Naringenin



Compound IDCDAMM00478
Common nameNaringenin
IUPAC name5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
Molecular formulaC15H12O5

Experimental data

Retention time6.65
Adduct[M+H]+
Actual mz273.077
Theoretical mz273.075
Error5.58
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score8.3148

Identifiers and class information

Inchi keyFTVWIRXFELQLPI-UGPWUYPHNA-N
SmilesO=C1C=2C(O)=CC(O)=CC2OC(C3=CC=C(O)C=C3)C1
SuperclassPhenylpropanoids and polyketides
ClassFlavonoids

Plant source

  • Piper longum L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)3
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)272.257
    Computed dipole moment(dipole)3.305
    Total solvent accessible surface area (SASA)499.535
    Hydrophobic component of SASA (FOSA)48.102
    Hydrophilic component of SASA (FISA)198.867
    Pie component of the SASA (PISA)252.566
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)835.825
    Number of hydrogen bond donors (donorHB)2
    Number of hydrogen bond acceptors (accptHB)4
    Free energy of solvation of dipole (dip^2/V)0.0130668
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0113242
    Globularity descriptor (glob)0.859031
    Predicted polarizability in cubic angstroms (QPpolrz)27.781
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.559
    Predicted octanol/gas partition coefficient (QPlogPoct)14.581
    Predicted water/gas partition coefficient (QPlogPw)10.199
    Predicted octanol/water partition coefficient (QPlogPo/w)1.622
    Predicted aqueous solubility (QPlogS)-3.429
    Conformation-independent predicted aqueous solubility (CIQPlogS)-3.927
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.018
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)128.838
    Predicted brain/blood partition coefficient (QPlogBB)-1.414
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)54.003
    Predicted skin permeability, log Kp (QPlogKp)-4.007
    PM3 calculated ionization potential (IP(ev))9.337
    PM3 calculated electron affinity (EA(eV))0.4
    Number of likely metabolic reactions (#metab)5
    Prediction of binding to human serum albumin (QPlogKhsa)-0.031
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)74.208
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)101.003
    Number of nitrogen and oxygen atoms (#NandO)5
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P36544CHRNA7Neuronal acetylcholine receptor protein alpha-7 subunitT34429SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    O43570CA12Carbonic anhydrase XIIT16987SwissTargetPrediction and SEA
    Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P41594GRM5Metabotropic glutamate receptor 5T99347SwissTargetPrediction
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P05067APPBeta amyloid A4 proteinT87024SwissTargetPrediction
    P42338PIK3CBPI3-kinase p110-beta subunitT05031SwissTargetPrediction
    P11712CYP2C9Cytochrome P450 2C9T19244SwissTargetPrediction
    P08684CYP3A4Cytochrome P450 3A4T37848SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    P06239LCKTyrosine-protein kinase LCKT12499SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P16083NQO2Quinone reductase 2T75498SwissTargetPrediction
    Q8IXJ6SIRT2NAD-dependent deacetylase sirtuin 2T83904SwissTargetPrediction
    P14555PLA2G2APhospholipase A2 group IIAT19160SwissTargetPrediction
    P04054PLA2G1BPhospholipase A2 group 1BT31479SwissTargetPrediction
    P43166CA7Carbonic anhydrase VIIT37541SwissTargetPrediction and SEA
    P23280CA6Carbonic anhydrase VIT06569SwissTargetPrediction
    P22748CA4Carbonic anhydrase IVT53378SwissTargetPrediction and SEA
    P27338MAOBMonoamine oxidase BT83011SwissTargetPrediction and SEA
    P15121AKR1B1Aldose reductaseT26623SwissTargetPrediction
    P24864CCNE1Cyclin-dependent kinase 2/cyclin E1T10052SwissTargetPrediction
    P23141CES1Acyl coenzyme A:cholesterol acyltransferaseT76369SwissTargetPrediction
    Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
    P42330AKR1C3Aldo-keto-reductase family 1 member C3T60857SwissTargetPrediction
    P11926ODC1Ornithine decarboxylaseT60366SEA
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction and SEA
    P35968KDRVascular endothelial growth factor receptor 2T80975SwissTargetPrediction
    P11511CYP19A1Cytochrome P450 19A1T13260SwissTargetPrediction and SEA
    P06746POLBDNA polymerase beta (by homology)T06958SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    P03372ESR1Estrogen receptor alphaT02506SwissTargetPrediction and SEA
    P13726F3Coagulation factor VII/tissue factorT72702SwissTargetPrediction
    P08069IGF1RInsulin-like growth factor I receptorT48069SwissTargetPrediction
    P05121SERPINE1Plasminogen activator inhibitor-1T15556SwissTargetPrediction
    Q07817BCL2L1Apoptosis regulator Bcl-XT56510SwissTargetPrediction
    P33527ABCC1Multidrug resistance-associated protein 1T11288SwissTargetPrediction and SEA
    P11474ESRRAEstrogen-related receptor alphaT72841SwissTargetPrediction
    O95718ESRRBEstrogen-related receptor betaT42025SwissTargetPrediction
    P14061HSD17B1Estradiol 17-beta-dehydrogenase 1T44011SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    P30291WEE1Serine/threonine-protein kinase WEE1T69991SwissTargetPrediction
    P06213INSRInsulin receptorT85435SwissTargetPrediction
    P55072VCPTransitional endoplasmic reticulum ATPaseT12646SwissTargetPrediction
    P11802CDK4Cyclin-dependent kinase 4T85799SwissTargetPrediction
    P56817BACE1Beta-secretase 1T79031SwissTargetPrediction
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P18054ALOX12Arachidonate 12-lipoxygenaseT35527SwissTargetPrediction
    P07858CTSBCathepsin (B and K)T61746SwissTargetPrediction
    P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SwissTargetPrediction
    P43116PTGER2Prostanoid EP2 receptorT38529SwissTargetPrediction
    O75460ERN1Serine/threonine-protein kinase/endoribonuclease IRE1T01003SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    P10721KITStem cell growth factor receptorT57700SwissTargetPrediction
    Q15078CDK5R1Cyclin-dependent kinase 5/CDK5 activator 1T09513SwissTargetPrediction
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    Q13627DYRK1ADual-specificity tyrosine-phosphorylation regulated kinase 1AT92803SwissTargetPrediction
    P49759CLK1Dual specificty protein kinase CLK1T46685SwissTargetPrediction
    Q9Y463DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1BT82720SwissTargetPrediction
    P06870KLK1Kallikrein 1T40000SwissTargetPrediction
    P20151KLK2Kallikrein 2T01908SwissTargetPrediction and SEA
    P15692VEGFAVascular endothelial growth factor AT20761SwissTargetPrediction and SEA
    P43115PTGER3Prostanoid EP3 receptorT85467SwissTargetPrediction
    P11362FGFR1Fibroblast growth factor receptor 1T47101SwissTargetPrediction
    P34995PTGER1Prostanoid EP1 receptorT15497SwissTargetPrediction
    P25101EDNRAEndothelin receptor ET-AT23499SwissTargetPrediction
    P39900MMP12Matrix metalloproteinase 12T03500SwissTargetPrediction
    P31639SLC5A2Sodium/glucose cotransporter 2T30085SwissTargetPrediction
    P19793RXRARetinoid X receptor alpha (by homology)T13726SwissTargetPrediction
    P17936IGFBP3Insulin-like growth factor binding protein 3T33455SwissTargetPrediction
    P49763PGFPlacenta growth factorT70792SwissTargetPrediction and SEA
    Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SwissTargetPrediction and SEA
    Q9NPH5NOX4NADPH oxidase 4T29741SwissTargetPrediction
    P47989XDHXanthine dehydrogenaseT40954SEA
    P10415BCL2Apoptosis regulator Bcl-2T31309SwissTargetPrediction
    P52209PGD6-phosphogluconate dehydrogenaseT76497SEA
    Q16678CYP1B1Cytochrome P450 1B1T92521SwissTargetPrediction and SEA
    P37840SNCAAlpha-synucleinT03644SwissTargetPrediction
    P16152CBR1Carbonyl reductase [NADPH] 1T70518SwissTargetPrediction and SEA
    P41235HNF4AHepatocyte nuclear factor 4-alphaT15514SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T34429DI0101Corneal disease[ICD-11: 9A76-9A78]P36544CHRNA7
    T34429DI0370Schizophrenia[ICD-11: 6A20]P36544CHRNA7
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
    T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T99347DI0152Fragile X chromosome[ICD-11: LD55]P41594GRM5
    T99347DI0331Parkinsonism[ICD-11: 8A00]P41594GRM5
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T87024DI0025Alzheimer disease[ICD-11: 8A20]P05067APP
    T87024DI0122Diagnostic imaging[ICD-11: N.A.]P05067APP
    T05031DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42338PIK3CB
    T19244DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P11712CYP2C9
    T37848DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P08684CYP3A4
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T75498DI0214Insomnia[ICD-11: 7A00-7A0Z]P16083NQO2
    T83904DI0365Retinopathy[ICD-11: 9B71]Q8IXJ6SIRT2
    T19160DI0062Breast cancer[ICD-11: 2C60-2C6Y]P14555PLA2G2A
    T31479DI0230Leishmaniasis[ICD-11: 1F54]P04054PLA2G1B
    T31479DI0335Peroxisomal disease[ICD-11: 5C57]P04054PLA2G1B
    T31479DI0367Rosacea[ICD-11: ED90]P04054PLA2G1B
    T31479DI0398Synthesis disorder[ICD-11: 5C52-5C59]P04054PLA2G1B
    T06569DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P23280CA6
    T06569DI0372Seborrhoeic dermatitis[ICD-11: EA81]P23280CA6
    T53378DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P22748CA4
    T53378DI0166Glaucoma[ICD-11: 9C61]P22748CA4
    T53378DI0372Seborrhoeic dermatitis[ICD-11: EA81]P22748CA4
    T83011DI0115Dementia[ICD-11: 6D80-6D8Z]P27338MAOB
    T83011DI0117Depression[ICD-11: 6A70-6A7Z]P27338MAOB
    T83011DI0190Hypertension[ICD-11: BA00-BA04]P27338MAOB
    T83011DI0243Malaria[ICD-11: 1F40-1F45]P27338MAOB
    T83011DI0264Migraine[ICD-11: 8A80]P27338MAOB
    T83011DI0331Parkinsonism[ICD-11: 8A00]P27338MAOB
    T26623DI0298Neuropathy[ICD-11: 8C0Z]P15121AKR1B1
    T26623DI0366Rheumatoid arthritis[ICD-11: FA20]P15121AKR1B1
    T76369DI0335Peroxisomal disease[ICD-11: 5C57]P23141CES1
    T76369DI0398Synthesis disorder[ICD-11: 5C52-5C59]P23141CES1
    T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
    T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
    T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
    T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
    T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
    T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
    T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
    T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
    T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
    T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
    T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
    T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
    T60857DI0145Female pelvic pain[ICD-11: GA34]P42330AKR1C3
    T60366DI0020African trypanosomiasis[ICD-11: 1F51]P11926ODC1
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T80975DI0062Breast cancer[ICD-11: 2C60-2C6Y]P35968KDR
    T80975DI0095Colorectal cancer[ICD-11: 2B91]P35968KDR
    T80975DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P35968KDR
    T80975DI0244Malignant digestive organ neoplasm[ICD-11: 2C11]P35968KDR
    T80975DI0361Renal cell carcinoma[ICD-11: 2C90]P35968KDR
    T80975DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35968KDR
    T80975DI0395Stomach cancer[ICD-11: 2B72]P35968KDR
    T80975DI0403Thrombocytopenia[ICD-11: 3B64]P35968KDR
    T80975DI0407Thyroid cancer[ICD-11: 2D10]P35968KDR
    T13260DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11511CYP19A1
    T13260DI0108Cushing syndrome[ICD-11: 5A70]P11511CYP19A1
    T06958DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06746POLB
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
    T72702DI0075Cervical cancer[ICD-11: 2C77]P13726F3
    T48069DI0276Multiple structural anomalies syndrome[ICD-11: LD2F]P08069IGF1R
    T48069DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P08069IGF1R
    T48069DI0408Thyrotoxicosis[ICD-11: 5A02]P08069IGF1R
    T15556DI0037Asthma[ICD-11: CA23]P05121SERPINE1
    T15556DI0405Thrombosis[ICD-11: DB61-GB90]P05121SERPINE1
    T56510DI0286Myeloproliferative neoplasm[ICD-11: 2A20]Q07817BCL2L1
    T11288DI0167Gout[ICD-11: FA25]P33527ABCC1
    T72841DI0366Rheumatoid arthritis[ICD-11: FA20]P11474ESRRA
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T69991DI0321Ovarian cancer[ICD-11: 2C73]P30291WEE1
    T69991DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P30291WEE1
    T69991DI0429Uterine ligament/parametrium/uterine adnexa neoplasm[ICD-11: 2C72]P30291WEE1
    T85435DI0009Acute diabete complication[ICD-11: 5A2Y]P06213INSR
    T85435DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P06213INSR
    T12646DI0012Acute myeloid leukaemia[ICD-11: 2A60]P55072VCP
    T12646DI0274Multiple myeloma[ICD-11: 2A83]P55072VCP
    T12646DI0284Myelodysplastic syndrome[ICD-11: 2A37]P55072VCP
    T12646DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P55072VCP
    T85799DI0062Breast cancer[ICD-11: 2C60-2C6Y]P11802CDK4
    T85799DI0238Lung cancer[ICD-11: 2C25]P11802CDK4
    T85799DI0351Psoriasis[ICD-11: EA90]P11802CDK4
    T79031DI0025Alzheimer disease[ICD-11: 8A20]P56817BACE1
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T61746DI0023Alopecia[ICD-11: ED70]P07858CTSB
    T61746DI0025Alzheimer disease[ICD-11: 8A20]P07858CTSB
    T61746DI0037Asthma[ICD-11: CA23]P07858CTSB
    T61746DI0055Bone cancer[ICD-11: 2B5Z]P07858CTSB
    T61746DI0060Brain cancer[ICD-11: 2A00]P07858CTSB
    T61746DI0067Cardiac arrest[ICD-11: MC82]P07858CTSB
    T61746DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P07858CTSB
    T61746DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07858CTSB
    T61746DI0087Chronic pain[ICD-11: MG30]P07858CTSB
    T61746DI0110Cystic fibrosis[ICD-11: CA25]P07858CTSB
    T61746DI0124Digestive system disease[ICD-11: DE2Z]P07858CTSB
    T61746DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P07858CTSB
    T61746DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P07858CTSB
    T61746DI0253Meningioma[ICD-11: 2A01]P07858CTSB
    T61746DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P07858CTSB
    T61746DI0275Multiple sclerosis[ICD-11: 8A40]P07858CTSB
    T61746DI0296Neurodegenerative disorder[ICD-11: 8A20-8A23]P07858CTSB
    T61746DI0320Osteoarthritis[ICD-11: FA00-FA05]P07858CTSB
    T61746DI0351Psoriasis[ICD-11: EA90]P07858CTSB
    T61746DI0366Rheumatoid arthritis[ICD-11: FA20]P07858CTSB
    T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
    T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
    T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
    T38529DI0003Abortion[ICD-11: JA00]P43116PTGER2
    T38529DI0102Coronary atherosclerosis[ICD-11: BA52]P43116PTGER2
    T38529DI0121Diabetic foot ulcer[ICD-11: BD54]P43116PTGER2
    T38529DI0166Glaucoma[ICD-11: 9C61]P43116PTGER2
    T38529DI0356Pulmonary hypertension[ICD-11: BB01]P43116PTGER2
    T38529DI0378Sexual dysfunction[ICD-11: HA00-HA01]P43116PTGER2
    T38529DI0413Transplant rejection[ICD-11: NE84]P43116PTGER2
    T01003DI0062Breast cancer[ICD-11: 2C60-2C6Y]O75460ERN1
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T57700DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P10721KIT
    T57700DI0095Colorectal cancer[ICD-11: 2B91]P10721KIT
    T57700DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P10721KIT
    T57700DI0250Mature B-cell lymphoma[ICD-11: 2A85]P10721KIT
    T57700DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P10721KIT
    T57700DI0361Renal cell carcinoma[ICD-11: 2C90]P10721KIT
    T57700DI0403Thrombocytopenia[ICD-11: 3B64]P10721KIT
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T92803DI0113Cytomegaloviral disease[ICD-11: 1D82]Q13627DYRK1A
    T01908DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P20151KLK2
    T20761DI0095Colorectal cancer[ICD-11: 2B91]P15692VEGFA
    T20761DI0365Retinopathy[ICD-11: 9B71]P15692VEGFA
    T20761DI0430Vascular system developmental anomaly[ICD-11: LA90]P15692VEGFA
    T85467DI0166Glaucoma[ICD-11: 9C61]P43115PTGER3
    T85467DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43115PTGER3
    T85467DI0414Transplanted organ/tissue[ICD-11: QB63]P43115PTGER3
    T47101DI0095Colorectal cancer[ICD-11: 2B91]P11362FGFR1
    T47101DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P11362FGFR1
    T47101DI0235Liver cancer[ICD-11: 2C12]P11362FGFR1
    T47101DI0403Thrombocytopenia[ICD-11: 3B64]P11362FGFR1
    T15497DI0405Thrombosis[ICD-11: DB61-GB90]P34995PTGER1
    T23499DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25101EDNRA
    T23499DI0356Pulmonary hypertension[ICD-11: BB01]P25101EDNRA
    T23499DI0425Urinary system clinical symptom[ICD-11: MF8Y]P25101EDNRA
    T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
    T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
    T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
    T30085DI0120Diabetes mellitus[ICD-11: 5A10]P31639SLC5A2
    T30085DI0175Heart failure[ICD-11: BD10-BD1Z]P31639SLC5A2
    T30085DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P31639SLC5A2
    T13726DI0225Kaposi sarcoma[ICD-11: 2B57]P19793RXRA
    T13726DI0283Mycosis fungoides[ICD-11: 2B01]P19793RXRA
    T33455DI0115Dementia[ICD-11: 6D80-6D8Z]P17936IGFBP3
    T70792DI0095Colorectal cancer[ICD-11: 2B91]P49763PGF
    T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
    T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
    T29741DI0146Fibrosis[ICD-11: GA14-GC01]Q9NPH5NOX4
    T40954DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]P47989XDH
    T40954DI0266Mineral deficiency[ICD-11: 5B5K]P47989XDH
    T31309DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10415BCL2
    T31309DI0249Mature B-cell leukaemia[ICD-11: 2A82]P10415BCL2
    T31309DI0273Motor neuron disease[ICD-11: 8B60]P10415BCL2
    T31309DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P10415BCL2
    T76497DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P52209PGD
    T03644DI0025Alzheimer disease[ICD-11: 8A20]P37840SNCA
    T03644DI0044Autonomic nervous system disorder[ICD-11: 8D87]P37840SNCA
    T03644DI0331Parkinsonism[ICD-11: 8A00]P37840SNCA
    T70518DI0037Asthma[ICD-11: CA23]P16152CBR1

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