Gingerenone B



Compound IDCDAMM00272
Common nameGingerenone B
IUPAC name(E)-7-(4-hydroxy-3,5-dimethoxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one
Molecular formulaC22H26O6

Experimental data

Retention time59.257
Adduct[M+H]+
Actual mz387.182
Theoretical mz387.18
Error4.61
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.77

Identifiers and class information

Inchi keyKIIBBJKLKFTNQO-WHFBIAKZSA-N
SmilesCOC1=CC(=CC(=C1O)OC)CCC=CC(=O)CCC2=CC(=C(C=C2)O)OC
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives

Plant source

  • Tribulus terrestris L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)1
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)12
    Number of reactive functional groups (#rtvFG)1
    Predicted central nervous system activity (CNS)-2
    Molecular weight (mol_MW)386.444
    Computed dipole moment(dipole)1.851
    Total solvent accessible surface area (SASA)711.678
    Hydrophobic component of SASA (FOSA)420.213
    Hydrophilic component of SASA (FISA)150.708
    Pie component of the SASA (PISA)140.757
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1281.07
    Number of hydrogen bond donors (donorHB)2
    Number of hydrogen bond acceptors (accptHB)5.75
    Free energy of solvation of dipole (dip^2/V)0.0026739
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0114261
    Globularity descriptor (glob)0.801549
    Predicted polarizability in cubic angstroms (QPpolrz)38.753
    Predicted hexadecane/gas partition coefficient (QPlogPC16)12.667
    Predicted octanol/gas partition coefficient (QPlogPoct)18.41
    Predicted water/gas partition coefficient (QPlogPw)9.36
    Predicted octanol/water partition coefficient (QPlogPo/w)3.881
    Predicted aqueous solubility (QPlogS)-5.078
    Conformation-independent predicted aqueous solubility (CIQPlogS)-5.436
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-5.414
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)368.751
    Predicted brain/blood partition coefficient (QPlogBB)-1.724
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)168.283
    Predicted skin permeability, log Kp (QPlogKp)-2.649
    PM3 calculated ionization potential (IP(ev))8.73
    PM3 calculated electron affinity (EA(eV))0.253
    Number of likely metabolic reactions (#metab)9
    Prediction of binding to human serum albumin (QPlogKhsa)0.415
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)95.612
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)93.76
    Number of nitrogen and oxygen atoms (#NandO)6
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)1

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    Q16790CA9Carbonic anhydrase IXT64567SwissTargetPrediction
    P04818TYMSThymidylate synthase (by homology)T98397SwissTargetPrediction
    P00915CA1Carbonic anhydrase IT13201SwissTargetPrediction
    P02766TTRTransthyretinT86462SEA
    P05067APPBeta amyloid A4 proteinT87024SEA
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P43166CA7Carbonic anhydrase VIIT37541SEA
    P23280CA6Carbonic anhydrase VIT06569SEA
    Q9ULX7CA14Carbonic anhydrase XIVT31992SwissTargetPrediction
    P08908HTR1ASerotonin 1a (5-HT1a) receptorT78709SwissTargetPrediction
    P07384CAPN1Calpain 1T92517SwissTargetPrediction
    P11926ODC1Ornithine decarboxylaseT60366SEA
    Q8NER1TRPV1Vanilloid receptorT83193SEA
    P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    P14780MMP9Matrix metalloproteinase 9T54156SwissTargetPrediction
    Q7Z2W7TRPM8Transient receptor potential cation channel subfamily M member 8T41955SEA
    P09917ALOX5Arachidonate 5-lipoxygenaseT00140SwissTargetPrediction and SEA
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    O00206TLR4Toll-like receptor 4 (by homology)T81443SwissTargetPrediction
    P13726F3Coagulation factor VII/tissue factorT72702SwissTargetPrediction
    P00338LDHAL-lactate dehydrogenase A chainT15053SwissTargetPrediction
    P07195LDHBL-lactate dehydrogenase B chainT88057SwissTargetPrediction
    P05121SERPINE1Plasminogen activator inhibitor-1T15556SwissTargetPrediction
    P21728DRD1Dopamine D1 receptorT22118SwissTargetPrediction
    P33527ABCC1Multidrug resistance-associated protein 1T11288SwissTargetPrediction
    P25100ADRA1DAlpha-1d adrenergic receptorT53381SwissTargetPrediction
    P35368ADRA1BAlpha-1b adrenergic receptorT29500SwissTargetPrediction
    Q15118PDK1Pyruvate dehydrogenase kinase isoform 1T20891SwissTargetPrediction
    O14757CHEK1Serine/threonine-protein kinase Chk1T62449SwissTargetPrediction
    P14061HSD17B1Estradiol 17-beta-dehydrogenase 1T44011SwissTargetPrediction
    P00519ABL1Tyrosine-protein kinase ABLT63505SwissTargetPrediction
    P06276BCHEButyrylcholinesteraseT99799SEA
    O14965AURKASerine/threonine-protein kinase Aurora-AT87675SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P78536ADAM17ADAM17T82393SwissTargetPrediction
    P09237MMP7Matrix metalloproteinase 7T73475SwissTargetPrediction
    P13497BMP1Bone morphogenetic protein 1T53350SwissTargetPrediction
    P19838NFKB1Nuclear factor NF-kappa-B p105 subunitT83145SEA
    P16050ALOX15Arachidonate 15-lipoxygenaseT16042SEA
    P11137MAP2Microtubule-associated protein 2T23276SwissTargetPrediction
    P35348ADRA1AAlpha-1a adrenergic receptorT92609SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    Q09472EP300Histone acetyltransferase p300T25956SEA
    O96017CHEK2Serine/threonine-protein kinase Chk2T28713SwissTargetPrediction
    P01375TNFTNF-alphaT20178SwissTargetPrediction
    Q02156PRKCEProtein kinase C epsilonT00895SwissTargetPrediction
    P08581METHepatocyte growth factor receptorT40474SEA
    P40763STAT3Signal transducer and activator of transcription 3T29130SwissTargetPrediction
    P23443RPS6KB1Ribosomal protein S6 kinase 1T94479SwissTargetPrediction
    P39900MMP12Matrix metalloproteinase 12T03500SwissTargetPrediction
    P50281MMP14Matrix metalloproteinase 14T65019SwissTargetPrediction
    P04049RAF1Serine/threonine-protein kinase RAFT51883SwissTargetPrediction
    P15056BRAFSerine/threonine-protein kinase B-rafT99089SwissTargetPrediction
    Q06187BTKTyrosine-protein kinase BTKT97719SwissTargetPrediction
    P29317EPHA2Ephrin type-A receptor 2T57278SwissTargetPrediction
    Q9NPH5NOX4NADPH oxidase 4T29741SwissTargetPrediction
    Q14680MELKMaternal embryonic leucine zipper kinaseT96892SwissTargetPrediction
    P51451BLKTyrosine-protein kinase BLKT74307SwissTargetPrediction
    P41240CSKTyrosine-protein kinase CSKT08741SwissTargetPrediction
    P29323EPHB2Ephrin type-B receptor 2T73756SwissTargetPrediction
    P51813BMXTyrosine-protein kinase BMXT99990SwissTargetPrediction
    P07948LYNTyrosine-protein kinase LynT68163SwissTargetPrediction
    O14672ADAM10ADAM10T31902SwissTargetPrediction
    P10636MAPTMicrotubule-associated protein tauT45593SEA
    Q04760GLO1Glyoxalase IT88285SEA
    P09769FGRTyrosine-protein kinase FGRT49925SwissTargetPrediction
    P29320EPHA3Ephrin type-A receptor 3T28413SwissTargetPrediction
    Q06418TYRO3Tyrosine-protein kinase receptor TYRO3T94880SwissTargetPrediction
    P42681TXKTyrosine-protein kinase TXKT32590SwissTargetPrediction
    P51512MMP16Matrix metalloproteinase 16T35824SwissTargetPrediction
    P19438TNFRSF1ATumor necrosis factor receptor R1T86552SEA
    Q16236NFE2L2Nuclear factor erythroid 2-related factor 2T88505SwissTargetPrediction and SEA
    P54756EPHA5Ephrin type-A receptor 5T18474SwissTargetPrediction
    P54764EPHA4Ephrin type-A receptor 4T70234SwissTargetPrediction
    Q9UF33EPHA6Ephrin type-A receptor 6T08647SwissTargetPrediction
    Q13882PTK6Tyrosine-protein kinase BRKT73694SwissTargetPrediction
    P54753EPHB3Ephrin type-B receptor 3T56121SwissTargetPrediction
    Q9Y3Q4HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4T30286SEA
    P21709EPHA1Ephrin type-A receptor 1T28418SwissTargetPrediction
    P22888LHCGRLuteinizing hormone/Choriogonadotropin receptorT79473SwissTargetPrediction
    Q9H4B7TUBB1Tubulin beta-1 chainT84397SwissTargetPrediction and SEA
    O43826SLC37A4Glucose-6-phosphate translocaseT47306SEA
    P02768ALBSerum albuminT63068SwissTargetPrediction
    P01100FOSProto-oncogene c-FosT28025SEA
    Q9NR20DYRK4Dual-specificity tyrosine-phosphorylation regulated kinase 4T20542SEA
    Q8N183NDUFAF2HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2T01453SEA
    Q9P0J0NDUFA13Mitochondrial complex IT82391SEA
    Q9Y6M9NDUFB9HUMAN NADH:ubiquinone oxidoreductase subunit B9T01465SEA
    Q8N183NDUFAF2HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2T01453SEA
    P03897MT-ND3NADH dehydrogenaseT77195SEA
    Q96HK3CALMCalmodulinT39610SEA
    O75751EMTHOrganic cation transporter 3T55948SEA

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
    T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
    T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
    T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
    T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
    T86462DI0026Amyloidosis[ICD-11: 5D00]P02766TTR
    T87024DI0025Alzheimer disease[ICD-11: 8A20]P05067APP
    T87024DI0122Diagnostic imaging[ICD-11: N.A.]P05067APP
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T06569DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P23280CA6
    T06569DI0372Seborrhoeic dermatitis[ICD-11: EA81]P23280CA6
    T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
    T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
    T78709DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P08908HTR1A
    T78709DI0117Depression[ICD-11: 6A70-6A7Z]P08908HTR1A
    T78709DI0190Hypertension[ICD-11: BA00-BA04]P08908HTR1A
    T78709DI0264Migraine[ICD-11: 8A80]P08908HTR1A
    T78709DI0270Mood disorder[ICD-11: 6A60-6E23]P08908HTR1A
    T60366DI0020African trypanosomiasis[ICD-11: 1F51]P11926ODC1
    T83193DI0163General pain disorder[ICD-11: 8E43]Q8NER1TRPV1
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
    T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
    T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
    T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
    T41955DI0422Upper respiratory tract disorder[ICD-11: CA0Z]Q7Z2W7TRPM8
    T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
    T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
    T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T81443DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]O00206TLR4
    T81443DI0346Prostate cancer[ICD-11: 2C82]O00206TLR4
    T81443DI0375Sepsis[ICD-11: 1G40-1G41]O00206TLR4
    T72702DI0075Cervical cancer[ICD-11: 2C77]P13726F3
    T15556DI0037Asthma[ICD-11: CA23]P05121SERPINE1
    T15556DI0405Thrombosis[ICD-11: DB61-GB90]P05121SERPINE1
    T22118DI0003Abortion[ICD-11: JA00]P21728DRD1
    T22118DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21728DRD1
    T22118DI0190Hypertension[ICD-11: BA00-BA04]P21728DRD1
    T22118DI0331Parkinsonism[ICD-11: 8A00]P21728DRD1
    T11288DI0167Gout[ICD-11: FA25]P33527ABCC1
    T53381DI0166Glaucoma[ICD-11: 9C61]P25100ADRA1D
    T53381DI0175Heart failure[ICD-11: BD10-BD1Z]P25100ADRA1D
    T53381DI0190Hypertension[ICD-11: BA00-BA04]P25100ADRA1D
    T53381DI0348Prostate hyperplasia[ICD-11: GA90]P25100ADRA1D
    T53381DI0378Sexual dysfunction[ICD-11: HA00-HA01]P25100ADRA1D
    T53381DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P25100ADRA1D
    T29500DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P35368ADRA1B
    T29500DI0190Hypertension[ICD-11: BA00-BA04]P35368ADRA1B
    T29500DI0256Mental/behavioural/neurodevelopmental disorder[ICD-11: 6E20-6E8Z]P35368ADRA1B
    T29500DI0308Obesity[ICD-11: 5B80-5B81]P35368ADRA1B
    T29500DI0324Pain[ICD-11: MG30-MG3Z]P35368ADRA1B
    T20891DI0241Lymphoma[ICD-11: 2A80-2A86]Q15118PDK1
    T62449DI0027Anal cancer[ICD-11: 2C00]O14757CHEK1
    T62449DI0172Head and neck cancer[ICD-11: 2D42]O14757CHEK1
    T62449DI0183Hodgkin lymphoma[ICD-11: 2B30]O14757CHEK1
    T62449DI0238Lung cancer[ICD-11: 2C25]O14757CHEK1
    T62449DI0241Lymphoma[ICD-11: 2A80-2A86]O14757CHEK1
    T62449DI0321Ovarian cancer[ICD-11: 2C73]O14757CHEK1
    T62449DI0326Pancreatic cancer[ICD-11: 2C10]O14757CHEK1
    T62449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14757CHEK1
    T63505DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00519ABL1
    T63505DI0220Ischemia[ICD-11: 8B10-8B11]P00519ABL1
    T63505DI0250Mature B-cell lymphoma[ICD-11: 2A85]P00519ABL1
    T63505DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00519ABL1
    T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
    T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
    T87675DI0009Acute diabete complication[ICD-11: 5A2Y]O14965AURKA
    T87675DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O14965AURKA
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T82393DI0062Breast cancer[ICD-11: 2C60-2C6Y]P78536ADAM17
    T82393DI0366Rheumatoid arthritis[ICD-11: FA20]P78536ADAM17
    T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
    T83145DI0218Irritable bowel syndrome[ICD-11: DD91]P19838NFKB1
    T83145DI0366Rheumatoid arthritis[ICD-11: FA20]P19838NFKB1
    T23276DI0036Arteries/arterioles disorder[ICD-11: BD52]P11137MAP2
    T23276DI0252Melanoma[ICD-11: 2C30]P11137MAP2
    T23276DI0326Pancreatic cancer[ICD-11: 2C10]P11137MAP2
    T23276DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11137MAP2
    T92609DI0190Hypertension[ICD-11: BA00-BA04]P35348ADRA1A
    T92609DI0348Prostate hyperplasia[ICD-11: GA90]P35348ADRA1A
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T25956DI0346Prostate cancer[ICD-11: 2C82]Q09472EP300
    T25956DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q09472EP300
    T28713DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O96017CHEK2
    T20178DI0035Arterial occlusive disease[ICD-11: BD40]P01375TNF
    T20178DI0274Multiple myeloma[ICD-11: 2A83]P01375TNF
    T20178DI0351Psoriasis[ICD-11: EA90]P01375TNF
    T20178DI0366Rheumatoid arthritis[ICD-11: FA20]P01375TNF
    T00895DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]Q02156PRKCE
    T00895DI0243Malaria[ICD-11: 1F40-1F45]Q02156PRKCE
    T40474DI0238Lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08581MET
    T40474DI0407Thyroid cancer[ICD-11: 2D10]P08581MET
    T29130DI0351Psoriasis[ICD-11: EA90]P40763STAT3
    T94479DI0025Alzheimer disease[ICD-11: 8A20]P23443RPS6KB1
    T94479DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P23443RPS6KB1
    T94479DI0419Ulcerative colitis[ICD-11: DD71]P23443RPS6KB1
    T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
    T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
    T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
    T65019DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P50281MMP14
    T51883DI0252Melanoma[ICD-11: 2C30]P04049RAF1
    T51883DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04049RAF1
    T51883DI0321Ovarian cancer[ICD-11: 2C73]P04049RAF1
    T51883DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04049RAF1
    T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
    T97719DI0231Leukaemia[ICD-11: 2A60-2B33]Q06187BTK
    T57278DI0060Brain cancer[ICD-11: 2A00]P29317EPHA2
    T57278DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29317EPHA2
    T29741DI0146Fibrosis[ICD-11: GA14-GC01]Q9NPH5NOX4
    T96892DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q14680MELK
    T96892DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q14680MELK
    T96892DI0249Mature B-cell leukaemia[ICD-11: 2A82]Q14680MELK
    T96892DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q14680MELK
    T96892DI0284Myelodysplastic syndrome[ICD-11: 2A37]Q14680MELK
    T96892DI0286Myeloproliferative neoplasm[ICD-11: 2A20]Q14680MELK
    T73756DI0225Kaposi sarcoma[ICD-11: 2B57]P29323EPHB2
    T73756DI0252Melanoma[ICD-11: 2C30]P29323EPHB2
    T73756DI0326Pancreatic cancer[ICD-11: 2C10]P29323EPHB2
    T73756DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29323EPHB2
    T68163DI0281Musculoskeletal disorder[ICD-11: FA00-FC0Z]P07948LYN
    T68163DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P07948LYN
    T31902DI0062Breast cancer[ICD-11: 2C60-2C6Y]O14672ADAM10
    T45593DI0012Acute myeloid leukaemia[ICD-11: 2A60]P10636MAPT
    T45593DI0025Alzheimer disease[ICD-11: 8A20]P10636MAPT
    T45593DI0265Mild neurocognitive disorder[ICD-11: 6D71]P10636MAPT
    T88285DI0210Influenza[ICD-11: 1E30-1E32]Q04760GLO1
    T28413DI0012Acute myeloid leukaemia[ICD-11: 2A60]P29320EPHA3
    T28413DI0060Brain cancer[ICD-11: 2A00]P29320EPHA3
    T28413DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P29320EPHA3
    T28413DI0284Myelodysplastic syndrome[ICD-11: 2A37]P29320EPHA3
    T94880DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06418TYRO3
    T86552DI0060Brain cancer[ICD-11: 2A00]P19438TNFRSF1A
    T86552DI0321Ovarian cancer[ICD-11: 2C73]P19438TNFRSF1A
    T88505DI0038Ataxic disorder[ICD-11: 8A03]Q16236NFE2L2
    T70234DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P54764EPHA4
    T73694DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]Q13882PTK6
    T73694DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q13882PTK6
    T79473DI0144Female infertility[ICD-11: GA31]P22888LHCGR
    T79473DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P22888LHCGR
    T84397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9H4B7TUBB1
    T63068DI0029Aneurysm/dissection[ICD-11: BD50]P02768ALB
    T63068DI0059Bowel habit change[ICD-11: ME05]P02768ALB
    T63068DI0077Cholelithiasis[ICD-11: DC11]P02768ALB
    T63068DI0202Inborn energy metabolism error[ICD-11: 5C53]P02768ALB
    T63068DI0218Irritable bowel syndrome[ICD-11: DD91]P02768ALB
    T63068DI0343Preprocedural examination[ICD-11: QA0B]P02768ALB
    T63068DI0366Rheumatoid arthritis[ICD-11: FA20]P02768ALB
    T63068DI0370Schizophrenia[ICD-11: 6A20]P02768ALB
    T63068DI0420Unspecific body region injury[ICD-11: ND56]P02768ALB
    T82391DI0069Cardiomyopathy[ICD-11: BC43]Q9P0J0NDUFA13
    T77195DI0331Parkinsonism[ICD-11: 8A00]P03897MT-ND3
    T39610DI0068Cardiac arrhythmia[ICD-11: BC9Z]Q96HK3CALM
    T39610DI0243Malaria[ICD-11: 1F40-1F45]Q96HK3CALM
    T39610DI0370Schizophrenia[ICD-11: 6A20]Q96HK3CALM

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