Alstophyllal



Compound IDCDAMM00506
Common nameAlstophyllal
IUPAC name6-methoxy-3,16,20-trimethyl-15-oxa-3,20-diazapentacyclo[10.7.1.02,10.04,9.013,18]icosa-2(10),4(9),5,7,16-pentaene-17-carbaldehyde
Molecular formulaC22H26N2O3

Experimental data

Retention time10.99
Adduct[M+Na]+
Actual mz389.183
Theoretical mz389.183
Error1.59
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.0475

Identifiers and class information

Inchi keyOKOHMBRGHIAYBH-ZTHXDYBINA-N
SmilesO=CC1=C(OCC2C1CC3C4=C(C=5C=CC(OC)=CC5N4C)CC2N3C)C
SuperclassAlkaloids and derivatives
ClassMacroline alkaloids

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)2
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)1
    Molecular weight (mol_MW)366.459
    Computed dipole moment(dipole)1.974
    Total solvent accessible surface area (SASA)618.924
    Hydrophobic component of SASA (FOSA)449.478
    Hydrophilic component of SASA (FISA)62.599
    Pie component of the SASA (PISA)106.848
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1141.11
    Number of hydrogen bond donors (donorHB)0
    Number of hydrogen bond acceptors (accptHB)5.5
    Free energy of solvation of dipole (dip^2/V)0.0034135
    Index of cohesive interaction in solids (ACxDN^.5/SA)0
    Globularity descriptor (glob)0.853256
    Predicted polarizability in cubic angstroms (QPpolrz)39.249
    Predicted hexadecane/gas partition coefficient (QPlogPC16)10.034
    Predicted octanol/gas partition coefficient (QPlogPoct)15.552
    Predicted water/gas partition coefficient (QPlogPw)7.338
    Predicted octanol/water partition coefficient (QPlogPo/w)3.226
    Predicted aqueous solubility (QPlogS)-3.521
    Conformation-independent predicted aqueous solubility (CIQPlogS)-4.001
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.142
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)629.765
    Predicted brain/blood partition coefficient (QPlogBB)0.268
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)332.021
    Predicted skin permeability, log Kp (QPlogKp)-4.167
    PM3 calculated ionization potential (IP(ev))8.112
    PM3 calculated electron affinity (EA(eV))0.111
    Number of likely metabolic reactions (#metab)6
    Prediction of binding to human serum albumin (QPlogKhsa)0.374
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)95.935
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)58.081
    Number of nitrogen and oxygen atoms (#NandO)5
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P34903GABRA3GABA A receptor alpha-3/beta-2/gamma-2T62292SwissTargetPrediction
    P47869GABRA2GABA A receptor alpha-2/beta-2/gamma-2T51452SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P21917DRD4Dopamine D4 receptorT24983SwissTargetPrediction
    P21397MAOAMonoamine oxidase AT83875SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P16083NQO2Quinone reductase 2T75498SwissTargetPrediction
    P14416DRD2Dopamine D2 receptorT67162SwissTargetPrediction
    P13866SLC5A1Sodium/glucose cotransporter 1T54771SwissTargetPrediction
    Q02083NAAAN-acylsphingosine-amidohydrolase (by homology)T78326SwissTargetPrediction
    P28223HTR2ASerotonin 2a (5-HT2a) receptorT32060SwissTargetPrediction
    P08913ADRA2AAlpha-2a adrenergic receptorT11448SwissTargetPrediction
    P08908HTR1ASerotonin 1a (5-HT1a) receptorT78709SwissTargetPrediction
    P50406HTR6Serotonin 6 (5-HT6) receptorT16691SwissTargetPrediction
    P14867GABRA1GABA-A receptor; alpha-1/beta-2/gamma-2T51487SwissTargetPrediction
    P15538CYP11B1Cytochrome P450 11B1T84621SwissTargetPrediction
    P19099CYP11B2Cytochrome P450 11B2T59056SwissTargetPrediction
    P07384CAPN1Calpain 1T92517SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    O60885BRD4Bromodomain-containing protein 4T00407SwissTargetPrediction
    P25440BRD2Bromodomain-containing protein 2T86597SwissTargetPrediction
    O00519FAAHAnandamide amidohydrolaseT11754SwissTargetPrediction
    P08235NR3C2Mineralocorticoid receptorT72168SwissTargetPrediction
    P11511CYP19A1Cytochrome P450 19A1T13260SwissTargetPrediction
    P51681CCR5C-C chemokine receptor type 5T09960SwissTargetPrediction
    P07339CTSDCathepsin DT67102SwissTargetPrediction
    Q9H3N8HRH4Histamine H4 receptorT26500SwissTargetPrediction
    P28845HSD11B111-beta-hydroxysteroid dehydrogenase 1T65200SwissTargetPrediction
    Q8TDU6GPBAR1G-protein coupled bile acid receptor 1T86273SwissTargetPrediction
    Q13133NR1H3LXR-alphaT52297SwissTargetPrediction
    P35462DRD3Dopamine D3 receptorT02551SwissTargetPrediction
    P18825ADRA2CAdrenergic receptor alpha-2T01777SwissTargetPrediction
    P08183ABCB1P-glycoprotein 1T25258SwissTargetPrediction
    P35372OPRM1Mu opioid receptorT47768SwissTargetPrediction
    Q9H2K2TNKS2Tankyrase-2T38087SwissTargetPrediction
    O95271TNKSTankyrase-1T83059SwissTargetPrediction
    P00519ABL1Tyrosine-protein kinase ABLT63505SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    Q16539MAPK14MAP kinase p38 alphaT65864SwissTargetPrediction
    P36888FLT3Tyrosine-protein kinase receptor FLT3T74312SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    Q9Y233PDE10APhosphodiesterase 10A (by homology)T84133SwissTargetPrediction
    P49327FASNFatty acid synthaseT16514SwissTargetPrediction
    P07711CTSLCathepsin LT98691SwissTargetPrediction
    P07858CTSBCathepsin (B and K)T61746SwissTargetPrediction
    P41143OPRD1Delta opioid receptorT58992SwissTargetPrediction
    P23946CMA1ChymaseT05114SwissTargetPrediction
    P62942FKBP1AFK506-binding protein 1AT76059SwissTargetPrediction
    Q08499PDE4DPhosphodiesterase 4DT02001SwissTargetPrediction
    Q96S37SLC22A12Solute carrier family 22 member 12T86057SwissTargetPrediction
    P49356FNTBFarnesyl protein transferaseT13127SwissTargetPrediction
    P80365HSD11B211-beta-hydroxysteroid dehydrogenase 2T43721SwissTargetPrediction
    P13500CCL2C-C motif chemokine 2T89988SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    P32246CCR1C-C chemokine receptor type 1T16016SwissTargetPrediction
    Q15858SCN9ASodium channel protein type IX alpha subunitT12119SwissTargetPrediction
    Q14432PDE3APhosphodiesterase 3T88975SwissTargetPrediction
    Q99572P2RX7P2X purinoceptor 7T63414SwissTargetPrediction
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    P25098GRK2G-protein coupled receptor kinase 2T62548SwissTargetPrediction
    P34947GRK5G protein-coupled receptor kinase 5T69612SwissTargetPrediction
    P24385CCND1Cyclin-dependent kinase 4/cyclin D1T12355SwissTargetPrediction
    P18089ADRA2BAlpha-2b adrenergic receptorT41580SwissTargetPrediction
    Q9UGL1KDM5BLysine-specific demethylase 5BT56871SwissTargetPrediction
    P31644GABRA5GABA receptor alpha-5 subunitT26368SwissTargetPrediction
    P07333CSF1RMacrophage colony stimulating factor receptorT20333SwissTargetPrediction
    P49840GSK3AGlycogen synthase kinase-3 alphaT76910SwissTargetPrediction
    P50750CDK9Cyclin-dependent kinase 9T44458SwissTargetPrediction
    Q12908SLC10A2Ileal bile acid transporterT24982SwissTargetPrediction
    P34998CRHR1Corticotropin releasing factor receptor 1 (by homology)T45262SwissTargetPrediction
    P49336CDK8Cell division protein kinase 8T10822SwissTargetPrediction
    Q00987MDM2p53-binding protein Mdm-2T00176SwissTargetPrediction
    Q08881ITKTyrosine-protein kinase ITK/TSKT77537SwissTargetPrediction
    Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SwissTargetPrediction
    O43614HCRTR2Orexin receptor 2T69485SwissTargetPrediction
    O43613HCRTR1Orexin receptor 1T73482SwissTargetPrediction
    Q02763TEKTyrosine-protein kinase TIE-2T92144SwissTargetPrediction
    P22460KCNA5Voltage-gated potassium channel subunit Kv1.5T17569SwissTargetPrediction
    P22001KCNA3Voltage-gated potassium channel subunit Kv1.3T76914SwissTargetPrediction
    Q13370PDE3BPhosphodiesterase 3BT21357SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SwissTargetPrediction
    P20248CCNA2CDK2/Cyclin AT58470SwissTargetPrediction
    P05129PRKCGProtein kinase C gammaT47107SwissTargetPrediction
    Q9NRA0SPHK2Sphingosine kinase 2T31989SwissTargetPrediction
    P55055NR1H2LXR-betaT13714SwissTargetPrediction
    P33316DUTdUTP pyrophosphataseT39054SwissTargetPrediction
    Q99814EPAS1Endothelial PAS domain-containing protein 1T21123SwissTargetPrediction
    P18507GABRG2GABA-A receptor; alpha-6/beta-3/gamma-2T08910SwissTargetPrediction
    Q6DWJ6GPR139Probable G-protein coupled receptor 139T84439SwissTargetPrediction
    P08311CTSGCathepsin GT86385SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T62292DI0216Intentional self-harm[ICD-11: PC91]P34903GABRA3
    T51452DI0216Intentional self-harm[ICD-11: PC91]P47869GABRA2
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T24983DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21917DRD4
    T24983DI0370Schizophrenia[ICD-11: 6A20]P21917DRD4
    T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
    T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T75498DI0214Insomnia[ICD-11: 7A00-7A0Z]P16083NQO2
    T67162DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P14416DRD2
    T67162DI0025Alzheimer disease[ICD-11: 8A20]P14416DRD2
    T67162DI0037Asthma[ICD-11: CA23]P14416DRD2
    T67162DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P14416DRD2
    T67162DI0051Bipolar disorder[ICD-11: 6A60]P14416DRD2
    T67162DI0063Breathing abnormality[ICD-11: MD11]P14416DRD2
    T67162DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P14416DRD2
    T67162DI0073Cerebral ischaemia[ICD-11: 8B1Z]P14416DRD2
    T67162DI0117Depression[ICD-11: 6A70-6A7Z]P14416DRD2
    T67162DI0124Digestive system disease[ICD-11: DE2Z]P14416DRD2
    T67162DI0137Essential hypertension[ICD-11: BA00]P14416DRD2
    T67162DI0142Faecal incontinence[ICD-11: ME07]P14416DRD2
    T67162DI0156Gangrene[ICD-11: MC85]P14416DRD2
    T67162DI0166Glaucoma[ICD-11: 9C61]P14416DRD2
    T67162DI0175Heart failure[ICD-11: BD10-BD1Z]P14416DRD2
    T67162DI0185Hyperaemia[ICD-11: 9A61-9B7Y]P14416DRD2
    T67162DI0190Hypertension[ICD-11: BA00-BA04]P14416DRD2
    T67162DI0196Hypotension[ICD-11: BA20-BA21]P14416DRD2
    T67162DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]P14416DRD2
    T67162DI0214Insomnia[ICD-11: 7A00-7A0Z]P14416DRD2
    T67162DI0222Itching[ICD-11: 1F28-1G07]P14416DRD2
    T67162DI0264Migraine[ICD-11: 8A80]P14416DRD2
    T67162DI0293Nausea/vomiting[ICD-11: MD90]P14416DRD2
    T67162DI0324Pain[ICD-11: MG30-MG3Z]P14416DRD2
    T67162DI0331Parkinsonism[ICD-11: 8A00]P14416DRD2
    T67162DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P14416DRD2
    T67162DI0340Postpartum haemorrhage[ICD-11: JA43]P14416DRD2
    T67162DI0354Psychotic disorder[ICD-11: 6A20-6A25]P14416DRD2
    T67162DI0356Pulmonary hypertension[ICD-11: BB01]P14416DRD2
    T67162DI0370Schizophrenia[ICD-11: 6A20]P14416DRD2
    T67162DI0396Substance abuse[ICD-11: 6C40]P14416DRD2
    T67162DI0408Thyrotoxicosis[ICD-11: 5A02]P14416DRD2
    T67162DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14416DRD2
    T54771DI0120Diabetes mellitus[ICD-11: 5A10]P13866SLC5A1
    T54771DI0175Heart failure[ICD-11: BD10-BD1Z]P13866SLC5A1
    T54771DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P13866SLC5A1
    T32060DI0009Acute diabete complication[ICD-11: 5A2Y]P28223HTR2A
    T32060DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P28223HTR2A
    T32060DI0073Cerebral ischaemia[ICD-11: 8B1Z]P28223HTR2A
    T32060DI0270Mood disorder[ICD-11: 6A60-6E23]P28223HTR2A
    T32060DI0331Parkinsonism[ICD-11: 8A00]P28223HTR2A
    T32060DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28223HTR2A
    T32060DI0370Schizophrenia[ICD-11: 6A20]P28223HTR2A
    T11448DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P08913ADRA2A
    T11448DI0317Opioid use disorder[ICD-11: 6C43]P08913ADRA2A
    T11448DI0396Substance abuse[ICD-11: 6C40]P08913ADRA2A
    T78709DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P08908HTR1A
    T78709DI0117Depression[ICD-11: 6A70-6A7Z]P08908HTR1A
    T78709DI0190Hypertension[ICD-11: BA00-BA04]P08908HTR1A
    T78709DI0264Migraine[ICD-11: 8A80]P08908HTR1A
    T78709DI0270Mood disorder[ICD-11: 6A60-6E23]P08908HTR1A
    T16691DI0025Alzheimer disease[ICD-11: 8A20]P50406HTR6
    T16691DI0370Schizophrenia[ICD-11: 6A20]P50406HTR6
    T51487DI0014Acute respiratory distress syndrome[ICD-11: CB00]P14867GABRA1
    T51487DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P14867GABRA1
    T51487DI0082Chronic insomnia[ICD-11: 7A00]P14867GABRA1
    T51487DI0087Chronic pain[ICD-11: MG30]P14867GABRA1
    T51487DI0101Corneal disease[ICD-11: 9A76-9A78]P14867GABRA1
    T51487DI0112Cystitis[ICD-11: GC00]P14867GABRA1
    T51487DI0117Depression[ICD-11: 6A70-6A7Z]P14867GABRA1
    T51487DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P14867GABRA1
    T51487DI0173Headache[ICD-11: 8A80-8A84]P14867GABRA1
    T51487DI0214Insomnia[ICD-11: 7A00-7A0Z]P14867GABRA1
    T51487DI0243Malaria[ICD-11: 1F40-1F45]P14867GABRA1
    T51487DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P14867GABRA1
    T51487DI0411Tonus and reflex abnormality[ICD-11: MB47]P14867GABRA1
    T84621DI0062Breast cancer[ICD-11: 2C60-2C6Y]P15538CYP11B1
    T84621DI0108Cushing syndrome[ICD-11: 5A70]P15538CYP11B1
    T59056DI0190Hypertension[ICD-11: BA00-BA04]P19099CYP11B2
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T86597DI0106COVID-19[ICD-11: 1D6Y]P25440BRD2
    T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
    T72168DI0018Adrenocortical insufficiency[ICD-11: 5A74]P08235NR3C2
    T72168DI0083Chronic kidney disease[ICD-11: GB61]P08235NR3C2
    T72168DI0100Contraceptive management[ICD-11: QA21]P08235NR3C2
    T72168DI0175Heart failure[ICD-11: BD10-BD1Z]P08235NR3C2
    T72168DI0190Hypertension[ICD-11: BA00-BA04]P08235NR3C2
    T72168DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P08235NR3C2
    T13260DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11511CYP19A1
    T13260DI0108Cushing syndrome[ICD-11: 5A70]P11511CYP19A1
    T09960DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P51681CCR5
    T67102DI0275Multiple sclerosis[ICD-11: 8A40]P07339CTSD
    T26500DI0037Asthma[ICD-11: CA23]Q9H3N8HRH4
    T26500DI0039Atopic eczema[ICD-11: EA80]Q9H3N8HRH4
    T26500DI0351Psoriasis[ICD-11: EA90]Q9H3N8HRH4
    T26500DI0366Rheumatoid arthritis[ICD-11: FA20]Q9H3N8HRH4
    T26500DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q9H3N8HRH4
    T65200DI0210Influenza[ICD-11: 1E30-1E32]P28845HSD11B1
    T65200DI0239Lupus erythematosus[ICD-11: 4A40]P28845HSD11B1
    T65200DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P28845HSD11B1
    T86273DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q8TDU6GPBAR1
    T52297DI0117Depression[ICD-11: 6A70-6A7Z]Q13133NR1H3
    T02551DI0051Bipolar disorder[ICD-11: 6A60]P35462DRD3
    T02551DI0331Parkinsonism[ICD-11: 8A00]P35462DRD3
    T01777DI0166Glaucoma[ICD-11: 9C61]P18825ADRA2C
    T01777DI0190Hypertension[ICD-11: BA00-BA04]P18825ADRA2C
    T01777DI0196Hypotension[ICD-11: BA20-BA21]P18825ADRA2C
    T01777DI0308Obesity[ICD-11: 5B80-5B81]P18825ADRA2C
    T01777DI0310Ocular disease[ICD-11: N.A.]P18825ADRA2C
    T01777DI0396Substance abuse[ICD-11: 6C40]P18825ADRA2C
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
    T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
    T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
    T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
    T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
    T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
    T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
    T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
    T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
    T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
    T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
    T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
    T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
    T38087DI0321Ovarian cancer[ICD-11: 2C73]Q9H2K2TNKS2
    T83059DI0060Brain cancer[ICD-11: 2A00]O95271TNKS
    T83059DI0062Breast cancer[ICD-11: 2C60-2C6Y]O95271TNKS
    T83059DI0321Ovarian cancer[ICD-11: 2C73]O95271TNKS
    T83059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O95271TNKS
    T63505DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00519ABL1
    T63505DI0220Ischemia[ICD-11: 8B10-8B11]P00519ABL1
    T63505DI0250Mature B-cell lymphoma[ICD-11: 2A85]P00519ABL1
    T63505DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00519ABL1
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T65864DI0102Coronary atherosclerosis[ICD-11: BA52]Q16539MAPK14
    T65864DI0287Myocardial infarction[ICD-11: BA41-BA43]Q16539MAPK14
    T65864DI0366Rheumatoid arthritis[ICD-11: FA20]Q16539MAPK14
    T65864DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]Q16539MAPK14
    T74312DI0012Acute myeloid leukaemia[ICD-11: 2A60]P36888FLT3
    T74312DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P36888FLT3
    T74312DI0095Colorectal cancer[ICD-11: 2B91]P36888FLT3
    T74312DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P36888FLT3
    T74312DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P36888FLT3
    T74312DI0248Mastocytosis[ICD-11: 2A21]P36888FLT3
    T74312DI0250Mature B-cell lymphoma[ICD-11: 2A85]P36888FLT3
    T74312DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P36888FLT3
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T84133DI0079Choreiform disorder[ICD-11: 8A01]Q9Y233PDE10A
    T84133DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q9Y233PDE10A
    T84133DI0218Irritable bowel syndrome[ICD-11: DD91]Q9Y233PDE10A
    T84133DI0370Schizophrenia[ICD-11: 6A20]Q9Y233PDE10A
    T84133DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9Y233PDE10A
    T16514DI0096concerning food/fluid intake symptom[ICD-11: MG43]P49327FASN
    T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
    T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
    T61746DI0023Alopecia[ICD-11: ED70]P07858CTSB
    T61746DI0025Alzheimer disease[ICD-11: 8A20]P07858CTSB
    T61746DI0037Asthma[ICD-11: CA23]P07858CTSB
    T61746DI0055Bone cancer[ICD-11: 2B5Z]P07858CTSB
    T61746DI0060Brain cancer[ICD-11: 2A00]P07858CTSB
    T61746DI0067Cardiac arrest[ICD-11: MC82]P07858CTSB
    T61746DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P07858CTSB
    T61746DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07858CTSB
    T61746DI0087Chronic pain[ICD-11: MG30]P07858CTSB
    T61746DI0110Cystic fibrosis[ICD-11: CA25]P07858CTSB
    T61746DI0124Digestive system disease[ICD-11: DE2Z]P07858CTSB
    T61746DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P07858CTSB
    T61746DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P07858CTSB
    T61746DI0253Meningioma[ICD-11: 2A01]P07858CTSB
    T61746DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P07858CTSB
    T61746DI0275Multiple sclerosis[ICD-11: 8A40]P07858CTSB
    T61746DI0296Neurodegenerative disorder[ICD-11: 8A20-8A23]P07858CTSB
    T61746DI0320Osteoarthritis[ICD-11: FA00-FA05]P07858CTSB
    T61746DI0351Psoriasis[ICD-11: EA90]P07858CTSB
    T61746DI0366Rheumatoid arthritis[ICD-11: FA20]P07858CTSB
    T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
    T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
    T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
    T05114DI0039Atopic eczema[ICD-11: EA80]P23946CMA1
    T05114DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P23946CMA1
    T05114DI0169Gram-positive bacterial infection[ICD-11: 1B74-1F40]P23946CMA1
    T05114DI0175Heart failure[ICD-11: BD10-BD1Z]P23946CMA1
    T05114DI0229Left ventricular failure[ICD-11: BD11]P23946CMA1
    T05114DI0287Myocardial infarction[ICD-11: BA41-BA43]P23946CMA1
    T76059DI0331Parkinsonism[ICD-11: 8A00]P62942FKBP1A
    T76059DI0349Pruritus[ICD-11: EC90]P62942FKBP1A
    T76059DI0413Transplant rejection[ICD-11: NE84]P62942FKBP1A
    T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
    T86057DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q96S37SLC22A12
    T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
    T43721DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P80365HSD11B2
    T89988DI0083Chronic kidney disease[ICD-11: GB61]P13500CCL2
    T89988DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P13500CCL2
    T89988DI0087Chronic pain[ICD-11: MG30]P13500CCL2
    T89988DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P13500CCL2
    T89988DI0252Melanoma[ICD-11: 2C30]P13500CCL2
    T89988DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P13500CCL2
    T89988DI0275Multiple sclerosis[ICD-11: 8A40]P13500CCL2
    T89988DI0326Pancreatic cancer[ICD-11: 2C10]P13500CCL2
    T89988DI0366Rheumatoid arthritis[ICD-11: FA20]P13500CCL2
    T89988DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P13500CCL2
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T16016DI0120Diabetes mellitus[ICD-11: 5A10]P32246CCR1
    T16016DI0366Rheumatoid arthritis[ICD-11: FA20]P32246CCR1
    T12119DI0051Bipolar disorder[ICD-11: 6A60]Q15858SCN9A
    T12119DI0087Chronic pain[ICD-11: MG30]Q15858SCN9A
    T12119DI0140Extremities vasodilatation[ICD-11: EG00]Q15858SCN9A
    T12119DI0163General pain disorder[ICD-11: 8E43]Q15858SCN9A
    T12119DI0320Osteoarthritis[ICD-11: FA00-FA05]Q15858SCN9A
    T12119DI0324Pain[ICD-11: MG30-MG3Z]Q15858SCN9A
    T12119DI0358Radiculopathy[ICD-11: 8B93]Q15858SCN9A
    T12119DI0415Trigeminal nerve disorder[ICD-11: 8B82]Q15858SCN9A
    T88975DI0035Arterial occlusive disease[ICD-11: BD40]Q14432PDE3A
    T88975DI0037Asthma[ICD-11: CA23]Q14432PDE3A
    T88975DI0175Heart failure[ICD-11: BD10-BD1Z]Q14432PDE3A
    T88975DI0404Thrombocytosis[ICD-11: 3B63]Q14432PDE3A
    T63414DI0224Joint pain[ICD-11: ME82]Q99572P2RX7
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T12355DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P24385CCND1
    T41580DI0396Substance abuse[ICD-11: 6C40]P18089ADRA2B
    T26368DI0216Intentional self-harm[ICD-11: PC91]P31644GABRA5
    T20333DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P07333CSF1R
    T76910DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P49840GSK3A
    T44458DI0012Acute myeloid leukaemia[ICD-11: 2A60]P50750CDK9
    T44458DI0241Lymphoma[ICD-11: 2A80-2A86]P50750CDK9
    T44458DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P50750CDK9
    T44458DI0249Mature B-cell leukaemia[ICD-11: 2A82]P50750CDK9
    T44458DI0250Mature B-cell lymphoma[ICD-11: 2A85]P50750CDK9
    T44458DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]P50750CDK9
    T44458DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50750CDK9
    T24982DI0349Pruritus[ICD-11: EC90]Q12908SLC10A2
    T45262DI0394Staphylococcal/streptococcal disease[ICD-11: 1B5Y]P34998CRHR1
    T10822DI0012Acute myeloid leukaemia[ICD-11: 2A60]P49336CDK8
    T10822DI0284Myelodysplastic syndrome[ICD-11: 2A37]P49336CDK8
    T00176DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q00987MDM2
    T00176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q00987MDM2
    T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
    T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
    T69485DI0214Insomnia[ICD-11: 7A00-7A0Z]O43614HCRTR2
    T73482DI0117Depression[ICD-11: 6A70-6A7Z]O43613HCRTR1
    T73482DI0214Insomnia[ICD-11: 7A00-7A0Z]O43613HCRTR1
    T73482DI0317Opioid use disorder[ICD-11: 6C43]O43613HCRTR1
    T92144DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q02763TEK
    T92144DI0081Chronic arterial occlusive disease[ICD-11: BD4Z]Q02763TEK
    T92144DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q02763TEK
    T92144DI0286Myeloproliferative neoplasm[ICD-11: 2A20]Q02763TEK
    T92144DI0365Retinopathy[ICD-11: 9B71]Q02763TEK
    T92144DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q02763TEK
    T17569DI0030Angina pectoris[ICD-11: BA40]P22460KCNA5
    T76914DI0198Idiopathic inflammatory myopathy[ICD-11: 4A41]P22001KCNA3
    T76914DI0351Psoriasis[ICD-11: EA90]P22001KCNA3
    T76914DI0352Psoriatic arthritis[ICD-11: FA21]P22001KCNA3
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T58470DI0363Retina cancer[ICD-11: 2D02]P20248CCNA2
    T47107DI0012Acute myeloid leukaemia[ICD-11: 2A60]P05129PRKCG
    T47107DI0248Mastocytosis[ICD-11: 2A21]P05129PRKCG
    T31989DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9NRA0SPHK2
    T13714DI0039Atopic eczema[ICD-11: EA80]P55055NR1H2
    T39054DI0238Lung cancer[ICD-11: 2C25]P33316DUT
    T39054DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P33316DUT
    T21123DI0019Adrenomedullary hyperfunction[ICD-11: 5A75]Q99814EPAS1
    T08910DI0117Depression[ICD-11: 6A70-6A7Z]P18507GABRG2
    T08910DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P18507GABRG2
    T08910DI0411Tonus and reflex abnormality[ICD-11: MB47]P18507GABRG2
    T84439DI0377Sex development malformative disorder[ICD-11: LD2A]Q6DWJ6GPR139
    T86385DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P08311CTSG

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