Uncinatone



Compound IDCDAMM00267
Common nameUncinatone
IUPAC name(9S,11bS)-7,11-dihydroxy-3,4,9,11b-tetramethyl-1,2,8,9-tetrahydronaphtho[2,1-f][1]benzofuran-6-one
Molecular formulaC20H22O4

Experimental data

Retention time59.494
Adduct[M+H]+
Actual mz327.163
Theoretical mz327.159
Error12.27
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score6.25

Identifiers and class information

Inchi keyIKKLDISSULFFQO-DJMILUHSSA-N
SmilesCC1CC2=C(C3=C(C(=C2O1)O)C4(CCC(=C(C4=CC3=O)C)C)C)O
SuperclassLipids and lipid-like molecules
ClassPrenol lipids

Plant source

  • Tribulus terrestris L.

    • Pharmacokinetic properties

    Number of descriptor values(#stars)0
    Number of non-conjugated amine groups (#amine)0
    Number of amidine and guanidine groups (#amidine)0
    Number of carboxylic acid groups (#acid)0
    Number of non-conjugated amide groups (#amide)0
    Number of rotatable bonds (#rotor)2
    Number of reactive functional groups (#rtvFG)0
    Predicted central nervous system activity (CNS)0
    Molecular weight (mol_MW)326.391
    Computed dipole moment(dipole)5.028
    Total solvent accessible surface area (SASA)561.979
    Hydrophobic component of SASA (FOSA)412.686
    Hydrophilic component of SASA (FISA)115.327
    Pie component of the SASA (PISA)33.966
    Weakly polar component of the SASA (WPSA)0
    Total solvent accesible volume (volume)1013.58
    Number of hydrogen bond donors (donorHB)1
    Number of hydrogen bond acceptors (accptHB)3.25
    Free energy of solvation of dipole (dip^2/V)0.0249404
    Index of cohesive interaction in solids (ACxDN^.5/SA)0.0057831
    Globularity descriptor (glob)0.868329
    Predicted polarizability in cubic angstroms (QPpolrz)33.45
    Predicted hexadecane/gas partition coefficient (QPlogPC16)8.975
    Predicted octanol/gas partition coefficient (QPlogPoct)14.207
    Predicted water/gas partition coefficient (QPlogPw)6.312
    Predicted octanol/water partition coefficient (QPlogPo/w)3.523
    Predicted aqueous solubility (QPlogS)-5.016
    Conformation-independent predicted aqueous solubility (CIQPlogS)-5.23
    Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-3.825
    Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)798.466
    Predicted brain/blood partition coefficient (QPlogBB)-0.577
    Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)387.883
    Predicted skin permeability, log Kp (QPlogKp)-3.333
    PM3 calculated ionization potential (IP(ev))8.721
    PM3 calculated electron affinity (EA(eV))0.635
    Number of likely metabolic reactions (#metab)6
    Prediction of binding to human serum albumin (QPlogKhsa)0.672
    Predicted qualitative human oral absorption (HumanOralAbsorption)3
    Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)100
    Solvent-accessible surface area of fluorine atoms (SAFluorine)0
    Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
    Van der Waals surface area (PSA)73.075
    Number of nitrogen and oxygen atoms (#NandO)4
    Number of violations of Lipinski’s rule of five (RuleOfFive)0
    Number of violations of Jorgensen’s rule of three (RuleOfThree)0

    Compound-target network

    Cytoscape Graph

    Protein targets associated with phytocompound

    Uniprot ID Gene name Target name TTD_ID Prediction source
    P06241FYNTyrosine-protein kinase FYNT17980SwissTargetPrediction
    P00533EGFREpidermal growth factor receptor erbB1T59328SwissTargetPrediction
    P29274ADORA2AAdenosine A2a receptorT77365SwissTargetPrediction
    Q07820MCL1Induced myeloid leukemia cell differentiation protein Mcl-1T14912SwissTargetPrediction
    P09874PARP1Poly [ADP-ribose] polymerase-1T06273SwissTargetPrediction
    P04818TYMSThymidylate synthase (by homology)T98397SwissTargetPrediction
    Q96KS0EIT6HIF-prolyl hydroxylase 1T53904SwissTargetPrediction
    P21917DRD4Dopamine D4 receptorT24983SwissTargetPrediction
    P43405SYKTyrosine-protein kinase SYKT62431SwissTargetPrediction
    P14416DRD2Dopamine D2 receptorT67162SwissTargetPrediction
    P21554CNR1Cannabinoid receptor 1 (by homology)T76685SwissTargetPrediction
    O60341KDM1ALysine-specific histone demethylase 1T16739SwissTargetPrediction
    P31645SLC6A4Serotonin transporter (by homology)T27812SwissTargetPrediction
    P08908HTR1ASerotonin 1a (5-HT1a) receptorT78709SwissTargetPrediction
    P29275ADORA2BAdenosine A2b receptorT86679SwissTargetPrediction
    Q9UBN7HDAC6Histone deacetylase 6T22274SwissTargetPrediction
    P15538CYP11B1Cytochrome P450 11B1T84621SwissTargetPrediction
    P19099CYP11B2Cytochrome P450 11B2T59056SwissTargetPrediction
    P22894MMP8Matrix metalloproteinase 8T08856SwissTargetPrediction
    P08254MMP3Matrix metalloproteinase 3T86702SwissTargetPrediction
    Q13547HDAC1Histone deacetylase 1T68547SwissTargetPrediction
    P03956MMP1Matrix metalloproteinase 1T52450SwissTargetPrediction
    Q9BY41HDAC8Histone deacetylase 8T28887SwissTargetPrediction
    P00338LDHAL-lactate dehydrogenase A chainT15053SwissTargetPrediction
    Q07817BCL2L1Apoptosis regulator Bcl-XT56510SwissTargetPrediction
    P04626ERBB2Receptor protein-tyrosine kinase erbB-2T14597SwissTargetPrediction
    Q16539MAPK14MAP kinase p38 alphaT65864SwissTargetPrediction
    P45452MMP13Matrix metalloproteinase 13T34296SwissTargetPrediction
    P78536ADAM17ADAM17T82393SwissTargetPrediction
    P09237MMP7Matrix metalloproteinase 7T73475SwissTargetPrediction
    P18054ALOX12Arachidonate 12-lipoxygenaseT35527SwissTargetPrediction
    P51449RORCNuclear receptor ROR-gammaT25307SwissTargetPrediction
    P49841GSK3BGlycogen synthase kinase-3 betaT70977SwissTargetPrediction
    P32246CCR1C-C chemokine receptor type 1T16016SwissTargetPrediction
    O00329PIK3CDPI3-kinase p110-delta subunitT67849SwissTargetPrediction
    P17948FLT1Vascular endothelial growth factor receptor 1T63966SwissTargetPrediction
    Q15078CDK5R1Cyclin-dependent kinase 5/CDK5 activator 1T09513SwissTargetPrediction
    Q13627DYRK1ADual-specificity tyrosine-phosphorylation regulated kinase 1AT92803SwissTargetPrediction
    P40763STAT3Signal transducer and activator of transcription 3T29130SwissTargetPrediction
    Q9Y463DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1BT82720SwissTargetPrediction
    Q9UNA0ADAMTS5ADAMTS5T98896SwissTargetPrediction
    P08263GSTA1Glutathione S-transferase A1T17221SwissTargetPrediction
    P34972CNR2Cannabinoid receptor 2T37693SwissTargetPrediction
    Q13443ADAM9ADAM9T03672SwissTargetPrediction
    P11362FGFR1Fibroblast growth factor receptor 1T47101SwissTargetPrediction
    Q99808SLC29A1Equilibrative nucleoside transporter 1T13491SwissTargetPrediction
    P25025CXCR2Interleukin-8 receptor BT56923SwissTargetPrediction
    P32239CCKBRCholecystokinin B receptor (by homology)T05849SwissTargetPrediction
    P48736PIK3CGPI3-kinase p110-gamma subunitT95913SwissTargetPrediction
    O76074PDE5APhosphodiesterase 5AT07663SwissTargetPrediction
    Q13093PLA2G7LDL-associated phospholipase A2T69912SwissTargetPrediction
    P20839IMPDH1Inosine-5'-monophosphate dehydrogenase 1T40111SwissTargetPrediction
    P41180CASRCalcium sensing receptorT92076SwissTargetPrediction
    P04049RAF1Serine/threonine-protein kinase RAFT51883SwissTargetPrediction
    P15056BRAFSerine/threonine-protein kinase B-rafT99089SwissTargetPrediction
    Q06187BTKTyrosine-protein kinase BTKT97719SwissTargetPrediction
    P29317EPHA2Ephrin type-A receptor 2T57278SwissTargetPrediction
    Q9NPH5NOX4NADPH oxidase 4T29741SwissTargetPrediction
    Q07343PDE4BPhosphodiesterase 4B (by homology)T10265SwissTargetPrediction
    P42226STAT6Signal transducer and activator of transcription 6T20585SwissTargetPrediction
    P29371TACR3Neurokinin 3 receptorT29683SwissTargetPrediction
    P51451BLKTyrosine-protein kinase BLKT74307SwissTargetPrediction
    Q15746MYLKMyosin light chain kinase, smooth muscleT97141SwissTargetPrediction
    P41240CSKTyrosine-protein kinase CSKT08741SwissTargetPrediction
    P29323EPHB2Ephrin type-B receptor 2T73756SwissTargetPrediction
    P51813BMXTyrosine-protein kinase BMXT99990SwissTargetPrediction
    P07948LYNTyrosine-protein kinase LynT68163SwissTargetPrediction
    P10415BCL2Apoptosis regulator Bcl-2T31309SwissTargetPrediction
    P09769FGRTyrosine-protein kinase FGRT49925SwissTargetPrediction
    P29320EPHA3Ephrin type-A receptor 3T28413SwissTargetPrediction
    Q06418TYRO3Tyrosine-protein kinase receptor TYRO3T94880SwissTargetPrediction
    P42681TXKTyrosine-protein kinase TXKT32590SwissTargetPrediction
    P54756EPHA5Ephrin type-A receptor 5T18474SwissTargetPrediction
    P54764EPHA4Ephrin type-A receptor 4T70234SwissTargetPrediction
    Q9UF33EPHA6Ephrin type-A receptor 6T08647SwissTargetPrediction
    Q13882PTK6Tyrosine-protein kinase BRKT73694SwissTargetPrediction
    P54753EPHB3Ephrin type-B receptor 3T56121SwissTargetPrediction
    Q96PY6NEK1Serine/threonine-protein kinase Nek1T43031SwissTargetPrediction
    P21709EPHA1Ephrin type-A receptor 1T28418SwissTargetPrediction
    Q9H4B7TUBB1Tubulin beta-1 chainT84397SwissTargetPrediction
    P21757MSR1Macrophage scavenger receptor types I and IIT50007SwissTargetPrediction
    Q9GZT9EGLN1Egl nine homolog 1T32880SwissTargetPrediction

    Target associated diseases

    TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
    T17980DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06241FYN
    T59328DI0030Angina pectoris[ICD-11: BA40]P00533EGFR
    T59328DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00533EGFR
    T59328DI0095Colorectal cancer[ICD-11: 2B91]P00533EGFR
    T59328DI0121Diabetic foot ulcer[ICD-11: BD54]P00533EGFR
    T59328DI0220Ischemia[ICD-11: 8B10-8B11]P00533EGFR
    T59328DI0238Lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0303Non-small-cell lung cancer[ICD-11: 2C25]P00533EGFR
    T59328DI0361Renal cell carcinoma[ICD-11: 2C90]P00533EGFR
    T59328DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P00533EGFR
    T59328DI0420Unspecific body region injury[ICD-11: ND56]P00533EGFR
    T77365DI0319Orthostatic hypotension[ICD-11: BA21]P29274ADORA2A
    T77365DI0331Parkinsonism[ICD-11: 8A00]P29274ADORA2A
    T77365DI0359Radionuclide imaging[ICD-11: N.A.]P29274ADORA2A
    T14912DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q07820MCL1
    T14912DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]Q07820MCL1
    T14912DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q07820MCL1
    T14912DI0252Melanoma[ICD-11: 2C30]Q07820MCL1
    T14912DI0274Multiple myeloma[ICD-11: 2A83]Q07820MCL1
    T14912DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q07820MCL1
    T06273DI0006Acquired cutaneous blood vessel malformation[ICD-11: EF20]P09874PARP1
    T06273DI0143Fallopian tube cancer[ICD-11: 2C74]P09874PARP1
    T06273DI0321Ovarian cancer[ICD-11: 2C73]P09874PARP1
    T06273DI0334Peritoneal cancer[ICD-11: 2C51]P09874PARP1
    T98397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04818TYMS
    T98397DI0395Stomach cancer[ICD-11: 2B72]P04818TYMS
    T53904DI0010Acute disease anaemia[ICD-11: 3A90]Q96KS0EIT6
    T24983DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P21917DRD4
    T24983DI0370Schizophrenia[ICD-11: 6A20]P21917DRD4
    T62431DI0403Thrombocytopenia[ICD-11: 3B64]P43405SYK
    T67162DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P14416DRD2
    T67162DI0025Alzheimer disease[ICD-11: 8A20]P14416DRD2
    T67162DI0037Asthma[ICD-11: CA23]P14416DRD2
    T67162DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P14416DRD2
    T67162DI0051Bipolar disorder[ICD-11: 6A60]P14416DRD2
    T67162DI0063Breathing abnormality[ICD-11: MD11]P14416DRD2
    T67162DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P14416DRD2
    T67162DI0073Cerebral ischaemia[ICD-11: 8B1Z]P14416DRD2
    T67162DI0117Depression[ICD-11: 6A70-6A7Z]P14416DRD2
    T67162DI0124Digestive system disease[ICD-11: DE2Z]P14416DRD2
    T67162DI0137Essential hypertension[ICD-11: BA00]P14416DRD2
    T67162DI0142Faecal incontinence[ICD-11: ME07]P14416DRD2
    T67162DI0156Gangrene[ICD-11: MC85]P14416DRD2
    T67162DI0166Glaucoma[ICD-11: 9C61]P14416DRD2
    T67162DI0175Heart failure[ICD-11: BD10-BD1Z]P14416DRD2
    T67162DI0185Hyperaemia[ICD-11: 9A61-9B7Y]P14416DRD2
    T67162DI0190Hypertension[ICD-11: BA00-BA04]P14416DRD2
    T67162DI0196Hypotension[ICD-11: BA20-BA21]P14416DRD2
    T67162DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]P14416DRD2
    T67162DI0214Insomnia[ICD-11: 7A00-7A0Z]P14416DRD2
    T67162DI0222Itching[ICD-11: 1F28-1G07]P14416DRD2
    T67162DI0264Migraine[ICD-11: 8A80]P14416DRD2
    T67162DI0293Nausea/vomiting[ICD-11: MD90]P14416DRD2
    T67162DI0324Pain[ICD-11: MG30-MG3Z]P14416DRD2
    T67162DI0331Parkinsonism[ICD-11: 8A00]P14416DRD2
    T67162DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P14416DRD2
    T67162DI0340Postpartum haemorrhage[ICD-11: JA43]P14416DRD2
    T67162DI0354Psychotic disorder[ICD-11: 6A20-6A25]P14416DRD2
    T67162DI0356Pulmonary hypertension[ICD-11: BB01]P14416DRD2
    T67162DI0370Schizophrenia[ICD-11: 6A20]P14416DRD2
    T67162DI0396Substance abuse[ICD-11: 6C40]P14416DRD2
    T67162DI0408Thyrotoxicosis[ICD-11: 5A02]P14416DRD2
    T67162DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14416DRD2
    T76685DI0031Anorexia nervosa[ICD-11: 6B80]P21554CNR1
    T76685DI0214Insomnia[ICD-11: 7A00-7A0Z]P21554CNR1
    T76685DI0308Obesity[ICD-11: 5B80-5B81]P21554CNR1
    T16739DI0012Acute myeloid leukaemia[ICD-11: 2A60]O60341KDM1A
    T16739DI0025Alzheimer disease[ICD-11: 8A20]O60341KDM1A
    T16739DI0138Ewing sarcoma[ICD-11: 2B52]O60341KDM1A
    T16739DI0238Lung cancer[ICD-11: 2C25]O60341KDM1A
    T16739DI0241Lymphoma[ICD-11: 2A80-2A86]O60341KDM1A
    T16739DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O60341KDM1A
    T16739DI0284Myelodysplastic syndrome[ICD-11: 2A37]O60341KDM1A
    T16739DI0286Myeloproliferative neoplasm[ICD-11: 2A20]O60341KDM1A
    T16739DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O60341KDM1A
    T27812DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P31645SLC6A4
    T27812DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P31645SLC6A4
    T27812DI0087Chronic pain[ICD-11: MG30]P31645SLC6A4
    T27812DI0096concerning food/fluid intake symptom[ICD-11: MG43]P31645SLC6A4
    T27812DI0101Corneal disease[ICD-11: 9A76-9A78]P31645SLC6A4
    T27812DI0105Cough[ICD-11: MD12]P31645SLC6A4
    T27812DI0117Depression[ICD-11: 6A70-6A7Z]P31645SLC6A4
    T27812DI0264Migraine[ICD-11: 8A80]P31645SLC6A4
    T27812DI0301Nicotine use disorder[ICD-11: 6C4A]P31645SLC6A4
    T27812DI0308Obesity[ICD-11: 5B80-5B81]P31645SLC6A4
    T27812DI0324Pain[ICD-11: MG30-MG3Z]P31645SLC6A4
    T78709DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]P08908HTR1A
    T78709DI0117Depression[ICD-11: 6A70-6A7Z]P08908HTR1A
    T78709DI0190Hypertension[ICD-11: BA00-BA04]P08908HTR1A
    T78709DI0264Migraine[ICD-11: 8A80]P08908HTR1A
    T78709DI0270Mood disorder[ICD-11: 6A60-6E23]P08908HTR1A
    T86679DI0180Herpes simplex infection[ICD-11: 1F00]P29275ADORA2B
    T86679DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P29275ADORA2B
    T22274DI0274Multiple myeloma[ICD-11: 2A83]Q9UBN7HDAC6
    T22274DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UBN7HDAC6
    T84621DI0062Breast cancer[ICD-11: 2C60-2C6Y]P15538CYP11B1
    T84621DI0108Cushing syndrome[ICD-11: 5A70]P15538CYP11B1
    T59056DI0190Hypertension[ICD-11: BA00-BA04]P19099CYP11B2
    T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
    T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
    T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
    T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
    T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
    T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
    T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
    T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
    T68547DI0274Multiple myeloma[ICD-11: 2A83]Q13547HDAC1
    T68547DI0283Mycosis fungoides[ICD-11: 2B01]Q13547HDAC1
    T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
    T28887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BY41HDAC8
    T56510DI0286Myeloproliferative neoplasm[ICD-11: 2A20]Q07817BCL2L1
    T14597DI0062Breast cancer[ICD-11: 2C60-2C6Y]P04626ERBB2
    T14597DI0238Lung cancer[ICD-11: 2C25]P04626ERBB2
    T14597DI0346Prostate cancer[ICD-11: 2C82]P04626ERBB2
    T65864DI0102Coronary atherosclerosis[ICD-11: BA52]Q16539MAPK14
    T65864DI0287Myocardial infarction[ICD-11: BA41-BA43]Q16539MAPK14
    T65864DI0366Rheumatoid arthritis[ICD-11: FA20]Q16539MAPK14
    T65864DI0437Vitamin deficiency[ICD-11: 5B55-5B5F]Q16539MAPK14
    T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
    T82393DI0062Breast cancer[ICD-11: 2C60-2C6Y]P78536ADAM17
    T82393DI0366Rheumatoid arthritis[ICD-11: FA20]P78536ADAM17
    T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
    T25307DI0042Autoimmune disease[ICD-11: 4A40-4A45]P51449RORC
    T25307DI0107Crohn disease[ICD-11: DD70]P51449RORC
    T25307DI0238Lung cancer[ICD-11: 2C25]P51449RORC
    T25307DI0275Multiple sclerosis[ICD-11: 8A40]P51449RORC
    T25307DI0351Psoriasis[ICD-11: EA90]P51449RORC
    T25307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P51449RORC
    T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
    T16016DI0120Diabetes mellitus[ICD-11: 5A10]P32246CCR1
    T16016DI0366Rheumatoid arthritis[ICD-11: FA20]P32246CCR1
    T67849DI0151Follicular lymphoma[ICD-11: 2A80]O00329PIK3CD
    T67849DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00329PIK3CD
    T67849DI0249Mature B-cell leukaemia[ICD-11: 2A82]O00329PIK3CD
    T67849DI0250Mature B-cell lymphoma[ICD-11: 2A85]O00329PIK3CD
    T67849DI0395Stomach cancer[ICD-11: 2B72]O00329PIK3CD
    T63966DI0361Renal cell carcinoma[ICD-11: 2C90]P17948FLT1
    T92803DI0113Cytomegaloviral disease[ICD-11: 1D82]Q13627DYRK1A
    T29130DI0351Psoriasis[ICD-11: EA90]P40763STAT3
    T98896DI0320Osteoarthritis[ICD-11: FA00-FA05]Q9UNA0ADAMTS5
    T37693DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]P34972CNR2
    T37693DI0214Insomnia[ICD-11: 7A00-7A0Z]P34972CNR2
    T03672DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q13443ADAM9
    T47101DI0095Colorectal cancer[ICD-11: 2B91]P11362FGFR1
    T47101DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P11362FGFR1
    T47101DI0235Liver cancer[ICD-11: 2C12]P11362FGFR1
    T47101DI0403Thrombocytopenia[ICD-11: 3B64]P11362FGFR1
    T13491DI0030Angina pectoris[ICD-11: BA40]Q99808SLC29A1
    T56923DI0155Fungal infection[ICD-11: 1F29-1F2F]P25025CXCR2
    T56923DI0324Pain[ICD-11: MG30-MG3Z]P25025CXCR2
    T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
    T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
    T95913DI0151Follicular lymphoma[ICD-11: 2A80]P48736PIK3CG
    T95913DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48736PIK3CG
    T95913DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48736PIK3CG
    T07663DI0190Hypertension[ICD-11: BA00-BA04]O76074PDE5A
    T07663DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]O76074PDE5A
    T07663DI0378Sexual dysfunction[ICD-11: HA00-HA01]O76074PDE5A
    T07663DI0411Tonus and reflex abnormality[ICD-11: MB47]O76074PDE5A
    T69912DI0025Alzheimer disease[ICD-11: 8A20]Q13093PLA2G7
    T69912DI0035Arterial occlusive disease[ICD-11: BD40]Q13093PLA2G7
    T69912DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]Q13093PLA2G7
    T40111DI0062Breast cancer[ICD-11: 2C60-2C6Y]P20839IMPDH1
    T40111DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P20839IMPDH1
    T40111DI0250Mature B-cell lymphoma[ICD-11: 2A85]P20839IMPDH1
    T40111DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P20839IMPDH1
    T40111DI0413Transplant rejection[ICD-11: NE84]P20839IMPDH1
    T92076DI0189Hyper-parathyroidism[ICD-11: 5A51]P41180CASR
    T51883DI0252Melanoma[ICD-11: 2C30]P04049RAF1
    T51883DI0303Non-small-cell lung cancer[ICD-11: 2C25]P04049RAF1
    T51883DI0321Ovarian cancer[ICD-11: 2C73]P04049RAF1
    T51883DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04049RAF1
    T99089DI0252Melanoma[ICD-11: 2C30]P15056BRAF
    T97719DI0231Leukaemia[ICD-11: 2A60-2B33]Q06187BTK
    T57278DI0060Brain cancer[ICD-11: 2A00]P29317EPHA2
    T57278DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29317EPHA2
    T29741DI0146Fibrosis[ICD-11: GA14-GC01]Q9NPH5NOX4
    T10265DI0037Asthma[ICD-11: CA23]Q07343PDE4B
    T10265DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q07343PDE4B
    T10265DI0265Mild neurocognitive disorder[ICD-11: 6D71]Q07343PDE4B
    T29683DI0254Menopausal disorder[ICD-11: GA30]P29371TACR3
    T97141DI0127Duodenal ulcer[ICD-11: DA63]Q15746MYLK
    T73756DI0225Kaposi sarcoma[ICD-11: 2B57]P29323EPHB2
    T73756DI0252Melanoma[ICD-11: 2C30]P29323EPHB2
    T73756DI0326Pancreatic cancer[ICD-11: 2C10]P29323EPHB2
    T73756DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P29323EPHB2
    T68163DI0281Musculoskeletal disorder[ICD-11: FA00-FC0Z]P07948LYN
    T68163DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P07948LYN
    T31309DI0062Breast cancer[ICD-11: 2C60-2C6Y]P10415BCL2
    T31309DI0249Mature B-cell leukaemia[ICD-11: 2A82]P10415BCL2
    T31309DI0273Motor neuron disease[ICD-11: 8B60]P10415BCL2
    T31309DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P10415BCL2
    T28413DI0012Acute myeloid leukaemia[ICD-11: 2A60]P29320EPHA3
    T28413DI0060Brain cancer[ICD-11: 2A00]P29320EPHA3
    T28413DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P29320EPHA3
    T28413DI0284Myelodysplastic syndrome[ICD-11: 2A37]P29320EPHA3
    T94880DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06418TYRO3
    T70234DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P54764EPHA4
    T73694DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]Q13882PTK6
    T73694DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q13882PTK6
    T84397DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9H4B7TUBB1

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