Piperettine



Compound IDCDAMM00498
Common namePiperettine
IUPAC name7-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylhepta-2,4,6-trien-1-one
Molecular formulaC19H21NO3

Experimental data

Retention time8.87
Adduct[M+Na]+
Actual mz334.138
Theoretical mz334.141
Error9.03
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.404

Identifiers and class information

Inchi keyDLKOUKNODPCIHZ-UMYWTXKFSA-N
SmilesO=C(C=CC=CC=CC1=CC=C2OCOC2=C1)N3CCCCC3
SuperclassOrganoheterocyclic compounds
ClassBenzodioxoles

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)1
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)7
    Number of reactive functional groups (#rtvFG)2
    Predicted central nervous system activity (CNS)0
    Molecular weight (mol_MW)311.38
    Computed dipole moment(dipole)3.569
    Total solvent accessible surface area (SASA)611.821
    Hydrophobic component of SASA (FOSA)364.252
    Hydrophilic component of SASA (FISA)39.775
    Pie component of the SASA (PISA)207.794
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1059.3
    Number of hydrogen bond donors (donorHB)0
    Number of hydrogen bond acceptors (accptHB)4.5
    Free energy of solvation of dipole (dip^2/V)0.0120214
    Index of cohesive interaction in solids (ACxDN^.5/SA)0
    Globularity descriptor (glob)0.821399
    Predicted polarizability in cubic angstroms (QPpolrz)33.729
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.765
    Predicted octanol/gas partition coefficient (QPlogPoct)12.939
    Predicted water/gas partition coefficient (QPlogPw)5.764
    Predicted octanol/water partition coefficient (QPlogPo/w)3.983
    Predicted aqueous solubility (QPlogS)-4.315
    Conformation-independent predicted aqueous solubility (CIQPlogS)-4.109
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.413
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)4156.34
    Predicted brain/blood partition coefficient (QPlogBB)-0.251
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)2307.3
    Predicted skin permeability, log Kp (QPlogKp)-0.848
    PM3 calculated ionization potential (IP(ev))8.566
    PM3 calculated electron affinity (EA(eV))1.049
    Number of likely metabolic reactions (#metab)0
    Prediction of binding to human serum albumin (QPlogKhsa)0.192
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)100
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)47.493
    Number of nitrogen and oxygen atoms (#NandO)4
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    Q99720SIGMAR1Sigma opioid receptorT46360SwissTargetPrediction
    P00734F2ThrombinT94033SwissTargetPrediction
    P06239LCKTyrosine-protein kinase LCKT12499SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    Q9NTG7SIRT3NAD-dependent deacetylase sirtuin 3T91959SwissTargetPrediction
    Q96RI1NR1H4Bile acid receptor FXRT51426SwissTargetPrediction
    P31213SRD5A2Steroid 5-alpha-reductase 2T71390SwissTargetPrediction
    P34913EPHX2Epoxide hydrataseT35734SwissTargetPrediction
    P27338MAOBMonoamine oxidase BT83011SwissTargetPrediction
    O00519FAAHAnandamide amidohydrolaseT11754SwissTargetPrediction
    Q8NER1TRPV1Vanilloid receptorT83193SEA
    P18405SRD5A1Steroid 5-alpha-reductase 1T70309SwissTargetPrediction
    P49137MAPKAPK2MAP kinase-activated protein kinase 2T21307SwissTargetPrediction
    P11474ESRRAEstrogen-related receptor alphaT72841SwissTargetPrediction
    P42345MTORSerine/threonine-protein kinase mTORT75243SwissTargetPrediction
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    P36888FLT3Tyrosine-protein kinase receptor FLT3T74312SwissTargetPrediction
    P11802CDK4Cyclin-dependent kinase 4T85799SwissTargetPrediction
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P49327FASNFatty acid synthaseT16514SwissTargetPrediction
    P08172CHRM2Muscarinic acetylcholine receptor M2T46185SEA
    P07711CTSLCathepsin LT98691SwissTargetPrediction
    P00742F10Thrombin and coagulation factor XT84631SwissTargetPrediction
    Q08499PDE4DPhosphodiesterase 4DT02001SwissTargetPrediction
    P20701ITGALIntercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2T35640SEA
    O75116ROCK2Rho-associated protein kinase 2T06093SwissTargetPrediction
    P31749AKT1Serine/threonine-protein kinase AKTT67619SwissTargetPrediction
    P10276RARARetinoic acid receptor alphaT94085SwissTargetPrediction
    O96017CHEK2Serine/threonine-protein kinase Chk2T28713SwissTargetPrediction
    O15111CHUKInhibitor of NF-kappa-B kinase (IKK)T78429SwissTargetPrediction
    P49810PSEN2Gamma-secretaseT99204SwissTargetPrediction
    P05362ICAM1Intercellular adhesion molecule-1T26203SEA
    P36897TGFBR1TGF-beta receptor type IT53389SwissTargetPrediction
    Q15078CDK5R1Cyclin-dependent kinase 5/CDK5 activator 1T09513SEA
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    P25098GRK2G-protein coupled receptor kinase 2T62548SwissTargetPrediction
    P06756ITGAVVitronectin receptor alphaT67103SwissTargetPrediction
    P09619PDGFRBPlatelet-derived growth factor receptor betaT59102SwissTargetPrediction
    P06493CDK1Cyclin-dependent kinase 1/cyclin B1T49898SwissTargetPrediction
    P04629NTRK1Nerve growth factor receptor Trk-AT07173SwissTargetPrediction
    Q00535CDK5Cyclin-dependent kinase 5/CDK5 activator 1T20973SEA
    O00763ACACBAcetyl-CoA carboxylase 2T08922SwissTargetPrediction
    P19793RXRARetinoid X receptor alpha (by homology)T13726SwissTargetPrediction
    P17936IGFBP3Insulin-like growth factor binding protein 3T33455SEA
    P21453S1PR1Sphingosine 1-phosphate receptor Edg-1T13852SwissTargetPrediction
    Q16602CALCRLCalcitonin gene-related peptide type 1 receptorT02226SwissTargetPrediction
    P27815PDE4APhosphodiesterase 4AT61744SwissTargetPrediction
    P15056BRAFSerine/threonine-protein kinase B-rafT99089SwissTargetPrediction
    O75908SOAT2Acyl coenzyme A:cholesterol acyltransferase 2T14463SwissTargetPrediction
    P03952KLKB1Plasma kallikreinT82739SwissTargetPrediction
    Q96GD4AURKBSerine/threonine-protein kinase Aurora-BT46781SwissTargetPrediction
    P30536TSPOTranslocator protein (by homology)T75440SwissTargetPrediction
    O60344ECE2Endothelin-converting enzyme 2T16799SEA
    P43490NAMPTNicotinamide phosphoribosyltransferaseT54582SwissTargetPrediction
    P25116F2RProteinase-activated receptor 1T36483SwissTargetPrediction
    P51812RPS6KA3Ribosomal protein S6 kinase alpha 3T03279SwissTargetPrediction
    Q92630DYRK2Dual-specificity tyrosine-phosphorylation regulated kinase 2T39486SEA
    Q9UBF8PI4KBPI4-kinase beta subunitT12541SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SwissTargetPrediction
    Q16665HIF1AHypoxia-inducible factor 1 alphaT55610SwissTargetPrediction
    O75907DGAT1Diacylglycerol O-acyltransferase 1T16688SwissTargetPrediction
    Q08493PDE4CPhosphodiesterase 4CT12081SwissTargetPrediction
    P13631RARGRetinoic acid receptor gammaT82146SwissTargetPrediction
    P48443RXRGRetinoid X receptor gammaT46456SwissTargetPrediction
    P10826RARBRetinoic acid receptor betaT61657SwissTargetPrediction
    Q8TDV5GPR119Glucose-dependent insulinotropic receptorT93788SwissTargetPrediction
    P06881CALCACalcitonin gene-related peptide 1T93509SwissTargetPrediction
    P23284PPIBCyclophilin BT25847SwissTargetPrediction
    P32249EBI2EBV-induced G-protein coupled receptor 2T59577SEA
    P51843NR0B1Orphan nuclear receptor DAX-1T23191SEA
    Q15717ELAVL1ELAV-like protein 1T78349SEA
    P05107ITGB2Integrin beta-2T10513SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T94033DI0052Bleeding disorder[ICD-11: GA20-GA21]P00734F2
    T94033DI0091Coagulation defect[ICD-11: 3B10]P00734F2
    T94033DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P00734F2
    T94033DI0275Multiple sclerosis[ICD-11: 8A40]P00734F2
    T94033DI0287Myocardial infarction[ICD-11: BA41-BA43]P00734F2
    T94033DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00734F2
    T94033DI0403Thrombocytopenia[ICD-11: 3B64]P00734F2
    T94033DI0405Thrombosis[ICD-11: DB61-GB90]P00734F2
    T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T51426DI0043Autoimmune liver disease[ICD-11: DB96]Q96RI1NR1H4
    T51426DI0077Cholelithiasis[ICD-11: DC11]Q96RI1NR1H4
    T51426DI0320Osteoarthritis[ICD-11: FA00-FA05]Q96RI1NR1H4
    T71390DI0348Prostate hyperplasia[ICD-11: GA90]P31213SRD5A2
    T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
    T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
    T83011DI0115Dementia[ICD-11: 6D80-6D8Z]P27338MAOB
    T83011DI0117Depression[ICD-11: 6A70-6A7Z]P27338MAOB
    T83011DI0190Hypertension[ICD-11: BA00-BA04]P27338MAOB
    T83011DI0243Malaria[ICD-11: 1F40-1F45]P27338MAOB
    T83011DI0264Migraine[ICD-11: 8A80]P27338MAOB
    T83011DI0331Parkinsonism[ICD-11: 8A00]P27338MAOB
    T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
    T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
    T70309DI0347Prostate disease[ICD-11: GA91]P18405SRD5A1
    T21307DI0011Acute laryngitis/tracheitis[ICD-11: CA05]P49137MAPKAPK2
    T21307DI0181Hidradenitis suppurativa[ICD-11: ED92]P49137MAPKAPK2
    T21307DI0269Monogenic autoinflammatory syndrome[ICD-11: 4A60]P49137MAPKAPK2
    T21307DI0334Peritoneal cancer[ICD-11: 2C51]P49137MAPKAPK2
    T21307DI0352Psoriatic arthritis[ICD-11: FA21]P49137MAPKAPK2
    T21307DI0366Rheumatoid arthritis[ICD-11: FA20]P49137MAPKAPK2
    T21307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49137MAPKAPK2
    T72841DI0366Rheumatoid arthritis[ICD-11: FA20]P11474ESRRA
    T75243DI0036Arteries/arterioles disorder[ICD-11: BD52]P42345MTOR
    T75243DI0085Chronic myelomonocytic leukaemia[ICD-11: 2A40]P42345MTOR
    T75243DI0274Multiple myeloma[ICD-11: 2A83]P42345MTOR
    T75243DI0361Renal cell carcinoma[ICD-11: 2C90]P42345MTOR
    T75243DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P42345MTOR
    T75243DI0413Transplant rejection[ICD-11: NE84]P42345MTOR
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T74312DI0012Acute myeloid leukaemia[ICD-11: 2A60]P36888FLT3
    T74312DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P36888FLT3
    T74312DI0095Colorectal cancer[ICD-11: 2B91]P36888FLT3
    T74312DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P36888FLT3
    T74312DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P36888FLT3
    T74312DI0248Mastocytosis[ICD-11: 2A21]P36888FLT3
    T74312DI0250Mature B-cell lymphoma[ICD-11: 2A85]P36888FLT3
    T74312DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P36888FLT3
    T85799DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11802CDK4
    T85799DI0238Lung cancer[ICD-11: 2C25]P11802CDK4
    T85799DI0351Psoriasis[ICD-11: EA90]P11802CDK4
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T16514DI0096concerning food/fluid intake symptom[ICD-11: MG43]P49327FASN
    T46185DI0037Asthma[ICD-11: CA23]P08172CHRM2
    T46185DI0166Glaucoma[ICD-11: 9C61]P08172CHRM2
    T46185DI0278Muscle disorder[ICD-11: FB32-FB3Z]P08172CHRM2
    T46185DI0333Peptic ulcer[ICD-11: DA61]P08172CHRM2
    T46185DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08172CHRM2
    T46185DI0371Sebaceous gland disorder[ICD-11: ED91]P08172CHRM2
    T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
    T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
    T84631DI0053Blood-forming organ disease[ICD-11: 3C0Z]P00742F10
    T84631DI0080Christmas disease[ICD-11: 3B11]P00742F10
    T84631DI0091Coagulation defect[ICD-11: 3B10]P00742F10
    T84631DI0103Coronary thrombosis[ICD-11: BA43]P00742F10
    T84631DI0114Deep vein thrombosis[ICD-11: BD71]P00742F10
    T84631DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P00742F10
    T84631DI0405Thrombosis[ICD-11: DB61-GB90]P00742F10
    T84631DI0433Venous thromboembolism[ICD-11: BD72]P00742F10
    T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
    T35640DI0351Psoriasis[ICD-11: EA90]P20701ITGAL
    T35640DI0436Visual system disease[ICD-11: 9E1Z]P20701ITGAL
    T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
    T67619DI0062Breast cancer[ICD-11: 2C60-2C6Y]P31749AKT1
    T94085DI0025Alzheimer disease[ICD-11: 8A20]P10276RARA
    T94085DI0251Mature T-cell lymphoma[ICD-11: 2A90]P10276RARA
    T28713DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O96017CHEK2
    T78429DI0250Mature B-cell lymphoma[ICD-11: 2A85]O15111CHUK
    T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
    T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
    T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
    T26203DI0436Visual system disease[ICD-11: 9E1Z]P05362ICAM1
    T53389DI0035Arterial occlusive disease[ICD-11: BD40]P36897TGFBR1
    T53389DI0238Lung cancer[ICD-11: 2C25]P36897TGFBR1
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T67103DI0095Colorectal cancer[ICD-11: 2B91]P06756ITGAV
    T67103DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06756ITGAV
    T59102DI0009Acute diabete complication[ICD-11: 5A2Y]P09619PDGFRB
    T59102DI0361Renal cell carcinoma[ICD-11: 2C90]P09619PDGFRB
    T59102DI0403Thrombocytopenia[ICD-11: 3B64]P09619PDGFRB
    T49898DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06493CDK1
    T49898DI0238Lung cancer[ICD-11: 2C25]P06493CDK1
    T49898DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P06493CDK1
    T49898DI0250Mature B-cell lymphoma[ICD-11: 2A85]P06493CDK1
    T49898DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06493CDK1
    T07173DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04629NTRK1
    T07173DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04629NTRK1
    T20973DI0308Obesity[ICD-11: 5B80-5B81]Q00535CDK5
    T08922DI0417Type 2 diabetes mellitus[ICD-11: 5A11]O00763ACACB
    T13726DI0225Kaposi sarcoma[ICD-11: 2B57]P19793RXRA
    T13726DI0283Mycosis fungoides[ICD-11: 2B01]P19793RXRA
    T33455DI0115Dementia[ICD-11: 6D80-6D8Z]P17936IGFBP3
    T13852DI0275Multiple sclerosis[ICD-11: 8A40]P21453S1PR1
    T13852DI0419Ulcerative colitis[ICD-11: DD71]P21453S1PR1
    T61744DI0037Asthma[ICD-11: CA23]P27815PDE4A
    T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
    T14463DI0017Adrenal cancer[ICD-11: 2D11]O75908SOAT2
    T82739DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P03952KLKB1
    T82739DI0364Retinal vascular occlusion[ICD-11: 9B74]P03952KLKB1
    T46781DI0009Acute diabete complication[ICD-11: 5A2Y]Q96GD4AURKB
    T46781DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q96GD4AURKB
    T75440DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P30536TSPO
    T75440DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P30536TSPO
    T75440DI0214Insomnia[ICD-11: 7A00-7A0Z]P30536TSPO
    T75440DI0216Intentional self-harm[ICD-11: PC91]P30536TSPO
    T75440DI0271Mood/affect symptom[ICD-11: MB24]P30536TSPO
    T75440DI0411Tonus and reflex abnormality[ICD-11: MB47]P30536TSPO
    T54582DI0231Leukaemia[ICD-11: 2A60-2B33]P43490NAMPT
    T54582DI0241Lymphoma[ICD-11: 2A80-2A86]P43490NAMPT
    T54582DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43490NAMPT
    T36483DI0287Myocardial infarction[ICD-11: BA41-BA43]P25116F2R
    T03279DI0249Mature B-cell leukaemia[ICD-11: 2A82]P51812RPS6KA3
    T12541DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]Q9UBF8PI4KB
    T12541DI0440Zoonotic viral diseaseICD-11: 1D6YQ9UBF8PI4KB
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T55610DI0241Lymphoma[ICD-11: 2A80-2A86]Q16665HIF1A
    T55610DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16665HIF1A
    T16688DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]O75907DGAT1
    T82146DI0005Acne vulgaris[ICD-11: ED80]P13631RARG
    T82146DI0012Acute myeloid leukaemia[ICD-11: 2A60]P13631RARG
    T82146DI0225Kaposi sarcoma[ICD-11: 2B57]P13631RARG
    T82146DI0277Muscle calcification/ossification[ICD-11: FB31]P13631RARG
    T82146DI0351Psoriasis[ICD-11: EA90]P13631RARG
    T46456DI0225Kaposi sarcoma[ICD-11: 2B57]P48443RXRG
    T46456DI0232Light sensitivity impairment[ICD-11: 9D45]P48443RXRG
    T61657DI0225Kaposi sarcoma[ICD-11: 2B57]P10826RARB
    T93788DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q8TDV5GPR119
    T93509DI0163General pain disorder[ICD-11: 8E43]P06881CALCA
    T25847DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P23284PPIB
    T10513DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P05107ITGB2

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