N-cyclohexyl-3-(3-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide



Compound IDCDAMM00330
Common nameN-cyclohexyl-3-(3-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide
IUPAC nameN-cyclohexyl-3-(3-methoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide
Molecular formulaC17H22N2O3

Experimental data

Retention time28.353
Adduct[M+H]+
Actual mz303.171
Theoretical mz303.17
Error0.92
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.72

Identifiers and class information

Inchi keyGOKNYOHQPLPAOF-UHFFFAOYNA-N
SmilesO=C(NC1CCCCC1)C2ON=C(C=3C=CC=C(OC)C3)C2
SuperclassBenzenoids
ClassPhenol ethers

Plant source

  • Pedalium murex L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)1
    Number of rotatable bonds (#rotor)3
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)0
    Molecular weight (mol_MW)302.372
    Computed dipole moment(dipole)7.744
    Total solvent accessible surface area (SASA)613.071
    Hydrophobic component of SASA (FOSA)382.135
    Hydrophilic component of SASA (FISA)85.292
    Pie component of the SASA (PISA)145.644
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1042.98
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)5.95
    Free energy of solvation of dipole (dip^2/V)0.0574964
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0097052
    Globularity descriptor (glob)0.811282
    Predicted polarizability in cubic angstroms (QPpolrz)35.051
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.703
    Predicted octanol/gas partition coefficient (QPlogPoct)16.48
    Predicted water/gas partition coefficient (QPlogPw)11.212
    Predicted octanol/water partition coefficient (QPlogPo/w)2.287
    Predicted aqueous solubility (QPlogS)-4.002
    Conformation-independent predicted aqueous solubility (CIQPlogS)-2.871
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-3.906
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)989.148
    Predicted brain/blood partition coefficient (QPlogBB)-0.481
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)788.06
    Predicted skin permeability, log Kp (QPlogKp)-2.29
    PM3 calculated ionization potential (IP(ev))9.175
    PM3 calculated electron affinity (EA(eV))0.394
    Number of likely metabolic reactions (#metab)3
    Prediction of binding to human serum albumin (QPlogKhsa)-0.159
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)93.947
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)24.098
    Van der Waals surface area (PSA)70.227
    Number of nitrogen and oxygen atoms (#NandO)5
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P36544CHRNA7Neuronal acetylcholine receptor protein alpha-7 subunitT34429SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    P30542ADORA1Adenosine A1 receptorT92072SwissTargetPrediction
    O43570CA12Carbonic anhydrase XIIT16987SwissTargetPrediction
    Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    P41594GRM5Metabotropic glutamate receptor 5T99347SwissTargetPrediction
    P21397MAOAMonoamine oxidase AT83875SwissTargetPrediction and SEA
    P42338PIK3CBPI3-kinase p110-beta subunitT05031SwissTargetPrediction
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P27487DPP4Dipeptidyl peptidase IVT31391SwissTargetPrediction
    P21554CNR1Cannabinoid receptor 1 (by homology)T76685SEA
    P34913EPHX2Epoxide hydrataseT35734SEA
    P27338MAOBMonoamine oxidase BT83011SwissTargetPrediction and SEA
    Q96RJ0TAAR1Trace amine-associated receptor 1 (by homology)T99524SwissTargetPrediction
    P50406HTR6Serotonin 6 (5-HT6) receptorT16691SwissTargetPrediction
    P43235CTSKCathepsin KT11388SwissTargetPrediction
    P45983MAPK8c-Jun N-terminal kinase 1T40097SwissTargetPrediction
    P35968KDRVascular endothelial growth factor receptor 2T80975SwissTargetPrediction
    O60885BRD4Bromodomain-containing protein 4T00407SwissTargetPrediction
    P25440BRD2Bromodomain-containing protein 2T86597SwissTargetPrediction
    Q15059BRD3Bromodomain-containing protein 3T42048SwissTargetPrediction
    O00519FAAHAnandamide amidohydrolaseT11754SEA
    Q8NER1TRPV1Vanilloid receptorT83193SwissTargetPrediction
    O14684PTGESProstaglandin E synthaseT02562SwissTargetPrediction
    P49137MAPKAPK2MAP kinase-activated protein kinase 2T21307SwissTargetPrediction
    Q9UM73ALKALK tyrosine kinase receptorT56418SwissTargetPrediction
    P11309PIM1Serine/threonine-protein kinase PIM1T50594SwissTargetPrediction
    Q9H2K2TNKS2Tankyrase-2T38087SwissTargetPrediction
    P00519ABL1Tyrosine-protein kinase ABLT63505SwissTargetPrediction
    Q16539MAPK14MAP kinase p38 alphaT65864SwissTargetPrediction
    P55072VCPTransitional endoplasmic reticulum ATPaseT12646SwissTargetPrediction and SEA
    P24941CDK2Cyclin-dependent kinase 2T70176SwissTargetPrediction
    P36888FLT3Tyrosine-protein kinase receptor FLT3T74312SwissTargetPrediction
    Q9P1W9PIM2Serine/threonine-protein kinase PIM2T07279SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    Q9Y233PDE10APhosphodiesterase 10A (by homology)T84133SwissTargetPrediction
    O43603GALR2Galanin receptor 2 (by homology)T13453SEA
    P47211GALR1Galanin receptor 1 (by homology)T78581SEA
    O43193MLNRMotilin receptorT62306SEA
    Q08499PDE4DPhosphodiesterase 4DT02001SwissTargetPrediction and SEA
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SEA
    Q92831KAT2BHistone acetyltransferase PCAFT16902SwissTargetPrediction
    Q5S007LRRK2Leucine-rich repeat serine/threonine-protein kinase 2T08123SwissTargetPrediction
    P49810PSEN2Gamma-secretaseT99204SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    P36897TGFBR1TGF-beta receptor type IT53389SwissTargetPrediction
    O00329PIK3CDPI3-kinase p110-delta subunitT67849SwissTargetPrediction
    P53779MAPK10c-Jun N-terminal kinase 3T85421SwissTargetPrediction and SEA
    P05186ALPLAlkaline phosphatase, tissue-nonspecific isozymeT09538SwissTargetPrediction
    P17948FLT1Vascular endothelial growth factor receptor 1T63966SwissTargetPrediction
    P10721KITStem cell growth factor receptorT57700SwissTargetPrediction
    Q15078CDK5R1Cyclin-dependent kinase 5/CDK5 activator 1T09513SwissTargetPrediction
    P12931SRCTyrosine-protein kinase SRCT85943SwissTargetPrediction
    Q13627DYRK1ADual-specificity tyrosine-phosphorylation regulated kinase 1AT92803SwissTargetPrediction
    P24385CCND1Cyclin-dependent kinase 4/cyclin D1T12355SwissTargetPrediction
    P40763STAT3Signal transducer and activator of transcription 3T29130SwissTargetPrediction
    P49759CLK1Dual specificty protein kinase CLK1T46685SwissTargetPrediction
    P48039MTNR1AMelatonin receptor 1AT97613SEA
    P49286MTNR1BMelatonin receptor 1BT48268SEA
    P34972CNR2Cannabinoid receptor 2T37693SEA
    P14091CTSECathepsin ET16891SEA
    Q14289PTK2BProtein tyrosine kinase 2 betaT07087SwissTargetPrediction
    O00311CDC7CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)T81358SwissTargetPrediction
    P28482MAPK1MAP kinase ERK2T58970SwissTargetPrediction
    P05556ITGB1Integrin alpha2/beta1T01851SwissTargetPrediction
    Q9BPW0PPP5CSerine/threonine-protein phosphataseT04123SEA
    P11362FGFR1Fibroblast growth factor receptor 1T47101SwissTargetPrediction
    P06493CDK1Cyclin-dependent kinase 1/cyclin B1T49898SwissTargetPrediction
    P50750CDK9Cyclin-dependent kinase 9T44458SwissTargetPrediction
    P49761CLK3Dual specificity protein kinase CLK3T21585SwissTargetPrediction
    P34998CRHR1Corticotropin releasing factor receptor 1 (by homology)T45262SwissTargetPrediction
    P32239CCKBRCholecystokinin B receptor (by homology)T05849SwissTargetPrediction
    Q02127DHODHDihydroorotate dehydrogenaseT61400SEA
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SwissTargetPrediction
    O76074PDE5APhosphodiesterase 5AT07663SwissTargetPrediction
    P43119PTGIRProstanoid IP receptorT99954SEA
    Q08881ITKTyrosine-protein kinase ITK/TSKT77537SwissTargetPrediction
    Q16875PFKFB36-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3T23787SwissTargetPrediction
    P27815PDE4APhosphodiesterase 4AT61744SwissTargetPrediction
    Q16581C3AR1C3a anaphylatoxin chemotactic receptorT30219SEA
    P30536TSPOTranslocator protein (by homology)T75440SwissTargetPrediction
    P51686CCR9C-C chemokine receptor type 9T97873SwissTargetPrediction
    Q9Y210TRPC6Short transient receptor potential channel 6T80165SwissTargetPrediction
    O43614HCRTR2Orexin receptor 2T69485SwissTargetPrediction
    O43613HCRTR1Orexin receptor 1T73482SwissTargetPrediction
    O14649KCNK3Potassium channel subfamily K member 3T15795SwissTargetPrediction
    Q9NPC2KCNK9Potassium channel subfamily K member 9T57613SwissTargetPrediction and SEA
    P53671LIMK2LIM domain kinase 2T09133SwissTargetPrediction
    P43490NAMPTNicotinamide phosphoribosyltransferaseT54582SwissTargetPrediction
    P17931LGALS3Galectin-3T72038SEA
    P16234PDGFRAPlatelet-derived growth factor receptorT53524SwissTargetPrediction
    P25106ACKR3C-X-C chemokine receptor type 7T10491SEA
    P51812RPS6KA3Ribosomal protein S6 kinase alpha 3T03279SwissTargetPrediction
    Q07343PDE4BPhosphodiesterase 4B (by homology)T10265SwissTargetPrediction and SEA
    P00746CFDComplement factor DT66383SwissTargetPrediction
    O00408PDE2APhosphodiesterase 2AT77400SwissTargetPrediction
    P01130LDLRLDL receptorT94692SwissTargetPrediction
    P19525EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinaseT04831SwissTargetPrediction
    Q92630DYRK2Dual-specificity tyrosine-phosphorylation regulated kinase 2T39486SwissTargetPrediction
    Q13464ROCK1Rho-associated protein kinase 1T51282SEA
    P17612PRKACAcAMP-dependent protein kinase alpha-catalytic subunitT12808SEA
    Q16665HIF1AHypoxia-inducible factor 1 alphaT55610SwissTargetPrediction
    P20248CCNA2CDK2/Cyclin AT58470SwissTargetPrediction
    P30281CCND3Cyclin-dependent kinase 4/cyclin DT72507SwissTargetPrediction
    Q08493PDE4CPhosphodiesterase 4CT12081SwissTargetPrediction and SEA
    P47901AVPR1BVasopressin V1b receptorT59881SEA
    P09382LGALS1Galectin-1T09544SEA
    P14618PKMPyruvate kinase isozymes M1/M2T65889SwissTargetPrediction
    Q00975CACNA1BVoltage-gated N-type calcium channel alpha-1B subunitT38338SEA
    P22888LHCGRLuteinizing hormone/Choriogonadotropin receptorT79473SEA
    Q10469MGAT2Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseT67812SEA
    Q96PD7DGAT2Diacylglycerol O-acyltransferase 2T95558SEA
    O35273SMAD3Mothers against decapentaplegic homolog 3T35445SEA
    P01100FOSProto-oncogene c-FosT28025SEA
    Q9UQ81MCH5Caspase-8T15700SEA
    Q9H4A3WNK1Serine/threonine-protein kinase WNK1T52638SEA
    P02708CHRNA1Neuronal acetylcholine receptor alpha-1T04689SEA
    O00482NR5A2Liver receptor homolog-1T13902SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T34429DI0101Corneal disease[ICD-11: 9A76-9A78]P36544CHRNA7
    T34429DI0370Schizophrenia[ICD-11: 6A20]P36544CHRNA7
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T92072DI0319Orthostatic hypotension[ICD-11: BA21]P30542ADORA1
    T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
    T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T99347DI0152Fragile X chromosome[ICD-11: LD55]P41594GRM5
    T99347DI0331Parkinsonism[ICD-11: 8A00]P41594GRM5
    T83875DI0117Depression[ICD-11: 6A70-6A7Z]P21397MAOA
    T83875DI0331Parkinsonism[ICD-11: 8A00]P21397MAOA
    T05031DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42338PIK3CB
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T31391DI0009Acute diabete complication[ICD-11: 5A2Y]P27487DPP4
    T31391DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P27487DPP4
    T76685DI0031Anorexia nervosa[ICD-11: 6B80]P21554CNR1
    T76685DI0214Insomnia[ICD-11: 7A00-7A0Z]P21554CNR1
    T76685DI0308Obesity[ICD-11: 5B80-5B81]P21554CNR1
    T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
    T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
    T83011DI0115Dementia[ICD-11: 6D80-6D8Z]P27338MAOB
    T83011DI0117Depression[ICD-11: 6A70-6A7Z]P27338MAOB
    T83011DI0190Hypertension[ICD-11: BA00-BA04]P27338MAOB
    T83011DI0243Malaria[ICD-11: 1F40-1F45]P27338MAOB
    T83011DI0264Migraine[ICD-11: 8A80]P27338MAOB
    T83011DI0331Parkinsonism[ICD-11: 8A00]P27338MAOB
    T99524DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q96RJ0TAAR1
    T99524DI0149Focal/segmental autonomic disorder[ICD-11: 8D8A]Q96RJ0TAAR1
    T99524DI0290Narcolepsy[ICD-11: 7A20]Q96RJ0TAAR1
    T16691DI0025Alzheimer disease[ICD-11: 8A20]P50406HTR6
    T16691DI0370Schizophrenia[ICD-11: 6A20]P50406HTR6
    T11388DI0237Low bone mass disorder[ICD-11: FB83]P43235CTSK
    T40097DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45983MAPK8
    T80975DI0062Breast cancer[ICD-11: 2C60-2C6Y]P35968KDR
    T80975DI0095Colorectal cancer[ICD-11: 2B91]P35968KDR
    T80975DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P35968KDR
    T80975DI0244Malignant digestive organ neoplasm[ICD-11: 2C11]P35968KDR
    T80975DI0361Renal cell carcinoma[ICD-11: 2C90]P35968KDR
    T80975DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35968KDR
    T80975DI0395Stomach cancer[ICD-11: 2B72]P35968KDR
    T80975DI0403Thrombocytopenia[ICD-11: 3B64]P35968KDR
    T80975DI0407Thyroid cancer[ICD-11: 2D10]P35968KDR
    T86597DI0106COVID-19[ICD-11: 1D6Y]P25440BRD2
    T42048DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q15059BRD3
    T42048DI0346Prostate cancer[ICD-11: 2C82]Q15059BRD3
    T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
    T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
    T02562DI0025Alzheimer disease[ICD-11: 8A20]O14684PTGES
    T21307DI0011Acute laryngitis/tracheitis[ICD-11: CA05]P49137MAPKAPK2
    T21307DI0181Hidradenitis suppurativa[ICD-11: ED92]P49137MAPKAPK2
    T21307DI0269Monogenic autoinflammatory syndrome[ICD-11: 4A60]P49137MAPKAPK2
    T21307DI0334Peritoneal cancer[ICD-11: 2C51]P49137MAPKAPK2
    T21307DI0352Psoriatic arthritis[ICD-11: FA21]P49137MAPKAPK2
    T21307DI0366Rheumatoid arthritis[ICD-11: FA20]P49137MAPKAPK2
    T21307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49137MAPKAPK2
    T56418DI0238Lung cancer[ICD-11: 2C25]Q9UM73ALK
    T56418DI0251Mature T-cell lymphoma[ICD-11: 2A90]Q9UM73ALK
    T56418DI0303Non-small-cell lung cancer[ICD-11: 2C25]Q9UM73ALK
    T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
    T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
    T38087DI0321Ovarian cancer[ICD-11: 2C73]Q9H2K2TNKS2
    T63505DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00519ABL1
    T63505DI0220Ischemia[ICD-11: 8B10-8B11]P00519ABL1
    T63505DI0250Mature B-cell lymphoma[ICD-11: 2A85]P00519ABL1
    T63505DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00519ABL1
    T65864DI0102Coronary atherosclerosis[ICD-11: BA52]Q16539MAPK14
    T65864DI0287Myocardial infarction[ICD-11: BA41-BA43]Q16539MAPK14
    T65864DI0366Rheumatoid arthritis[ICD-11: FA20]Q16539MAPK14
    T65864DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]Q16539MAPK14
    T12646DI0012Acute myeloid leukaemia[ICD-11: 2A60]P55072VCP
    T12646DI0274Multiple myeloma[ICD-11: 2A83]P55072VCP
    T12646DI0284Myelodysplastic syndrome[ICD-11: 2A37]P55072VCP
    T12646DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P55072VCP
    T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
    T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
    T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
    T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
    T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
    T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
    T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
    T74312DI0012Acute myeloid leukaemia[ICD-11: 2A60]P36888FLT3
    T74312DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P36888FLT3
    T74312DI0095Colorectal cancer[ICD-11: 2B91]P36888FLT3
    T74312DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P36888FLT3
    T74312DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P36888FLT3
    T74312DI0248Mastocytosis[ICD-11: 2A21]P36888FLT3
    T74312DI0250Mature B-cell lymphoma[ICD-11: 2A85]P36888FLT3
    T74312DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P36888FLT3
    T07279DI0274Multiple myeloma[ICD-11: 2A83]Q9P1W9PIM2
    T07279DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9P1W9PIM2
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T84133DI0079Choreiform disorder[ICD-11: 8A01]Q9Y233PDE10A
    T84133DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q9Y233PDE10A
    T84133DI0218Irritable bowel syndrome[ICD-11: DD91]Q9Y233PDE10A
    T84133DI0370Schizophrenia[ICD-11: 6A20]Q9Y233PDE10A
    T84133DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9Y233PDE10A
    T78581DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P47211GALR1
    T62306DI0124Digestive system disease[ICD-11: DE2Z]O43193MLNR
    T62306DI0159Gastroduodenal motor/secretory disorder[ICD-11: DA41]O43193MLNR
    T62306DI0161Gastro-oesophageal reflux disease[ICD-11: DA22]O43193MLNR
    T62306DI0218Irritable bowel syndrome[ICD-11: DD91]O43193MLNR
    T62306DI0324Pain[ICD-11: MG30-MG3Z]O43193MLNR
    T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T08123DI0331Parkinsonism[ICD-11: 8A00]Q5S007LRRK2
    T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
    T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
    T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T53389DI0035Arterial occlusive disease[ICD-11: BD40]P36897TGFBR1
    T53389DI0238Lung cancer[ICD-11: 2C25]P36897TGFBR1
    T67849DI0151Follicular lymphoma[ICD-11: 2A80]O00329PIK3CD
    T67849DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00329PIK3CD
    T67849DI0249Mature B-cell leukaemia[ICD-11: 2A82]O00329PIK3CD
    T67849DI0250Mature B-cell lymphoma[ICD-11: 2A85]O00329PIK3CD
    T67849DI0395Stomach cancer[ICD-11: 2B72]O00329PIK3CD
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T09538DI0164Genetic prion disease[ICD-11: 8E02]P05186ALPL
    T09538DI0330Parasitic infection[ICD-11: 1D0Y-1G2Z]P05186ALPL
    T63966DI0361Renal cell carcinoma[ICD-11: 2C90]P17948FLT1
    T57700DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P10721KIT
    T57700DI0095Colorectal cancer[ICD-11: 2B91]P10721KIT
    T57700DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P10721KIT
    T57700DI0250Mature B-cell lymphoma[ICD-11: 2A85]P10721KIT
    T57700DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P10721KIT
    T57700DI0361Renal cell carcinoma[ICD-11: 2C90]P10721KIT
    T57700DI0403Thrombocytopenia[ICD-11: 3B64]P10721KIT
    T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
    T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
    T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
    T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
    T92803DI0113Cytomegaloviral disease[ICD-11: 1D82]Q13627DYRK1A
    T12355DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P24385CCND1
    T29130DI0351Psoriasis[ICD-11: EA90]P40763STAT3
    T97613DI0214Insomnia[ICD-11: 7A00-7A0Z]P48039MTNR1A
    T48268DI0214Insomnia[ICD-11: 7A00-7A0Z]P49286MTNR1B
    T37693DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34972CNR2
    T37693DI0214Insomnia[ICD-11: 7A00-7A0Z]P34972CNR2
    T81358DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00311CDC7
    T81358DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O00311CDC7
    T58970DI0036Arteries/arterioles disorder[ICD-11: BD52]P28482MAPK1
    T58970DI0252Melanoma[ICD-11: 2C30]P28482MAPK1
    T58970DI0326Pancreatic cancer[ICD-11: 2C10]P28482MAPK1
    T58970DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28482MAPK1
    T01851DI0060Brain cancer[ICD-11: 2A00]P05556ITGB1
    T01851DI0238Lung cancer[ICD-11: 2C25]P05556ITGB1
    T01851DI0365Retinopathy[ICD-11: 9B71]P05556ITGB1
    T47101DI0095Colorectal cancer[ICD-11: 2B91]P11362FGFR1
    T47101DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P11362FGFR1
    T47101DI0235Liver cancer[ICD-11: 2C12]P11362FGFR1
    T47101DI0403Thrombocytopenia[ICD-11: 3B64]P11362FGFR1
    T49898DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06493CDK1
    T49898DI0238Lung cancer[ICD-11: 2C25]P06493CDK1
    T49898DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P06493CDK1
    T49898DI0250Mature B-cell lymphoma[ICD-11: 2A85]P06493CDK1
    T49898DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06493CDK1
    T44458DI0012Acute myeloid leukaemia[ICD-11: 2A60]P50750CDK9
    T44458DI0241Lymphoma[ICD-11: 2A80-2A86]P50750CDK9
    T44458DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P50750CDK9
    T44458DI0249Mature B-cell leukaemia[ICD-11: 2A82]P50750CDK9
    T44458DI0250Mature B-cell lymphoma[ICD-11: 2A85]P50750CDK9
    T44458DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]P50750CDK9
    T44458DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50750CDK9
    T45262DI0394Staphylococcal/streptococcal disease[ICD-11: 1B5Y]P34998CRHR1
    T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
    T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
    T61400DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q02127DHODH
    T61400DI0275Multiple sclerosis[ICD-11: 8A40]Q02127DHODH
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T07663DI0190Hypertension[ICD-11: BA00-BA04]O76074PDE5A
    T07663DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]O76074PDE5A
    T07663DI0378Sexual dysfunction[ICD-11: HA00-HA01]O76074PDE5A
    T07663DI0411Tonus and reflex abnormality[ICD-11: MB47]O76074PDE5A
    T99954DI0003Abortion[ICD-11: JA00]P43119PTGIR
    T99954DI0102Coronary atherosclerosis[ICD-11: BA52]P43119PTGIR
    T99954DI0356Pulmonary hypertension[ICD-11: BB01]P43119PTGIR
    T23787DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16875PFKFB3
    T61744DI0037Asthma[ICD-11: CA23]P27815PDE4A
    T75440DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P30536TSPO
    T75440DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P30536TSPO
    T75440DI0214Insomnia[ICD-11: 7A00-7A0Z]P30536TSPO
    T75440DI0216Intentional self-harm[ICD-11: PC91]P30536TSPO
    T75440DI0271Mood/affect symptom[ICD-11: MB24]P30536TSPO
    T75440DI0411Tonus and reflex abnormality[ICD-11: MB47]P30536TSPO
    T97873DI0107Crohn disease[ICD-11: DD70]P51686CCR9
    T69485DI0214Insomnia[ICD-11: 7A00-7A0Z]O43614HCRTR2
    T73482DI0117Depression[ICD-11: 6A70-6A7Z]O43613HCRTR1
    T73482DI0214Insomnia[ICD-11: 7A00-7A0Z]O43613HCRTR1
    T73482DI0317Opioid use disorder[ICD-11: 6C43]O43613HCRTR1
    T15795DI0309Obstructive sleep apnoea[ICD-11: 7A41]O14649KCNK3
    T54582DI0231Leukaemia[ICD-11: 2A60-2B33]P43490NAMPT
    T54582DI0241Lymphoma[ICD-11: 2A80-2A86]P43490NAMPT
    T54582DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43490NAMPT
    T72038DI0190Hypertension[ICD-11: BA00-BA04]P17931LGALS3
    T72038DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P17931LGALS3
    T72038DI0252Melanoma[ICD-11: 2C30]P17931LGALS3
    T72038DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]P17931LGALS3
    T72038DI0351Psoriasis[ICD-11: EA90]P17931LGALS3
    T53524DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P16234PDGFRA
    T53524DI0225Kaposi sarcoma[ICD-11: 2B57]P16234PDGFRA
    T53524DI0403Thrombocytopenia[ICD-11: 3B64]P16234PDGFRA
    T10491DI0037Asthma[ICD-11: CA23]P25106ACKR3
    T10491DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P25106ACKR3
    T03279DI0249Mature B-cell leukaemia[ICD-11: 2A82]P51812RPS6KA3
    T10265DI0037Asthma[ICD-11: CA23]Q07343PDE4B
    T10265DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q07343PDE4B
    T10265DI0265Mild neurocognitive disorder[ICD-11: 6D71]Q07343PDE4B
    T66383DI0170Haemolytic anemia[ICD-11: 3A20-3A2Z]P00746CFD
    T66383DI0365Retinopathy[ICD-11: 9B71]P00746CFD
    T77400DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]O00408PDE2A
    T77400DI0207Indeterminate colitis[ICD-11: DD72]O00408PDE2A
    T77400DI0218Irritable bowel syndrome[ICD-11: DD91]O00408PDE2A
    T77400DI0270Mood disorder[ICD-11: 6A60-6E23]O00408PDE2A
    T94692DI0238Lung cancer[ICD-11: 2C25]P01130LDLR
    T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
    T12808DI0279Muscular atrophy[ICD-11: 8B61]P17612PRKACA
    T55610DI0241Lymphoma[ICD-11: 2A80-2A86]Q16665HIF1A
    T55610DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16665HIF1A
    T58470DI0363Retina cancer[ICD-11: 2D02]P20248CCNA2
    T59881DI0009Acute diabete complication[ICD-11: 5A2Y]P47901AVPR1B
    T59881DI0041Autism spectrum disorder[ICD-11: 6A02]P47901AVPR1B
    T59881DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P47901AVPR1B
    T65889DI0361Renal cell carcinoma[ICD-11: 2C90]P14618PKM
    T38338DI0264Migraine[ICD-11: 8A80]Q00975CACNA1B
    T38338DI0305Non-thrombocytopenic purpura[ICD-11: 3B60]Q00975CACNA1B
    T38338DI0324Pain[ICD-11: MG30-MG3Z]Q00975CACNA1B
    T79473DI0144Female infertility[ICD-11: GA31]P22888LHCGR
    T79473DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P22888LHCGR
    T95558DI0203Inborn lipid metabolism error[ICD-11: 5C52]Q96PD7DGAT2
    T35445DI0226Kidney fibrosis[ICD-11: GC01]O35273SMAD3
    T15700DI0120Diabetes mellitus[ICD-11: 5A10]Q9UQ81MCH5
    T15700DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UQ81MCH5
    T04689DI0411Tonus and reflex abnormality[ICD-11: MB47]P02708CHRNA1

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