Alpha-Linolenic acid



Compound IDCDAMM00327
Common nameAlpha-Linolenic acid
IUPAC name(9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
Molecular formulaC18H30O2

Experimental data

Retention time56.517
Adduct[M+H]+
Actual mz279.233
Theoretical mz279.232
Error3.38
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.7

Identifiers and class information

Inchi keyDTOSIQBPPRVQHS-PDBXOOCHSA-N
SmilesO=C(O)CCCCCCCC=CCC=CCC=CCC
SuperclassLipids and lipid-like molecules
ClassFatty Acyls

Plant source

  • Pedalium murex L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)1
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)1
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)13
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)278.434
    Computed dipole moment(dipole)6.294
    Total solvent accessible surface area (SASA)615.323
    Hydrophobic component of SASA (FOSA)455.979
    Hydrophilic component of SASA (FISA)108.386
    Pie component of the SASA (PISA)50.957
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1117.91
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)2
    Free energy of solvation of dipole (dip^2/V)0.0354315
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0032503
    Globularity descriptor (glob)0.846576
    Predicted polarizability in cubic angstroms (QPpolrz)30.724
    Predicted hexadecane/gas partition coefficient (QPlogPC16)9.964
    Predicted octanol/gas partition coefficient (QPlogPoct)12.307
    Predicted water/gas partition coefficient (QPlogPw)2.851
    Predicted octanol/water partition coefficient (QPlogPo/w)5.284
    Predicted aqueous solubility (QPlogS)-4.637
    Conformation-independent predicted aqueous solubility (CIQPlogS)-4.028
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-2.45
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)235.329
    Predicted brain/blood partition coefficient (QPlogBB)-1.228
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)131.717
    Predicted skin permeability, log Kp (QPlogKp)-2.089
    PM3 calculated ionization potential (IP(ev))9.958
    PM3 calculated electron affinity (EA(eV))-0.719
    Number of likely metabolic reactions (#metab)5
    Prediction of binding to human serum albumin (QPlogKhsa)0.571
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)87.374
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)51.08
    Number of nitrogen and oxygen atoms (#NandO)2
    Number of violations of Lipinski’s rule of five (RuleOfFive)1
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P35228NOS2Nitric oxide synthase, inducibleT02703SwissTargetPrediction
    P24046GABRR1GABA receptor rho-1 subunitT99665SEA
    O75899GABBR2GABA-B receptorT42446SEA
    P48066SLC6A11GABA transporter 3T38200SEA
    O75899GABBR2GABA-B receptorT42446SEA
    P0DMS8ADORA3Adenosine A3 receptorT36059SwissTargetPrediction
    Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
    P04054PLA2G1BPhospholipase A2 group 1BT31479SwissTargetPrediction
    P31213SRD5A2Steroid 5-alpha-reductase 2T71390SwissTargetPrediction
    P21554CNR1Cannabinoid receptor 1 (by homology)T76685SwissTargetPrediction and SEA
    P34913EPHX2Epoxide hydrataseT35734SEA
    P41595HTR2BSerotonin 2b (5-HT2b) receptorT31204SwissTargetPrediction
    Q14416GRM2Metabotropic glutamate receptor 2T62820SwissTargetPrediction
    Q9H3R0KDM4CLysine-specific demethylase 4CT73863SEA
    P23141CES1Acyl coenzyme A:cholesterol acyltransferaseT76369SEA
    Q5T7T8COX1Prostaglandin G/H synthase 1T60529SwissTargetPrediction
    P35354PTGS2Cyclooxygenase-2T66665SwissTargetPrediction
    P53985SLC16A1Monocarboxylate transporter 1 (by homology)T95842SwissTargetPrediction
    O75164KDM4ALysine-specific demethylase 4AT18904SEA
    P10275ARAndrogen ReceptorT11211SwissTargetPrediction
    Q92731ESR2Estrogen receptor betaT80896SwissTargetPrediction
    O00519FAAHAnandamide amidohydrolaseT11754SwissTargetPrediction and SEA
    Q8NER1TRPV1Vanilloid receptorT83193SwissTargetPrediction and SEA
    P08235NR3C2Mineralocorticoid receptorT72168SwissTargetPrediction
    P04150NR3C1Glucocorticoid receptorT40016SwissTargetPrediction
    P06401PGRProgesterone receptorT22939SwissTargetPrediction
    P08185SERPINA6Corticosteroid binding globulinT88452SwissTargetPrediction
    P07148FABP1Fatty acid-binding protein, liver (by homology)T73712SwissTargetPrediction
    Q9UHC9NPC1L1Niemann-Pick C1-like protein 1T33901SwissTargetPrediction
    O14684PTGESProstaglandin E synthaseT02562SwissTargetPrediction
    P29350PTPN6Protein-tyrosine phosphatase 1CT98264SwissTargetPrediction
    P18031PTPN1Protein-tyrosine phosphatase 1BT16347SwissTargetPrediction
    P17706PTPN2T-cell protein-tyrosine phosphataseT49156SwissTargetPrediction and SEA
    Q07075ENPEPAminopeptidase AT31956SEA
    P15090FABP4Fatty acid binding protein adipocyteT07217SwissTargetPrediction and SEA
    Q07869PPARAPeroxisome proliferator-activated receptor alphaT86591SwissTargetPrediction and SEA
    Q01469FABP5Fatty acid binding protein epidermalT21507SwissTargetPrediction
    Q03181PPARDPeroxisome proliferator-activated receptor deltaT36557SwissTargetPrediction and SEA
    O14842FFAR1Free fatty acid receptor 1T25608SwissTargetPrediction and SEA
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SwissTargetPrediction
    P28845HSD11B111-beta-hydroxysteroid dehydrogenase 1T65200SwissTargetPrediction
    P06746POLBDNA polymerase beta (by homology)T06958SwissTargetPrediction
    P08253MMP2Matrix metalloproteinase 2T68251SwissTargetPrediction
    Q7Z2W7TRPM8Transient receptor potential cation channel subfamily M member 8T41955SwissTargetPrediction
    P03372ESR1Estrogen receptor alphaT02506SwissTargetPrediction
    Q13133NR1H3LXR-alphaT52297SwissTargetPrediction
    P09917ALOX5Arachidonate 5-lipoxygenaseT00140SwissTargetPrediction
    P21731TBXA2RThromboxane A2 receptorT76198SEA
    P06276BCHEButyrylcholinesteraseT99799SwissTargetPrediction
    Q16539MAPK14MAP kinase p38 alphaT65864SwissTargetPrediction
    P16050ALOX15Arachidonate 15-lipoxygenaseT16042SwissTargetPrediction
    P18054ALOX12Arachidonate 12-lipoxygenaseT35527SwissTargetPrediction and SEA
    P23946CMA1ChymaseT05114SwissTargetPrediction
    P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SwissTargetPrediction and SEA
    O14746TERTTelomerase reverse transcriptaseT86052SwissTargetPrediction
    O00767SCDAcyl-CoA desaturaseT10897SwissTargetPrediction
    P48147PREPProlyl endopeptidaseT86161SwissTargetPrediction
    P51449RORCNuclear receptor ROR-gammaT25307SwissTargetPrediction
    Q08499PDE4DPhosphodiesterase 4DT02001SwissTargetPrediction
    P43116PTGER2Prostanoid EP2 receptorT38529SwissTargetPrediction and SEA
    Q96S37SLC22A12Solute carrier family 22 member 12T86057SwissTargetPrediction
    Q9Y5Y4PTGDR2G protein-coupled receptor 44T61722SwissTargetPrediction
    P49356FNTBFarnesyl protein transferaseT13127SwissTargetPrediction
    P24723PRKCHProtein kinase C etaT40149SwissTargetPrediction
    P80365HSD11B211-beta-hydroxysteroid dehydrogenase 2T43721SwissTargetPrediction
    Q06124PTPN11Protein-tyrosine phosphatase 2CT13057SwissTargetPrediction
    P04035HMGCRHMG-CoA reductaseT53585SwissTargetPrediction and SEA
    P11413G6PDGlucose-6-phosphate 1-dehydrogenaseT63484SwissTargetPrediction
    Q16850CYP51A1Cytochrome P450 51 (by homology)T32972SwissTargetPrediction
    Q15722LTB4RLeukotriene B4 receptor 1T59626SwissTargetPrediction and SEA
    P05093CYP17A1Cytochrome P450 17A1T89041SwissTargetPrediction
    P11137MAP2Microtubule-associated protein 2T23276SwissTargetPrediction
    P11387TOP1DNA topoisomerase IT09826SwissTargetPrediction
    P20701ITGALIntercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2T35640SwissTargetPrediction
    P11388TOP2ADNA topoisomerase II alphaT17048SwissTargetPrediction
    Q99685MGLLMonoglyceride lipaseT18664SEA
    P49810PSEN2Gamma-secretaseT99204SwissTargetPrediction
    P18089ADRA2BAlpha-2b adrenergic receptorT41580SwissTargetPrediction
    P34972CNR2Cannabinoid receptor 2T37693SEA
    P47712PLA2G4ACytosolic phospholipase A2T14834SwissTargetPrediction and SEA
    P35408PTGER4Prostanoid EP4 receptorT18876SwissTargetPrediction and SEA
    P43115PTGER3Prostanoid EP3 receptorT85467SEA
    P30307CDC25CDual specificity phosphatase Cdc25CT40569SwissTargetPrediction
    P28482MAPK1MAP kinase ERK2T58970SwissTargetPrediction
    P34995PTGER1Prostanoid EP1 receptorT15497SwissTargetPrediction
    P25101EDNRAEndothelin receptor ET-AT23499SwissTargetPrediction
    Q13258PTGDRProstanoid DP receptorT68782SwissTargetPrediction
    O43174CYP26A1Cytochrome P450 26A1T84634SwissTargetPrediction
    Q8TDS5OXER1Oxoeicosanoid receptor 1T68834SwissTargetPrediction and SEA
    P43088PTGFRProstanoid FP receptorT75797SEA
    Q00987MDM2p53-binding protein Mdm-2T00176SwissTargetPrediction
    P02753RBP4Plasma retinol-binding proteinT55703SwissTargetPrediction
    P35398RORANuclear receptor ROR-alphaT43206SwissTargetPrediction
    P43119PTGIRProstanoid IP receptorT99954SwissTargetPrediction
    Q9Y4D2DAGLASn1-specific diacylglycerol lipase alphaT03150SwissTargetPrediction and SEA
    P12268IMPDH2Inosine-5'-monophosphate dehydrogenase 2T89360SwissTargetPrediction
    Q6ZMT4KDM7ALysine-specific demethylase 7A/7BT18784SEA
    P00390GSRGlutathione reductaseT30803SEA
    O75907DGAT1Diacylglycerol O-acyltransferase 1T16688SwissTargetPrediction
    Q13822ENPP2AutotaxinT63512SwissTargetPrediction
    Q9Y478PRKAB1AMP-activated protein kinase, beta-1 subunitT38875SwissTargetPrediction
    Q9HBW0LPAR2Lysophosphatidic acid receptor Edg-4T39380SEA
    P28702RXRBRetinoid X receptor betaT60077SwissTargetPrediction
    O75908SOAT2Acyl coenzyme A:cholesterol acyltransferase 2T14463SEA
    P41235HNF4AHepatocyte nuclear factor 4-alphaT15514SwissTargetPrediction
    P43657LPAR6Lysophosphatidic acid receptor 6T13484SEA
    Q9UPC5GPR34Probable G-protein coupled receptor 34T73859SEA
    O00398P2RY10Putative P2Y purinoceptor 10T00488SEA
    Q9BXC1GPR174Probable G-protein coupled receptor 174T87661SEA
    Q9UBY5LPAR3Lysophosphatidic acid receptor Edg-7T95923SEA
    Q92633LPAR1Lysophosphatidic acid receptor Edg-2T92640SEA
    Q99677LPAR4Lysophosphatidic acid receptor 4T58130SEA
    Q92753RORBNuclear receptor ROR-betaT48812SwissTargetPrediction
    P05231IL6Interleukin-6T32578SwissTargetPrediction
    P08311CTSGCathepsin GT86385SwissTargetPrediction
    Q9UJM8HAO1Hydroxyacid oxidase 1T63170SEA
    Q9UP65PLA2G4CCytosolic phospholipase A2 gammaT91113SEA
    Q5NUL3FFAR4G-protein coupled receptor 120T51385SwissTargetPrediction
    P24557TBXAS1Thromboxane-A synthaseT78356SEA
    Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
    Q9UN88GABRQGABA(A) receptor thetaT15161SEA
    P78329CYP4F2Cytochrome P450 4fT82604SEA
    O60603TLR2Toll-like receptor 2T82078SEA
    Q92887CMOATMultidrug resistance-associated protein 2T61792SEA
    Q92959SLCO2A1Prostaglandin transporterT15518SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T02703DI0083Chronic kidney disease[ICD-11: GB61]P35228NOS2
    T02703DI0320Osteoarthritis[ICD-11: FA00-FA05]P35228NOS2
    T02703DI0375Sepsis[ICD-11: 1G40-1G41]P35228NOS2
    T02703DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35228NOS2
    T42446DI0117Depression[ICD-11: 6A70-6A7Z]O75899GABBR2
    T42446DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]O75899GABBR2
    T42446DI0275Multiple sclerosis[ICD-11: 8A40]O75899GABBR2
    T42446DI0290Narcolepsy[ICD-11: 7A20]O75899GABBR2
    T38200DI0207Indeterminate colitis[ICD-11: DD72]P48066SLC6A11
    T42446DI0117Depression[ICD-11: 6A70-6A7Z]O75899GABBR2
    T42446DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]O75899GABBR2
    T42446DI0275Multiple sclerosis[ICD-11: 8A40]O75899GABBR2
    T42446DI0290Narcolepsy[ICD-11: 7A20]O75899GABBR2
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
    T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
    T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
    T31479DI0230Leishmaniasis[ICD-11: 1F54]P04054PLA2G1B
    T31479DI0335Peroxisomal disease[ICD-11: 5C57]P04054PLA2G1B
    T31479DI0367Rosacea[ICD-11: ED90]P04054PLA2G1B
    T31479DI0398Synthesis disorder[ICD-11: 5C52-5C59]P04054PLA2G1B
    T71390DI0348Prostate hyperplasia[ICD-11: GA90]P31213SRD5A2
    T76685DI0031Anorexia nervosa[ICD-11: 6B80]P21554CNR1
    T76685DI0214Insomnia[ICD-11: 7A00-7A0Z]P21554CNR1
    T76685DI0308Obesity[ICD-11: 5B80-5B81]P21554CNR1
    T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
    T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
    T31204DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P41595HTR2B
    T31204DI0117Depression[ICD-11: 6A70-6A7Z]P41595HTR2B
    T31204DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P41595HTR2B
    T31204DI0354Psychotic disorder[ICD-11: 6A20-6A25]P41595HTR2B
    T62820DI0025Alzheimer disease[ICD-11: 8A20]Q14416GRM2
    T62820DI0051Bipolar disorder[ICD-11: 6A60]Q14416GRM2
    T62820DI0116Dengue fever[ICD-11: 1D2Z]Q14416GRM2
    T62820DI0117Depression[ICD-11: 6A70-6A7Z]Q14416GRM2
    T62820DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]Q14416GRM2
    T62820DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]Q14416GRM2
    T62820DI0308Obesity[ICD-11: 5B80-5B81]Q14416GRM2
    T62820DI0354Psychotic disorder[ICD-11: 6A20-6A25]Q14416GRM2
    T62820DI0370Schizophrenia[ICD-11: 6A20]Q14416GRM2
    T76369DI0335Peroxisomal disease[ICD-11: 5C57]P23141CES1
    T76369DI0398Synthesis disorder[ICD-11: 5C52-5C59]P23141CES1
    T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
    T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
    T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
    T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
    T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
    T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
    T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
    T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
    T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
    T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
    T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
    T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
    T66665DI0087Chronic pain[ICD-11: MG30]P35354PTGS2
    T66665DI0145Female pelvic pain[ICD-11: GA34]P35354PTGS2
    T66665DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P35354PTGS2
    T66665DI0207Indeterminate colitis[ICD-11: DD72]P35354PTGS2
    T66665DI0227Knee osteoarthritis[ICD-11: FA01]P35354PTGS2
    T66665DI0320Osteoarthritis[ICD-11: FA00-FA05]P35354PTGS2
    T66665DI0324Pain[ICD-11: MG30-MG3Z]P35354PTGS2
    T66665DI0366Rheumatoid arthritis[ICD-11: FA20]P35354PTGS2
    T66665DI0416Tuberculosis[ICD-11: 1B10-1B12]P35354PTGS2
    T11211DI0005Acne vulgaris[ICD-11: ED80]P10275AR
    T11211DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10275AR
    T11211DI0021Alcoholic liver disease[ICD-11: DB94]P10275AR
    T11211DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10275AR
    T11211DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P10275AR
    T11211DI0145Female pelvic pain[ICD-11: GA34]P10275AR
    T11211DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P10275AR
    T11211DI0237Low bone mass disorder[ICD-11: FB83]P10275AR
    T11211DI0247Mammary tumour[ICD-11: 2C60-2C6Z]P10275AR
    T11211DI0346Prostate cancer[ICD-11: 2C82]P10275AR
    T11211DI0401Testicular dysfunction[ICD-11: 5A81]P10275AR
    T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
    T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
    T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
    T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
    T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
    T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
    T72168DI0018Adrenocortical insufficiency[ICD-11: 5A74]P08235NR3C2
    T72168DI0083Chronic kidney disease[ICD-11: GB61]P08235NR3C2
    T72168DI0100Contraceptive management[ICD-11: QA21]P08235NR3C2
    T72168DI0175Heart failure[ICD-11: BD10-BD1Z]P08235NR3C2
    T72168DI0190Hypertension[ICD-11: BA00-BA04]P08235NR3C2
    T72168DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P08235NR3C2
    T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
    T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
    T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
    T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
    T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
    T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
    T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
    T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
    T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
    T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
    T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
    T22939DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06401PGR
    T22939DI0100Contraceptive management[ICD-11: QA21]P06401PGR
    T22939DI0255Menstrual cycle bleeding disorder[ICD-11: GA20]P06401PGR
    T22939DI0344Preterm labour/delivery[ICD-11: JB00]P06401PGR
    T22939DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06401PGR
    T88452DI0037Asthma[ICD-11: CA23]P08185SERPINA6
    T88452DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P08185SERPINA6
    T88452DI0362Respiratory system disease[ICD-11: CB40-CB7Z]P08185SERPINA6
    T73712DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P07148FABP1
    T33901DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q9UHC9NPC1L1
    T02562DI0025Alzheimer disease[ICD-11: 8A20]O14684PTGES
    T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
    T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
    T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
    T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
    T49156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P17706PTPN2
    T31956DI0190Hypertension[ICD-11: BA00-BA04]Q07075ENPEP
    T86591DI0187Hyperlipidemia[ICD-11: 5C80]Q07869PPARA
    T86591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q07869PPARA
    T86591DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q07869PPARA
    T36557DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]Q03181PPARD
    T36557DI0308Obesity[ICD-11: 5B80-5B81]Q03181PPARD
    T25608DI0417Type 2 diabetes mellitus[ICD-11: 5A11]O14842FFAR1
    T65200DI0210Influenza[ICD-11: 1E30-1E32]P28845HSD11B1
    T65200DI0239Lupus erythematosus[ICD-11: 4A40]P28845HSD11B1
    T65200DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P28845HSD11B1
    T06958DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06746POLB
    T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
    T41955DI0422Upper respiratory tract disorder[ICD-11: CA0Z]Q7Z2W7TRPM8
    T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
    T52297DI0117Depression[ICD-11: 6A70-6A7Z]Q13133NR1H3
    T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
    T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
    T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
    T76198DI0102Coronary atherosclerosis[ICD-11: BA52]P21731TBXA2R
    T76198DI0121Diabetic foot ulcer[ICD-11: BD54]P21731TBXA2R
    T76198DI0287Myocardial infarction[ICD-11: BA41-BA43]P21731TBXA2R
    T76198DI0378Sexual dysfunction[ICD-11: HA00-HA01]P21731TBXA2R
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T65864DI0102Coronary atherosclerosis[ICD-11: BA52]Q16539MAPK14
    T65864DI0287Myocardial infarction[ICD-11: BA41-BA43]Q16539MAPK14
    T65864DI0366Rheumatoid arthritis[ICD-11: FA20]Q16539MAPK14
    T65864DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]Q16539MAPK14
    T05114DI0039Atopic eczema[ICD-11: EA80]P23946CMA1
    T05114DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P23946CMA1
    T05114DI0169Gram-positive bacterial infection[ICD-11: 1B74-1F40]P23946CMA1
    T05114DI0175Heart failure[ICD-11: BD10-BD1Z]P23946CMA1
    T05114DI0229Left ventricular failure[ICD-11: BD11]P23946CMA1
    T05114DI0287Myocardial infarction[ICD-11: BA41-BA43]P23946CMA1
    T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
    T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
    T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
    T86052DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]O14746TERT
    T86052DI0284Myelodysplastic syndrome[ICD-11: 2A37]O14746TERT
    T86052DI0326Pancreatic cancer[ICD-11: 2C10]O14746TERT
    T10897DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O00767SCD
    T86161DI0092Coeliac disease[ICD-11: DA95]P48147PREP
    T86161DI0210Influenza[ICD-11: 1E30-1E32]P48147PREP
    T86161DI0238Lung cancer[ICD-11: 2C25]P48147PREP
    T86161DI0265Mild neurocognitive disorder[ICD-11: 6D71]P48147PREP
    T25307DI0042Autoimmune disease[ICD-11: 4A40-4A45]P51449RORC
    T25307DI0107Crohn disease[ICD-11: DD70]P51449RORC
    T25307DI0238Lung cancer[ICD-11: 2C25]P51449RORC
    T25307DI0275Multiple sclerosis[ICD-11: 8A40]P51449RORC
    T25307DI0351Psoriasis[ICD-11: EA90]P51449RORC
    T25307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P51449RORC
    T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
    T38529DI0003Abortion[ICD-11: JA00]P43116PTGER2
    T38529DI0102Coronary atherosclerosis[ICD-11: BA52]P43116PTGER2
    T38529DI0121Diabetic foot ulcer[ICD-11: BD54]P43116PTGER2
    T38529DI0166Glaucoma[ICD-11: 9C61]P43116PTGER2
    T38529DI0356Pulmonary hypertension[ICD-11: BB01]P43116PTGER2
    T38529DI0378Sexual dysfunction[ICD-11: HA00-HA01]P43116PTGER2
    T38529DI0413Transplant rejection[ICD-11: NE84]P43116PTGER2
    T86057DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q96S37SLC22A12
    T61722DI0102Coronary atherosclerosis[ICD-11: BA52]Q9Y5Y4PTGDR2
    T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
    T40149DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P24723PRKCH
    T43721DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P80365HSD11B2
    T13057DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06124PTPN11
    T53585DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P04035HMGCR
    T53585DI0102Coronary atherosclerosis[ICD-11: BA52]P04035HMGCR
    T53585DI0128Dyslipidemia[ICD-11: 5C80-5C81]P04035HMGCR
    T53585DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P04035HMGCR
    T53585DI0275Multiple sclerosis[ICD-11: 8A40]P04035HMGCR
    T53585DI0287Myocardial infarction[ICD-11: BA41-BA43]P04035HMGCR
    T53585DI0324Pain[ICD-11: MG30-MG3Z]P04035HMGCR
    T63484DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P11413G6PD
    T32972DI0209Infectious meningitis[ICD-11: 1D01]Q16850CYP51A1
    T32972DI0289Nail/perionychium infection[ICD-11: EE12]Q16850CYP51A1
    T32972DI0316Onchocerciasis[ICD-11: 1F6A]Q16850CYP51A1
    T59626DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]Q15722LTB4R
    T59626DI0355Pulmonary disease[ICD-11: 1B10-1F85]Q15722LTB4R
    T59626DI0361Renal cell carcinoma[ICD-11: 2C90]Q15722LTB4R
    T89041DI0346Prostate cancer[ICD-11: 2C82]P05093CYP17A1
    T23276DI0036Arteries/arterioles disorder[ICD-11: BD52]P11137MAP2
    T23276DI0252Melanoma[ICD-11: 2C30]P11137MAP2
    T23276DI0326Pancreatic cancer[ICD-11: 2C10]P11137MAP2
    T23276DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11137MAP2
    T09826DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P11387TOP1
    T09826DI0095Colorectal cancer[ICD-11: 2B91]P11387TOP1
    T09826DI0238Lung cancer[ICD-11: 2C25]P11387TOP1
    T09826DI0321Ovarian cancer[ICD-11: 2C73]P11387TOP1
    T09826DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11387TOP1
    T35640DI0351Psoriasis[ICD-11: EA90]P20701ITGAL
    T35640DI0436Visual system disease[ICD-11: 9E1Z]P20701ITGAL
    T17048DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11388TOP2A
    T17048DI0225Kaposi sarcoma[ICD-11: 2B57]P11388TOP2A
    T17048DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11388TOP2A
    T18664DI0163General pain disorder[ICD-11: 8E43]Q99685MGLL
    T18664DI0409Tic disorder[ICD-11: 8A05]Q99685MGLL
    T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
    T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
    T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
    T41580DI0396Substance abuse[ICD-11: 6C40]P18089ADRA2B
    T37693DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34972CNR2
    T37693DI0214Insomnia[ICD-11: 7A00-7A0Z]P34972CNR2
    T14834DI0039Atopic eczema[ICD-11: EA80]P47712PLA2G4A
    T18876DI0037Asthma[ICD-11: CA23]P35408PTGER4
    T18876DI0175Heart failure[ICD-11: BD10-BD1Z]P35408PTGER4
    T18876DI0264Migraine[ICD-11: 8A80]P35408PTGER4
    T18876DI0303Non-small-cell lung cancer[ICD-11: 2C25]P35408PTGER4
    T18876DI0324Pain[ICD-11: MG30-MG3Z]P35408PTGER4
    T18876DI0360Rectum cancer[ICD-11: 2B92]P35408PTGER4
    T18876DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35408PTGER4
    T18876DI0414Transplanted organ/tissue[ICD-11: QB63]P35408PTGER4
    T85467DI0166Glaucoma[ICD-11: 9C61]P43115PTGER3
    T85467DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43115PTGER3
    T85467DI0414Transplanted organ/tissue[ICD-11: QB63]P43115PTGER3
    T58970DI0036Arteries/arterioles disorder[ICD-11: BD52]P28482MAPK1
    T58970DI0252Melanoma[ICD-11: 2C30]P28482MAPK1
    T58970DI0326Pancreatic cancer[ICD-11: 2C10]P28482MAPK1
    T58970DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28482MAPK1
    T15497DI0405Thrombosis[ICD-11: DB61-GB90]P34995PTGER1
    T23499DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25101EDNRA
    T23499DI0356Pulmonary hypertension[ICD-11: BB01]P25101EDNRA
    T23499DI0425Urinary system clinical symptom[ICD-11: MF8Y]P25101EDNRA
    T68782DI0102Coronary atherosclerosis[ICD-11: BA52]Q13258PTGDR
    T84634DI0314Oesophagitis[ICD-11: DA24]O43174CYP26A1
    T75797DI0003Abortion[ICD-11: JA00]P43088PTGFR
    T75797DI0102Coronary atherosclerosis[ICD-11: BA52]P43088PTGFR
    T75797DI0166Glaucoma[ICD-11: 9C61]P43088PTGFR
    T00176DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q00987MDM2
    T00176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q00987MDM2
    T55703DI0212Inherited retinal dystrophy[ICD-11: 9B70]P02753RBP4
    T43206DI0235Liver cancer[ICD-11: 2C12]P35398RORA
    T43206DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P35398RORA
    T99954DI0003Abortion[ICD-11: JA00]P43119PTGIR
    T99954DI0102Coronary atherosclerosis[ICD-11: BA52]P43119PTGIR
    T99954DI0356Pulmonary hypertension[ICD-11: BB01]P43119PTGIR
    T89360DI0413Transplant rejection[ICD-11: NE84]P12268IMPDH2
    T30803DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00390GSR
    T16688DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]O75907DGAT1
    T63512DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q13822ENPP2
    T38875DI0009Acute diabete complication[ICD-11: 5A2Y]Q9Y478PRKAB1
    T60077DI0225Kaposi sarcoma[ICD-11: 2B57]P28702RXRB
    T14463DI0017Adrenal cancer[ICD-11: 2D11]O75908SOAT2
    T95923DI0146Fibrosis[ICD-11: GA14-GC01]Q9UBY5LPAR3
    T95923DI0399Systemic sclerosis[ICD-11: 4A42]Q9UBY5LPAR3
    T92640DI0146Fibrosis[ICD-11: GA14-GC01]Q92633LPAR1
    T92640DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q92633LPAR1
    T92640DI0351Psoriasis[ICD-11: EA90]Q92633LPAR1
    T92640DI0399Systemic sclerosis[ICD-11: 4A42]Q92633LPAR1
    T32578DI0028Anemia[ICD-11: 3A00-3A9Z]P05231IL6
    T86385DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P08311CTSG
    T63170DI0201Inborn carbohydrate metabolism error[ICD-11: 5C51]Q9UJM8HAO1
    T78356DI0030Angina pectoris[ICD-11: BA40]P24557TBXAS1
    T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
    T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
    T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
    T82078DI0346Prostate cancer[ICD-11: 2C82]O60603TLR2

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