Compound details

Aurantiamide

Compound ID	CDAMM00273
Common name	Aurantiamide
IUPAC name	N-[(2S)-1-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]benzamide
Molecular formula	C₂₅H₂₆N₂O₃

Experimental data

Retention time	57.879
Adduct	[M+H]+
Actual mz	403.203
Theoretical mz	403.202
Error	4.66
Ionizaton mode	Positive
Instrument type	LC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score	6.09

Identifiers and class information

Inchi key	HFRZSVYKDDZRQY-AATRIKPKSA-N
Smiles	C1=CC=C(C=C1)CC(CO)NC(=O)C(CC2=CC=CC=C2)NC(=O)C3=CC=CC=C3
Superclass	Lipids and lipid-like molecules
Class	Prenol lipids

Plant source

Tribulus terrestris L.

Pedalium murex L.

External sources

HMDB ID
KNApSAcK ID	C00041367
FooDB ID
DrugBank ID
ChEBI ID
Pubchem Compound ID	185904
PlantCyc ID
UNPD ID	UNPD127863
Coconut ID
LipidMAPS ID
NANPDB ID

Pharmacokinetic properties

Number of descriptor values(#stars)	1
Number of non-conjugated amine groups (#amine)	0
Number of amidine and guanidine groups (#amidine)	0
Number of carboxylic acid groups (#acid)	0
Number of non-conjugated amide groups (#amide)	1
Number of rotatable bonds (#rotor)	10
Number of reactive functional groups (#rtvFG)	0
Predicted central nervous system activity (CNS)	-1
Molecular weight (mol_MW)	402.492
Computed dipole moment(dipole)	3.518
Total solvent accessible surface area (SASA)	707.3
Hydrophobic component of SASA (FOSA)	117.806
Hydrophilic component of SASA (FISA)	75.696
Pie component of the SASA (PISA)	513.798
Weakly polar component of the SASA (WPSA)	0
Total solvent accesible volume (volume)	1318.44
Number of hydrogen bond donors (donorHB)	2.25
Number of hydrogen bond acceptors (accptHB)	5.95
Free energy of solvation of dipole (dip^2/V)	0.0093864
Index of cohesive interaction in solids (ACxDN^.5/SA)	0.0126184
Globularity descriptor (glob)	0.82212
Predicted polarizability in cubic angstroms (QPpolrz)	45.096
Predicted hexadecane/gas partition coefficient (QPlogPC16)	15.126
Predicted octanol/gas partition coefficient (QPlogPoct)	21.596
Predicted water/gas partition coefficient (QPlogPw)	14.044
Predicted octanol/water partition coefficient (QPlogPo/w)	4.336
Predicted aqueous solubility (QPlogS)	-4.491
Conformation-independent predicted aqueous solubility (CIQPlogS)	-5.379
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)	-5.486
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)	1256.8
Predicted brain/blood partition coefficient (QPlogBB)	-0.786
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)	988.367
Predicted skin permeability, log Kp (QPlogKp)	-0.145
PM3 calculated ionization potential (IP(ev))	9.31
PM3 calculated electron affinity (EA(eV))	0.214
Number of likely metabolic reactions (#metab)	4
Prediction of binding to human serum albumin (QPlogKhsa)	0.239
Predicted qualitative human oral absorption (HumanOralAbsorption)	3
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)	100
Solvent-accessible surface area of fluorine atoms (SAFluorine)	0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)	22.464
Van der Waals surface area (PSA)	86.844
Number of nitrogen and oxygen atoms (#NandO)	5
Number of violations of Lipinski’s rule of five (RuleOfFive)	0
Number of violations of Jorgensen’s rule of three (RuleOfThree)	0

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID	Gene name	Target name	TTD_ID	Prediction source
Q12809	KCNH2	HERG	T20251	SwissTargetPrediction
P12821	ACE	Angiotensin-converting enzyme	T98311	SwissTargetPrediction
P00797	REN	Renin	T61622	SwissTargetPrediction and SEA
P15144	ANPEP	Aminopeptidase N	T67272	SEA
P00734	F2	Thrombin	T94033	SwissTargetPrediction and SEA
P09960	LTA4H	Leukotriene A4 hydrolase	T03691	SEA
O15379	HDAC3	Histone deacetylase 3	T05090	SEA
P00915	CA1	Carbonic anhydrase I	T13201	SwissTargetPrediction and SEA
P00918	CA2	Carbonic anhydrase II	T20401	SwissTargetPrediction and SEA
P14416	DRD2	Dopamine D2 receptor	T67162	SwissTargetPrediction
Q9NTG7	SIRT3	NAD-dependent deacetylase sirtuin 3	T91959	SEA
Q8IXJ6	SIRT2	NAD-dependent deacetylase sirtuin 2	T83904	SEA
Q4U2R8	SLC22A6	Solute carrier family 22 member 6 (by homology)	T70680	SEA
P08514	ITGA2B	Integrin alpha-IIb/beta-3	T50688	SwissTargetPrediction and SEA
P98170	XIAP	Inhibitor of apoptosis protein 3	T16769	SwissTargetPrediction and SEA
P78352	DLG4	Disks large homolog 4	T04507	SEA
P08473	MME	Neprilysin	T05409	SEA
P34913	EPHX2	Epoxide hydratase	T35734	SwissTargetPrediction and SEA
P27338	MAOB	Monoamine oxidase B	T83011	SwissTargetPrediction
O60341	KDM1A	Lysine-specific histone demethylase 1	T16739	SwissTargetPrediction
P28223	HTR2A	Serotonin 2a (5-HT2a) receptor	T32060	SwissTargetPrediction
P28335	HTR2C	Serotonin 2c (5-HT2c) receptor	T83813	SwissTargetPrediction
Q96RJ0	TAAR1	Trace amine-associated receptor 1 (by homology)	T99524	SEA
P42785	PRCP	Lysosomal Pro-X carboxypeptidase	T20371	SwissTargetPrediction
P42261	GRIA1	Glutamate receptor ionotropic, AMPA 1	T33584	SwissTargetPrediction
P00747	PLG	Plasminogen	T89034	SEA
P24864	CCNE1	Cyclin-dependent kinase 2/cyclin E1	T10052	SwissTargetPrediction
Q9UQL6	HDAC5	Histone deacetylase 5	T07930	SEA
P56524	HDAC4	Histone deacetylase 4	T63816	SEA
P43235	CTSK	Cathepsin K	T11388	SwissTargetPrediction and SEA
Q9UBN7	HDAC6	Histone deacetylase 6	T22274	SwissTargetPrediction
P07384	CAPN1	Calpain 1	T92517	SwissTargetPrediction
Q92769	HDAC2	Histone deacetylase 2	T51191	SwissTargetPrediction and SEA
P35354	PTGS2	Cyclooxygenase-2	T66665	SwissTargetPrediction
Q9H4A4	RNPEP	Aminopeptidase B	T57818	SEA
Q16719	KYNU	Kynureninase	T99912	SEA
P07339	CTSD	Cathepsin D	T67102	SwissTargetPrediction and SEA
P29350	PTPN6	Protein-tyrosine phosphatase 1C	T98264	SEA
P18031	PTPN1	Protein-tyrosine phosphatase 1B	T16347	SEA
P17706	PTPN2	T-cell protein-tyrosine phosphatase	T49156	SEA
Q07075	ENPEP	Aminopeptidase A	T31956	SEA
Q01650	SLC7A5	L-type amino acid transporter 1 (by homology)	T48330	SEA
Q07869	PPARA	Peroxisome proliferator-activated receptor alpha	T86591	SEA
P28845	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	T65200	SwissTargetPrediction
P08253	MMP2	Matrix metalloproteinase 2	T68251	SwissTargetPrediction and SEA
P22894	MMP8	Matrix metalloproteinase 8	T08856	SwissTargetPrediction and SEA
P08254	MMP3	Matrix metalloproteinase 3	T86702	SwissTargetPrediction and SEA
P14780	MMP9	Matrix metalloproteinase 9	T54156	SwissTargetPrediction and SEA
P03956	MMP1	Matrix metalloproteinase 1	T52450	SwissTargetPrediction and SEA
O00206	TLR4	Toll-like receptor 4 (by homology)	T81443	SwissTargetPrediction
P17655	CAPN2	Calpain 2	T86837	SEA
Q9BY41	HDAC8	Histone deacetylase 8	T28887	SwissTargetPrediction
P35372	OPRM1	Mu opioid receptor	T47768	SwissTargetPrediction and SEA
P41145	OPRK1	Kappa Opioid receptor	T60693	SwissTargetPrediction and SEA
P62993	GRB2	Growth factor receptor-bound protein 2	T30926	SEA
P11309	PIM1	Serine/threonine-protein kinase PIM1	T50594	SwissTargetPrediction
O60674	JAK2	Tyrosine-protein kinase JAK2	T08391	SwissTargetPrediction
P06213	INSR	Insulin receptor	T85435	SwissTargetPrediction
P24941	CDK2	Cyclin-dependent kinase 2	T70176	SwissTargetPrediction
P11802	CDK4	Cyclin-dependent kinase 4	T85799	SwissTargetPrediction
Q9P1W9	PIM2	Serine/threonine-protein kinase PIM2	T07279	SwissTargetPrediction
Q86V86	PIM3	Serine/threonine-protein kinase PIM3	T16596	SwissTargetPrediction
P56817	BACE1	Beta-secretase 1	T79031	SwissTargetPrediction and SEA
Q9Y233	PDE10A	Phosphodiesterase 10A (by homology)	T84133	SwissTargetPrediction
P09237	MMP7	Matrix metalloproteinase 7	T73475	SEA
P13497	BMP1	Bone morphogenetic protein 1	T53350	SEA
P35270	SPR	Substance-P receptor	T47094	SwissTargetPrediction and SEA
P37288	AVPR1A	Vasopressin V1a receptor (by homology)	T79232	SwissTargetPrediction and SEA
P04229	HLA-DRB1	HLA class II histocompatibility antigen DRB1-1	T83611	SEA
P07711	CTSL	Cathepsin L	T98691	SwissTargetPrediction and SEA
O43603	GALR2	Galanin receptor 2 (by homology)	T13453	SwissTargetPrediction
P47211	GALR1	Galanin receptor 1 (by homology)	T78581	SwissTargetPrediction
P32245	MC4R	Melanocortin receptor 4	T72458	SwissTargetPrediction and SEA
P07858	CTSB	Cathepsin (B and K)	T61746	SwissTargetPrediction and SEA
Q92847	GHSR	Ghrelin receptor	T59604	SEA
P41143	OPRD1	Delta opioid receptor	T58992	SwissTargetPrediction and SEA
Q01726	MC1R	Melanocortin receptor 1	T35842	SEA
P41968	MC3R	Melanocortin receptor 3	T76846	SEA
P23946	CMA1	Chymase	T05114	SEA
P00742	F10	Thrombin and coagulation factor X	T84631	SwissTargetPrediction and SEA
P00750	PLAT	Tissue-type plasminogen activator	T45299	SEA
Q9HAN5	TRP1	Cationic trypsinogen	T27602	SwissTargetPrediction
P37231	PPARG	Peroxisome proliferator-activated receptor gamma	T58921	SEA
P49356	FNTB	Farnesyl protein transferase	T13127	SwissTargetPrediction and SEA
P04035	HMGCR	HMG-CoA reductase	T53585	SwissTargetPrediction and SEA
Q16850	CYP51A1	Cytochrome P450 51 (by homology)	T32972	SEA
P20701	ITGAL	Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2	T35640	SwissTargetPrediction
P32246	CCR1	C-C chemokine receptor type 1	T16016	SwissTargetPrediction and SEA
P49810	PSEN2	Gamma-secretase	T99204	SwissTargetPrediction
P53779	MAPK10	c-Jun N-terminal kinase 3	T85421	SwissTargetPrediction
Q15078	CDK5R1	Cyclin-dependent kinase 5/CDK5 activator 1	T09513	SwissTargetPrediction
P29466	CASP1	Caspase-1	T98269	SwissTargetPrediction and SEA
P12931	SRC	Tyrosine-protein kinase SRC	T85943	SwissTargetPrediction
Q13627	DYRK1A	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	T92803	SwissTargetPrediction
P24385	CCND1	Cyclin-dependent kinase 4/cyclin D1	T12355	SwissTargetPrediction
P25774	CTSS	Cathepsin S	T68290	SwissTargetPrediction and SEA
P52333	JAK3	Tyrosine-protein kinase JAK3	T23172	SwissTargetPrediction
P08263	GSTA1	Glutathione S-transferase A1	T17221	SEA
Q6P179	ERAP2	Endoplasmic reticulum aminopeptidase 2	T65818	SEA
P06870	KLK1	Kallikrein 1	T40000	SEA
P20151	KLK2	Kallikrein 2	T01908	SEA
P00813	ADA	Adenosine deaminase	T03661	SEA
P20142	PGC	Pepsinogen C (by homology)	T45601	SEA
P04439	HLA-A	HLA class I histocompatibility antigen A-3	T08985	SwissTargetPrediction and SEA
P14091	CTSE	Cathepsin E	T16891	SwissTargetPrediction
P25090	FPR2	Lipoxin A4 receptor (by homology)	T97917	SEA
Q9ULA0	DNPEP	Aspartyl aminopeptidase	T45287	SEA
P06756	ITGAV	Vitronectin receptor alpha	T67103	SEA
Q9BYF1	ACE2	Angiotensin-converting enzyme 2	T27889	SEA
P42892	ECE1	Endothelin-converting enzyme 1	T50970	SEA
P28482	MAPK1	MAP kinase ERK2	T58970	SwissTargetPrediction
P05556	ITGB1	Integrin alpha2/beta1	T01851	SwissTargetPrediction and SEA
Q9ULW8	PADI3	Protein-arginine deiminase type-3	T36612	SEA
Q9UM07	PADI4	Protein-arginine deiminase type-4	T50429	SEA
P06493	CDK1	Cyclin-dependent kinase 1/cyclin B1	T49898	SwissTargetPrediction
P39900	MMP12	Matrix metalloproteinase 12	T03500	SEA
P50613	CDK7	Cyclin-dependent kinase 7	T58449	SwissTargetPrediction
Q00535	CDK5	Cyclin-dependent kinase 5/CDK5 activator 1	T20973	SwissTargetPrediction
P06737	PYGL	Liver glycogen phosphorylase	T19184	SEA
P42574	CASP3	Caspase-3	T57943	SEA
P41146	OPRL1	Nociceptin receptor	T52921	SwissTargetPrediction
P34998	CRHR1	Corticotropin releasing factor receptor 1 (by homology)	T45262	SwissTargetPrediction
Q9Y5Z0	BACE2	Beta secretase 2	T01280	SwissTargetPrediction
P15085	CPA1	Carboxypeptidase A1	T33966	SEA
Q99895	CTRC	Chymotrypsin C	T10118	SEA
O43174	CYP26A1	Cytochrome P450 26A1	T84634	SEA
P32239	CCKBR	Cholecystokinin B receptor (by homology)	T05849	SwissTargetPrediction and SEA
Q13976	PRKG1	cGMP-dependent protein kinase 1 beta	T78543	SEA
P00749	PLAU	Urokinase-type plasminogen activator	T17758	SEA
P56373	P2RX3	P2X purinoceptor 3	T17140	SwissTargetPrediction
P32238	CCKAR	Cholecystokinin A receptor	T28330	SEA
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	T30219	SEA
P03952	KLKB1	Plasma kallikrein	T82739	SEA
P08709	F7	Coagulation factor VII	T43332	SEA
Q96GD4	AURKB	Serine/threonine-protein kinase Aurora-B	T46781	SwissTargetPrediction
P28074	PSMB5	Proteasome Macropain subunit MB1	T49031	SEA
P24530	EDNRB	Endothelin receptor ET-B	T92828	SwissTargetPrediction
Q9NPC2	KCNK9	Potassium channel subfamily K member 9	T57613	SEA
O60760	HPGDS	Hematopoietic prostaglandin D synthase	T19433	SEA
P43490	NAMPT	Nicotinamide phosphoribosyltransferase	T54582	SEA
P14679	TYR	Tyrosinase	T97035	SEA
Q9Y3Q0	NAALAD2	NAALADase II	T70036	SEA
P25116	F2R	Proteinase-activated receptor 1	T36483	SwissTargetPrediction and SEA
P21452	TACR2	Neurokinin 2 receptor	T52790	SwissTargetPrediction and SEA
O15151	MDM4	Protein Mdm4	T36741	SEA
P26010	ITGB7	Integrin alpha-4/beta-7	T07403	SEA
P09238	MMP10	Matrix metalloproteinase 10	T40488	SEA
P01584	IL1B	Interleukin-1 beta	T42000	SEA
O75582	RPS6KA5	Ribosomal protein S6 kinase alpha 5	T50224	SEA
Q9UKP6	UTS2R	Urotensin II receptor	T49072	SEA
Q13526	PIN1	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	T16308	SwissTargetPrediction and SEA
P42226	STAT6	Signal transducer and activator of transcription 6	T20585	SEA
P29371	TACR3	Neurokinin 3 receptor	T29683	SwissTargetPrediction and SEA
Q9UIQ6	LNPEP	Cystinyl aminopeptidase	T97537	SEA
P41240	CSK	Tyrosine-protein kinase CSK	T08741	SEA
P48729	CSNK1A1	Casein kinase I alpha	T13075	SwissTargetPrediction
Q13237	PRKG2	cGMP-dependent protein kinase 2	T23606	SEA
Q9UK32	RPS6KA6	Ribosomal protein S6 kinase alpha 6	T95878	SEA
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	T63846	SEA
Q13464	ROCK1	Rho-associated protein kinase 1	T51282	SEA
P17612	PRKACA	cAMP-dependent protein kinase alpha-catalytic subunit	T12808	SEA
P28065	PSMB9	Proteasome subunit beta type-9	T06792	SEA
P28062	PSMB8	Proteasome subunit beta type-8	T77350	SEA
P43403	ZAP70	Tyrosine-protein kinase ZAP-70	T64553	SEA
Q12866	MERTK	Proto-oncogene tyrosine-protein kinase MER	T55781	SwissTargetPrediction
P20248	CCNA2	CDK2/Cyclin A	T58470	SwissTargetPrediction and SEA
Q06418	TYRO3	Tyrosine-protein kinase receptor TYRO3	T94880	SwissTargetPrediction
P03951	F11	Coagulation factor XI	T46040	SEA
Q9Y5Y6	ST14	Matriptase	T31543	SEA
P40189	IL6ST	Interleukin-6 receptor subunit beta	T93440	SwissTargetPrediction
Q5VT25	CDC42BPA	Serine or threonine-protein kinase MRCK-A	T00075	SEA
O96013	PAK4	Serine/threonine-protein kinase PAK 4	T98293	SwissTargetPrediction
Q9UNI1	CELA1	Elastase 1	T22839	SEA
P28336	NMBR	Neuromedin B receptor	T68887	SEA
O60911	CTSV	Cathepsin (V and K)	T93653	SwissTargetPrediction and SEA
P53634	CTSC	Dipeptidyl peptidase I	T70490	SEA
P28336	NMBR	Neuromedin B receptor	T68887	SEA
P06734	FCER2	Immunoglobulin epsilon Fc receptor	T67207	SEA
Q969S8	HDAC10	Histone deacetylase 10	T94324	SEA
P13612	ITGA4	Integrin alpha-4	T97587	SEA
Q9H2K8	TAOK3	Serine/threonine-protein kinase TAO3	T63682	SEA
P07288	KLK3	Prostate specific antigen	T36935	SEA
Q9UBX1	CTSF	Cathepsin F	T77236	SEA
Q16513	PKN2	Protein kinase N2	T94197	SEA
Q9NZ08	ERAP1	Endoplasmic reticulum aminopeptidase 1	T72849	SEA
P55157	MTTP	Microsomal triglyceride transfer protein large subunit	T46628	SEA
Q7L7X3	TAOK1	Serine/threonine-protein kinase TAO1	T97016	SEA
Q00975	CACNA1B	Voltage-gated N-type calcium channel alpha-1B subunit	T38338	SEA
Q9Y345	SLC6A5	Glycine transporter 2	T58937	SEA
P21462	FPR1	Formyl peptide receptor 1	T87831	SEA
Q03405	PLAUR	Urokinase plasminogen activator surface receptor	T74363	SEA
P51684	CCR6	C-C chemokine receptor type 6	T63165	SEA
Q9UBY5	LPAR3	Lysophosphatidic acid receptor Edg-7	T95923	SEA
Q92633	LPAR1	Lysophosphatidic acid receptor Edg-2	T92640	SEA
Q6DWJ6	GPR139	Probable G-protein coupled receptor 139	T84439	SEA
O95931	CBX7	Chromobox protein homolog 7	T72319	SwissTargetPrediction and SEA
Q9Y337	KLK5	Kallikrein 5	T11808	SEA
P40306	PSMB10	26S proteosome	T09022	SEA
P22888	LHCGR	Luteinizing hormone/Choriogonadotropin receptor	T79473	SEA
P08311	CTSG	Cathepsin G	T86385	SEA
Q04756	HGFAC	Hepatocyte growth factor activator	T38584	SEA
Q9UJM8	HAO1	Hydroxyacid oxidase 1	T63170	SEA
P09668	CTSH	Cathepsin (H and K)	T40103	SEA
Q9P0U3	SENP1	Sentrin-specific protease 1	T96435	SEA
Q14145	KEAP1	Kelch-like ECH-associated protein 1	T83198	SEA
O95822	MLYCD	Malonyl-CoA decarboxylase	T98078	SEA
O60235	TMPRSS11D	Transmembrane protease serine 11D	T00302	SEA
O95551	TDP2	Tyrosyl-DNA phosphodiesterase 2	T04696	SEA
Q8IWU9	TPH2	Tryptophan hydroxylase	T51593	SEA
P04070	PROC	Vitamin K-dependent protein C	T24836	SwissTargetPrediction and SEA
Q04609	FOLH1	Glutamate carboxypeptidase II	T97071	SEA
Q4U2R8	SLC22A6	Solute carrier family 22 member 6 (by homology)	T70680	SEA
P09958	FUR	HUMAN dibasic-processing enzyme	T98945	SEA
P29120	PCSK1	Neuroendocrine convertase 1	T36445	SEA
Q92824	PCSK5	Proprotein convertase subtilisin/kexin type 5	T38581	SEA
Q9GZQ6	NPFFR1	Neuropeptide FF receptor 1	T79780	SEA
Q9Y5X5	NPFFR2	Neuropeptide FF receptor 2	T90818	SEA
O60259	KLK8	Neuropsin	T43289	SEA
Q9BY41	HDAC8	Histone deacetylase 8	T28887	SEA
Q9Y5K2	KLK4	Kallikrein-4	T79400	SEA
Q06609	RAD51	DNA repair protein RAD51 homolog 1	T63083	SEA
Q9Y4G9	PCSK6	Proprotein convertase subtilisin/kexin type 6	T86503	SEA
P04632	CAPNS1	HUMAN calpain-1 or calpain small subunit 1 heterodimer	T00099	SEA
Q7RTX1	TAS1R1	Taste receptor	T41263	SEA
P05106	ITGB3	Integrin beta-3	T26457	SEA
P49356	FNTB	Farnesyl protein transferase	T13127	SEA
Q9HAN5	TRP1	Cationic trypsinogen	T27602	SEA
P05981	HPN	Serine protease hepsin	T73471	SEA
Q9ULZ9	MMP17	Matrix metalloproteinase-17	T55616	SEA
Q96BR1	SGK3	Serum-and glucocorticoid-inducible kinase SGK	T64102	SEA
P25786	PSMA1	Core proteasome 20S complex	T61997	SEA
P28072	PSMB6	Proteasome beta-1	T54973	SEA
Q99436	PSMB7	Proteasome beta-2	T55986	SEA
Q96T53	FKSG89	Ghrelin O acyltransferase	T45228	SEA
P23467	PTPRB	Protein tyrosine phosphatase beta	T57034	SEA
P14672	GLUT4	Glucose transporter type 4	T67658	SEA
P01008	SERPINC1	Antithrombin-III	T73476	SEA
P68104	EEF1A1	Elongation factor 1A	T72269	SEA

Target associated diseases

TTD_ID	Disease_ID	Disease name	ICD_11	Uniprot ID	Gene names
T20251	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	Q12809	KCNH2
T98311	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P12821	ACE
T98311	DI0190	Hypertension	[ICD-11: BA00-BA04]	P12821	ACE
T61622	DI0190	Hypertension	[ICD-11: BA00-BA04]	P00797	REN
T67272	DI0351	Psoriasis	[ICD-11: EA90]	P15144	ANPEP
T94033	DI0052	Bleeding disorder	[ICD-11: GA20-GA21]	P00734	F2
T94033	DI0091	Coagulation defect	[ICD-11: 3B10]	P00734	F2
T94033	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P00734	F2
T94033	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P00734	F2
T94033	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00734	F2
T94033	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P00734	F2
T94033	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P00734	F2
T94033	DI0405	Thrombosis	[ICD-11: DB61-GB90]	P00734	F2
T03691	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P09960	LTA4H
T05090	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O15379	HDAC3
T05090	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O15379	HDAC3
T13201	DI0166	Glaucoma	[ICD-11: 9C61]	P00915	CA1
T13201	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00915	CA1
T20401	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P00918	CA2
T20401	DI0137	Essential hypertension	[ICD-11: BA00]	P00918	CA2
T20401	DI0166	Glaucoma	[ICD-11: 9C61]	P00918	CA2
T20401	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P00918	CA2
T20401	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P00918	CA2
T20401	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00918	CA2
T67162	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	P14416	DRD2
T67162	DI0025	Alzheimer disease	[ICD-11: 8A20]	P14416	DRD2
T67162	DI0037	Asthma	[ICD-11: CA23]	P14416	DRD2
T67162	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P14416	DRD2
T67162	DI0051	Bipolar disorder	[ICD-11: 6A60]	P14416	DRD2
T67162	DI0063	Breathing abnormality	[ICD-11: MD11]	P14416	DRD2
T67162	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P14416	DRD2
T67162	DI0073	Cerebral ischaemia	[ICD-11: 8B1Z]	P14416	DRD2
T67162	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P14416	DRD2
T67162	DI0124	Digestive system disease	[ICD-11: DE2Z]	P14416	DRD2
T67162	DI0137	Essential hypertension	[ICD-11: BA00]	P14416	DRD2
T67162	DI0142	Faecal incontinence	[ICD-11: ME07]	P14416	DRD2
T67162	DI0156	Gangrene	[ICD-11: MC85]	P14416	DRD2
T67162	DI0166	Glaucoma	[ICD-11: 9C61]	P14416	DRD2
T67162	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P14416	DRD2
T67162	DI0185	Hyperaemia	[ICD-11: 9A61-9B7Y]	P14416	DRD2
T67162	DI0190	Hypertension	[ICD-11: BA00-BA04]	P14416	DRD2
T67162	DI0196	Hypotension	[ICD-11: BA20-BA21]	P14416	DRD2
T67162	DI0205	Inborn porphyrin/heme metabolism error	[ICD-11: 5C58]	P14416	DRD2
T67162	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P14416	DRD2
T67162	DI0222	Itching	[ICD-11: 1F28-1G07]	P14416	DRD2
T67162	DI0264	Migraine	[ICD-11: 8A80]	P14416	DRD2
T67162	DI0293	Nausea/vomiting	[ICD-11: MD90]	P14416	DRD2
T67162	DI0324	Pain	[ICD-11: MG30-MG3Z]	P14416	DRD2
T67162	DI0331	Parkinsonism	[ICD-11: 8A00]	P14416	DRD2
T67162	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P14416	DRD2
T67162	DI0340	Postpartum haemorrhage	[ICD-11: JA43]	P14416	DRD2
T67162	DI0354	Psychotic disorder	[ICD-11: 6A20-6A25]	P14416	DRD2
T67162	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P14416	DRD2
T67162	DI0370	Schizophrenia	[ICD-11: 6A20]	P14416	DRD2
T67162	DI0396	Substance abuse	[ICD-11: 6C40]	P14416	DRD2
T67162	DI0408	Thyrotoxicosis	[ICD-11: 5A02]	P14416	DRD2
T67162	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P14416	DRD2
T83904	DI0365	Retinopathy	[ICD-11: 9B71]	Q8IXJ6	SIRT2
T70680	DI0167	Gout	[ICD-11: FA25]	Q4U2R8	SLC22A6
T70680	DI0206	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Q4U2R8	SLC22A6
T70680	DI0310	Ocular disease	[ICD-11: N.A.]	Q4U2R8	SLC22A6
T50688	DI0007	Acquired hypermelanosis	[ICD-11: ED60]	P08514	ITGA2B
T50688	DI0030	Angina pectoris	[ICD-11: BA40]	P08514	ITGA2B
T50688	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P08514	ITGA2B
T16769	DI0259	Metastatic lymph node neoplasm	[ICD-11: 2D60]	P98170	XIAP
T04507	DI0073	Cerebral ischaemia	[ICD-11: 8B1Z]	P78352	DLG4
T04507	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P78352	DLG4
T05409	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P08473	MME
T35734	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P34913	EPHX2
T35734	DI0190	Hypertension	[ICD-11: BA00-BA04]	P34913	EPHX2
T83011	DI0115	Dementia	[ICD-11: 6D80-6D8Z]	P27338	MAOB
T83011	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P27338	MAOB
T83011	DI0190	Hypertension	[ICD-11: BA00-BA04]	P27338	MAOB
T83011	DI0243	Malaria	[ICD-11: 1F40-1F45]	P27338	MAOB
T83011	DI0264	Migraine	[ICD-11: 8A80]	P27338	MAOB
T83011	DI0331	Parkinsonism	[ICD-11: 8A00]	P27338	MAOB
T16739	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	O60341	KDM1A
T16739	DI0025	Alzheimer disease	[ICD-11: 8A20]	O60341	KDM1A
T16739	DI0138	Ewing sarcoma	[ICD-11: 2B52]	O60341	KDM1A
T16739	DI0238	Lung cancer	[ICD-11: 2C25]	O60341	KDM1A
T16739	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O60341	KDM1A
T16739	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	O60341	KDM1A
T16739	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	O60341	KDM1A
T16739	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	O60341	KDM1A
T16739	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O60341	KDM1A
T32060	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P28223	HTR2A
T32060	DI0033	Anxiety disorder	[ICD-11: 6B00-6B0Z]	P28223	HTR2A
T32060	DI0073	Cerebral ischaemia	[ICD-11: 8B1Z]	P28223	HTR2A
T32060	DI0270	Mood disorder	[ICD-11: 6A60-6E23]	P28223	HTR2A
T32060	DI0331	Parkinsonism	[ICD-11: 8A00]	P28223	HTR2A
T32060	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P28223	HTR2A
T32060	DI0370	Schizophrenia	[ICD-11: 6A20]	P28223	HTR2A
T83813	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P28335	HTR2C
T83813	DI0264	Migraine	[ICD-11: 8A80]	P28335	HTR2C
T83813	DI0308	Obesity	[ICD-11: 5B80-5B81]	P28335	HTR2C
T83813	DI0324	Pain	[ICD-11: MG30-MG3Z]	P28335	HTR2C
T83813	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P28335	HTR2C
T99524	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	Q96RJ0	TAAR1
T99524	DI0149	Focal/segmental autonomic disorder	[ICD-11: 8D8A]	Q96RJ0	TAAR1
T99524	DI0290	Narcolepsy	[ICD-11: 7A20]	Q96RJ0	TAAR1
T33584	DI0298	Neuropathy	[ICD-11: 8C0Z]	P42261	GRIA1
T89034	DI0030	Angina pectoris	[ICD-11: BA40]	P00747	PLG
T89034	DI0052	Bleeding disorder	[ICD-11: GA20-GA21]	P00747	PLG
T89034	DI0254	Menopausal disorder	[ICD-11: GA30]	P00747	PLG
T89034	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00747	PLG
T89034	DI0345	Procedure injury	[ICD-11: NE81]	P00747	PLG
T89034	DI0357	Pulmonary thromboembolism	[ICD-11: BB00]	P00747	PLG
T63816	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P56524	HDAC4
T11388	DI0237	Low bone mass disorder	[ICD-11: FB83]	P43235	CTSK
T22274	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q9UBN7	HDAC6
T22274	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9UBN7	HDAC6
T51191	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q92769	HDAC2
T51191	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q92769	HDAC2
T66665	DI0087	Chronic pain	[ICD-11: MG30]	P35354	PTGS2
T66665	DI0145	Female pelvic pain	[ICD-11: GA34]	P35354	PTGS2
T66665	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P35354	PTGS2
T66665	DI0207	Indeterminate colitis	[ICD-11: DD72]	P35354	PTGS2
T66665	DI0227	Knee osteoarthritis	[ICD-11: FA01]	P35354	PTGS2
T66665	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P35354	PTGS2
T66665	DI0324	Pain	[ICD-11: MG30-MG3Z]	P35354	PTGS2
T66665	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P35354	PTGS2
T66665	DI0416	Tuberculosis	[ICD-11: 1B10-1B12]	P35354	PTGS2
T99912	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q16719	KYNU
T99912	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q16719	KYNU
T67102	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P07339	CTSD
T16347	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P18031	PTPN1
T16347	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P18031	PTPN1
T16347	DI0308	Obesity	[ICD-11: 5B80-5B81]	P18031	PTPN1
T16347	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P18031	PTPN1
T49156	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P17706	PTPN2
T31956	DI0190	Hypertension	[ICD-11: BA00-BA04]	Q07075	ENPEP
T86591	DI0187	Hyperlipidemia	[ICD-11: 5C80]	Q07869	PPARA
T86591	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	Q07869	PPARA
T86591	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	Q07869	PPARA
T65200	DI0210	Influenza	[ICD-11: 1E30-1E32]	P28845	HSD11B1
T65200	DI0239	Lupus erythematosus	[ICD-11: 4A40]	P28845	HSD11B1
T65200	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P28845	HSD11B1
T68251	DI0238	Lung cancer	[ICD-11: 2C25]	P08253	MMP2
T08856	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P22894	MMP8
T86702	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P08254	MMP3
T86702	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P08254	MMP3
T86702	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P08254	MMP3
T86702	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P08254	MMP3
T86702	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P08254	MMP3
T86702	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P08254	MMP3
T86702	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P08254	MMP3
T54156	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P14780	MMP9
T54156	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P14780	MMP9
T54156	DI0395	Stomach cancer	[ICD-11: 2B72]	P14780	MMP9
T54156	DI0419	Ulcerative colitis	[ICD-11: DD71]	P14780	MMP9
T52450	DI0238	Lung cancer	[ICD-11: 2C25]	P03956	MMP1
T81443	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	O00206	TLR4
T81443	DI0346	Prostate cancer	[ICD-11: 2C82]	O00206	TLR4
T81443	DI0375	Sepsis	[ICD-11: 1G40-1G41]	O00206	TLR4
T86837	DI0106	COVID-19	[ICD-11: 1D6Y]	P17655	CAPN2
T28887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9BY41	HDAC8
T47768	DI0013	Acute pain	[ICD-11: MG31]	P35372	OPRM1
T47768	DI0059	Bowel habit change	[ICD-11: ME05]	P35372	OPRM1
T47768	DI0087	Chronic pain	[ICD-11: MG30]	P35372	OPRM1
T47768	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P35372	OPRM1
T47768	DI0105	Cough	[ICD-11: MD12]	P35372	OPRM1
T47768	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P35372	OPRM1
T47768	DI0124	Digestive system disease	[ICD-11: DE2Z]	P35372	OPRM1
T47768	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P35372	OPRM1
T47768	DI0228	Large intestine motility disorder	[ICD-11: DB32]	P35372	OPRM1
T47768	DI0317	Opioid use disorder	[ICD-11: 6C43]	P35372	OPRM1
T47768	DI0324	Pain	[ICD-11: MG30-MG3Z]	P35372	OPRM1
T47768	DI0349	Pruritus	[ICD-11: EC90]	P35372	OPRM1
T47768	DI0374	Sensation disturbance	[ICD-11: MB40]	P35372	OPRM1
T60693	DI0304	Non-specific cutaneous vascular symptom	[ICD-11: ME64]	P41145	OPRK1
T60693	DI0324	Pain	[ICD-11: MG30-MG3Z]	P41145	OPRK1
T60693	DI0349	Pruritus	[ICD-11: EC90]	P41145	OPRK1
T30926	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P62993	GRB2
T30926	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P62993	GRB2
T30926	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P62993	GRB2
T30926	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	P62993	GRB2
T30926	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P62993	GRB2
T50594	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P11309	PIM1
T50594	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P11309	PIM1
T08391	DI0039	Atopic eczema	[ICD-11: EA80]	O60674	JAK2
T08391	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	O60674	JAK2
T08391	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	O60674	JAK2
T08391	DI0404	Thrombocytosis	[ICD-11: 3B63]	O60674	JAK2
T85435	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P06213	INSR
T85435	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P06213	INSR
T70176	DI0060	Brain cancer	[ICD-11: 2A00]	P24941	CDK2
T70176	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P24941	CDK2
T70176	DI0238	Lung cancer	[ICD-11: 2C25]	P24941	CDK2
T70176	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P24941	CDK2
T70176	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P24941	CDK2
T70176	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P24941	CDK2
T70176	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P24941	CDK2
T70176	DI0406	Thymoma	[ICD-11: 2C27]	P24941	CDK2
T85799	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P11802	CDK4
T85799	DI0238	Lung cancer	[ICD-11: 2C25]	P11802	CDK4
T85799	DI0351	Psoriasis	[ICD-11: EA90]	P11802	CDK4
T07279	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q9P1W9	PIM2
T07279	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9P1W9	PIM2
T79031	DI0025	Alzheimer disease	[ICD-11: 8A20]	P56817	BACE1
T84133	DI0079	Choreiform disorder	[ICD-11: 8A01]	Q9Y233	PDE10A
T84133	DI0206	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Q9Y233	PDE10A
T84133	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	Q9Y233	PDE10A
T84133	DI0370	Schizophrenia	[ICD-11: 6A20]	Q9Y233	PDE10A
T84133	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9Y233	PDE10A
T73475	DI0238	Lung cancer	[ICD-11: 2C25]	P09237	MMP7
T47094	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P35270	SPR
T47094	DI0293	Nausea/vomiting	[ICD-11: MD90]	P35270	SPR
T79232	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P37288	AVPR1A
T79232	DI0041	Autism spectrum disorder	[ICD-11: 6A02]	P37288	AVPR1A
T79232	DI0190	Hypertension	[ICD-11: BA00-BA04]	P37288	AVPR1A
T79232	DI0194	Hypo-osmolality/hyponatraemia	[ICD-11: 5C72]	P37288	AVPR1A
T79232	DI0236	Localisation	[ICD-11: N.A.]	P37288	AVPR1A
T83611	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P04229	HLA-DRB1
T98691	DI0263	Middle East Respiratory Syndrome	[ICD-11: 1D64]	P07711	CTSL
T98691	DI0376	Severe acute respiratory syndrome	[ICD-11: 1D65]	P07711	CTSL
T78581	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P47211	GALR1
T72458	DI0192	Hypoactive sexual desire dysfunction	[ICD-11: HA00]	P32245	MC4R
T72458	DI0228	Large intestine motility disorder	[ICD-11: DB32]	P32245	MC4R
T72458	DI0308	Obesity	[ICD-11: 5B80-5B81]	P32245	MC4R
T61746	DI0023	Alopecia	[ICD-11: ED70]	P07858	CTSB
T61746	DI0025	Alzheimer disease	[ICD-11: 8A20]	P07858	CTSB
T61746	DI0037	Asthma	[ICD-11: CA23]	P07858	CTSB
T61746	DI0055	Bone cancer	[ICD-11: 2B5Z]	P07858	CTSB
T61746	DI0060	Brain cancer	[ICD-11: 2A00]	P07858	CTSB
T61746	DI0067	Cardiac arrest	[ICD-11: MC82]	P07858	CTSB
T61746	DI0074	Cerebral ischaemic stroke	[ICD-11: 8B11]	P07858	CTSB
T61746	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P07858	CTSB
T61746	DI0087	Chronic pain	[ICD-11: MG30]	P07858	CTSB
T61746	DI0110	Cystic fibrosis	[ICD-11: CA25]	P07858	CTSB
T61746	DI0124	Digestive system disease	[ICD-11: DE2Z]	P07858	CTSB
T61746	DI0178	Hepatic fibrosis/cirrhosis	[ICD-11: DB93]	P07858	CTSB
T61746	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P07858	CTSB
T61746	DI0253	Meningioma	[ICD-11: 2A01]	P07858	CTSB
T61746	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	P07858	CTSB
T61746	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P07858	CTSB
T61746	DI0296	Neurodegenerative disorder	[ICD-11: 8A20-8A23]	P07858	CTSB
T61746	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P07858	CTSB
T61746	DI0351	Psoriasis	[ICD-11: EA90]	P07858	CTSB
T61746	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P07858	CTSB
T59604	DI0087	Chronic pain	[ICD-11: MG30]	Q92847	GHSR
T59604	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	Q92847	GHSR
T58992	DI0059	Bowel habit change	[ICD-11: ME05]	P41143	OPRD1
T58992	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P41143	OPRD1
T58992	DI0324	Pain	[ICD-11: MG30-MG3Z]	P41143	OPRD1
T35842	DI0192	Hypoactive sexual desire dysfunction	[ICD-11: HA00]	Q01726	MC1R
T35842	DI0205	Inborn porphyrin/heme metabolism error	[ICD-11: 5C58]	Q01726	MC1R
T76846	DI0308	Obesity	[ICD-11: 5B80-5B81]	P41968	MC3R
T76846	DI0378	Sexual dysfunction	[ICD-11: HA00-HA01]	P41968	MC3R
T76846	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P41968	MC3R
T05114	DI0039	Atopic eczema	[ICD-11: EA80]	P23946	CMA1
T05114	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P23946	CMA1
T05114	DI0169	Gram-positive bacterial infection	[ICD-11: 1B74-1F40]	P23946	CMA1
T05114	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P23946	CMA1
T05114	DI0229	Left ventricular failure	[ICD-11: BD11]	P23946	CMA1
T05114	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P23946	CMA1
T84631	DI0053	Blood-forming organ disease	[ICD-11: 3C0Z]	P00742	F10
T84631	DI0080	Christmas disease	[ICD-11: 3B11]	P00742	F10
T84631	DI0091	Coagulation defect	[ICD-11: 3B10]	P00742	F10
T84631	DI0103	Coronary thrombosis	[ICD-11: BA43]	P00742	F10
T84631	DI0114	Deep vein thrombosis	[ICD-11: BD71]	P00742	F10
T84631	DI0397	Supraventricular tachyarrhythmia	[ICD-11: BC81]	P00742	F10
T84631	DI0405	Thrombosis	[ICD-11: DB61-GB90]	P00742	F10
T84631	DI0433	Venous thromboembolism	[ICD-11: BD72]	P00742	F10
T45299	DI0052	Bleeding disorder	[ICD-11: GA20-GA21]	P00750	PLAT
T45299	DI0345	Procedure injury	[ICD-11: NE81]	P00750	PLAT
T27602	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q9HAN5	TRP1
T27602	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q9HAN5	TRP1
T58921	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P37231	PPARG
T58921	DI0025	Alzheimer disease	[ICD-11: 8A20]	P37231	PPARG
T58921	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P37231	PPARG
T13127	DI0342	Premature ageing appearance	[ICD-11: LD2B]	P49356	FNTB
T53585	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P04035	HMGCR
T53585	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	P04035	HMGCR
T53585	DI0128	Dyslipidemia	[ICD-11: 5C80-5C81]	P04035	HMGCR
T53585	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P04035	HMGCR
T53585	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P04035	HMGCR
T53585	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P04035	HMGCR
T53585	DI0324	Pain	[ICD-11: MG30-MG3Z]	P04035	HMGCR
T32972	DI0209	Infectious meningitis	[ICD-11: 1D01]	Q16850	CYP51A1
T32972	DI0289	Nail/perionychium infection	[ICD-11: EE12]	Q16850	CYP51A1
T32972	DI0316	Onchocerciasis	[ICD-11: 1F6A]	Q16850	CYP51A1
T35640	DI0351	Psoriasis	[ICD-11: EA90]	P20701	ITGAL
T35640	DI0436	Visual system disease	[ICD-11: 9E1Z]	P20701	ITGAL
T16016	DI0120	Diabetes mellitus	[ICD-11: 5A10]	P32246	CCR1
T16016	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P32246	CCR1
T99204	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P49810	PSEN2
T99204	DI0380	Shoulder lesion	[ICD-11: FB53]	P49810	PSEN2
T99204	DI0390	Soft tissue disorder	[ICD-11: FB56]	P49810	PSEN2
T85421	DI0125	Dissociative neurological symptom disorder	[ICD-11: 6B60]	P53779	MAPK10
T98269	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P29466	CASP1
T98269	DI0146	Fibrosis	[ICD-11: GA14-GC01]	P29466	CASP1
T98269	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P29466	CASP1
T98269	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P29466	CASP1
T85943	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P12931	SRC
T85943	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P12931	SRC
T85943	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P12931	SRC
T85943	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P12931	SRC
T92803	DI0113	Cytomegaloviral disease	[ICD-11: 1D82]	Q13627	DYRK1A
T12355	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P24385	CCND1
T68290	DI0042	Autoimmune disease	[ICD-11: 4A40-4A45]	P25774	CTSS
T68290	DI0092	Coeliac disease	[ICD-11: DA95]	P25774	CTSS
T68290	DI0107	Crohn disease	[ICD-11: DD70]	P25774	CTSS
T68290	DI0120	Diabetes mellitus	[ICD-11: 5A10]	P25774	CTSS
T68290	DI0163	General pain disorder	[ICD-11: 8E43]	P25774	CTSS
T68290	DI0324	Pain	[ICD-11: MG30-MG3Z]	P25774	CTSS
T68290	DI0382	Sjogren syndrome	[ICD-11: 4A43]	P25774	CTSS
T23172	DI0023	Alopecia	[ICD-11: ED70]	P52333	JAK3
T23172	DI0039	Atopic eczema	[ICD-11: EA80]	P52333	JAK3
T23172	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P52333	JAK3
T23172	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P52333	JAK3
T01908	DI0213	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	P20151	KLK2
T03661	DI0016	Adaptive immunity immunodeficiency	[ICD-11: 4A01]	P00813	ADA
T03661	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P00813	ADA
T03661	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	P00813	ADA
T97917	DI0025	Alzheimer disease	[ICD-11: 8A20]	P25090	FPR2
T45287	DI0190	Hypertension	[ICD-11: BA00-BA04]	Q9ULA0	DNPEP
T67103	DI0095	Colorectal cancer	[ICD-11: 2B91]	P06756	ITGAV
T67103	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P06756	ITGAV
T27889	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	Q9BYF1	ACE2
T27889	DI0217	Intrathoracic organs injury	[ICD-11: NB32]	Q9BYF1	ACE2
T27889	DI0356	Pulmonary hypertension	[ICD-11: BB01]	Q9BYF1	ACE2
T58970	DI0036	Arteries/arterioles disorder	[ICD-11: BD52]	P28482	MAPK1
T58970	DI0252	Melanoma	[ICD-11: 2C30]	P28482	MAPK1
T58970	DI0326	Pancreatic cancer	[ICD-11: 2C10]	P28482	MAPK1
T58970	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P28482	MAPK1
T01851	DI0060	Brain cancer	[ICD-11: 2A00]	P05556	ITGB1
T01851	DI0238	Lung cancer	[ICD-11: 2C25]	P05556	ITGB1
T01851	DI0365	Retinopathy	[ICD-11: 9B71]	P05556	ITGB1
T49898	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P06493	CDK1
T49898	DI0238	Lung cancer	[ICD-11: 2C25]	P06493	CDK1
T49898	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P06493	CDK1
T49898	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P06493	CDK1
T49898	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P06493	CDK1
T03500	DI0037	Asthma	[ICD-11: CA23]	P39900	MMP12
T03500	DI0238	Lung cancer	[ICD-11: 2C25]	P39900	MMP12
T03500	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P39900	MMP12
T58449	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P50613	CDK7
T58449	DI0238	Lung cancer	[ICD-11: 2C25]	P50613	CDK7
T58449	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P50613	CDK7
T58449	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P50613	CDK7
T20973	DI0308	Obesity	[ICD-11: 5B80-5B81]	Q00535	CDK5
T57943	DI0060	Brain cancer	[ICD-11: 2A00]	P42574	CASP3
T52921	DI0039	Atopic eczema	[ICD-11: EA80]	P41146	OPRL1
T52921	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P41146	OPRL1
T52921	DI0173	Headache	[ICD-11: 8A80-8A84]	P41146	OPRL1
T52921	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P41146	OPRL1
T45262	DI0394	Staphylococcal/streptococcal disease	[ICD-11: 1B5Y]	P34998	CRHR1
T01280	DI0425	Urinary system clinical symptom	[ICD-11: MF8Y]	Q9Y5Z0	BACE2
T84634	DI0314	Oesophagitis	[ICD-11: DA24]	O43174	CYP26A1
T05849	DI0122	Diagnostic imaging	[ICD-11: N.A.]	P32239	CCKBR
T05849	DI0327	Pancreatic internal secretion disorder	[ICD-11: 5A4Y]	P32239	CCKBR
T17758	DI0211	Inherited coagulation factor deficiency	[ICD-11: 3B14]	P00749	PLAU
T17758	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00749	PLAU
T17140	DI0105	Cough	[ICD-11: MD12]	P56373	P2RX3
T28330	DI0210	Influenza	[ICD-11: 1E30-1E32]	P32238	CCKAR
T28330	DI0328	Pancreatic malfunction	[ICD-11: DC30-DC3Z]	P32238	CCKAR
T82739	DI0213	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	P03952	KLKB1
T82739	DI0364	Retinal vascular occlusion	[ICD-11: 9B74]	P03952	KLKB1
T43332	DI0091	Coagulation defect	[ICD-11: 3B10]	P08709	F7
T46781	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	Q96GD4	AURKB
T46781	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q96GD4	AURKB
T92828	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P24530	EDNRB
T92828	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P24530	EDNRB
T19433	DI0148	Flatworm infection	[ICD-11: 1F70-1F86]	O60760	HPGDS
T54582	DI0231	Leukaemia	[ICD-11: 2A60-2B33]	P43490	NAMPT
T54582	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P43490	NAMPT
T54582	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P43490	NAMPT
T97035	DI0007	Acquired hypermelanosis	[ICD-11: ED60]	P14679	TYR
T97035	DI0008	Acquired hypomelanotic disorder	[ICD-11: ED63]	P14679	TYR
T36483	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P25116	F2R
T52790	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P21452	TACR2
T36741	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	O15151	MDM4
T36741	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	O15151	MDM4
T36741	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	O15151	MDM4
T36741	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O15151	MDM4
T07403	DI0107	Crohn disease	[ICD-11: DD70]	P26010	ITGB7
T42000	DI0267	Mineral excesses	[ICD-11: 5B91]	P01584	IL1B
T42000	DI0269	Monogenic autoinflammatory syndrome	[ICD-11: 4A60]	P01584	IL1B
T42000	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P01584	IL1B
T42000	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P01584	IL1B
T49072	DI0037	Asthma	[ICD-11: CA23]	Q9UKP6	UTS2R
T16308	DI0238	Lung cancer	[ICD-11: 2C25]	Q13526	PIN1
T29683	DI0254	Menopausal disorder	[ICD-11: GA30]	P29371	TACR3
T13075	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P48729	CSNK1A1
T13075	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P48729	CSNK1A1
T95878	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	Q9UK32	RPS6KA6
T51282	DI0166	Glaucoma	[ICD-11: 9C61]	Q13464	ROCK1
T12808	DI0279	Muscular atrophy	[ICD-11: 8B61]	P17612	PRKACA
T77350	DI0274	Multiple myeloma	[ICD-11: 2A83]	P28062	PSMB8
T55781	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q12866	MERTK
T55781	DI0025	Alzheimer disease	[ICD-11: 8A20]	Q12866	MERTK
T55781	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	Q12866	MERTK
T55781	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q12866	MERTK
T58470	DI0363	Retina cancer	[ICD-11: 2D02]	P20248	CCNA2
T94880	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q06418	TYRO3
T46040	DI0074	Cerebral ischaemic stroke	[ICD-11: 8B11]	P03951	F11
T46040	DI0089	Clotting disorder	[ICD-11: 3B4Z]	P03951	F11
T93440	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P40189	IL6ST
T98293	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	O96013	PAK4
T98293	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O96013	PAK4
T22839	DI0024	Alpha-1-antitrypsin deficiency	[ICD-11: 5C5A]	Q9UNI1	CELA1
T22839	DI0065	Bronchitis	[ICD-11: CA20]	Q9UNI1	CELA1
T68887	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P28336	NMBR
T68887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P28336	NMBR
T93653	DI0055	Bone cancer	[ICD-11: 2B5Z]	O60911	CTSV
T93653	DI0087	Chronic pain	[ICD-11: MG30]	O60911	CTSV
T70490	DI0064	Bronchiectasis	[ICD-11: CA24]	P53634	CTSC
T68887	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P28336	NMBR
T68887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P28336	NMBR
T67207	DI0231	Leukaemia	[ICD-11: 2A60-2B33]	P06734	FCER2
T94324	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q969S8	HDAC10
T97587	DI0107	Crohn disease	[ICD-11: DD70]	P13612	ITGA4
T97587	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P13612	ITGA4
T97587	DI0419	Ulcerative colitis	[ICD-11: DD71]	P13612	ITGA4
T36935	DI0036	Arteries/arterioles disorder	[ICD-11: BD52]	P07288	KLK3
T36935	DI0346	Prostate cancer	[ICD-11: 2C82]	P07288	KLK3
T36935	DI0348	Prostate hyperplasia	[ICD-11: GA90]	P07288	KLK3
T77236	DI0055	Bone cancer	[ICD-11: 2B5Z]	Q9UBX1	CTSF
T77236	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	Q9UBX1	CTSF
T77236	DI0087	Chronic pain	[ICD-11: MG30]	Q9UBX1	CTSF
T77236	DI0124	Digestive system disease	[ICD-11: DE2Z]	Q9UBX1	CTSF
T77236	DI0178	Hepatic fibrosis/cirrhosis	[ICD-11: DB93]	Q9UBX1	CTSF
T77236	DI0275	Multiple sclerosis	[ICD-11: 8A40]	Q9UBX1	CTSF
T77236	DI0351	Psoriasis	[ICD-11: EA90]	Q9UBX1	CTSF
T46628	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P55157	MTTP
T38338	DI0264	Migraine	[ICD-11: 8A80]	Q00975	CACNA1B
T38338	DI0305	Non-thrombocytopenic purpura	[ICD-11: 3B60]	Q00975	CACNA1B
T38338	DI0324	Pain	[ICD-11: MG30-MG3Z]	Q00975	CACNA1B
T87831	DI0333	Peptic ulcer	[ICD-11: DA61]	P21462	FPR1
T74363	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	Q03405	PLAUR
T74363	DI0404	Thrombocytosis	[ICD-11: 3B63]	Q03405	PLAUR
T63165	DI0207	Indeterminate colitis	[ICD-11: DD72]	P51684	CCR6
T95923	DI0146	Fibrosis	[ICD-11: GA14-GC01]	Q9UBY5	LPAR3
T95923	DI0399	Systemic sclerosis	[ICD-11: 4A42]	Q9UBY5	LPAR3
T92640	DI0146	Fibrosis	[ICD-11: GA14-GC01]	Q92633	LPAR1
T92640	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	Q92633	LPAR1
T92640	DI0351	Psoriasis	[ICD-11: EA90]	Q92633	LPAR1
T92640	DI0399	Systemic sclerosis	[ICD-11: 4A42]	Q92633	LPAR1
T84439	DI0377	Sex development malformative disorder	[ICD-11: LD2A]	Q6DWJ6	GPR139
T79473	DI0144	Female infertility	[ICD-11: GA31]	P22888	LHCGR
T79473	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P22888	LHCGR
T86385	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P08311	CTSG
T63170	DI0201	Inborn carbohydrate metabolism error	[ICD-11: 5C51]	Q9UJM8	HAO1
T83198	DI0356	Pulmonary hypertension	[ICD-11: BB01]	Q14145	KEAP1
T83198	DI0425	Urinary system clinical symptom	[ICD-11: MF8Y]	Q14145	KEAP1
T51593	DI0066	Carcinoid syndrome	[ICD-11: 5B10]	Q8IWU9	TPH2
T51593	DI0389	Small intestine developmental anomaly	[ICD-11: DA90]	Q8IWU9	TPH2
T24836	DI0084	Chronic lower extremities peripheral venous insufficiency	[ICD-11: BD74]	P04070	PROC
T24836	DI0177	Hemangioma	[ICD-11: 2E81-2F2Y]	P04070	PROC
T97071	DI0122	Diagnostic imaging	[ICD-11: N.A.]	Q04609	FOLH1
T97071	DI0346	Prostate cancer	[ICD-11: 2C82]	Q04609	FOLH1
T70680	DI0167	Gout	[ICD-11: FA25]	Q4U2R8	SLC22A6
T70680	DI0206	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Q4U2R8	SLC22A6
T70680	DI0310	Ocular disease	[ICD-11: N.A.]	Q4U2R8	SLC22A6
T98945	DI0263	Middle East Respiratory Syndrome	[ICD-11: 1D64]	P09958	FUR
T28887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9BY41	HDAC8
T63083	DI0048	B-cell lymphoma	[ICD-11: 2A86]	Q06609	RAD51
T63083	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q06609	RAD51
T00099	DI0106	COVID-19	[ICD-11: 1D6Y]	P04632	CAPNS1
T41263	DI0078	Cholera	[ICD-11: 1A00]	Q7RTX1	TAS1R1
T13127	DI0342	Premature ageing appearance	[ICD-11: LD2B]	P49356	FNTB
T27602	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q9HAN5	TRP1
T27602	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q9HAN5	TRP1
T45228	DI0308	Obesity	[ICD-11: 5B80-5B81]	Q96T53	FKSG89
T45228	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	Q96T53	FKSG89
T57034	DI0081	Chronic arterial occlusive disease	[ICD-11: BD4Z]	P23467	PTPRB
T57034	DI0365	Retinopathy	[ICD-11: 9B71]	P23467	PTPRB
T67658	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P14672	GLUT4
T73476	DI0091	Coagulation defect	[ICD-11: 3B10]	P01008	SERPINC1
T73476	DI0103	Coronary thrombosis	[ICD-11: BA43]	P01008	SERPINC1
T73476	DI0114	Deep vein thrombosis	[ICD-11: BD71]	P01008	SERPINC1
T73476	DI0410	Tinnitus	[ICD-11: MC41]	P01008	SERPINC1
T72269	DI0252	Melanoma	[ICD-11: 2C30]	P68104	EEF1A1