1-O-Acetyllycorine



Compound IDCDAMM00334
Common name1-O-Acetyllycorine
IUPAC name[(1S,17S,18S,19S)-17-hydroxy-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraen-18-yl] acetate
Molecular formulaC18H19NO5

Experimental data

Retention time50.178
Adduct[M+H]+
Actual mz330.125
Theoretical mz330.134
Error27.25
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.21

Identifiers and class information

Inchi keyBIGUPJIJZYZJMV-JAPGCXTFNA-N
SmilesO=C(OC1C(O)C=C2CCN3CC4=CC=5OCOC5C=C4C1C23)C
SuperclassAlkaloids and derivatives
ClassAmaryllidaceae alkaloids

Plant source

  • Pedalium murex L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)1
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)2
    Number of reactive functional groups (#rtvFG)2
    Predicted central nervous system activity (CNS)1
    Molecular weight (mol_MW)329.352
    Computed dipole moment(dipole)4.353
    Total solvent accessible surface area (SASA)518.86
    Hydrophobic component of SASA (FOSA)333.715
    Hydrophilic component of SASA (FISA)86.955
    Pie component of the SASA (PISA)98.19
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)958.897
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)7.2
    Free energy of solvation of dipole (dip^2/V)0.0197625
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0138766
    Globularity descriptor (glob)0.906351
    Predicted polarizability in cubic angstroms (QPpolrz)31.875
    Predicted hexadecane/gas partition coefficient (QPlogPC16)8.895
    Predicted octanol/gas partition coefficient (QPlogPoct)15.776
    Predicted water/gas partition coefficient (QPlogPw)10.343
    Predicted octanol/water partition coefficient (QPlogPo/w)1.346
    Predicted aqueous solubility (QPlogS)-1.72
    Conformation-independent predicted aqueous solubility (CIQPlogS)-2.631
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.242
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)370.004
    Predicted brain/blood partition coefficient (QPlogBB)0.136
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)186.858
    Predicted skin permeability, log Kp (QPlogKp)-4.647
    PM3 calculated ionization potential (IP(ev))8.891
    PM3 calculated electron affinity (EA(eV))-0.087
    Number of likely metabolic reactions (#metab)5
    Prediction of binding to human serum albumin (QPlogKhsa)-0.192
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)80.795
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)81.081
    Number of nitrogen and oxygen atoms (#NandO)6
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P43681CHRNA4Neuronal acetylcholine receptor; alpha4/beta2T70967SwissTargetPrediction
    Q9Y5N1HRH3Histamine H3 receptorT64765SwissTargetPrediction
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P22303ACHEAcetylcholinesteraseT30082SwissTargetPrediction
    P10635CYP2D6Cytochrome P450 2D6T57392SwissTargetPrediction
    Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    Q99720SIGMAR1Sigma opioid receptorT46360SwissTargetPrediction
    P00734F2ThrombinT94033SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P21397MAOAMonoamine oxidase AT83875SwissTargetPrediction
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P00918CA2Carbonic anhydrase IIT20401SwissTargetPrediction
    P98170XIAPInhibitor of apoptosis protein 3T16769SwissTargetPrediction
    Q05586GRIN1Glutamate NMDA receptor; GRIN1/GRIN2BT62276SwissTargetPrediction
    Q96FL8SLC47A1Multidrug and toxin extrusion protein 1T39676SwissTargetPrediction
    P22748CA4Carbonic anhydrase IVT53378SwissTargetPrediction
    O60341KDM1ALysine-specific histone demethylase 1T16739SwissTargetPrediction
    P28223HTR2ASerotonin 2a (5-HT2a) receptorT32060SwissTargetPrediction
    P28335HTR2CSerotonin 2c (5-HT2c) receptorT83813SwissTargetPrediction
    P41595HTR2BSerotonin 2b (5-HT2b) receptorT31204SwissTargetPrediction
    P32297CHRNA3Neuronal acetylcholine receptor; alpha3/beta4T74166SwissTargetPrediction
    P28222HTR1BSerotonin 1b (5-HT1b) receptorT07806SwissTargetPrediction
    P08588ADRB1Beta-1 adrenergic receptorT44068SwissTargetPrediction
    P50406HTR6Serotonin 6 (5-HT6) receptorT16691SwissTargetPrediction
    P11086PNMTPhenylethanolamine N-methyltransferaseT56496SwissTargetPrediction
    Q99705MCHR1Melanin-concentrating hormone receptor 1T09572SwissTargetPrediction
    P00491PNPPurine nucleoside phosphorylaseT78198SwissTargetPrediction
    P10275ARAndrogen ReceptorT11211SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    P53779MAPK10c-Jun N-terminal kinase 3T85421SwissTargetPrediction
    P35367HRH1Histamine H1 receptorT77913SwissTargetPrediction
    P14902IDO1Indoleamine 2,3-dioxygenaseT89697SwissTargetPrediction
    P21728DRD1Dopamine D1 receptorT22118SEA
    P07550ADRB2Adrenergic receptor betaT52522SwissTargetPrediction
    P23975SLC6A2Norepinephrine transporterT21945SwissTargetPrediction
    P13945ADRB3Beta-3 adrenergic receptorT51408SwissTargetPrediction
    Q13639HTR4Serotonin 4 (5-HT4) receptorT59679SwissTargetPrediction
    P08183ABCB1P-glycoprotein 1T25258SwissTargetPrediction
    P35372OPRM1Mu opioid receptorT47768SwissTargetPrediction
    P25100ADRA1DAlpha-1d adrenergic receptorT53381SwissTargetPrediction
    P35368ADRA1BAlpha-1b adrenergic receptorT29500SwissTargetPrediction
    P41145OPRK1Kappa Opioid receptorT60693SwissTargetPrediction
    P04626ERBB2Receptor protein-tyrosine kinase erbB-2T14597SwissTargetPrediction
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    Q16539MAPK14MAP kinase p38 alphaT65864SwissTargetPrediction
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SwissTargetPrediction
    Q9Y233PDE10APhosphodiesterase 10A (by homology)T84133SwissTargetPrediction
    P18054ALOX12Arachidonate 12-lipoxygenaseT35527SwissTargetPrediction
    P41143OPRD1Delta opioid receptorT58992SwissTargetPrediction
    P00742F10Thrombin and coagulation factor XT84631SwissTargetPrediction
    Q13490BIRC2Baculoviral IAP repeat-containing protein 2T84780SwissTargetPrediction
    P11388TOP2ADNA topoisomerase II alphaT17048SwissTargetPrediction
    Q9UHL4DPP7Dipeptidyl peptidase IIT50773SwissTargetPrediction
    O75116ROCK2Rho-associated protein kinase 2T06093SwissTargetPrediction
    P23458JAK1Tyrosine-protein kinase JAK1T62460SwissTargetPrediction
    P41743PRKCIProtein kinase C iotaT83174SwissTargetPrediction
    Q5S007LRRK2Leucine-rich repeat serine/threonine-protein kinase 2T08123SwissTargetPrediction
    Q02750MAP2K1Dual specificity mitogen-activated protein kinase kinase 1T99057SwissTargetPrediction
    Q12884FAPFibroblast activation protein alpha (by homology)T53764SwissTargetPrediction
    P50579METAP2Methionine aminopeptidase 2T75596SwissTargetPrediction
    Q9NWZ3IRAK4Interleukin-1 receptor-associated kinase 4T55398SwissTargetPrediction
    P23443RPS6KB1Ribosomal protein S6 kinase 1T94479SwissTargetPrediction
    P07333CSF1RMacrophage colony stimulating factor receptorT20333SwissTargetPrediction
    P50750CDK9Cyclin-dependent kinase 9T44458SwissTargetPrediction
    P41146OPRL1Nociceptin receptorT52921SwissTargetPrediction
    P46098HTR3ASerotonin 3a (5-HT3a) receptorT64591SwissTargetPrediction
    O76074PDE5APhosphodiesterase 5AT07663SwissTargetPrediction
    P41180CASRCalcium sensing receptorT92076SwissTargetPrediction
    Q96GD4AURKBSerine/threonine-protein kinase Aurora-BT46781SwissTargetPrediction
    P22460KCNA5Voltage-gated potassium channel subunit Kv1.5T17569SwissTargetPrediction
    Q9UKP6UTS2RUrotensin II receptorT49072SwissTargetPrediction
    P30939HTR1FSerotonin 1f (5-HT1f) receptorT78656SwissTargetPrediction
    O76083PDE9APhosphodiesterase 9AT17852SwissTargetPrediction
    Q15759MAPK11MAP kinase p38 betaT55729SwissTargetPrediction
    Q14123PDE1CPhosphodiesterase 1CT92439SwissTargetPrediction
    P63316TNNC1Troponin, cardiac muscleT12966SwissTargetPrediction
    Q13126MTAPS-methyl-5-thioadenosine phosphorylaseT40787SwissTargetPrediction
    P53634CTSCDipeptidyl peptidase IT70490SwissTargetPrediction
    Q9HCR9PDE11APhosphodiesterase 11AT99802SwissTargetPrediction
    P48048KCNJ1ATP-sensitive inward rectifier potassium channel 1T78710SwissTargetPrediction
    Q8NET8TRPV3Transient receptor potential cation channel subfamily V member 3T58496SwissTargetPrediction
    Q86VL8SLC47A2Multidrug and toxin extrusion protein 2T78127SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T70967DI0029Aneurysm/dissection[ICD-11: BD50]P43681CHRNA4
    T70967DI0191Hypertensive crisis[ICD-11: BA03]P43681CHRNA4
    T70967DI0196Hypotension[ICD-11: BA20-BA21]P43681CHRNA4
    T64765DI0392Somnolence[ICD-11: MG42]Q9Y5N1HRH3
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T57392DI0214Insomnia[ICD-11: 7A00-7A0Z]P10635CYP2D6
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
    T94033DI0052Bleeding disorder[ICD-11: GA20-GA21]P00734F2
    T94033DI0091Coagulation defect[ICD-11: 3B10]P00734F2
    T94033DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P00734F2
    T94033DI0275Multiple sclerosis[ICD-11: 8A40]P00734F2
    T94033DI0287Myocardial infarction[ICD-11: BA41-BA43]P00734F2
    T94033DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00734F2
    T94033DI0403Thrombocytopenia[ICD-11: 3B64]P00734F2
    T94033DI0405Thrombosis[ICD-11: DB61-GB90]P00734F2
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
    T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
    T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
    T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
    T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
    T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
    T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
    T16769DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]P98170XIAP
    T62276DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q05586GRIN1
    T62276DI0182HIV-infected patients with tuberculosis[ICD-11: 1B10-1B14]Q05586GRIN1
    T39676DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q96FL8SLC47A1
    T53378DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P22748CA4
    T53378DI0166Glaucoma[ICD-11: 9C61]P22748CA4
    T53378DI0372Seborrhoeic dermatitis[ICD-11: EA81]P22748CA4
    T16739DI0012Acute myeloid leukaemia[ICD-11: 2A60]O60341KDM1A
    T16739DI0025Alzheimer disease[ICD-11: 8A20]O60341KDM1A
    T16739DI0138Ewing sarcoma[ICD-11: 2B52]O60341KDM1A
    T16739DI0238Lung cancer[ICD-11: 2C25]O60341KDM1A
    T16739DI0241Lymphoma[ICD-11: 2A80-2A86]O60341KDM1A
    T16739DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O60341KDM1A
    T16739DI0284Myelodysplastic syndrome[ICD-11: 2A37]O60341KDM1A
    T16739DI0286Myeloproliferative neoplasm[ICD-11: 2A20]O60341KDM1A
    T16739DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O60341KDM1A
    T32060DI0009Acute diabete complication[ICD-11: 5A2Y]P28223HTR2A
    T32060DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P28223HTR2A
    T32060DI0073Cerebral ischaemia[ICD-11: 8B1Z]P28223HTR2A
    T32060DI0270Mood disorder[ICD-11: 6A60-6E23]P28223HTR2A
    T32060DI0331Parkinsonism[ICD-11: 8A00]P28223HTR2A
    T32060DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28223HTR2A
    T32060DI0370Schizophrenia[ICD-11: 6A20]P28223HTR2A
    T83813DI0117Depression[ICD-11: 6A70-6A7Z]P28335HTR2C
    T83813DI0264Migraine[ICD-11: 8A80]P28335HTR2C
    T83813DI0308Obesity[ICD-11: 5B80-5B81]P28335HTR2C
    T83813DI0324Pain[ICD-11: MG30-MG3Z]P28335HTR2C
    T83813DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28335HTR2C
    T31204DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P41595HTR2B
    T31204DI0117Depression[ICD-11: 6A70-6A7Z]P41595HTR2B
    T31204DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P41595HTR2B
    T31204DI0354Psychotic disorder[ICD-11: 6A20-6A25]P41595HTR2B
    T74166DI0105Cough[ICD-11: MD12]P32297CHRNA3
    T07806DI0264Migraine[ICD-11: 8A80]P28222HTR1B
    T07806DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P28222HTR1B
    T07806DI0354Psychotic disorder[ICD-11: 6A20-6A25]P28222HTR1B
    T07806DI0370Schizophrenia[ICD-11: 6A20]P28222HTR1B
    T44068DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P08588ADRB1
    T44068DI0037Asthma[ICD-11: CA23]P08588ADRB1
    T44068DI0068Cardiac arrhythmia[ICD-11: BC9Z]P08588ADRB1
    T44068DI0071Central and peripheral nervous disease[ICD-11: 8A04-8E7Z]P08588ADRB1
    T44068DI0088Circulatory system disease[ICD-11: BE2Z]P08588ADRB1
    T44068DI0097Conduction disorder[ICD-11: BC63]P08588ADRB1
    T44068DI0102Coronary atherosclerosis[ICD-11: BA52]P08588ADRB1
    T44068DI0137Essential hypertension[ICD-11: BA00]P08588ADRB1
    T44068DI0166Glaucoma[ICD-11: 9C61]P08588ADRB1
    T44068DI0175Heart failure[ICD-11: BD10-BD1Z]P08588ADRB1
    T44068DI0190Hypertension[ICD-11: BA00-BA04]P08588ADRB1
    T44068DI0264Migraine[ICD-11: 8A80]P08588ADRB1
    T44068DI0375Sepsis[ICD-11: 1G40-1G41]P08588ADRB1
    T44068DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P08588ADRB1
    T44068DI0434Ventricular tachyarrhythmia[ICD-11: BC71]P08588ADRB1
    T16691DI0025Alzheimer disease[ICD-11: 8A20]P50406HTR6
    T16691DI0370Schizophrenia[ICD-11: 6A20]P50406HTR6
    T09572DI0308Obesity[ICD-11: 5B80-5B81]Q99705MCHR1
    T78198DI0120Diabetes mellitus[ICD-11: 5A10]P00491PNP
    T78198DI0167Gout[ICD-11: FA25]P00491PNP
    T78198DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P00491PNP
    T78198DI0283Mycosis fungoides[ICD-11: 2B01]P00491PNP
    T78198DI0351Psoriasis[ICD-11: EA90]P00491PNP
    T11211DI0005Acne vulgaris[ICD-11: ED80]P10275AR
    T11211DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10275AR
    T11211DI0021Alcoholic liver disease[ICD-11: DB94]P10275AR
    T11211DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10275AR
    T11211DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P10275AR
    T11211DI0145Female pelvic pain[ICD-11: GA34]P10275AR
    T11211DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P10275AR
    T11211DI0237Low bone mass disorder[ICD-11: FB83]P10275AR
    T11211DI0247Mammary tumour[ICD-11: 2C60-2C6Z]P10275AR
    T11211DI0346Prostate cancer[ICD-11: 2C82]P10275AR
    T11211DI0401Testicular dysfunction[ICD-11: 5A81]P10275AR
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T77913DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P35367HRH1
    T77913DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P35367HRH1
    T77913DI0063Breathing abnormality[ICD-11: MD11]P35367HRH1
    T77913DI0099Conjunctiva disorder[ICD-11: 9A60]P35367HRH1
    T77913DI0105Cough[ICD-11: MD12]P35367HRH1
    T77913DI0117Depression[ICD-11: 6A70-6A7Z]P35367HRH1
    T77913DI0136Episodic vestibular syndrome[ICD-11: AB31]P35367HRH1
    T77913DI0173Headache[ICD-11: 8A80-8A84]P35367HRH1
    T77913DI0214Insomnia[ICD-11: 7A00-7A0Z]P35367HRH1
    T77913DI0272Morning sickness disorder[ICD-11: SC00]P35367HRH1
    T77913DI0292Nasopharyngitis[ICD-11: CA00]P35367HRH1
    T77913DI0293Nausea/vomiting[ICD-11: MD90]P35367HRH1
    T77913DI0331Parkinsonism[ICD-11: 8A00]P35367HRH1
    T77913DI0349Pruritus[ICD-11: EC90]P35367HRH1
    T77913DI0366Rheumatoid arthritis[ICD-11: FA20]P35367HRH1
    T77913DI0388Sleep-wake disorder[ICD-11: 7A00-7B2Z]P35367HRH1
    T77913DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P35367HRH1
    T89697DI0117Depression[ICD-11: 6A70-6A7Z]P14902IDO1
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T52522DI0037Asthma[ICD-11: CA23]P07550ADRB2
    T52522DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07550ADRB2
    T52522DI0097Conduction disorder[ICD-11: BC63]P07550ADRB2
    T52522DI0344Preterm labour/delivery[ICD-11: JB00]P07550ADRB2
    T52522DI0387Sleep-related breathing disorder[ICD-11: 7A4Z]P07550ADRB2
    T21945DI0013Acute pain[ICD-11: MG31]P23975SLC6A2
    T21945DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P23975SLC6A2
    T21945DI0087Chronic pain[ICD-11: MG30]P23975SLC6A2
    T21945DI0101Corneal disease[ICD-11: 9A76-9A78]P23975SLC6A2
    T21945DI0117Depression[ICD-11: 6A70-6A7Z]P23975SLC6A2
    T21945DI0166Glaucoma[ICD-11: 9C61]P23975SLC6A2
    T21945DI0264Migraine[ICD-11: 8A80]P23975SLC6A2
    T21945DI0301Nicotine use disorder[ICD-11: 6C4A]P23975SLC6A2
    T21945DI0308Obesity[ICD-11: 5B80-5B81]P23975SLC6A2
    T21945DI0324Pain[ICD-11: MG30-MG3Z]P23975SLC6A2
    T21945DI0395Stomach cancer[ICD-11: 2B72]P23975SLC6A2
    T51408DI0030Angina pectoris[ICD-11: BA40]P13945ADRB3
    T51408DI0037Asthma[ICD-11: CA23]P13945ADRB3
    T51408DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P13945ADRB3
    T51408DI0129Dystonic disorder[ICD-11: 8A02]P13945ADRB3
    T51408DI0154Functional bladder disorder[ICD-11: GC50]P13945ADRB3
    T51408DI0190Hypertension[ICD-11: BA00-BA04]P13945ADRB3
    T51408DI0331Parkinsonism[ICD-11: 8A00]P13945ADRB3
    T59679DI0161Gastro-oesophageal reflux disease[ICD-11: DA22]Q13639HTR4
    T59679DI0218Irritable bowel syndrome[ICD-11: DD91]Q13639HTR4
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
    T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
    T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
    T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
    T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
    T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
    T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
    T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
    T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
    T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
    T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
    T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
    T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
    T53381DI0166Glaucoma[ICD-11: 9C61]P25100ADRA1D
    T53381DI0175Heart failure[ICD-11: BD10-BD1Z]P25100ADRA1D
    T53381DI0190Hypertension[ICD-11: BA00-BA04]P25100ADRA1D
    T53381DI0348Prostate hyperplasia[ICD-11: GA90]P25100ADRA1D
    T53381DI0378Sexual dysfunction[ICD-11: HA00-HA01]P25100ADRA1D
    T53381DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P25100ADRA1D
    T29500DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P35368ADRA1B
    T29500DI0190Hypertension[ICD-11: BA00-BA04]P35368ADRA1B
    T29500DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P35368ADRA1B
    T29500DI0308Obesity[ICD-11: 5B80-5B81]P35368ADRA1B
    T29500DI0324Pain[ICD-11: MG30-MG3Z]P35368ADRA1B
    T60693DI0304Non-specific cutaneous vascular symptom[ICD-11: ME64]P41145OPRK1
    T60693DI0324Pain[ICD-11: MG30-MG3Z]P41145OPRK1
    T60693DI0349Pruritus[ICD-11: EC90]P41145OPRK1
    T14597DI0062Breast cancer[ICD-11: 2C60-2C6Y]P04626ERBB2
    T14597DI0238Lung cancer[ICD-11: 2C25]P04626ERBB2
    T14597DI0346Prostate cancer[ICD-11: 2C82]P04626ERBB2
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T65864DI0102Coronary atherosclerosis[ICD-11: BA52]Q16539MAPK14
    T65864DI0287Myocardial infarction[ICD-11: BA41-BA43]Q16539MAPK14
    T65864DI0366Rheumatoid arthritis[ICD-11: FA20]Q16539MAPK14
    T65864DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]Q16539MAPK14
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T84133DI0079Choreiform disorder[ICD-11: 8A01]Q9Y233PDE10A
    T84133DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q9Y233PDE10A
    T84133DI0218Irritable bowel syndrome[ICD-11: DD91]Q9Y233PDE10A
    T84133DI0370Schizophrenia[ICD-11: 6A20]Q9Y233PDE10A
    T84133DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9Y233PDE10A
    T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
    T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
    T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
    T84631DI0053Blood-forming organ disease[ICD-11: 3C0Z]P00742F10
    T84631DI0080Christmas disease[ICD-11: 3B11]P00742F10
    T84631DI0091Coagulation defect[ICD-11: 3B10]P00742F10
    T84631DI0103Coronary thrombosis[ICD-11: BA43]P00742F10
    T84631DI0114Deep vein thrombosis[ICD-11: BD71]P00742F10
    T84631DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P00742F10
    T84631DI0405Thrombosis[ICD-11: DB61-GB90]P00742F10
    T84631DI0433Venous thromboembolism[ICD-11: BD72]P00742F10
    T84780DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]Q13490BIRC2
    T17048DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11388TOP2A
    T17048DI0225Kaposi sarcoma[ICD-11: 2B57]P11388TOP2A
    T17048DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11388TOP2A
    T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
    T62460DI0039Atopic eczema[ICD-11: EA80]P23458JAK1
    T62460DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P23458JAK1
    T62460DI0366Rheumatoid arthritis[ICD-11: FA20]P23458JAK1
    T62460DI0404Thrombocytosis[ICD-11: 3B63]P23458JAK1
    T83174DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P41743PRKCI
    T08123DI0331Parkinsonism[ICD-11: 8A00]Q5S007LRRK2
    T99057DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]Q02750MAP2K1
    T99057DI0336Phakomatoses/hamartoneoplastic syndrome[ICD-11: LD2D]Q02750MAP2K1
    T53764DI0300Neutropenia[ICD-11: 4B00]Q12884FAP
    T75596DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50579METAP2
    T55398DI0039Atopic eczema[ICD-11: EA80]Q9NWZ3IRAK4
    T55398DI0109Cutaneous lupus erythematosus[ICD-11: EB50-EB5Z]Q9NWZ3IRAK4
    T55398DI0241Lymphoma[ICD-11: 2A80-2A86]Q9NWZ3IRAK4
    T55398DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q9NWZ3IRAK4
    T55398DI0351Psoriasis[ICD-11: EA90]Q9NWZ3IRAK4
    T55398DI0366Rheumatoid arthritis[ICD-11: FA20]Q9NWZ3IRAK4
    T94479DI0025Alzheimer disease[ICD-11: 8A20]P23443RPS6KB1
    T94479DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P23443RPS6KB1
    T94479DI0419Ulcerative colitis[ICD-11: DD71]P23443RPS6KB1
    T20333DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P07333CSF1R
    T44458DI0012Acute myeloid leukaemia[ICD-11: 2A60]P50750CDK9
    T44458DI0241Lymphoma[ICD-11: 2A80-2A86]P50750CDK9
    T44458DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P50750CDK9
    T44458DI0249Mature B-cell leukaemia[ICD-11: 2A82]P50750CDK9
    T44458DI0250Mature B-cell lymphoma[ICD-11: 2A85]P50750CDK9
    T44458DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]P50750CDK9
    T44458DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50750CDK9
    T52921DI0039Atopic eczema[ICD-11: EA80]P41146OPRL1
    T52921DI0117Depression[ICD-11: 6A70-6A7Z]P41146OPRL1
    T52921DI0173Headache[ICD-11: 8A80-8A84]P41146OPRL1
    T52921DI0175Heart failure[ICD-11: BD10-BD1Z]P41146OPRL1
    T64591DI0087Chronic pain[ICD-11: MG30]P46098HTR3A
    T64591DI0101Corneal disease[ICD-11: 9A76-9A78]P46098HTR3A
    T64591DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P46098HTR3A
    T64591DI0218Irritable bowel syndrome[ICD-11: DD91]P46098HTR3A
    T64591DI0293Nausea/vomiting[ICD-11: MD90]P46098HTR3A
    T07663DI0190Hypertension[ICD-11: BA00-BA04]O76074PDE5A
    T07663DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]O76074PDE5A
    T07663DI0378Sexual dysfunction[ICD-11: HA00-HA01]O76074PDE5A
    T07663DI0411Tonus and reflex abnormality[ICD-11: MB47]O76074PDE5A
    T92076DI0189Hyper-parathyroidism[ICD-11: 5A51]P41180CASR
    T46781DI0009Acute diabete complication[ICD-11: 5A2Y]Q96GD4AURKB
    T46781DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q96GD4AURKB
    T17569DI0030Angina pectoris[ICD-11: BA40]P22460KCNA5
    T49072DI0037Asthma[ICD-11: CA23]Q9UKP6UTS2R
    T78656DI0264Migraine[ICD-11: 8A80]P30939HTR1F
    T78656DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30939HTR1F
    T17852DI0025Alzheimer disease[ICD-11: 8A20]O76083PDE9A
    T17852DI0115Dementia[ICD-11: 6D80-6D8Z]O76083PDE9A
    T17852DI0165Genitourinary disease[ICD-11: GA0Z-GC8Z]O76083PDE9A
    T17852DI0175Heart failure[ICD-11: BD10-BD1Z]O76083PDE9A
    T17852DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]O76083PDE9A
    T17852DI0331Parkinsonism[ICD-11: 8A00]O76083PDE9A
    T17852DI0370Schizophrenia[ICD-11: 6A20]O76083PDE9A
    T17852DI0381Sickle-cell disorder[ICD-11: 3A51]O76083PDE9A
    T55729DI0025Alzheimer disease[ICD-11: 8A20]Q15759MAPK11
    T55729DI0366Rheumatoid arthritis[ICD-11: FA20]Q15759MAPK11
    T12966DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P63316TNNC1
    T12966DI0175Heart failure[ICD-11: BD10-BD1Z]P63316TNNC1
    T40787DI0275Multiple sclerosis[ICD-11: 8A40]Q13126MTAP
    T70490DI0064Bronchiectasis[ICD-11: CA24]P53634CTSC
    T58496DI0324Pain[ICD-11: MG30-MG3Z]Q8NET8TRPV3

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