3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole-5-carboxylic acid ethyl ester



Compound IDCDAMM00326
Common name3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole-5-carboxylic acid ethyl ester
IUPAC nameethyl 3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole-5-carboxylate
Molecular formulaC13H14N2O5

Experimental data

Retention time58.1
Adduct[M+H]+
Actual mz279.095
Theoretical mz279.098
Error9.12
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.45

Identifiers and class information

Inchi keyUAOQPEANZVBDPV-UHFFFAOYSA-N
SmilesO=C(OCC)C1=NC(=NO1)C=2C=CC(OC)=C(OC)C2
SuperclassOrganoheterocyclic compounds
ClassAzoles

Plant source

  • Pedalium murex L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)4
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)-1
    Molecular weight (mol_MW)278.264
    Computed dipole moment(dipole)3.677
    Total solvent accessible surface area (SASA)561.136
    Hydrophobic component of SASA (FOSA)330.951
    Hydrophilic component of SASA (FISA)122.406
    Pie component of the SASA (PISA)107.779
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)924.578
    Number of hydrogen bond donors (donorHB)0
    Number of hydrogen bond acceptors (accptHB)6.5
    Free energy of solvation of dipole (dip^2/V)0.0146221
    Index of cohesive interaction in solids (ACxDN^.5/SA)0
    Globularity descriptor (glob)0.817949
    Predicted polarizability in cubic angstroms (QPpolrz)29.309
    Predicted hexadecane/gas partition coefficient (QPlogPC16)8.285
    Predicted octanol/gas partition coefficient (QPlogPoct)12.816
    Predicted water/gas partition coefficient (QPlogPw)8.155
    Predicted octanol/water partition coefficient (QPlogPo/w)1.441
    Predicted aqueous solubility (QPlogS)-2.796
    Conformation-independent predicted aqueous solubility (CIQPlogS)-2.627
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-4.992
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)684.108
    Predicted brain/blood partition coefficient (QPlogBB)-0.897
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)328.201
    Predicted skin permeability, log Kp (QPlogKp)-3.012
    PM3 calculated ionization potential (IP(ev))8.94
    PM3 calculated electron affinity (EA(eV))1.421
    Number of likely metabolic reactions (#metab)2
    Prediction of binding to human serum albumin (QPlogKhsa)-0.607
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)86.124
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)91.343
    Number of nitrogen and oxygen atoms (#NandO)7
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    Q9GZV3SLC5A7High-affinity choline transporter (by homology)T83143SEA
    P22303ACHEAcetylcholinesteraseT30082SEA
    Q16790CA9Carbonic anhydrase IXT64567SEA
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    P04818TYMSThymidylate synthase (by homology)T98397SwissTargetPrediction
    P47869GABRA2GABA A receptor alpha-2/beta-2/gamma-2T51452SEA
    P0DMS8ADORA3Adenosine A3 receptorT36059SEA
    Q14833GRM4Metabotropic glutamate receptor 4T99402SwissTargetPrediction
    P41594GRM5Metabotropic glutamate receptor 5T99347SEA
    P00915CA1Carbonic anhydrase IT13201SEA
    P42338PIK3CBPI3-kinase p110-beta subunitT05031SEA
    P42336PIK3CAPI3-kinase p110-alpha subunitT80276SEA
    P43405SYKTyrosine-protein kinase SYKT62431SEA
    P43166CA7Carbonic anhydrase VIIT37541SEA
    Q9ULX7CA14Carbonic anhydrase XIVT31992SEA
    O15303GRM6Metabotropic glutamate receptor 6T55956SEA
    P56524HDAC4Histone deacetylase 4T63816SEA
    Q92769HDAC2Histone deacetylase 2T51191SEA
    P25440BRD2Bromodomain-containing protein 2T86597SEA
    Q15059BRD3Bromodomain-containing protein 3T42048SEA
    Q03181PPARDPeroxisome proliferator-activated receptor deltaT36557SEA
    P33527ABCC1Multidrug resistance-associated protein 1T11288SEA
    P08183ABCB1P-glycoprotein 1T25258SEA
    P54760EPHB4Ephrin receptorT49507SwissTargetPrediction
    P25105PTAFRPlatelet activating factor receptorT87023SEA
    P16050ALOX15Arachidonate 15-lipoxygenaseT16042SwissTargetPrediction
    P30559OXTROxytocin receptor (by homology)T84486SwissTargetPrediction
    Q08499PDE4DPhosphodiesterase 4DT02001SEA
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction and SEA
    O96017CHEK2Serine/threonine-protein kinase Chk2T28713SEA
    P01375TNFTNF-alphaT20178SEA
    P08581METHepatocyte growth factor receptorT40474SwissTargetPrediction
    Q9Y5Y9SCN10ASodium channel protein type X alpha subunit (by homology)T43739SEA
    O00329PIK3CDPI3-kinase p110-delta subunitT67849SEA
    P51955NEK2Serine/threonine-protein kinase NEK2T49102SEA
    P53779MAPK10c-Jun N-terminal kinase 3T85421SwissTargetPrediction
    P05186ALPLAlkaline phosphatase, tissue-nonspecific isozymeT09538SwissTargetPrediction and SEA
    P10721KITStem cell growth factor receptorT57700SEA
    Q15078CDK5R1Cyclin-dependent kinase 5/CDK5 activator 1T09513SwissTargetPrediction
    P24385CCND1Cyclin-dependent kinase 4/cyclin D1T12355SwissTargetPrediction
    P52333JAK3Tyrosine-protein kinase JAK3T23172SwissTargetPrediction and SEA
    P09211GSTP1Glutathione S-transferase PiT21669SEA
    Q9Y251HPSEHeparanaseT47623SEA
    P34972CNR2Cannabinoid receptor 2T37693SwissTargetPrediction
    O00311CDC7CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)T81358SEA
    P09619PDGFRBPlatelet-derived growth factor receptor betaT59102SEA
    P06493CDK1Cyclin-dependent kinase 1/cyclin B1T49898SwissTargetPrediction
    P50750CDK9Cyclin-dependent kinase 9T44458SwissTargetPrediction
    P16591FERTyrosine-protein kinase FERT16993SEA
    Q12908SLC10A2Ileal bile acid transporterT24982SEA
    P10619CTSALysosomal protective proteinT37154SEA
    Q02127DHODHDihydroorotate dehydrogenaseT61400SEA
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SEA
    Q13976PRKG1cGMP-dependent protein kinase 1 betaT78543SEA
    Q04759PRKCQProtein kinase C thetaT23995SEA
    P35398RORANuclear receptor ROR-alphaT43206SEA
    P78527PRKDCDNA-dependent protein kinaseT81735SEA
    O14976GAKSerine or threonine-protein kinase GAKT00043SEA
    Q9H228S1PR5Sphingosine 1-phosphate receptor Edg-8T50089SEA
    P21453S1PR1Sphingosine 1-phosphate receptor Edg-1T13852SEA
    P00749PLAUUrokinase-type plasminogen activatorT17758SEA
    P27815PDE4APhosphodiesterase 4AT61744SEA
    O75908SOAT2Acyl coenzyme A:cholesterol acyltransferase 2T14463SEA
    P30536TSPOTranslocator protein (by homology)T75440SEA
    Q9UNQ0ABCG2ATP-binding cassette sub-family G member 2T56556SEA
    O43613HCRTR1Orexin receptor 1T73482SEA
    P08236GUSBBeta-glucuronidaseT96413SEA
    P16234PDGFRAPlatelet-derived growth factor receptorT53524SEA
    P00374DHFRDihydrofolate reductaseT17345SEA
    O75582RPS6KA5Ribosomal protein S6 kinase alpha 5T50224SEA
    Q9Y2T6GPR55G-protein coupled receptor 55T87670SEA
    Q07343PDE4BPhosphodiesterase 4B (by homology)T10265SEA
    P08631HCKTyrosine-protein kinase HCKT31406SEA
    O95819MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4T71367SEA
    P51451BLKTyrosine-protein kinase BLKT74307SEA
    Q9UBF8PI4KBPI4-kinase beta subunitT12541SEA
    Q13936CACNA1CVoltage-gated L-type calcium channel alpha-1C subunitT51115SEA
    P42224STAT1Signal transducer and activator of transcription 1-alpha/betaT64205SEA
    Q16678CYP1B1Cytochrome P450 1B1T92521SEA
    Q05513PRKCZProtein kinase C (PKC)T59190SEA
    Q9NRA0SPHK2Sphingosine kinase 2T31989SEA
    Q08493PDE4CPhosphodiesterase 4CT12081SEA
    P19438TNFRSF1ATumor necrosis factor receptor R1T86552SEA
    Q99500S1PR3Sphingosine 1-phosphate receptor Edg-3T11241SEA
    Q9Y256RCE1Prenyl protein specific proteaseT10756SEA
    P18507GABRG2GABA-A receptor; alpha-6/beta-3/gamma-2T08910SEA
    Q96SB4SRPK1Serine/threonine-protein kinase SRPK1T94201SEA
    Q12851MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2T07191SEA
    O95977S1PR4Sphingosine 1-phosphate receptor Edg-6T17523SEA
    P22413ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1T63194SEA
    Q9Y337KLK5Kallikrein 5T11808SEA
    Q9H2X6HIPK2Homeodomain-interacting protein kinase 2T53952SEA
    O43781DYRK3Dual-specificity tyrosine-phosphorylation regulated kinase 3T97149SEA
    P22735TGM1Protein-glutamine gamma-glutamyltransferase KT63217SEA
    Q9H8M2BRD9Bromodomain-containing protein 9T46216SEA
    P04156PRNPPrion proteinT08722SEA
    Q9P0G3KLK14Kallikrein-14T39195SEA
    P49862KLK7Kallikrein-7T79155SEA
    Q9BY41HDAC8Histone deacetylase 8T28887SEA
    Q9UBS0RPS6KB2Ribosomal protein S6 kinase beta-2T42760SEA
    Q7RTX1TAS1R1Taste receptorT41263SEA
    P01100FOSProto-oncogene c-FosT28025SEA
    P47870GABRB2GABA(A) receptor beta-2T80387SEA
    Q9NXA8SIRT5NAD-dependent deacetylase sirtuin-5T91940SEA
    P10323ACRAcrosinT24595SEA
    Q92560BAP1Ubiquitin carboxyl-terminal hydrolase BAP1T92628SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T30082DI0025Alzheimer disease[ICD-11: 8A20]P22303ACHE
    T30082DI0166Glaucoma[ICD-11: 9C61]P22303ACHE
    T30082DI0282Myasthenia gravis[ICD-11: 8C6Y]P22303ACHE
    T30082DI0313Oesophageal/gastroduodenal disorder[ICD-11: DD90]P22303ACHE
    T30082DI0332Pediculosis[ICD-11: 1G00]P22303ACHE
    T30082DI0421Unspecific substance harmful effect[ICD-11: NE6Z]P22303ACHE
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
    T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
    T51452DI0216Intentional self-harm[ICD-11: PC91]P47869GABRA2
    T36059DI0351Psoriasis[ICD-11: EA90]P0DMS8ADORA3
    T36059DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P0DMS8ADORA3
    T99402DI0331Parkinsonism[ICD-11: 8A00]Q14833GRM4
    T99347DI0152Fragile X chromosome[ICD-11: LD55]P41594GRM5
    T99347DI0331Parkinsonism[ICD-11: 8A00]P41594GRM5
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T05031DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42338PIK3CB
    T80276DI0062Breast cancer[ICD-11: 2C60-2C6Y]P42336PIK3CA
    T80276DI0151Follicular lymphoma[ICD-11: 2A80]P42336PIK3CA
    T80276DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P42336PIK3CA
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
    T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
    T63816DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P56524HDAC4
    T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
    T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
    T86597DI0106COVID-19[ICD-11: 1D6Y]P25440BRD2
    T42048DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q15059BRD3
    T42048DI0346Prostate cancer[ICD-11: 2C82]Q15059BRD3
    T36557DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]Q03181PPARD
    T36557DI0308Obesity[ICD-11: 5B80-5B81]Q03181PPARD
    T11288DI0167Gout[ICD-11: FA25]P33527ABCC1
    T25258DI0238Lung cancer[ICD-11: 2C25]P08183ABCB1
    T49507DI0060Brain cancer[ICD-11: 2A00]P54760EPHB4
    T49507DI0111Cystic/dysplastic kidney disease[ICD-11: GB8Y]P54760EPHB4
    T49507DI0238Lung cancer[ICD-11: 2C25]P54760EPHB4
    T49507DI0261Metastatic meninges neoplasm[ICD-11: 2D51]P54760EPHB4
    T49507DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P54760EPHB4
    T87023DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P25105PTAFR
    T84486DI0009Acute diabete complication[ICD-11: 5A2Y]P30559OXTR
    T84486DI0041Autism spectrum disorder[ICD-11: 6A02]P30559OXTR
    T84486DI0340Postpartum haemorrhage[ICD-11: JA43]P30559OXTR
    T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T28713DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O96017CHEK2
    T20178DI0035Arterial occlusive disease[ICD-11: BD40]P01375TNF
    T20178DI0274Multiple myeloma[ICD-11: 2A83]P01375TNF
    T20178DI0351Psoriasis[ICD-11: EA90]P01375TNF
    T20178DI0366Rheumatoid arthritis[ICD-11: FA20]P01375TNF
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T43739DI0101Corneal disease[ICD-11: 9A76-9A78]Q9Y5Y9SCN10A
    T43739DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]Q9Y5Y9SCN10A
    T43739DI0374Sensation disturbance[ICD-11: MB40]Q9Y5Y9SCN10A
    T43739DI0396Substance abuse[ICD-11: 6C40]Q9Y5Y9SCN10A
    T67849DI0151Follicular lymphoma[ICD-11: 2A80]O00329PIK3CD
    T67849DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00329PIK3CD
    T67849DI0249Mature B-cell leukaemia[ICD-11: 2A82]O00329PIK3CD
    T67849DI0250Mature B-cell lymphoma[ICD-11: 2A85]O00329PIK3CD
    T67849DI0395Stomach cancer[ICD-11: 2B72]O00329PIK3CD
    T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
    T09538DI0164Genetic prion disease[ICD-11: 8E02]P05186ALPL
    T09538DI0330Parasitic infection[ICD-11: 1D0Y-1G2Z]P05186ALPL
    T57700DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P10721KIT
    T57700DI0095Colorectal cancer[ICD-11: 2B91]P10721KIT
    T57700DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P10721KIT
    T57700DI0250Mature B-cell lymphoma[ICD-11: 2A85]P10721KIT
    T57700DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P10721KIT
    T57700DI0361Renal cell carcinoma[ICD-11: 2C90]P10721KIT
    T57700DI0403Thrombocytopenia[ICD-11: 3B64]P10721KIT
    T12355DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P24385CCND1
    T23172DI0023Alopecia[ICD-11: ED70]P52333JAK3
    T23172DI0039Atopic eczema[ICD-11: EA80]P52333JAK3
    T23172DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P52333JAK3
    T23172DI0366Rheumatoid arthritis[ICD-11: FA20]P52333JAK3
    T21669DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P09211GSTP1
    T47623DI0020African trypanosomiasis[ICD-11: 1F51]Q9Y251HPSE
    T47623DI0310Ocular disease[ICD-11: N.A.]Q9Y251HPSE
    T37693DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34972CNR2
    T37693DI0214Insomnia[ICD-11: 7A00-7A0Z]P34972CNR2
    T81358DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00311CDC7
    T81358DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O00311CDC7
    T59102DI0009Acute diabete complication[ICD-11: 5A2Y]P09619PDGFRB
    T59102DI0361Renal cell carcinoma[ICD-11: 2C90]P09619PDGFRB
    T59102DI0403Thrombocytopenia[ICD-11: 3B64]P09619PDGFRB
    T49898DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06493CDK1
    T49898DI0238Lung cancer[ICD-11: 2C25]P06493CDK1
    T49898DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P06493CDK1
    T49898DI0250Mature B-cell lymphoma[ICD-11: 2A85]P06493CDK1
    T49898DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06493CDK1
    T44458DI0012Acute myeloid leukaemia[ICD-11: 2A60]P50750CDK9
    T44458DI0241Lymphoma[ICD-11: 2A80-2A86]P50750CDK9
    T44458DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P50750CDK9
    T44458DI0249Mature B-cell leukaemia[ICD-11: 2A82]P50750CDK9
    T44458DI0250Mature B-cell lymphoma[ICD-11: 2A85]P50750CDK9
    T44458DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]P50750CDK9
    T44458DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50750CDK9
    T24982DI0349Pruritus[ICD-11: EC90]Q12908SLC10A2
    T37154DI0009Acute diabete complication[ICD-11: 5A2Y]P10619CTSA
    T61400DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q02127DHODH
    T61400DI0275Multiple sclerosis[ICD-11: 8A40]Q02127DHODH
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T23995DI0413Transplant rejection[ICD-11: NE84]Q04759PRKCQ
    T43206DI0235Liver cancer[ICD-11: 2C12]P35398RORA
    T43206DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P35398RORA
    T81735DI0360Rectum cancer[ICD-11: 2B92]P78527PRKDC
    T81735DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P78527PRKDC
    T00043DI0366Rheumatoid arthritis[ICD-11: FA20]O14976GAK
    T50089DI0275Multiple sclerosis[ICD-11: 8A40]Q9H228S1PR5
    T13852DI0275Multiple sclerosis[ICD-11: 8A40]P21453S1PR1
    T13852DI0419Ulcerative colitis[ICD-11: DD71]P21453S1PR1
    T17758DI0211Inherited coagulation factor deficiency[ICD-11: 3B14]P00749PLAU
    T17758DI0287Myocardial infarction[ICD-11: BA41-BA43]P00749PLAU
    T61744DI0037Asthma[ICD-11: CA23]P27815PDE4A
    T14463DI0017Adrenal cancer[ICD-11: 2D11]O75908SOAT2
    T75440DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P30536TSPO
    T75440DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P30536TSPO
    T75440DI0214Insomnia[ICD-11: 7A00-7A0Z]P30536TSPO
    T75440DI0216Intentional self-harm[ICD-11: PC91]P30536TSPO
    T75440DI0271Mood/affect symptom[ICD-11: MB24]P30536TSPO
    T75440DI0411Tonus and reflex abnormality[ICD-11: MB47]P30536TSPO
    T56556DI0218Irritable bowel syndrome[ICD-11: DD91]Q9UNQ0ABCG2
    T56556DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UNQ0ABCG2
    T73482DI0117Depression[ICD-11: 6A70-6A7Z]O43613HCRTR1
    T73482DI0214Insomnia[ICD-11: 7A00-7A0Z]O43613HCRTR1
    T73482DI0317Opioid use disorder[ICD-11: 6C43]O43613HCRTR1
    T96413DI0242Lysosomal disease[ICD-11: 5C56]P08236GUSB
    T53524DI0160Gastrointestinal stromal tumour[ICD-11: 2B5B]P16234PDGFRA
    T53524DI0225Kaposi sarcoma[ICD-11: 2B57]P16234PDGFRA
    T53524DI0403Thrombocytopenia[ICD-11: 3B64]P16234PDGFRA
    T17345DI0207Indeterminate colitis[ICD-11: DD72]P00374DHFR
    T17345DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00374DHFR
    T17345DI0416Tuberculosis[ICD-11: 1B10-1B12]P00374DHFR
    T17345DI0427Urinary tract infection[ICD-11: GC08]P00374DHFR
    T87670DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q9Y2T6GPR55
    T10265DI0037Asthma[ICD-11: CA23]Q07343PDE4B
    T10265DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q07343PDE4B
    T10265DI0265Mild neurocognitive disorder[ICD-11: 6D71]Q07343PDE4B
    T31406DI0207Indeterminate colitis[ICD-11: DD72]P08631HCK
    T12541DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]Q9UBF8PI4KB
    T12541DI0440Zoonotic viral diseaseICD-11: 1D6YQ9UBF8PI4KB
    T51115DI0025Alzheimer disease[ICD-11: 8A20]Q13936CACNA1C
    T64205DI0383Skin and skin-structure infection[ICD-11: 1F28-1G0Z]P42224STAT1
    T59190DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q05513PRKCZ
    T31989DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9NRA0SPHK2
    T86552DI0060Brain cancer[ICD-11: 2A00]P19438TNFRSF1A
    T86552DI0321Ovarian cancer[ICD-11: 2C73]P19438TNFRSF1A
    T11241DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q99500S1PR3
    T08910DI0117Depression[ICD-11: 6A70-6A7Z]P18507GABRG2
    T08910DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P18507GABRG2
    T08910DI0411Tonus and reflex abnormality[ICD-11: MB47]P18507GABRG2
    T94201DI0365Retinopathy[ICD-11: 9B71]Q96SB4SRPK1
    T07191DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q12851MAP4K2
    T63194DI0350Pseudoxanthoma elasticumICD-11: EC40P22413ENPP1
    T63194DI0438Vitamin/non-protein cofactor absorption/transport disorderICD-11: 5C63P22413ENPP1
    T63217DI0045Autosomal Recessive Ichthyosis[ICD-11: EC20]P22735TGM1
    T46216DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q9H8M2BRD9
    T28887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BY41HDAC8
    T42760DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9UBS0RPS6KB2
    T41263DI0078Cholera[ICD-11: 1A00]Q7RTX1TAS1R1
    T80387DI0117Depression[ICD-11: 6A70-6A7Z]P47870GABRB2
    T80387DI0214Insomnia[ICD-11: 7A00-7A0Z]P47870GABRB2
    T80387DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P47870GABRB2
    T80387DI0411Tonus and reflex abnormality[ICD-11: MB47]P47870GABRB2

    Copyright © 2025