Salutaridine



Compound IDCDAMM00558
Common nameSalutaridine
IUPAC name3-hydroxy-4,13-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10,13-pentaen-12-one
Molecular formulaC19H21NO4

Experimental data

Retention time8.87
Adduct[2M+Na]+
Actual mz677.276
Theoretical mz677.283
Error11.4
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.8072

Identifiers and class information

Inchi keyGVTRUVGBZQJVTF-KINVLMLONA-N
SmilesO=C1C=C2C3N(C)CCC2(C=C1OC)C4=C(O)C(OC)=CC=C4C3
SuperclassBenzenoids
ClassPhenanthrenes and derivatives

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)3
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)1
    Molecular weight (mol_MW)327.379
    Computed dipole moment(dipole)8.566
    Total solvent accessible surface area (SASA)554.283
    Hydrophobic component of SASA (FOSA)360.155
    Hydrophilic component of SASA (FISA)81.852
    Pie component of the SASA (PISA)112.276
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1001.27
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)6.25
    Free energy of solvation of dipole (dip^2/V)0.0732904
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0112758
    Globularity descriptor (glob)0.873243
    Predicted polarizability in cubic angstroms (QPpolrz)33.063
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.194
    Predicted octanol/gas partition coefficient (QPlogPoct)16.293
    Predicted water/gas partition coefficient (QPlogPw)9.333
    Predicted octanol/water partition coefficient (QPlogPo/w)2.022
    Predicted aqueous solubility (QPlogS)-2.466
    Conformation-independent predicted aqueous solubility (CIQPlogS)-3.036
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.845
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)413.619
    Predicted brain/blood partition coefficient (QPlogBB)0.066
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)210.776
    Predicted skin permeability, log Kp (QPlogKp)-4.407
    PM3 calculated ionization potential (IP(ev))9.042
    PM3 calculated electron affinity (EA(eV))0.565
    Number of likely metabolic reactions (#metab)8
    Prediction of binding to human serum albumin (QPlogKhsa)0.03
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)85.617
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)67.069
    Number of nitrogen and oxygen atoms (#NandO)5
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    Q9Y5N1HRH3Histamine H3 receptorT64765SwissTargetPrediction
    P08173CHRM4Muscarinic acetylcholine receptor M4T20709SwissTargetPrediction
    P08912CHRM5Muscarinic acetylcholine receptor M5T79961SwissTargetPrediction
    Q12809KCNH2HERGT20251SwissTargetPrediction
    P20309CHRM3Muscarinic acetylcholine receptor M3T67684SwissTargetPrediction
    P10635CYP2D6Cytochrome P450 2D6T57392SwissTargetPrediction
    Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction
    P29475NOS1Nitric-oxide synthase, brainT16117SwissTargetPrediction
    P35228NOS2Nitric oxide synthase, inducibleT02703SwissTargetPrediction
    P09960LTA4HLeukotriene A4 hydrolaseT03691SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P21397MAOAMonoamine oxidase AT83875SwissTargetPrediction
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    P16083NQO2Quinone reductase 2T75498SwissTargetPrediction
    P98170XIAPInhibitor of apoptosis protein 3T16769SwissTargetPrediction
    P17612PRKACAcAMP-dependent protein kinase alpha-catalytic subunitT12808SwissTargetPrediction
    P27338MAOBMonoamine oxidase BT83011SwissTargetPrediction
    O60341KDM1ALysine-specific histone demethylase 1T16739SwissTargetPrediction
    P28335HTR2CSerotonin 2c (5-HT2c) receptorT83813SwissTargetPrediction
    P41595HTR2BSerotonin 2b (5-HT2b) receptorT31204SwissTargetPrediction
    P28221HTR1DSerotonin 1d (5-HT1d) receptorT11072SwissTargetPrediction
    P34969HTR7Serotonin 7 (5-HT7) receptorT79062SwissTargetPrediction
    P50406HTR6Serotonin 6 (5-HT6) receptorT16691SwissTargetPrediction
    P24864CCNE1Cyclin-dependent kinase 2/cyclin E1T10052SwissTargetPrediction
    P05164MPOMyeloperoxidaseT23471SwissTargetPrediction
    Q99705MCHR1Melanin-concentrating hormone receptor 1T09572SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    Q9H3N8HRH4Histamine H4 receptorT26500SwissTargetPrediction
    P25021HRH2Histamine H2 receptorT30985SwissTargetPrediction
    P35367HRH1Histamine H1 receptorT77913SwissTargetPrediction
    P21918DRD5Dopamine D5 receptorT46828SwissTargetPrediction
    P23975SLC6A2Norepinephrine transporterT21945SwissTargetPrediction
    P35372OPRM1Mu opioid receptorT47768SwissTargetPrediction and SEA
    P25100ADRA1DAlpha-1d adrenergic receptorT53381SwissTargetPrediction
    P41145OPRK1Kappa Opioid receptorT60693SwissTargetPrediction and SEA
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    O60674JAK2Tyrosine-protein kinase JAK2T08391SwissTargetPrediction
    Q9Y233PDE10APhosphodiesterase 10A (by homology)T84133SwissTargetPrediction
    P35270SPRSubstance-P receptorT47094SwissTargetPrediction
    P32245MC4RMelanocortin receptor 4T72458SwissTargetPrediction
    P41143OPRD1Delta opioid receptorT58992SwissTargetPrediction and SEA
    Q13490BIRC2Baculoviral IAP repeat-containing protein 2T84780SwissTargetPrediction
    P24723PRKCHProtein kinase C etaT40149SwissTargetPrediction
    Q9UHL4DPP7Dipeptidyl peptidase IIT50773SwissTargetPrediction
    O75116ROCK2Rho-associated protein kinase 2T06093SwissTargetPrediction
    P23458JAK1Tyrosine-protein kinase JAK1T62460SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    Q02156PRKCEProtein kinase C epsilonT00895SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    P30411BDKRB2Bradykinin B2 receptorT23714SwissTargetPrediction
    Q12884FAPFibroblast activation protein alpha (by homology)T53764SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    P29597TYK2Tyrosine-protein kinase TYK2T78932SwissTargetPrediction
    P48039MTNR1AMelatonin receptor 1AT97613SwissTargetPrediction
    P49286MTNR1BMelatonin receptor 1BT48268SwissTargetPrediction
    Q05655PRKCDProtein kinase C deltaT44861SwissTargetPrediction
    P07333CSF1RMacrophage colony stimulating factor receptorT20333SwissTargetPrediction
    P35346SSTR5Somatostatin receptor 5T64830SwissTargetPrediction
    P46098HTR3ASerotonin 3a (5-HT3a) receptorT64591SwissTargetPrediction
    P31391SSTR4Somatostatin receptor 4T62974SwissTargetPrediction
    P30872SSTR1Somatostatin receptor 1T16633SwissTargetPrediction
    P19793RXRARetinoid X receptor alpha (by homology)T13726SwissTargetPrediction
    Q13976PRKG1cGMP-dependent protein kinase 1 betaT78543SwissTargetPrediction
    Q04759PRKCQProtein kinase C thetaT23995SwissTargetPrediction
    P68400CSNK2A1Casein kinase II alphaT51565SwissTargetPrediction
    Q6V1X1DPP8Dipeptidyl peptidase VIIIT15855SwissTargetPrediction
    Q86TI2DPP9Dipeptidyl peptidase IXT66252SwissTargetPrediction
    P19784CSNK2A2Casein kinase II alpha (prime)T80526SwissTargetPrediction
    Q14680MELKMaternal embryonic leucine zipper kinaseT96892SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SwissTargetPrediction
    Q96KB5PBKPDZ-binding kinaseT98642SwissTargetPrediction
    Q99873PRMT1Protein-arginine N-methyltransferase 1T16808SwissTargetPrediction
    P15559NQO1Quinone reductase 1T52389SwissTargetPrediction
    P30939HTR1FSerotonin 1f (5-HT1f) receptorT78656SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T64765DI0392Somnolence[ICD-11: MG42]Q9Y5N1HRH3
    T20709DI0037Asthma[ICD-11: CA23]P08173CHRM4
    T20709DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]P08173CHRM4
    T20709DI0166Glaucoma[ICD-11: 9C61]P08173CHRM4
    T20709DI0293Nausea/vomiting[ICD-11: MD90]P08173CHRM4
    T20709DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08173CHRM4
    T79961DI0002Abnormal micturition[ICD-11: MF50]P08912CHRM5
    T79961DI0032Anterior uveitis[ICD-11: 9A96]P08912CHRM5
    T79961DI0034Appearance/behaviour symptom[ICD-11: MB23]P08912CHRM5
    T79961DI0037Asthma[ICD-11: CA23]P08912CHRM5
    T79961DI0061Brain disease[ICD-11: 8C70-8E61]P08912CHRM5
    T79961DI0071Central and peripheral nervous disease[ICD-11: 8A04-8E7Z]P08912CHRM5
    T79961DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P08912CHRM5
    T79961DI0093Cognition symptoms/signs/clinical symptom[ICD-11: MB21]P08912CHRM5
    T79961DI0105Cough[ICD-11: MD12]P08912CHRM5
    T79961DI0124Digestive system disease[ICD-11: DE2Z]P08912CHRM5
    T79961DI0145Female pelvic pain[ICD-11: GA34]P08912CHRM5
    T79961DI0154Functional bladder disorder[ICD-11: GC50]P08912CHRM5
    T79961DI0158Gastritis[ICD-11: DA42]P08912CHRM5
    T79961DI0162General examination[ICD-11: QA00]P08912CHRM5
    T79961DI0166Glaucoma[ICD-11: 9C61]P08912CHRM5
    T79961DI0190Hypertension[ICD-11: BA00-BA04]P08912CHRM5
    T79961DI0208Infectious gastroenteritis/colitis[ICD-11: 1A40]P08912CHRM5
    T79961DI0218Irritable bowel syndrome[ICD-11: DD91]P08912CHRM5
    T79961DI0307Nystagmus[ICD-11: 9C84]P08912CHRM5
    T79961DI0315Oesophagus motility disorder[ICD-11: DA21]P08912CHRM5
    T79961DI0324Pain[ICD-11: MG30-MG3Z]P08912CHRM5
    T79961DI0329Pancreatitis[ICD-11: DC31-DC34]P08912CHRM5
    T79961DI0331Parkinsonism[ICD-11: 8A00]P08912CHRM5
    T79961DI0333Peptic ulcer[ICD-11: DA61]P08912CHRM5
    T79961DI0338Polyuria[ICD-11: MF55]P08912CHRM5
    T79961DI0411Tonus and reflex abnormality[ICD-11: MB47]P08912CHRM5
    T79961DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P08912CHRM5
    T79961DI0424Urgency[ICD-11: N.A.]P08912CHRM5
    T20251DI0175Heart failure[ICD-11: BD10-BD1Z]Q12809KCNH2
    T67684DI0037Asthma[ICD-11: CA23]P20309CHRM3
    T67684DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P20309CHRM3
    T67684DI0154Functional bladder disorder[ICD-11: GC50]P20309CHRM3
    T67684DI0166Glaucoma[ICD-11: 9C61]P20309CHRM3
    T67684DI0293Nausea/vomiting[ICD-11: MD90]P20309CHRM3
    T67684DI0333Peptic ulcer[ICD-11: DA61]P20309CHRM3
    T67684DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P20309CHRM3
    T67684DI0371Sebaceous gland disorder[ICD-11: ED91]P20309CHRM3
    T67684DI0382Sjogren syndrome[ICD-11: 4A43]P20309CHRM3
    T67684DI0411Tonus and reflex abnormality[ICD-11: MB47]P20309CHRM3
    T57392DI0214Insomnia[ICD-11: 7A00-7A0Z]P10635CYP2D6
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T16117DI0173Headache[ICD-11: 8A80-8A84]P29475NOS1
    T16117DI0264Migraine[ICD-11: 8A80]P29475NOS1
    T02703DI0083Chronic kidney disease[ICD-11: GB61]P35228NOS2
    T02703DI0320Osteoarthritis[ICD-11: FA00-FA05]P35228NOS2
    T02703DI0375Sepsis[ICD-11: 1G40-1G41]P35228NOS2
    T02703DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35228NOS2
    T03691DI0012Acute myeloid leukaemia[ICD-11: 2A60]P09960LTA4H
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
    T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T75498DI0214Insomnia[ICD-11: 7A00-7A0Z]P16083NQO2
    T16769DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]P98170XIAP
    T12808DI0279Muscular atrophy[ICD-11: 8B61]P17612PRKACA
    T83011DI0115Dementia[ICD-11: 6D80-6D8Z]P27338MAOB
    T83011DI0117Depression[ICD-11: 6A70-6A7Z]P27338MAOB
    T83011DI0190Hypertension[ICD-11: BA00-BA04]P27338MAOB
    T83011DI0243Malaria[ICD-11: 1F40-1F45]P27338MAOB
    T83011DI0264Migraine[ICD-11: 8A80]P27338MAOB
    T83011DI0331Parkinsonism[ICD-11: 8A00]P27338MAOB
    T16739DI0012Acute myeloid leukaemia[ICD-11: 2A60]O60341KDM1A
    T16739DI0025Alzheimer disease[ICD-11: 8A20]O60341KDM1A
    T16739DI0138Ewing sarcoma[ICD-11: 2B52]O60341KDM1A
    T16739DI0238Lung cancer[ICD-11: 2C25]O60341KDM1A
    T16739DI0241Lymphoma[ICD-11: 2A80-2A86]O60341KDM1A
    T16739DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O60341KDM1A
    T16739DI0284Myelodysplastic syndrome[ICD-11: 2A37]O60341KDM1A
    T16739DI0286Myeloproliferative neoplasm[ICD-11: 2A20]O60341KDM1A
    T16739DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O60341KDM1A
    T83813DI0117Depression[ICD-11: 6A70-6A7Z]P28335HTR2C
    T83813DI0264Migraine[ICD-11: 8A80]P28335HTR2C
    T83813DI0308Obesity[ICD-11: 5B80-5B81]P28335HTR2C
    T83813DI0324Pain[ICD-11: MG30-MG3Z]P28335HTR2C
    T83813DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28335HTR2C
    T31204DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P41595HTR2B
    T31204DI0117Depression[ICD-11: 6A70-6A7Z]P41595HTR2B
    T31204DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P41595HTR2B
    T31204DI0354Psychotic disorder[ICD-11: 6A20-6A25]P41595HTR2B
    T11072DI0264Migraine[ICD-11: 8A80]P28221HTR1D
    T11072DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28221HTR1D
    T79062DI0025Alzheimer disease[ICD-11: 8A20]P34969HTR7
    T79062DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34969HTR7
    T79062DI0051Bipolar disorder[ICD-11: 6A60]P34969HTR7
    T79062DI0117Depression[ICD-11: 6A70-6A7Z]P34969HTR7
    T79062DI0265Mild neurocognitive disorder[ICD-11: 6D71]P34969HTR7
    T79062DI0331Parkinsonism[ICD-11: 8A00]P34969HTR7
    T79062DI0370Schizophrenia[ICD-11: 6A20]P34969HTR7
    T16691DI0025Alzheimer disease[ICD-11: 8A20]P50406HTR6
    T16691DI0370Schizophrenia[ICD-11: 6A20]P50406HTR6
    T23471DI0229Left ventricular failure[ICD-11: BD11]P05164MPO
    T23471DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P05164MPO
    T09572DI0308Obesity[ICD-11: 5B80-5B81]Q99705MCHR1
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T26500DI0037Asthma[ICD-11: CA23]Q9H3N8HRH4
    T26500DI0039Atopic eczema[ICD-11: EA80]Q9H3N8HRH4
    T26500DI0351Psoriasis[ICD-11: EA90]Q9H3N8HRH4
    T26500DI0366Rheumatoid arthritis[ICD-11: FA20]Q9H3N8HRH4
    T26500DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q9H3N8HRH4
    T30985DI0161Gastro-oesophageal reflux disease[ICD-11: DA22]P25021HRH2
    T30985DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P25021HRH2
    T30985DI0333Peptic ulcer[ICD-11: DA61]P25021HRH2
    T77913DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P35367HRH1
    T77913DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P35367HRH1
    T77913DI0063Breathing abnormality[ICD-11: MD11]P35367HRH1
    T77913DI0099Conjunctiva disorder[ICD-11: 9A60]P35367HRH1
    T77913DI0105Cough[ICD-11: MD12]P35367HRH1
    T77913DI0117Depression[ICD-11: 6A70-6A7Z]P35367HRH1
    T77913DI0136Episodic vestibular syndrome[ICD-11: AB31]P35367HRH1
    T77913DI0173Headache[ICD-11: 8A80-8A84]P35367HRH1
    T77913DI0214Insomnia[ICD-11: 7A00-7A0Z]P35367HRH1
    T77913DI0272Morning sickness disorder[ICD-11: SC00]P35367HRH1
    T77913DI0292Nasopharyngitis[ICD-11: CA00]P35367HRH1
    T77913DI0293Nausea/vomiting[ICD-11: MD90]P35367HRH1
    T77913DI0331Parkinsonism[ICD-11: 8A00]P35367HRH1
    T77913DI0349Pruritus[ICD-11: EC90]P35367HRH1
    T77913DI0366Rheumatoid arthritis[ICD-11: FA20]P35367HRH1
    T77913DI0388Sleep-wake disorder[ICD-11: 7A00-7B2Z]P35367HRH1
    T77913DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P35367HRH1
    T46828DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21918DRD5
    T21945DI0013Acute pain[ICD-11: MG31]P23975SLC6A2
    T21945DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P23975SLC6A2
    T21945DI0087Chronic pain[ICD-11: MG30]P23975SLC6A2
    T21945DI0101Corneal disease[ICD-11: 9A76-9A78]P23975SLC6A2
    T21945DI0117Depression[ICD-11: 6A70-6A7Z]P23975SLC6A2
    T21945DI0166Glaucoma[ICD-11: 9C61]P23975SLC6A2
    T21945DI0264Migraine[ICD-11: 8A80]P23975SLC6A2
    T21945DI0301Nicotine use disorder[ICD-11: 6C4A]P23975SLC6A2
    T21945DI0308Obesity[ICD-11: 5B80-5B81]P23975SLC6A2
    T21945DI0324Pain[ICD-11: MG30-MG3Z]P23975SLC6A2
    T21945DI0395Stomach cancer[ICD-11: 2B72]P23975SLC6A2
    T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
    T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
    T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
    T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
    T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
    T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
    T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
    T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
    T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
    T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
    T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
    T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
    T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
    T53381DI0166Glaucoma[ICD-11: 9C61]P25100ADRA1D
    T53381DI0175Heart failure[ICD-11: BD10-BD1Z]P25100ADRA1D
    T53381DI0190Hypertension[ICD-11: BA00-BA04]P25100ADRA1D
    T53381DI0348Prostate hyperplasia[ICD-11: GA90]P25100ADRA1D
    T53381DI0378Sexual dysfunction[ICD-11: HA00-HA01]P25100ADRA1D
    T53381DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P25100ADRA1D
    T60693DI0304Non-specific cutaneous vascular symptom[ICD-11: ME64]P41145OPRK1
    T60693DI0324Pain[ICD-11: MG30-MG3Z]P41145OPRK1
    T60693DI0349Pruritus[ICD-11: EC90]P41145OPRK1
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T08391DI0039Atopic eczema[ICD-11: EA80]O60674JAK2
    T08391DI0286Myeloproliferative neoplasm[ICD-11: 2A20]O60674JAK2
    T08391DI0366Rheumatoid arthritis[ICD-11: FA20]O60674JAK2
    T08391DI0404Thrombocytosis[ICD-11: 3B63]O60674JAK2
    T84133DI0079Choreiform disorder[ICD-11: 8A01]Q9Y233PDE10A
    T84133DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q9Y233PDE10A
    T84133DI0218Irritable bowel syndrome[ICD-11: DD91]Q9Y233PDE10A
    T84133DI0370Schizophrenia[ICD-11: 6A20]Q9Y233PDE10A
    T84133DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9Y233PDE10A
    T47094DI0117Depression[ICD-11: 6A70-6A7Z]P35270SPR
    T47094DI0293Nausea/vomiting[ICD-11: MD90]P35270SPR
    T72458DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]P32245MC4R
    T72458DI0228Large intestine motility disorder[ICD-11: DB32]P32245MC4R
    T72458DI0308Obesity[ICD-11: 5B80-5B81]P32245MC4R
    T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
    T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
    T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
    T84780DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]Q13490BIRC2
    T40149DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P24723PRKCH
    T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
    T62460DI0039Atopic eczema[ICD-11: EA80]P23458JAK1
    T62460DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P23458JAK1
    T62460DI0366Rheumatoid arthritis[ICD-11: FA20]P23458JAK1
    T62460DI0404Thrombocytosis[ICD-11: 3B63]P23458JAK1
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T00895DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]Q02156PRKCE
    T00895DI0243Malaria[ICD-11: 1F40-1F45]Q02156PRKCE
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T23714DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P30411BDKRB2
    T53764DI0300Neutropenia[ICD-11: 4B00]Q12884FAP
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T78932DI0351Psoriasis[ICD-11: EA90]P29597TYK2
    T97613DI0214Insomnia[ICD-11: 7A00-7A0Z]P48039MTNR1A
    T48268DI0214Insomnia[ICD-11: 7A00-7A0Z]P49286MTNR1B
    T44861DI0287Myocardial infarction[ICD-11: BA41-BA43]Q05655PRKCD
    T20333DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P07333CSF1R
    T64830DI0108Cushing syndrome[ICD-11: 5A70]P35346SSTR5
    T64591DI0087Chronic pain[ICD-11: MG30]P46098HTR3A
    T64591DI0101Corneal disease[ICD-11: 9A76-9A78]P46098HTR3A
    T64591DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P46098HTR3A
    T64591DI0218Irritable bowel syndrome[ICD-11: DD91]P46098HTR3A
    T64591DI0293Nausea/vomiting[ICD-11: MD90]P46098HTR3A
    T62974DI0087Chronic pain[ICD-11: MG30]P31391SSTR4
    T62974DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P31391SSTR4
    T16633DI0108Cushing syndrome[ICD-11: 5A70]P30872SSTR1
    T16633DI0395Stomach cancer[ICD-11: 2B72]P30872SSTR1
    T13726DI0225Kaposi sarcoma[ICD-11: 2B57]P19793RXRA
    T13726DI0283Mycosis fungoides[ICD-11: 2B01]P19793RXRA
    T23995DI0413Transplant rejection[ICD-11: NE84]Q04759PRKCQ
    T51565DI0104Coronavirus infection[ICD-11: 1D92]P68400CSNK2A1
    T51565DI0235Liver cancer[ICD-11: 2C12]P68400CSNK2A1
    T51565DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P68400CSNK2A1
    T15855DI0300Neutropenia[ICD-11: 4B00]Q6V1X1DPP8
    T66252DI0300Neutropenia[ICD-11: 4B00]Q86TI2DPP9
    T96892DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q14680MELK
    T96892DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q14680MELK
    T96892DI0249Mature B-cell leukaemia[ICD-11: 2A82]Q14680MELK
    T96892DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q14680MELK
    T96892DI0284Myelodysplastic syndrome[ICD-11: 2A37]Q14680MELK
    T96892DI0286Myeloproliferative neoplasm[ICD-11: 2A20]Q14680MELK
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T98642DI0291Nasopharyngeal cancer[ICD-11: 2B6B]Q96KB5PBK
    T16808DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q99873PRMT1
    T52389DI0079Choreiform disorder[ICD-11: 8A01]P15559NQO1
    T52389DI0090CNS anomalies syndrome[ICD-11: LD20]P15559NQO1
    T52389DI0202Inborn energy metabolism error[ICD-11: 5C53]P15559NQO1
    T52389DI0215Intellectual development disorder[ICD-11: LD90]P15559NQO1
    T52389DI0326Pancreatic cancer[ICD-11: 2C10]P15559NQO1
    T52389DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P15559NQO1
    T78656DI0264Migraine[ICD-11: 8A80]P30939HTR1F
    T78656DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30939HTR1F

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