Compound details

Adenosine

Compound ID	CDAMM00323
Common name	Adenosine
IUPAC name	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Molecular formula	C₁₀H₁₃N₅O₄

Experimental data

Retention time	10.942
Adduct	[M+H]+
Actual mz	268.105
Theoretical mz	268.104
Error	2.87
Ionizaton mode	Positive
Instrument type	LC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score	8.01

Identifiers and class information

Inchi key	OIRDTQYFTABQOQ-KQYNXXCUSA-N
Smiles	OCC1OC(N2C=NC=3C(=NC=NC32)N)C(O)C1O
Superclass	Nucleosides, nucleotides, and analogues
Class	Purine nucleosides

Plant source

Pedalium murex L.

Plumbago zeylanica Linn.

Baliospermum solanifolium (Burm.) Suresh

Asparagus gonoclados Baker

External sources

HMDB ID	HMDB0000050
KNApSAcK ID	C00007444
FooDB ID	FDB003554
DrugBank ID	DB00194
ChEBI ID	CHEBI:16335
Pubchem Compound ID	60961
PlantCyc ID	ADENOSINE
UNPD ID	UNPD128026
Coconut ID
LipidMAPS ID
NANPDB ID	NANPDB_3517

Pharmacokinetic properties

Number of descriptor values(#stars)	0
Number of non-conjugated amine groups (#amine)	0
Number of amidine and guanidine groups (#amidine)	0
Number of carboxylic acid groups (#acid)	0
Number of non-conjugated amide groups (#amide)	0
Number of rotatable bonds (#rotor)	5
Number of reactive functional groups (#rtvFG)	0
Predicted central nervous system activity (CNS)	-2
Molecular weight (mol_MW)	267.244
Computed dipole moment(dipole)	7.904
Total solvent accessible surface area (SASA)	473.676
Hydrophobic component of SASA (FOSA)	95.984
Hydrophilic component of SASA (FISA)	275.715
Pie component of the SASA (PISA)	101.977
Weakly polar component of the SASA (WPSA)	0
Total solvent accesible volume (volume)	794.227
Number of hydrogen bond donors (donorHB)	5
Number of hydrogen bond acceptors (accptHB)	10.8
Free energy of solvation of dipole (dip^2/V)	0.0786529
Index of cohesive interaction in solids (ACxDN^.5/SA)	0.0509832
Globularity descriptor (glob)	0.875615
Predicted polarizability in cubic angstroms (QPpolrz)	23.394
Predicted hexadecane/gas partition coefficient (QPlogPC16)	9.397
Predicted octanol/gas partition coefficient (QPlogPoct)	22.086
Predicted water/gas partition coefficient (QPlogPw)	20.286
Predicted octanol/water partition coefficient (QPlogPo/w)	-1.81
Predicted aqueous solubility (QPlogS)	-1.813
Conformation-independent predicted aqueous solubility (CIQPlogS)	-1.506
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)	-4.031
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)	24.06
Predicted brain/blood partition coefficient (QPlogBB)	-2.135
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)	8.805
Predicted skin permeability, log Kp (QPlogKp)	-5.762
PM3 calculated ionization potential (IP(ev))	8.453
PM3 calculated electron affinity (EA(eV))	0.208
Number of likely metabolic reactions (#metab)	5
Prediction of binding to human serum albumin (QPlogKhsa)	-0.89
Predicted qualitative human oral absorption (HumanOralAbsorption)	2
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)	41.072
Solvent-accessible surface area of fluorine atoms (SAFluorine)	0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)	0
Van der Waals surface area (PSA)	142.606
Number of nitrogen and oxygen atoms (#NandO)	9
Number of violations of Lipinski’s rule of five (RuleOfFive)	0
Number of violations of Jorgensen’s rule of three (RuleOfThree)	0

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID	Gene name	Target name	TTD_ID	Prediction source
P00533	EGFR	Epidermal growth factor receptor erbB1	T59328	SwissTargetPrediction
Q86X55	CARM1	Histone-arginine methyltransferase CARM1	T12837	SwissTargetPrediction
P29274	ADORA2A	Adenosine A2a receptor	T77365	SwissTargetPrediction and SEA
P30542	ADORA1	Adenosine A1 receptor	T92072	SwissTargetPrediction and SEA
P07327	ADH1A	Alcohol dehydrogenase alpha chain	T65570	SEA
O43570	CA12	Carbonic anhydrase XII	T16987	SwissTargetPrediction
Q16790	CA9	Carbonic anhydrase IX	T64567	SwissTargetPrediction
Q07820	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	T14912	SwissTargetPrediction
P0DMS8	ADORA3	Adenosine A3 receptor	T36059	SwissTargetPrediction and SEA
P00915	CA1	Carbonic anhydrase I	T13201	SwissTargetPrediction
P00918	CA2	Carbonic anhydrase II	T20401	SwissTargetPrediction
P10253	GAA	Lysosomal alpha-glucosidase (by homology)	T31514	SwissTargetPrediction
P27487	DPP4	Dipeptidyl peptidase IV	T31391	SwissTargetPrediction
P43166	CA7	Carbonic anhydrase VII	T37541	SwissTargetPrediction
Q9ULX7	CA14	Carbonic anhydrase XIV	T31992	SwissTargetPrediction and SEA
P11086	PNMT	Phenylethanolamine N-methyltransferase	T56496	SwissTargetPrediction
P29275	ADORA2B	Adenosine A2b receptor	T86679	SwissTargetPrediction and SEA
P00491	PNP	Purine nucleoside phosphorylase	T78198	SwissTargetPrediction and SEA
P04183	TK1	Thymidine kinase, cytosolic	T30081	SEA
P14902	IDO1	Indoleamine 2,3-dioxygenase	T89697	SwissTargetPrediction
P49137	MAPKAPK2	MAP kinase-activated protein kinase 2	T21307	SwissTargetPrediction
P09467	FBP1	Fructose-1,6-bisphosphatase	T83391	SwissTargetPrediction and SEA
P11309	PIM1	Serine/threonine-protein kinase PIM1	T50594	SwissTargetPrediction
P14061	HSD17B1	Estradiol 17-beta-dehydrogenase 1	T44011	SwissTargetPrediction
P0DMV8	HSPA1A	Heat shock 70 kDa protein 1	T49639	SwissTargetPrediction
P12931	SRC	Tyrosine-protein kinase SRC	T85943	SwissTargetPrediction
P24385	CCND1	Cyclin-dependent kinase 4/cyclin D1	T12355	SwissTargetPrediction
P26358	DNMT1	DNA (cytosine-5)-methyltransferase 1 (by homology)	T88304	SEA
P32320	CDA	Cytidine deaminase (by homology)	T79027	SwissTargetPrediction and SEA
P00813	ADA	Adenosine deaminase	T03661	SwissTargetPrediction and SEA
P04062	GBA	Beta-glucocerebrosidase	T84173	SwissTargetPrediction
P28482	MAPK1	MAP kinase ERK2	T58970	SwissTargetPrediction
P55263	ADK	Adenosine kinase	T91661	SwissTargetPrediction and SEA
O60502	OGA	Bifunctional protein NCOAT	T19567	SwissTargetPrediction
P11142	HSPA8	Heat shock cognate 71 kDa protein	T12817	SwissTargetPrediction
P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase liver	T39321	SwissTargetPrediction and SEA
Q99808	SLC29A1	Equilibrative nucleoside transporter 1	T13491	SwissTargetPrediction and SEA
P11021	HSPA5	78 kDa glucose-regulated protein	T77594	SwissTargetPrediction
O43868	SLC28A2	Sodium/nucleoside cotransporter 2	T94627	SwissTargetPrediction and SEA
P23526	AHCY	Adenosylhomocysteinase	T68698	SwissTargetPrediction and SEA
P16455	MGMT	6-O-methylguanine-DNA methyltransferase	T24587	SEA
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	T40111	SEA
P12268	IMPDH2	Inosine-5'-monophosphate dehydrogenase 2	T89360	SEA
Q9H244	P2RY12	Purinergic receptor P2Y12 (by homology)	T46937	SEA
P19971	TYMP	Thymidine phosphorylase	T59929	SEA
Q8TEK3	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific	T87686	SwissTargetPrediction and SEA
P17612	PRKACA	cAMP-dependent protein kinase alpha-catalytic subunit	T12808	SEA
P55786	NPEPPS	Puromycin-sensitive aminopeptidase	T15610	SEA
P47900	P2RY1	Purinergic receptor P2Y1	T67818	SwissTargetPrediction and SEA
P41231	P2RY2	Purinergic receptor P2Y2	T93515	SEA
P63000	RAC1	Ras-related C3 botulinum toxin substrate 1	T88752	SEA
Q15910	EZH2	EZH2/SUZ12/EED/RBBP7/RBBP4	T25265	SwissTargetPrediction and SEA
Q99873	PRMT1	Protein-arginine N-methyltransferase 1	T16808	SwissTargetPrediction and SEA
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	T53251	SwissTargetPrediction and SEA
P16885	PLCG2	Phospholipase C-gamma-2	T93922	SEA
Q9Y478	PRKAB1	AMP-activated protein kinase, beta-1 subunit	T38875	SEA
Q13126	MTAP	S-methyl-5-thioadenosine phosphorylase	T40787	SwissTargetPrediction
P06865	HEXA	Beta-hexosaminidase subunit alpha	T63196	SEA
P07686	HEXB	Beta-N-acetyl-D-hexosaminidase-A/B	T63197	SEA
P23919	DTYMK	Thymidylate kinase	T94400	SEA
Q9NRG4	SMYD2	N-lysine methyltransferase SMYD2	T15797	SwissTargetPrediction and SEA
O94759	TRPM2	Transient receptor potential cation channel subfamily M member 2	T78205	SEA
P41252	IARS	Isoleucyl-tRNA synthetase	T46515	SwissTargetPrediction
Q9H9B1	EHMT1	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5	T39996	SwissTargetPrediction and SEA
Q9UBC3	DNMT3B	DNA (cytosine-5)-methyltransferase 3B	T65501	SwissTargetPrediction and SEA
Q15391	P2RY14	Purinergic receptor P2Y14	T16555	SEA
P49789	FHIT	Bis(5'-adenosyl)-triphosphatase	T59720	SwissTargetPrediction
Q05823	RNASEL	RNase L	T25200	SEA
P51575	P2RX1	P2X purinoceptor 1	T69091	SwissTargetPrediction and SEA
P17707	AMD1	S-adenosylmethionine decarboxylase 1	T55922	SwissTargetPrediction and SEA
Q8WTS6	SETD7	Histone-lysine N-methyltransferase SETD7	T73184	SwissTargetPrediction and SEA
Q9NVM4	PRMT7	Protein arginine N-methyltransferase 7	T79501	SwissTargetPrediction and SEA
Q9BYW2	SETD2	Histone-lysine N-methyltransferase SETD2	T73551	SwissTargetPrediction
O43463	SUV39H1	Histone-lysine N-methyltransferase SUV39H1	T39519	SwissTargetPrediction and SEA
Q92800	EZH1	Histone-lysine N-methyltransferase EZH1	T17986	SwissTargetPrediction and SEA
Q99571	P2RX4	P2X purinoceptor 4	T60330	SEA
Q13304	GPR17	Uracil nucleotide/cysteinyl leukotriene receptor	T33902	SEA
Q86Y97	KMT5C	Histone-lysine N-methyltransferase KMT5C	T68490	SEA
O95622	ADCY5	Adenylate cyclase type 5	T19531	SEA
Q9NZ70	TAK1	TGF-beta-activated kinase 1	T04361	SEA
Q9Y4W7	PARG	Poly(ADP-ribose) glycohydrolase	T66935	SwissTargetPrediction and SEA
Q07108	CD69	Early activation antigen CD69	T48780	SEA
O60755	GALR3	Galanin receptor	T98494	SEA

Target associated diseases

TTD_ID	Disease_ID	Disease name	ICD_11	Uniprot ID	Gene names
T59328	DI0030	Angina pectoris	[ICD-11: BA40]	P00533	EGFR
T59328	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P00533	EGFR
T59328	DI0095	Colorectal cancer	[ICD-11: 2B91]	P00533	EGFR
T59328	DI0121	Diabetic foot ulcer	[ICD-11: BD54]	P00533	EGFR
T59328	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P00533	EGFR
T59328	DI0238	Lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P00533	EGFR
T59328	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P00533	EGFR
T59328	DI0420	Unspecific body region injury	[ICD-11: ND56]	P00533	EGFR
T77365	DI0319	Orthostatic hypotension	[ICD-11: BA21]	P29274	ADORA2A
T77365	DI0331	Parkinsonism	[ICD-11: 8A00]	P29274	ADORA2A
T77365	DI0359	Radionuclide imaging	[ICD-11: N.A.]	P29274	ADORA2A
T92072	DI0319	Orthostatic hypotension	[ICD-11: BA21]	P30542	ADORA1
T65570	DI0139	Exposure to noxious substances harmful effect	[ICD-11: NE61]	P07327	ADH1A
T16987	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	O43570	CA12
T16987	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	O43570	CA12
T64567	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q16790	CA9
T14912	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q07820	MCL1
T14912	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	Q07820	MCL1
T14912	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q07820	MCL1
T14912	DI0252	Melanoma	[ICD-11: 2C30]	Q07820	MCL1
T14912	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q07820	MCL1
T14912	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q07820	MCL1
T36059	DI0351	Psoriasis	[ICD-11: EA90]	P0DMS8	ADORA3
T36059	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P0DMS8	ADORA3
T13201	DI0166	Glaucoma	[ICD-11: 9C61]	P00915	CA1
T13201	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00915	CA1
T20401	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P00918	CA2
T20401	DI0137	Essential hypertension	[ICD-11: BA00]	P00918	CA2
T20401	DI0166	Glaucoma	[ICD-11: 9C61]	P00918	CA2
T20401	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P00918	CA2
T20401	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P00918	CA2
T20401	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00918	CA2
T31514	DI0201	Inborn carbohydrate metabolism error	[ICD-11: 5C51]	P10253	GAA
T31391	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P27487	DPP4
T31391	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P27487	DPP4
T31992	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q9ULX7	CA14
T31992	DI0204	Inborn metabolism deficiency	[ICD-11: 5C50-5C59]	Q9ULX7	CA14
T86679	DI0180	Herpes simplex infection	[ICD-11: 1F00]	P29275	ADORA2B
T86679	DI0397	Supraventricular tachyarrhythmia	[ICD-11: BC81]	P29275	ADORA2B
T78198	DI0120	Diabetes mellitus	[ICD-11: 5A10]	P00491	PNP
T78198	DI0167	Gout	[ICD-11: FA25]	P00491	PNP
T78198	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P00491	PNP
T78198	DI0283	Mycosis fungoides	[ICD-11: 2B01]	P00491	PNP
T78198	DI0351	Psoriasis	[ICD-11: EA90]	P00491	PNP
T30081	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P04183	TK1
T30081	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	P04183	TK1
T89697	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P14902	IDO1
T21307	DI0011	Acute laryngitis/tracheitis	[ICD-11: CA05]	P49137	MAPKAPK2
T21307	DI0181	Hidradenitis suppurativa	[ICD-11: ED92]	P49137	MAPKAPK2
T21307	DI0269	Monogenic autoinflammatory syndrome	[ICD-11: 4A60]	P49137	MAPKAPK2
T21307	DI0334	Peritoneal cancer	[ICD-11: 2C51]	P49137	MAPKAPK2
T21307	DI0352	Psoriatic arthritis	[ICD-11: FA21]	P49137	MAPKAPK2
T21307	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P49137	MAPKAPK2
T21307	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P49137	MAPKAPK2
T83391	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P09467	FBP1
T50594	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P11309	PIM1
T50594	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P11309	PIM1
T49639	DI0121	Diabetic foot ulcer	[ICD-11: BD54]	P0DMV8	HSPA1A
T49639	DI0180	Herpes simplex infection	[ICD-11: 1F00]	P0DMV8	HSPA1A
T49639	DI0231	Leukaemia	[ICD-11: 2A60-2B33]	P0DMV8	HSPA1A
T49639	DI0244	Malignant digestive organ neoplasm	[ICD-11: 2C11]	P0DMV8	HSPA1A
T49639	DI0260	Metastatic malignant neoplasm	[ICD-11: 2D50-2E09]	P0DMV8	HSPA1A
T49639	DI0298	Neuropathy	[ICD-11: 8C0Z]	P0DMV8	HSPA1A
T49639	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P0DMV8	HSPA1A
T49639	DI0395	Stomach cancer	[ICD-11: 2B72]	P0DMV8	HSPA1A
T85943	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P12931	SRC
T85943	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P12931	SRC
T85943	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P12931	SRC
T85943	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P12931	SRC
T12355	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P24385	CCND1
T88304	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P26358	DNMT1
T88304	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	P26358	DNMT1
T88304	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P26358	DNMT1
T79027	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P32320	CDA
T03661	DI0016	Adaptive immunity immunodeficiency	[ICD-11: 4A01]	P00813	ADA
T03661	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P00813	ADA
T03661	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	P00813	ADA
T84173	DI0257	Metabolic disorder	[ICD-11: 5C50-5D2Z]	P04062	GBA
T58970	DI0036	Arteries/arterioles disorder	[ICD-11: BD52]	P28482	MAPK1
T58970	DI0252	Melanoma	[ICD-11: 2C30]	P28482	MAPK1
T58970	DI0326	Pancreatic cancer	[ICD-11: 2C10]	P28482	MAPK1
T58970	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P28482	MAPK1
T91661	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P55263	ADK
T19567	DI0025	Alzheimer disease	[ICD-11: 8A20]	O60502	OGA
T19567	DI0331	Parkinsonism	[ICD-11: 8A00]	O60502	OGA
T39321	DI0279	Muscular atrophy	[ICD-11: 8B61]	P04406	GAPDH
T39321	DI0280	Muscular dystrophy	[ICD-11: 8C70]	P04406	GAPDH
T13491	DI0030	Angina pectoris	[ICD-11: BA40]	Q99808	SLC29A1
T77594	DI0252	Melanoma	[ICD-11: 2C30]	P11021	HSPA5
T77594	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P11021	HSPA5
T24587	DI0369	Sarcoma	[ICD-11: 2A60-2C35]	P16455	MGMT
T40111	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P20839	IMPDH1
T40111	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P20839	IMPDH1
T40111	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P20839	IMPDH1
T40111	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P20839	IMPDH1
T40111	DI0413	Transplant rejection	[ICD-11: NE84]	P20839	IMPDH1
T89360	DI0413	Transplant rejection	[ICD-11: NE84]	P12268	IMPDH2
T46937	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	Q9H244	P2RY12
T46937	DI0405	Thrombosis	[ICD-11: DB61-GB90]	Q9H244	P2RY12
T59929	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P19971	TYMP
T87686	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q8TEK3	DOT1L
T87686	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	Q8TEK3	DOT1L
T87686	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q8TEK3	DOT1L
T12808	DI0279	Muscular atrophy	[ICD-11: 8B61]	P17612	PRKACA
T15610	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P55786	NPEPPS
T15610	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	P55786	NPEPPS
T93515	DI0436	Visual system disease	[ICD-11: 9E1Z]	P41231	P2RY2
T88752	DI0025	Alzheimer disease	[ICD-11: 8A20]	P63000	RAC1
T25265	DI0151	Follicular lymphoma	[ICD-11: 2A80]	Q15910	EZH2
T16808	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q99873	PRMT1
T53251	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q96KQ7	EHMT2
T53251	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	Q96KQ7	EHMT2
T53251	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q96KQ7	EHMT2
T38875	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	Q9Y478	PRKAB1
T40787	DI0275	Multiple sclerosis	[ICD-11: 8A40]	Q13126	MTAP
T63196	DI0242	Lysosomal disease	[ICD-11: 5C56]	P06865	HEXA
T63197	DI0242	Lysosomal disease	[ICD-11: 5C56]	P07686	HEXB
T15797	DI0238	Lung cancer	[ICD-11: 2C25]	Q9NRG4	SMYD2
T15797	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9NRG4	SMYD2
T39996	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q9H9B1	EHMT1
T39996	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9H9B1	EHMT1
T65501	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9UBC3	DNMT3B
T59720	DI0293	Nausea/vomiting	[ICD-11: MD90]	P49789	FHIT
T55922	DI0004	Acidosis	[ICD-11: 5C73]	P17707	AMD1
T73184	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q8WTS6	SETD7
T17986	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q92800	EZH1
T17986	DI0238	Lung cancer	[ICD-11: 2C25]	Q92800	EZH1
T17986	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	Q92800	EZH1
T17986	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q92800	EZH1
T17986	DI0251	Mature T-cell lymphoma	[ICD-11: 2A90]	Q92800	EZH1
T17986	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	Q92800	EZH1
T17986	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q92800	EZH1
T17986	DI0423	Ureteral cancer	[ICD-11: 2C92]	Q92800	EZH1
T04361	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q9NZ70	TAK1
T98494	DI0265	Mild neurocognitive disorder	[ICD-11: 6D71]	O60755	GALR3