(-)-beta-Peltatin;beta-Peltatin



Compound IDCDAMM00512
Common name(-)-beta-Peltatin;beta-Peltatin
IUPAC name4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
Molecular formulaC22H22O8

Experimental data

Retention time8.21
Adduct[M+Na]+
Actual mz437.126
Theoretical mz437.12
Error12.54
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score8.6733

Identifiers and class information

Inchi keyHLBPOYVRLSXWJJ-XUGCUHNJNA-N
SmilesO=C1OCC2CC3=C(O)C=4OCOC4C=C3C(C5=CC(OC)=C(OC)C(OC)=C5)C12
SuperclassLignans, neolignans and related compounds
ClassLignan lactones

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)4
    Number of reactive functional groups (#rtvFG)2
    Predicted central nervous system activity (CNS)0
    Molecular weight (mol_MW)414.411
    Computed dipole moment(dipole)6.814
    Total solvent accessible surface area (SASA)598.185
    Hydrophobic component of SASA (FOSA)441.023
    Hydrophilic component of SASA (FISA)89.484
    Pie component of the SASA (PISA)67.678
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1137.88
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)7.5
    Free energy of solvation of dipole (dip^2/V)0.0407992
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0125379
    Globularity descriptor (glob)0.881171
    Predicted polarizability in cubic angstroms (QPpolrz)37.462
    Predicted hexadecane/gas partition coefficient (QPlogPC16)10.208
    Predicted octanol/gas partition coefficient (QPlogPoct)18.071
    Predicted water/gas partition coefficient (QPlogPw)10.197
    Predicted octanol/water partition coefficient (QPlogPo/w)2.782
    Predicted aqueous solubility (QPlogS)-3.826
    Conformation-independent predicted aqueous solubility (CIQPlogS)-5.563
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-3.778
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)1403.86
    Predicted brain/blood partition coefficient (QPlogBB)-0.446
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)713.823
    Predicted skin permeability, log Kp (QPlogKp)-2.546
    PM3 calculated ionization potential (IP(ev))9.057
    PM3 calculated electron affinity (EA(eV))0.274
    Number of likely metabolic reactions (#metab)7
    Prediction of binding to human serum albumin (QPlogKhsa)0.104
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)100
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)101.357
    Number of nitrogen and oxygen atoms (#NandO)8
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    O43570CA12Carbonic anhydrase XIIT16987SwissTargetPrediction
    Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    Q96KS0EIT6HIF-prolyl hydroxylase 1T53904SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P42338PIK3CBPI3-kinase p110-beta subunitT05031SwissTargetPrediction
    P11712CYP2C9Cytochrome P450 2C9T19244SwissTargetPrediction
    P08684CYP3A4Cytochrome P450 3A4T37848SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P06239LCKTyrosine-protein kinase LCKT12499SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    Q8IXJ6SIRT2NAD-dependent deacetylase sirtuin 2T83904SwissTargetPrediction
    P43166CA7Carbonic anhydrase VIIT37541SwissTargetPrediction
    P28335HTR2CSerotonin 2c (5-HT2c) receptorT83813SwissTargetPrediction
    Q96RJ0TAAR1Trace amine-associated receptor 1 (by homology)T99524SwissTargetPrediction
    P07949RETKinesin-1 heavy chain/ Tyrosine-protein kinase receptor RETT60631SwissTargetPrediction
    Q01959SLC6A3Dopamine transporterT55959SwissTargetPrediction
    P15121AKR1B1Aldose reductaseT26623SwissTargetPrediction
    P07384CAPN1Calpain 1T92517SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P49137MAPKAPK2MAP kinase-activated protein kinase 2T21307SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    Q7Z2W7TRPM8Transient receptor potential cation channel subfamily M member 8T41955SwissTargetPrediction
    P14174MIFMacrophage migration inhibitory factorT39977SwissTargetPrediction
    O00206TLR4Toll-like receptor 4 (by homology)T81443SEA
    P23975SLC6A2Norepinephrine transporterT21945SwissTargetPrediction
    P08183ABCB1P-glycoprotein 1T25258SEA
    P54760EPHB4Ephrin receptorT49507SwissTargetPrediction
    Q15118PDK1Pyruvate dehydrogenase kinase isoform 1T20891SwissTargetPrediction
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    P00519ABL1Tyrosine-protein kinase ABLT63505SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    P24941CDK2Cyclin-dependent kinase 2T70176SwissTargetPrediction
    Q9P1W9PIM2Serine/threonine-protein kinase PIM2T07279SwissTargetPrediction
    P56817BACE1Beta-secretase 1T79031SwissTargetPrediction
    Q16769QPCTGlutaminyl-peptide cyclotransferaseT46245SwissTargetPrediction
    P30559OXTROxytocin receptor (by homology)T84486SwissTargetPrediction
    P00742F10Thrombin and coagulation factor XT84631SwissTargetPrediction
    O14746TERTTelomerase reverse transcriptaseT86052SwissTargetPrediction
    O75460ERN1Serine/threonine-protein kinase/endoribonuclease IRE1T01003SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    P08238HSP90AB1Heat shock protein HSP 90-betaT96623SwissTargetPrediction
    P07900HSP90AA1Heat shock protein HSP 90-alphaT18477SwissTargetPrediction
    P47871GCGRGlucagon receptorT60182SwissTargetPrediction
    Q05397PTK2Focal adhesion kinase 1T15068SwissTargetPrediction
    P49810PSEN2Gamma-secretaseT99204SwissTargetPrediction
    Q02750MAP2K1Dual specificity mitogen-activated protein kinase kinase 1T99057SwissTargetPrediction
    O00329PIK3CDPI3-kinase p110-delta subunitT67849SwissTargetPrediction
    P05186ALPLAlkaline phosphatase, tissue-nonspecific isozymeT09538SwissTargetPrediction
    Q13627DYRK1ADual-specificity tyrosine-phosphorylation regulated kinase 1AT92803SwissTargetPrediction
    P29375KDM5ALysine-specific demethylase 5AT28052SwissTargetPrediction
    P40763STAT3Signal transducer and activator of transcription 3T29130SwissTargetPrediction
    Q9Y463DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1BT82720SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction
    Q96EB6SIRT1NAD-dependent deacetylase sirtuin 1T14731SwissTargetPrediction
    Q14289PTK2BProtein tyrosine kinase 2 betaT07087SwissTargetPrediction
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SwissTargetPrediction
    P25101EDNRAEndothelin receptor ET-AT23499SwissTargetPrediction and SEA
    P23526AHCYAdenosylhomocysteinaseT68698SwissTargetPrediction
    P34998CRHR1Corticotropin releasing factor receptor 1 (by homology)T45262SwissTargetPrediction
    Q9Y5Z0BACE2Beta secretase 2T01280SwissTargetPrediction
    Q02127DHODHDihydroorotate dehydrogenaseT61400SwissTargetPrediction
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SwissTargetPrediction
    O76074PDE5APhosphodiesterase 5AT07663SwissTargetPrediction
    P20839IMPDH1Inosine-5'-monophosphate dehydrogenase 1T40111SwissTargetPrediction
    P78527PRKDCDNA-dependent protein kinaseT81735SwissTargetPrediction
    P04049RAF1Serine/threonine-protein kinase RAFT51883SwissTargetPrediction
    P15056BRAFSerine/threonine-protein kinase B-rafT99089SwissTargetPrediction
    Q96GD4AURKBSerine/threonine-protein kinase Aurora-BT46781SwissTargetPrediction
    Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SwissTargetPrediction
    P51164ATP4BPotassium-transporting ATPaseT92687SwissTargetPrediction
    Q12791KCNMA1Calcium-activated potassium channel subunit alpha-1T66538SwissTargetPrediction
    P08236GUSBBeta-glucuronidaseT96413SwissTargetPrediction
    P51812RPS6KA3Ribosomal protein S6 kinase alpha 3T03279SwissTargetPrediction
    Q9NPH5NOX4NADPH oxidase 4T29741SwissTargetPrediction
    O00408PDE2APhosphodiesterase 2AT77400SwissTargetPrediction
    P19525EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinaseT04831SwissTargetPrediction
    P08631HCKTyrosine-protein kinase HCKT31406SwissTargetPrediction
    Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SwissTargetPrediction
    Q9HCP0CSNK1G1Casein kinase I gamma 1T41702SwissTargetPrediction
    Q15418RPS6KA1Ribosomal protein S6 kinase alpha 1T83202SwissTargetPrediction
    Q9UBF8PI4KBPI4-kinase beta subunitT12541SwissTargetPrediction
    P29323EPHB2Ephrin type-B receptor 2T73756SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SwissTargetPrediction
    P17612PRKACAcAMP-dependent protein kinase alpha-catalytic subunitT12808SwissTargetPrediction
    Q16678CYP1B1Cytochrome P450 1B1T92521SwissTargetPrediction
    P29320EPHA3Ephrin type-A receptor 3T28413SwissTargetPrediction
    P30281CCND3Cyclin-dependent kinase 4/cyclin DT72507SwissTargetPrediction
    Q9BUB5MKNK1MAP kinase-interacting serine/threonine-protein kinase MNK1T97136SwissTargetPrediction
    P63316TNNC1Troponin, cardiac muscleT12966SwissTargetPrediction
    P37173TGFBR2TGF-beta receptor type IIT49989SwissTargetPrediction
    P00740F9Coagulation factor IXT83369SwissTargetPrediction
    P51843NR0B1Orphan nuclear receptor DAX-1T23191SEA
    Q02880TOP2BDNA topoisomerase II betaT85733SEA
    H3BPQ1TCF4Transcription factor 7-like 2T54646SEA
    Q9GZT9EGLN1Egl nine homolog 1T32880SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
    T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T53904DI0010Acute disease anaemia[ICD-11: 3A90]Q96KS0EIT6
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T05031DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42338PIK3CB
    T19244DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P11712CYP2C9
    T37848DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P08684CYP3A4
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T83904DI0365Retinopathy[ICD-11: 9B71]Q8IXJ6SIRT2
    T83813DI0117Depression[ICD-11: 6A70-6A7Z]P28335HTR2C
    T83813DI0264Migraine[ICD-11: 8A80]P28335HTR2C
    T83813DI0308Obesity[ICD-11: 5B80-5B81]P28335HTR2C
    T83813DI0324Pain[ICD-11: MG30-MG3Z]P28335HTR2C
    T83813DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28335HTR2C
    T99524DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q96RJ0TAAR1
    T99524DI0149Focal/segmental autonomic disorder[ICD-11: 8D8A]Q96RJ0TAAR1
    T99524DI0290Narcolepsy[ICD-11: 7A20]Q96RJ0TAAR1
    T60631DI0095Colorectal cancer[ICD-11: 2B91]P07949RET
    T60631DI0238Lung cancer[ICD-11: 2C25]P07949RET
    T60631DI0250Mature B-cell lymphoma[ICD-11: 2A85]P07949RET
    T60631DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P07949RET
    T60631DI0403Thrombocytopenia[ICD-11: 3B64]P07949RET
    T60631DI0407Thyroid cancer[ICD-11: 2D10]P07949RET
    T55959DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q01959SLC6A3
    T55959DI0051Bipolar disorder[ICD-11: 6A60]Q01959SLC6A3
    T55959DI0101Corneal disease[ICD-11: 9A76-9A78]Q01959SLC6A3
    T55959DI0290Narcolepsy[ICD-11: 7A20]Q01959SLC6A3
    T55959DI0308Obesity[ICD-11: 5B80-5B81]Q01959SLC6A3
    T55959DI0331Parkinsonism[ICD-11: 8A00]Q01959SLC6A3
    T26623DI0298Neuropathy[ICD-11: 8C0Z]P15121AKR1B1
    T26623DI0366Rheumatoid arthritis[ICD-11: FA20]P15121AKR1B1
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T21307DI0011Acute laryngitis/tracheitis[ICD-11: CA05]P49137MAPKAPK2
    T21307DI0181Hidradenitis suppurativa[ICD-11: ED92]P49137MAPKAPK2
    T21307DI0269Monogenic autoinflammatory syndrome[ICD-11: 4A60]P49137MAPKAPK2
    T21307DI0334Peritoneal cancer[ICD-11: 2C51]P49137MAPKAPK2
    T21307DI0352Psoriatic arthritis[ICD-11: FA21]P49137MAPKAPK2
    T21307DI0366Rheumatoid arthritis[ICD-11: FA20]P49137MAPKAPK2
    T21307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49137MAPKAPK2
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T41955DI0422Upper respiratory tract disorder[ICD-11: CA0Z]Q7Z2W7TRPM8
    T39977DI0403Thrombocytopenia[ICD-11: 3B64]P14174MIF
    T81443DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]O00206TLR4
    T81443DI0346Prostate cancer[ICD-11: 2C82]O00206TLR4
    T81443DI0375Sepsis[ICD-11: 1G40-1G41]O00206TLR4
    T21945DI0013Acute pain[ICD-11: MG31]P23975SLC6A2
    T21945DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P23975SLC6A2
    T21945DI0087Chronic pain[ICD-11: MG30]P23975SLC6A2
    T21945DI0101Corneal disease[ICD-11: 9A76-9A78]P23975SLC6A2
    T21945DI0117Depression[ICD-11: 6A70-6A7Z]P23975SLC6A2
    T21945DI0166Glaucoma[ICD-11: 9C61]P23975SLC6A2
    T21945DI0264Migraine[ICD-11: 8A80]P23975SLC6A2
    T21945DI0301Nicotine use disorder[ICD-11: 6C4A]P23975SLC6A2
    T21945DI0308Obesity[ICD-11: 5B80-5B81]P23975SLC6A2
    T21945DI0324Pain[ICD-11: MG30-MG3Z]P23975SLC6A2
    T21945DI0395Stomach cancer[ICD-11: 2B72]P23975SLC6A2
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T49507DI0060Brain cancer[ICD-11: 2A00]P54760EPHB4
    T49507DI0111Cystic/dysplastic kidney disease[ICD-11: GB8Y]P54760EPHB4
    T49507DI0238Lung cancer[ICD-11: 2C25]P54760EPHB4
    T49507DI0261Metastatic meninges neoplasm[ICD-11: 2D51]P54760EPHB4
    T49507DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P54760EPHB4
    T20891DI0241Lymphoma[ICD-11: 2A80-2A86]Q15118PDK1
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T63505DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00519ABL1
    T63505DI0220Ischemia[ICD-11: 8B10-8B11]P00519ABL1
    T63505DI0250Mature B-cell lymphoma[ICD-11: 2A85]P00519ABL1
    T63505DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00519ABL1
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
    T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
    T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
    T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
    T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
    T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
    T07279DI0274Multiple myeloma[ICD-11: 2A83]Q9P1W9PIM2
    T07279DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9P1W9PIM2
    T79031DI0025Alzheimer disease[ICD-11: 8A20]P56817BACE1
    T46245DI0115Dementia[ICD-11: 6D80-6D8Z]Q16769QPCT
    T84486DI0009Acute diabete complication[ICD-11: 5A2Y]P30559OXTR
    T84486DI0041Autism spectrum disorder[ICD-11: 6A02]P30559OXTR
    T84486DI0340Postpartum haemorrhage[ICD-11: JA43]P30559OXTR
    T84631DI0053Blood-forming organ disease[ICD-11: 3C0Z]P00742F10
    T84631DI0080Christmas disease[ICD-11: 3B11]P00742F10
    T84631DI0091Coagulation defect[ICD-11: 3B10]P00742F10
    T84631DI0103Coronary thrombosis[ICD-11: BA43]P00742F10
    T84631DI0114Deep vein thrombosis[ICD-11: BD71]P00742F10
    T84631DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P00742F10
    T84631DI0405Thrombosis[ICD-11: DB61-GB90]P00742F10
    T84631DI0433Venous thromboembolism[ICD-11: BD72]P00742F10
    T86052DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]O14746TERT
    T86052DI0284Myelodysplastic syndrome[ICD-11: 2A37]O14746TERT
    T86052DI0326Pancreatic cancer[ICD-11: 2C10]O14746TERT
    T01003DI0062Breast cancer[ICD-11: 2C60-2C6Y]O75460ERN1
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T96623DI0062Breast cancer[ICD-11: 2C60-2C6Y]P08238HSP90AB1
    T96623DI0238Lung cancer[ICD-11: 2C25]P08238HSP90AB1
    T96623DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P08238HSP90AB1
    T96623DI0249Mature B-cell leukaemia[ICD-11: 2A82]P08238HSP90AB1
    T96623DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P08238HSP90AB1
    T96623DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P08238HSP90AB1
    T96623DI0395Stomach cancer[ICD-11: 2B72]P08238HSP90AB1
    T18477DI0015Acute upper respiratory infection[ICD-11: CA07]P07900HSP90AA1
    T18477DI0037Asthma[ICD-11: CA23]P07900HSP90AA1
    T60182DI0193Hypo-glycaemia[ICD-11: 5A41]P47871GCGR
    T15068DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q05397PTK2
    T15068DI0321Ovarian cancer[ICD-11: 2C73]Q05397PTK2
    T15068DI0326Pancreatic cancer[ICD-11: 2C10]Q05397PTK2
    T15068DI0334Peritoneal cancer[ICD-11: 2C51]Q05397PTK2
    T15068DI0356Pulmonary hypertension[ICD-11: BB01]Q05397PTK2
    T15068DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q05397PTK2
    T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
    T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
    T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
    T99057DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q02750MAP2K1
    T99057DI0336Phakomatoses/hamartoneoplastic syndrome[ICD-11: LD2D]Q02750MAP2K1
    T67849DI0151Follicular lymphoma[ICD-11: 2A80]O00329PIK3CD
    T67849DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00329PIK3CD
    T67849DI0249Mature B-cell leukaemia[ICD-11: 2A82]O00329PIK3CD
    T67849DI0250Mature B-cell lymphoma[ICD-11: 2A85]O00329PIK3CD
    T67849DI0395Stomach cancer[ICD-11: 2B72]O00329PIK3CD
    T09538DI0164Genetic prion disease[ICD-11: 8E02]P05186ALPL
    T09538DI0330Parasitic infection[ICD-11: 1D0Y-1G2Z]P05186ALPL
    T92803DI0113Cytomegaloviral disease[ICD-11: 1D82]Q13627DYRK1A
    T29130DI0351Psoriasis[ICD-11: EA90]P40763STAT3
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T14731DI0366Rheumatoid arthritis[ICD-11: FA20]Q96EB6SIRT1
    T14731DI0399Systemic sclerosis[ICD-11: 4A42]Q96EB6SIRT1
    T14731DI0431Vasculitis[ICD-11: 4A44]Q96EB6SIRT1
    T23499DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25101EDNRA
    T23499DI0356Pulmonary hypertension[ICD-11: BB01]P25101EDNRA
    T23499DI0425Urinary system clinical symptom[ICD-11: MF8Y]P25101EDNRA
    T45262DI0394Staphylococcal/streptococcal disease[ICD-11: 1B5Y]P34998CRHR1
    T01280DI0425Urinary system clinical symptom[ICD-11: MF8Y]Q9Y5Z0BACE2
    T61400DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q02127DHODH
    T61400DI0275Multiple sclerosis[ICD-11: 8A40]Q02127DHODH
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T07663DI0190Hypertension[ICD-11: BA00-BA04]O76074PDE5A
    T07663DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]O76074PDE5A
    T07663DI0378Sexual dysfunction[ICD-11: HA00-HA01]O76074PDE5A
    T07663DI0411Tonus and reflex abnormality[ICD-11: MB47]O76074PDE5A
    T40111DI0062Breast cancer[ICD-11: 2C60-2C6Y]P20839IMPDH1
    T40111DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P20839IMPDH1
    T40111DI0250Mature B-cell lymphoma[ICD-11: 2A85]P20839IMPDH1
    T40111DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P20839IMPDH1
    T40111DI0413Transplant rejection[ICD-11: NE84]P20839IMPDH1
    T81735DI0360Rectum cancer[ICD-11: 2B92]P78527PRKDC
    T81735DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P78527PRKDC
    T51883DI0252Melanoma[ICD-11: 2C30]P04049RAF1
    T51883DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04049RAF1
    T51883DI0321Ovarian cancer[ICD-11: 2C73]P04049RAF1
    T51883DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04049RAF1
    T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
    T46781DI0009Acute diabete complication[ICD-11: 5A2Y]Q96GD4AURKB
    T46781DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q96GD4AURKB
    T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
    T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
    T92687DI0161Gastro-oesophageal reflux disease[ICD-11: DA22]P51164ATP4B
    T92687DI0176Helicobacter infection[ICD-11: DA42-DA63]P51164ATP4B
    T92687DI0312Oesophageal ulcer[ICD-11: DA25]P51164ATP4B
    T92687DI0333Peptic ulcer[ICD-11: DA61]P51164ATP4B
    T66538DI0037Asthma[ICD-11: CA23]Q12791KCNMA1
    T66538DI0154Functional bladder disorder[ICD-11: GC50]Q12791KCNMA1
    T96413DI0242Lysosomal disease[ICD-11: 5C56]P08236GUSB
    T03279DI0249Mature B-cell leukaemia[ICD-11: 2A82]P51812RPS6KA3
    T29741DI0146Fibrosis[ICD-11: GA14-GC01]Q9NPH5NOX4
    T77400DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]O00408PDE2A
    T77400DI0207Indeterminate colitis[ICD-11: DD72]O00408PDE2A
    T77400DI0218Irritable bowel syndrome[ICD-11: DD91]O00408PDE2A
    T77400DI0270Mood disorder[ICD-11: 6A60-6E23]O00408PDE2A
    T31406DI0207Indeterminate colitis[ICD-11: DD72]P08631HCK
    T83202DI0249Mature B-cell leukaemia[ICD-11: 2A82]Q15418RPS6KA1
    T12541DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]Q9UBF8PI4KB
    T12541DI0440Zoonotic viral diseaseICD-11: 1D6YQ9UBF8PI4KB
    T73756DI0225Kaposi sarcoma[ICD-11: 2B57]P29323EPHB2
    T73756DI0252Melanoma[ICD-11: 2C30]P29323EPHB2
    T73756DI0326Pancreatic cancer[ICD-11: 2C10]P29323EPHB2
    T73756DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29323EPHB2
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T12808DI0279Muscular atrophy[ICD-11: 8B61]P17612PRKACA
    T28413DI0012Acute myeloid leukaemia[ICD-11: 2A60]P29320EPHA3
    T28413DI0060Brain cancer[ICD-11: 2A00]P29320EPHA3
    T28413DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P29320EPHA3
    T28413DI0284Myelodysplastic syndrome[ICD-11: 2A37]P29320EPHA3
    T97136DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9BUB5MKNK1
    T97136DI0095Colorectal cancer[ICD-11: 2B91]Q9BUB5MKNK1
    T97136DI0235Liver cancer[ICD-11: 2C12]Q9BUB5MKNK1
    T97136DI0241Lymphoma[ICD-11: 2A80-2A86]Q9BUB5MKNK1
    T97136DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BUB5MKNK1
    T12966DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P63316TNNC1
    T12966DI0175Heart failure[ICD-11: BD10-BD1Z]P63316TNNC1
    T49989DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P37173TGFBR2
    T83369DI0052Bleeding disorder[ICD-11: GA20-GA21]P00740F9
    T83369DI0091Coagulation defect[ICD-11: 3B10]P00740F9
    T85733DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q02880TOP2B
    T85733DI0076Chemoprotection[ICD-11: N.A.]Q02880TOP2B

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