombocytopenia[ICD-11: 3B64]P11362FGFR1
    T49898DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06493CDK1
    T49898DI0238Lung cancer[ICD-11: 2C25]P06493CDK1
    T49898DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P06493CDK1
    T49898DI0250Mature B-cell lymphoma[ICD-11: 2A85]P06493CDK1
    T49898DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06493CDK1
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T40694DI0012Acute myeloid leukaemia[ICD-11: 2A60]P53350PLK1
    T40694DI0284Myelodysplastic syndrome[ICD-11: 2A37]P53350PLK1
    T40694DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P53350PLK1
    T51883DI0252Melanoma[ICD-11: 2C30]P04049RAF1
    T51883DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04049RAF1
    T51883DI0321Ovarian cancer[ICD-11: 2C73]P04049RAF1
    T51883DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04049RAF1
    T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
    T46781DI0009Acute diabete complication[ICD-11: 5A2Y]Q96GD4AURKB
    T46781DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q96GD4AURKB
    T97035DI0007Acquired hypermelanosis[ICD-11: ED60]P14679TYR
    T97035DI0008Acquired hypomelanotic disorder[ICD-11: ED63]P14679TYR
    T29741DI0146Fibrosis[ICD-11: GA14-GC01]Q9NPH5NOX4
    T83202DI0249Mature B-cell leukaemia[ICD-11: 2A82]Q15418RPS6KA1
    T31902DI0062Breast cancer[ICD-11: 2C60-2C6Y]O14672ADAM10
    T97136DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9BUB5MKNK1
    T97136DI0095Colorectal cancer[ICD-11: 2B91]Q9BUB5MKNK1
    T97136DI0235Liver cancer[ICD-11: 2C12]Q9BUB5MKNK1
    T97136DI0241Lymphoma[ICD-11: 2A80-2A86]Q9BUB5MKNK1
    T97136DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BUB5MKNK1
    T98293DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O96013PAK4
    T98293DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O96013PAK4
    T64682DI0346Prostate cancer[ICD-11: 2C82]O00141SGK1
    T84397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9H4B7TUBB1
    T28043DI0249Mature B-cell leukaemia[ICD-11: 2A82]Q15349RPS6KA2

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