Vanillic acid



Compound IDCDAMM00403
Common nameVanillic acid
IUPAC name4-hydroxy-3-methoxybenzoic acid
Molecular formulaC8H8O4

Experimental data

Retention time18.365
Adduct[M+H]+
Actual mz169.051
Theoretical mz169.05
Error5.7
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.55

Identifiers and class information

Inchi keyWKOLLVMJNQIZCI-UHFFFAOYSA-N
SmilesCOC1=C(C=CC(=C1)C(=O)O)O
SuperclassBenzenoids
ClassBenzene and substituted derivatives

Pharmacokinetic properties

Number of descriptor values(#stars)0
Number of non-conjugated amine groups (#amine)0
Number of amidine and guanidine groups (#amidine)0
Number of carboxylic acid groups (#acid)1
Number of non-conjugated amide groups (#amide)0
Number of rotatable bonds (#rotor)3
Number of reactive functional groups (#rtvFG)0
Predicted central nervous system activity (CNS)-1
Molecular weight (mol_MW)168.149
Computed dipole moment(dipole)4.865
Total solvent accessible surface area (SASA)361.519
Hydrophobic component of SASA (FOSA)93.351
Hydrophilic component of SASA (FISA)159.772
Pie component of the SASA (PISA)108.396
Weakly polar component of the SASA (WPSA)0
Total solvent accesible volume (volume)564.574
Number of hydrogen bond donors (donorHB)2
Number of hydrogen bond acceptors (accptHB)3.5
Free energy of solvation of dipole (dip^2/V)0.0419301
Index of cohesive interaction in solids (ACxDN^.5/SA)0.0136915
Globularity descriptor (glob)0.913794
Predicted polarizability in cubic angstroms (QPpolrz)15.549
Predicted hexadecane/gas partition coefficient (QPlogPC16)5.86
Predicted octanol/gas partition coefficient (QPlogPoct)10.096
Predicted water/gas partition coefficient (QPlogPw)8.128
Predicted octanol/water partition coefficient (QPlogPo/w)1.046
Predicted aqueous solubility (QPlogS)-1.413
Conformation-independent predicted aqueous solubility (CIQPlogS)-1.69
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-1.636
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)76.628
Predicted brain/blood partition coefficient (QPlogBB)-0.893
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)39.169
Predicted skin permeability, log Kp (QPlogKp)-3.794
PM3 calculated ionization potential (IP(ev))9.283
PM3 calculated electron affinity (EA(eV))0.61
Number of likely metabolic reactions (#metab)2
Prediction of binding to human serum albumin (QPlogKhsa)-0.743
Predicted qualitative human oral absorption (HumanOralAbsorption)3
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)66.795
Solvent-accessible surface area of fluorine atoms (SAFluorine)0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
Van der Waals surface area (PSA)79.697
Number of nitrogen and oxygen atoms (#NandO)4
Number of violations of Lipinski’s rule of five (RuleOfFive)0
Number of violations of Jorgensen’s rule of three (RuleOfThree)0

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID Gene name Target name TTD_ID Prediction source
Q9GZV3SLC5A7High-affinity choline transporter (by homology)T83143SEA
P06241FYNTyrosine-protein kinase FYNT17980SwissTargetPrediction and SEA
P00533EGFREpidermal growth factor receptor erbB1T59328SEA
P22303ACHEAcetylcholinesteraseT30082SEA
O43570CA12Carbonic anhydrase XIIT16987SwissTargetPrediction and SEA
Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction and SEA
Q07820MCL1Induced myeloid leukemia cell differentiation protein Mcl-1T14912SEA
Q96KS0EIT6HIF-prolyl hydroxylase 1T53904SEA
P21397MAOAMonoamine oxidase AT83875SEA
P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction and SEA
P02766TTRTransthyretinT86462SwissTargetPrediction and SEA
P05067APPBeta amyloid A4 proteinT87024SEA
P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction and SEA
P06239LCKTyrosine-protein kinase LCKT12499SwissTargetPrediction
Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
Q15125EBPAnti-estrogen binding site (AEBS)T25317SEA
Q96RI1NR1H4Bile acid receptor FXRT51426SEA
P31213SRD5A2Steroid 5-alpha-reductase 2T71390SEA
P43166CA7Carbonic anhydrase VIIT37541SwissTargetPrediction and SEA
P23280CA6Carbonic anhydrase VIT06569SwissTargetPrediction and SEA
Q9ULX7CA14Carbonic anhydrase XIVT31992SwissTargetPrediction and SEA
P22748CA4Carbonic anhydrase IVT53378SwissTargetPrediction and SEA
P27338MAOBMonoamine oxidase BT83011SEA
Q96RJ0TAAR1Trace amine-associated receptor 1 (by homology)T99524SEA
P05164MPOMyeloperoxidaseT23471SEA
Q9H3R0KDM4CLysine-specific demethylase 4CT73863SwissTargetPrediction and SEA
P23141CES1Acyl coenzyme A:cholesterol acyltransferaseT76369SEA
P42330AKR1C3Aldo-keto-reductase family 1 member C3T60857SwissTargetPrediction and SEA
Q6B0I6KDM4DLysine-specific demethylase 4DT17036SwissTargetPrediction and SEA
O75164KDM4ALysine-specific demethylase 4AT18904SwissTargetPrediction and SEA
Q6B0I6KDM4DLysine-specific demethylase 4DT17036SEA
P11926ODC1Ornithine decarboxylaseT60366SEA
O15229KMOKynurenine 3-monooxygenaseT50973SEA
Q8NER1TRPV1Vanilloid receptorT83193SEA
P18405SRD5A1Steroid 5-alpha-reductase 1T70309SEA
P29350PTPN6Protein-tyrosine phosphatase 1CT98264SEA
P18031PTPN1Protein-tyrosine phosphatase 1BT16347SEA
P08575PTPRCLeukocyte common antigenT43115SEA
P06746POLBDNA polymerase beta (by homology)T06958SwissTargetPrediction and SEA
P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
Q7Z2W7TRPM8Transient receptor potential cation channel subfamily M member 8T41955SEA
P09467FBP1Fructose-1,6-bisphosphataseT83391SwissTargetPrediction
P09917ALOX5Arachidonate 5-lipoxygenaseT00140SEA
P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
Q9Y4C1KDM3ALysine-specific demethylase 3AT25362SwissTargetPrediction and SEA
O15054KDM6BLysine-specific demethylase 6BT56057SwissTargetPrediction and SEA
P13726F3Coagulation factor VII/tissue factorT72702SEA
Q14534SQLESqualene monooxygenase (by homology)T93344SwissTargetPrediction
P05121SERPINE1Plasminogen activator inhibitor-1T15556SwissTargetPrediction
P21728DRD1Dopamine D1 receptorT22118SEA
P33527ABCC1Multidrug resistance-associated protein 1T11288SEA
P08183ABCB1P-glycoprotein 1T25258SEA
P10827THRAThyroid hormone receptor alphaT79591SEA
P10828THRBThyroid hormone receptor beta-1T98933SEA
P27695APEX1DNA-(apurinic or apyrimidinic site) lyaseT13348SEA
O14757CHEK1Serine/threonine-protein kinase Chk1T62449SEA
P19838NFKB1Nuclear factor NF-kappa-B p105 subunitT83145SEA
Q08499PDE4DPhosphodiesterase 4DT02001SEA
Q15722LTB4RLeukotriene B4 receptor 1T59626SEA
O75116ROCK2Rho-associated protein kinase 2T06093SEA
Q09472EP300Histone acetyltransferase p300T25956SEA
P10276RARARetinoic acid receptor alphaT94085SEA
O96017CHEK2Serine/threonine-protein kinase Chk2T28713SEA
P47871GCGRGlucagon receptorT60182SEA
Q05397PTK2Focal adhesion kinase 1T15068SEA
Q5S007LRRK2Leucine-rich repeat serine/threonine-protein kinase 2T08123SEA
P41229KDM5CLysine-specific demethylase 5CT85540SEA
P05186ALPLAlkaline phosphatase, tissue-nonspecific isozymeT09538SEA
P08842STSSteryl-sulfataseT33489SEA
P15692VEGFAVascular endothelial growth factor AT20761SEA
Q9Y251HPSEHeparanaseT47623SEA
P47712PLA2G4ACytosolic phospholipase A2T14834SEA
Q9UGL1KDM5BLysine-specific demethylase 5BT56871SEA
Q9Y2K7KDM2ALysine-specific demethylase 2AT71949SwissTargetPrediction and SEA
P34995PTGER1Prostanoid EP1 receptorT15497SEA
P06737PYGLLiver glycogen phosphorylaseT19184SEA
Q92793CREBBPCREB-binding protein/p53T03634SEA
Q86YT5SLC13A5Solute carrier family 13 member 5T81547SEA
O43174CYP26A1Cytochrome P450 26A1T84634SEA
P19793RXRARetinoid X receptor alpha (by homology)T13726SEA
P14151SELLLeukocyte adhesion molecule-1T60526SEA
P17936IGFBP3Insulin-like growth factor binding protein 3T33455SEA
P68400CSNK2A1Casein kinase II alphaT51565SEA
P19784CSNK2A2Casein kinase II alpha (prime)T80526SEA
P14735IDEInsulin-degrading enzymeT81900SEA
P04049RAF1Serine/threonine-protein kinase RAFT51883SEA
Q9UQM7CAMK2ACaM kinase II alphaT18299SEA
P15056BRAFSerine/threonine-protein kinase B-rafT99089SEA
Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SEA
Q12791KCNMA1Calcium-activated potassium channel subunit alpha-1T66538SEA
Q9NPC2KCNK9Potassium channel subfamily K member 9T57613SEA
P08236GUSBBeta-glucuronidaseT96413SEA
P16234PDGFRAPlatelet-derived growth factor receptorT53524SEA
Q9NPH5NOX4NADPH oxidase 4T29741SEA
Q07343PDE4BPhosphodiesterase 4B (by homology)T10265SEA
P15735PHKG2Phosphorylase kinase gamma subunit 2T69208SEA
O43293DAPK3Death-associated protein kinase 3T81623SEA
P78368CSNK1G2Casein kinase I gamma 2T82773SEA
Q13464ROCK1Rho-associated protein kinase 1T51282SEA
Q16678CYP1B1Cytochrome P450 1B1T92521SEA
P10636MAPTMicrotubule-associated protein tauT45593SEA
Q04760GLO1Glyoxalase IT88285SEA
Q96KB5PBKPDZ-binding kinaseT98642SEA
Q92523CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform (by homology)T75888SEA
P30281CCND3Cyclin-dependent kinase 4/cyclin DT72507SEA
P51512MMP16Matrix metalloproteinase 16T35824SEA
Q08493PDE4CPhosphodiesterase 4CT12081SEA
P10696ALPGAlkaline phosphatase placental-likeT35565SEA
P51511MMP15Matrix metalloproteinase 15T81658SEA
P19438TNFRSF1ATumor necrosis factor receptor R1T86552SEA
Q16236NFE2L2Nuclear factor erythroid 2-related factor 2T88505SEA
P28702RXRBRetinoid X receptor betaT60077SEA
P13631RARGRetinoic acid receptor gammaT82146SEA
P48443RXRGRetinoid X receptor gammaT46456SEA
P10826RARBRetinoic acid receptor betaT61657SEA
Q9UQM7CAMK2ACaM kinase II alphaT18299SEA
P22736NR4A1Nuclear receptor subfamily 4 group A member 1T41119SEA
P41235HNF4AHepatocyte nuclear factor 4-alphaT15514SEA
Q9H1C0LPAR5Lysophosphatidic acid receptor 5T18616SEA
Q15120PDK3Pyruvate dehydrogenase kinase isoform 3T99029SEA
Q9Y256RCE1Prenyl protein specific proteaseT10756SEA
Q9UQM7CAMK2ACaM kinase II alphaT18299SEA
Q96SB4SRPK1Serine/threonine-protein kinase SRPK1T94201SEA
Q7L7X3TAOK1Serine/threonine-protein kinase TAO1T97016SEA
Q9Y345SLC6A5Glycine transporter 2T58937SEA
Q92633LPAR1Lysophosphatidic acid receptor Edg-2T92640SEA
Q9Y337KLK5Kallikrein 5T11808SEA
O75884RBBP9Putative hydrolase RBBP9T12084SEA
Q9H4B7TUBB1Tubulin beta-1 chainT84397SwissTargetPrediction and SEA
O43826SLC37A4Glucose-6-phosphate translocaseT47306SEA
P24593IGFBP5Insulin-like growth factor binding protein 5T17008SEA
Q14721KCNB1Potassium voltage-gated channel subfamily B member 1T44516SEA
P41586ADCYAP1R1Pituitary adenylate cyclase-activating polypeptide type I receptorT92185SEA
Q96PF2TSSK2Testis-specific serine/threonine-protein kinase 2T04413SEA
P24592IGFBP6Insulin-like growth factor binding protein 6T61800SEA
P18065IGFBP2Insulin-like growth factor binding protein 2T64268SEA
P08833IGFBP1Insulin-like growth factor binding protein 1T15048SEA
O43781DYRK3Dual-specificity tyrosine-phosphorylation regulated kinase 3T97149SEA
Q9UEE5STK17ASerine/threonine-protein kinase 17AT91323SEA
P11717IGF2RInsulin-like growth factor II receptorT59550SEA
Q9UPY5SLC7A11Cystine/glutamate transporterT11615SEA
P13674P4HA1Prolyl 4-hydroxylasesubunit alpha-1T61729SEA
P49019HCAR3Hydroxycarboxylic acid receptor 3T00890SEA
P49862KLK7Kallikrein-7T79155SEA
Q04609FOLH1Glutamate carboxypeptidase IIT97071SEA
Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
Q9BY41HDAC8Histone deacetylase 8T28887SEA
Q9UBS0RPS6KB2Ribosomal protein S6 kinase beta-2T42760SEA
O15427SLC16A3Monocarboxylate transporter 4T31788SEA
Q5T7T8COX1Prostaglandin G/H synthase 1T60529SEA
Q7RTX1TAS1R1Taste receptorT41263SEA
P01100FOSProto-oncogene c-FosT28025SEA
Q9NXA8SIRT5NAD-dependent deacetylase sirtuin-5T91940SEA
Q9NR20DYRK4Dual-specificity tyrosine-phosphorylation regulated kinase 4T20542SEA
P43354NR4A2Orphan nuclear receptor NURR1T67163SEA
Q8N183NDUFAF2HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2T01453SEA
Q9P0J0NDUFA13Mitochondrial complex IT82391SEA
Q9Y6M9NDUFB9HUMAN NADH:ubiquinone oxidoreductase subunit B9T01465SEA
Q8N183NDUFAF2HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2T01453SEA
P03897MT-ND3NADH dehydrogenaseT77195SEA
O75751EMTHOrganic cation transporter 3T55948SEA
Q8TDC3BRSK1BR serine/threonine kinase 1T20053SEA
Q9Y6M4CSNK1G3Casein kinase I gamma-3T29728SEA
P01106MYCProto-oncogene c-MycT36121SEA
Q9GZT9EGLN1Egl nine homolog 1T32880SEA

Target associated diseases

TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
T17980DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06241FYN
T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
T14912DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q07820MCL1
T14912DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]Q07820MCL1
T14912DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q07820MCL1
T14912DI0252Melanoma[ICD-11: 2C30]Q07820MCL1
T14912DI0274Multiple myeloma[ICD-11: 2A83]Q07820MCL1
T14912DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q07820MCL1
T53904DI0010Acute disease anaemia[ICD-11: 3A90]Q96KS0EIT6
T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
T86462DI0026Amyloidosis[ICD-11: 5D00]P02766TTR
T87024DI0025Alzheimer disease[ICD-11: 8A20]P05067APP
T87024DI0122Diagnostic imaging[ICD-11: N.A.]P05067APP
T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
T25317DI0366Rheumatoid arthritis[ICD-11: FA20]Q15125EBP
T51426DI0043Autoimmune liver disease[ICD-11: DB96]Q96RI1NR1H4
T51426DI0077Cholelithiasis[ICD-11: DC11]Q96RI1NR1H4
T51426DI0320Osteoarthritis[ICD-11: FA00-FA05]Q96RI1NR1H4
T71390DI0348Prostate hyperplasia[ICD-11: GA90]P31213SRD5A2
T06569DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P23280CA6
T06569DI0372Seborrhoeic dermatitis[ICD-11: EA81]P23280CA6
T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
T53378DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P22748CA4
T53378DI0166Glaucoma[ICD-11: 9C61]P22748CA4
T53378DI0372Seborrhoeic dermatitis[ICD-11: EA81]P22748CA4
T83011DI0115Dementia[ICD-11: 6D80-6D8Z]P27338MAOB
T83011DI0117Depression[ICD-11: 6A70-6A7Z]P27338MAOB
T83011DI0190Hypertension[ICD-11: BA00-BA04]P27338MAOB
T83011DI0243Malaria[ICD-11: 1F40-1F45]P27338MAOB
T83011DI0264Migraine[ICD-11: 8A80]P27338MAOB
T83011DI0331Parkinsonism[ICD-11: 8A00]P27338MAOB
T99524DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q96RJ0TAAR1
T99524DI0149Focal/segmental autonomic disorder[ICD-11: 8D8A]Q96RJ0TAAR1
T99524DI0290Narcolepsy[ICD-11: 7A20]Q96RJ0TAAR1
T23471DI0229Left ventricular failure[ICD-11: BD11]P05164MPO
T23471DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P05164MPO
T76369DI0335Peroxisomal disease[ICD-11: 5C57]P23141CES1
T76369DI0398Synthesis disorder[ICD-11: 5C52-5C59]P23141CES1
T60857DI0145Female pelvic pain[ICD-11: GA34]P42330AKR1C3
T60366DI0020African trypanosomiasis[ICD-11: 1F51]P11926ODC1
T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
T70309DI0347Prostate disease[ICD-11: GA91]P18405SRD5A1
T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
T43115DI0012Acute myeloid leukaemia[ICD-11: 2A60]P08575PTPRC
T43115DI0414Transplanted organ/tissue[ICD-11: QB63]P08575PTPRC
T06958DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06746POLB
T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
T41955DI0422Upper respiratory tract disorder[ICD-11: CA0Z]Q7Z2W7TRPM8
T83391DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P09467FBP1
T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
T72702DI0075Cervical cancer[ICD-11: 2C77]P13726F3
T93344DI0118Dermatophytosis[ICD-11: 1F28]Q14534SQLE
T93344DI0385Skin fungal infection disorder[ICD-11: EA60]Q14534SQLE
T15556DI0037Asthma[ICD-11: CA23]P05121SERPINE1
T15556DI0405Thrombosis[ICD-11: DB61-GB90]P05121SERPINE1
T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
T11288DI0167Gout[ICD-11: FA25]P33527ABCC1
T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
T79591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10827THRA
T79591DI0197Hypo-thyroidism[ICD-11: 5A00]P10827THRA
T98933DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10828THRB
T13348DI0365Retinopathy[ICD-11: 9B71]P27695APEX1
T13348DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P27695APEX1
T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
T83145DI0218Irritable bowel syndrome[ICD-11: DD91]P19838NFKB1
T83145DI0366Rheumatoid arthritis[ICD-11: FA20]P19838NFKB1
T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
T59626DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]Q15722LTB4R
T59626DI0355Pulmonary disease[ICD-11: 1B10-1F85]Q15722LTB4R
T59626DI0361Renal cell carcinoma[ICD-11: 2C90]Q15722LTB4R
T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
T25956DI0346Prostate cancer[ICD-11: 2C82]Q09472EP300
T25956DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q09472EP300
T94085DI0025Alzheimer disease[ICD-11: 8A20]P10276RARA
T94085DI0251Mature T-cell lymphoma[ICD-11: 2A90]P10276RARA
T28713DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O96017CHEK2
T60182DI0193Hypo-glycaemia[ICD-11: 5A41]P47871GCGR
T15068DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q05397PTK2
T15068DI0321Ovarian cancer[ICD-11: 2C73]Q05397PTK2
T15068DI0326Pancreatic cancer[ICD-11: 2C10]Q05397PTK2
T15068DI0334Peritoneal cancer[ICD-11: 2C51]Q05397PTK2
T15068DI0356Pulmonary hypertension[ICD-11: BB01]Q05397PTK2
T15068DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q05397PTK2
T08123DI0331Parkinsonism[ICD-11: 8A00]Q5S007LRRK2
T09538DI0164Genetic prion disease[ICD-11: 8E02]P05186ALPL
T09538DI0330Parasitic infection[ICD-11: 1D0Y-1G2Z]P05186ALPL
T33489DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P08842STS
T20761DI0095Colorectal cancer[ICD-11: 2B91]P15692VEGFA
T20761DI0365Retinopathy[ICD-11: 9B71]P15692VEGFA
T20761DI0430Vascular system developmental anomaly[ICD-11: LA90]P15692VEGFA
T47623DI0020African trypanosomiasis[ICD-11: 1F51]Q9Y251HPSE
T47623DI0310Ocular disease[ICD-11: N.A.]Q9Y251HPSE
T14834DI0039Atopic eczema[ICD-11: EA80]P47712PLA2G4A
T15497DI0405Thrombosis[ICD-11: DB61-GB90]P34995PTGER1
T03634DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q92793CREBBP
T03634DI0346Prostate cancer[ICD-11: 2C82]Q92793CREBBP
T03634DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92793CREBBP
T03634DI0399Systemic sclerosis[ICD-11: 4A42]Q92793CREBBP
T84634DI0314Oesophagitis[ICD-11: DA24]O43174CYP26A1
T13726DI0225Kaposi sarcoma[ICD-11: 2B57]P19793RXRA
T13726DI0283Mycosis fungoides[ICD-11: 2B01]P19793RXRA
T60526DI0037Asthma[ICD-11: CA23]P14151SELL
T60526DI0088Circulatory system disease[ICD-11: BE2Z]P14151SELL
T33455DI0115Dementia[ICD-11: 6D80-6D8Z]P17936IGFBP3
T51565DI0104Coronavirus infection[ICD-11: 1D92]P68400CSNK2A1
T51565DI0235Liver cancer[ICD-11: 2C12]P68400CSNK2A1
T51565DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P68400CSNK2A1
T81900DI0383Skin and skin-structure infection[ICD-11: 1F28-1G0Z]P14735IDE
T51883DI0252Melanoma[ICD-11: 2C30]P04049RAF1
T51883DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04049RAF1
T51883DI0321Ovarian cancer[ICD-11: 2C73]P04049RAF1
T51883DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04049RAF1
T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
T66538DI0037Asthma[ICD-11: CA23]Q12791KCNMA1
T66538DI0154Functional bladder disorder[ICD-11: GC50]Q12791KCNMA1
T96413DI0242Lysosomal disease[ICD-11: 5C56]P08236GUSB
T53524DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P16234PDGFRA
T53524DI0225Kaposi sarcoma[ICD-11: 2B57]P16234PDGFRA
T53524DI0403Thrombocytopenia[ICD-11: 3B64]P16234PDGFRA
T29741DI0146Fibrosis[ICD-11: GA14-GC01]Q9NPH5NOX4
T10265DI0037Asthma[ICD-11: CA23]Q07343PDE4B
T10265DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q07343PDE4B
T10265DI0265Mild neurocognitive disorder[ICD-11: 6D71]Q07343PDE4B
T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
T45593DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10636MAPT
T45593DI0025Alzheimer disease[ICD-11: 8A20]P10636MAPT
T45593DI0265Mild neurocognitive disorder[ICD-11: 6D71]P10636MAPT
T88285DI0210Influenza[ICD-11: 1E30-1E32]Q04760GLO1
T98642DI0291Nasopharyngeal cancer[ICD-11: 2B6B]Q96KB5PBK
T75888DI0030Angina pectoris[ICD-11: BA40]Q92523CPT1B
T75888DI0265Mild neurocognitive disorder[ICD-11: 6D71]Q92523CPT1B
T75888DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q92523CPT1B
T86552DI0060Brain cancer[ICD-11: 2A00]P19438TNFRSF1A
T86552DI0321Ovarian cancer[ICD-11: 2C73]P19438TNFRSF1A
T88505DI0038Ataxic disorder[ICD-11: 8A03]Q16236NFE2L2
T60077DI0225Kaposi sarcoma[ICD-11: 2B57]P28702RXRB
T82146DI0005Acne vulgaris[ICD-11: ED80]P13631RARG
T82146DI0012Acute myeloid leukaemia[ICD-11: 2A60]P13631RARG
T82146DI0225Kaposi sarcoma[ICD-11: 2B57]P13631RARG
T82146DI0277Muscle calcification/ossification[ICD-11: FB31]P13631RARG
T82146DI0351Psoriasis[ICD-11: EA90]P13631RARG
T46456DI0225Kaposi sarcoma[ICD-11: 2B57]P48443RXRG
T46456DI0232Light sensitivity impairment[ICD-11: 9D45]P48443RXRG
T61657DI0225Kaposi sarcoma[ICD-11: 2B57]P10826RARB
T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
T94201DI0365Retinopathy[ICD-11: 9B71]Q96SB4SRPK1
T92640DI0146Fibrosis[ICD-11: GA14-GC01]Q92633LPAR1
T92640DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q92633LPAR1
T92640DI0351Psoriasis[ICD-11: EA90]Q92633LPAR1
T92640DI0399Systemic sclerosis[ICD-11: 4A42]Q92633LPAR1
T84397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9H4B7TUBB1
T92185DI0264Migraine[ICD-11: 8A80]P41586ADCYAP1R1
T59550DI0146Fibrosis[ICD-11: GA14-GC01]P11717IGF2R
T59550DI0368Sarcoidosis[ICD-11: 4B20]P11717IGF2R
T11615DI0054Body-focused behaviour disorder[ICD-11: 6B25]Q9UPY5SLC7A11
T61729DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P13674P4HA1
T61729DI0413Transplant rejection[ICD-11: NE84]P13674P4HA1
T00890DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P49019HCAR3
T00890DI0128Dyslipidemia[ICD-11: 5C80-5C81]P49019HCAR3
T00890DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P49019HCAR3
T00890DI0351Psoriasis[ICD-11: EA90]P49019HCAR3
T97071DI0122Diagnostic imaging[ICD-11: N.A.]Q04609FOLH1
T97071DI0346Prostate cancer[ICD-11: 2C82]Q04609FOLH1
T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
T28887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BY41HDAC8
T42760DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9UBS0RPS6KB2
T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
T41263DI0078Cholera[ICD-11: 1A00]Q7RTX1TAS1R1
T82391DI0069Cardiomyopathy[ICD-11: BC43]Q9P0J0NDUFA13
T77195DI0331Parkinsonism[ICD-11: 8A00]P03897MT-ND3

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