Compound details

Subaphylline

Compound ID	CDAMM00262
Common name	Subaphylline
IUPAC name	(E)-N-(4-aminobutyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
Molecular formula	C₁₄H₂₀N₂O₃

Experimental data

Retention time	25.749
Adduct	[M+H]+
Actual mz	265.156
Theoretical mz	265.155
Error	3.88
Ionizaton mode	Positive
Instrument type	LC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score	8.16

Identifiers and class information

Inchi key	FZWGECJQACGGTI-UHFFFAOYSA-N
Smiles	COC1=C(C=CC(=C1)C=CC(=O)NCCCCN)O
Superclass	Organoheterocyclic compounds
Class	Imidazopyrimidines

Plant source

Tribulus terrestris L.

Pedalium murex L.

Baliospermum solanifolium (Burm.) Suresh

External sources

HMDB ID	HMDB0033463
KNApSAcK ID	C00002780
FooDB ID	FDB011505
DrugBank ID
ChEBI ID	CHEBI:9299
Pubchem Compound ID	5281796
PlantCyc ID
UNPD ID	UNPD160889
Coconut ID
LipidMAPS ID
NANPDB ID	NANPDB_3812

Pharmacokinetic properties

Number of descriptor values(#stars)	0
Number of non-conjugated amine groups (#amine)	1
Number of amidine and guanidine groups (#amidine)	0
Number of carboxylic acid groups (#acid)	0
Number of non-conjugated amide groups (#amide)	0
Number of rotatable bonds (#rotor)	10
Number of reactive functional groups (#rtvFG)	1
Predicted central nervous system activity (CNS)	-2
Molecular weight (mol_MW)	264.324
Computed dipole moment(dipole)	4.772
Total solvent accessible surface area (SASA)	577.428
Hydrophobic component of SASA (FOSA)	278.986
Hydrophilic component of SASA (FISA)	168.217
Pie component of the SASA (PISA)	130.225
Weakly polar component of the SASA (WPSA)	0
Total solvent accesible volume (volume)	958.369
Number of hydrogen bond donors (donorHB)	4
Number of hydrogen bond acceptors (accptHB)	5
Free energy of solvation of dipole (dip^2/V)	0.0237635
Index of cohesive interaction in solids (ACxDN^.5/SA)	0.0173182
Globularity descriptor (glob)	0.814121
Predicted polarizability in cubic angstroms (QPpolrz)	27.023
Predicted hexadecane/gas partition coefficient (QPlogPC16)	10.012
Predicted octanol/gas partition coefficient (QPlogPoct)	17.202
Predicted water/gas partition coefficient (QPlogPw)	11.716
Predicted octanol/water partition coefficient (QPlogPo/w)	1.142
Predicted aqueous solubility (QPlogS)	-1.819
Conformation-independent predicted aqueous solubility (CIQPlogS)	-1.783
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)	-5.887
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)	62.748
Predicted brain/blood partition coefficient (QPlogBB)	-1.333
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)	27.452
Predicted skin permeability, log Kp (QPlogKp)	-5.263
PM3 calculated ionization potential (IP(ev))	8.844
PM3 calculated electron affinity (EA(eV))	0.667
Number of likely metabolic reactions (#metab)	4
Prediction of binding to human serum albumin (QPlogKhsa)	-0.35
Predicted qualitative human oral absorption (HumanOralAbsorption)	3
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)	65.808
Solvent-accessible surface area of fluorine atoms (SAFluorine)	0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)	0
Van der Waals surface area (PSA)	95.068
Number of nitrogen and oxygen atoms (#NandO)	5
Number of violations of Lipinski’s rule of five (RuleOfFive)	0
Number of violations of Jorgensen’s rule of three (RuleOfThree)	0

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID	Gene name	Target name	TTD_ID	Prediction source
P00533	EGFR	Epidermal growth factor receptor erbB1	T59328	SwissTargetPrediction
P22303	ACHE	Acetylcholinesterase	T30082	SwissTargetPrediction and SEA
O43570	CA12	Carbonic anhydrase XII	T16987	SEA
Q16790	CA9	Carbonic anhydrase IX	T64567	SEA
Q07820	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	T14912	SEA
P09874	PARP1	Poly [ADP-ribose] polymerase-1	T06273	SwissTargetPrediction
Q16853	AOC3	Amine oxidase, copper containing	T69619	SwissTargetPrediction
Q96KS0	EIT6	HIF-prolyl hydroxylase 1	T53904	SwissTargetPrediction
O15379	HDAC3	Histone deacetylase 3	T05090	SEA
P21397	MAOA	Monoamine oxidase A	T83875	SEA
P00915	CA1	Carbonic anhydrase I	T13201	SEA
P02766	TTR	Transthyretin	T86462	SEA
P05067	APP	Beta amyloid A4 protein	T87024	SEA
P00918	CA2	Carbonic anhydrase II	T20401	SEA
P43405	SYK	Tyrosine-protein kinase SYK	T62431	SwissTargetPrediction
P14416	DRD2	Dopamine D2 receptor	T67162	SwissTargetPrediction and SEA
P19838	NFKB1	Nuclear factor NF-kappa-B p105 subunit	T83145	SEA
P06280	GLA	Alpha-galactosidase A	T61339	SEA
Q05586	GRIN1	Glutamate NMDA receptor; GRIN1/GRIN2B	T62276	SEA
Q12879	GRIN2A	Glutamate NMDA receptor; GRIN1/GRIN2A	T22285	SEA
P43166	CA7	Carbonic anhydrase VII	T37541	SEA
P23280	CA6	Carbonic anhydrase VI	T06569	SEA
Q9ULX7	CA14	Carbonic anhydrase XIV	T31992	SEA
P22748	CA4	Carbonic anhydrase IV	T53378	SEA
P27338	MAOB	Monoamine oxidase B	T83011	SwissTargetPrediction and SEA
Q15118	PDK1	Pyruvate dehydrogenase kinase isoform 1	T20891	SwissTargetPrediction
P42261	GRIA1	Glutamate receptor ionotropic, AMPA 1	T33584	SEA
P15121	AKR1B1	Aldose reductase	T26623	SEA
P24864	CCNE1	Cyclin-dependent kinase 2/cyclin E1	T10052	SwissTargetPrediction
Q8WUI4	HDAC7	Histone deacetylase 7	T98698	SEA
P56524	HDAC4	Histone deacetylase 4	T63816	SEA
Q9UKV0	HDAC9	Histone deacetylase 9	T03687	SEA
P05164	MPO	Myeloperoxidase	T23471	SwissTargetPrediction and SEA
Q92769	HDAC2	Histone deacetylase 2	T51191	SEA
Q9H3R0	KDM4C	Lysine-specific demethylase 4C	T73863	SwissTargetPrediction
P35354	PTGS2	Cyclooxygenase-2	T66665	SwissTargetPrediction
P42330	AKR1C3	Aldo-keto-reductase family 1 member C3	T60857	SEA
Q6B0I6	KDM4D	Lysine-specific demethylase 4D	T17036	SwissTargetPrediction
P11926	ODC1	Ornithine decarboxylase	T60366	SEA
P45983	MAPK8	c-Jun N-terminal kinase 1	T40097	SwissTargetPrediction
P53779	MAPK10	c-Jun N-terminal kinase 3	T85421	SwissTargetPrediction
O60885	BRD4	Bromodomain-containing protein 4	T00407	SwissTargetPrediction
Q8NER1	TRPV1	Vanilloid receptor	T83193	SEA
O14684	PTGES	Prostaglandin E synthase	T02562	SEA
P29350	PTPN6	Protein-tyrosine phosphatase 1C	T98264	SEA
P18031	PTPN1	Protein-tyrosine phosphatase 1B	T16347	SEA
Q9H3N8	HRH4	Histamine H4 receptor	T26500	SwissTargetPrediction
P49137	MAPKAPK2	MAP kinase-activated protein kinase 2	T21307	SwissTargetPrediction
P08253	MMP2	Matrix metalloproteinase 2	T68251	SwissTargetPrediction and SEA
P14780	MMP9	Matrix metalloproteinase 9	T54156	SwissTargetPrediction and SEA
P09917	ALOX5	Arachidonate 5-lipoxygenase	T00140	SEA
P03956	MMP1	Matrix metalloproteinase 1	T52450	SwissTargetPrediction and SEA
P13726	F3	Coagulation factor VII/tissue factor	T72702	SEA
P35462	DRD3	Dopamine D3 receptor	T02551	SwissTargetPrediction and SEA
Q13639	HTR4	Serotonin 4 (5-HT4) receptor	T59679	SwissTargetPrediction
P08183	ABCB1	P-glycoprotein 1	T25258	SEA
Q8N5Z0	AADAT	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	T82668	SwissTargetPrediction
P52732	KIF11	Kinesin-like protein 1	T28484	SwissTargetPrediction
O14757	CHEK1	Serine/threonine-protein kinase Chk1	T62449	SwissTargetPrediction
P00519	ABL1	Tyrosine-protein kinase ABL	T63505	SwissTargetPrediction
P06276	BCHE	Butyrylcholinesterase	T99799	SwissTargetPrediction and SEA
P30291	WEE1	Serine/threonine-protein kinase WEE1	T69991	SwissTargetPrediction
P24941	CDK2	Cyclin-dependent kinase 2	T70176	SwissTargetPrediction
P56817	BACE1	Beta-secretase 1	T79031	SEA
P13497	BMP1	Bone morphogenetic protein 1	T53350	SwissTargetPrediction
P25105	PTAFR	Platelet activating factor receptor	T87023	SEA
P19838	NFKB1	Nuclear factor NF-kappa-B p105 subunit	T83145	SEA
P43116	PTGER2	Prostanoid EP2 receptor	T38529	SEA
Q15722	LTB4R	Leukotriene B4 receptor 1	T59626	SEA
P11388	TOP2A	DNA topoisomerase II alpha	T17048	SEA
P13500	CCL2	C-C motif chemokine 2	T89988	SwissTargetPrediction and SEA
O75116	ROCK2	Rho-associated protein kinase 2	T06093	SwissTargetPrediction
Q09472	EP300	Histone acetyltransferase p300	T25956	SwissTargetPrediction and SEA
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	T18477	SwissTargetPrediction
O96017	CHEK2	Serine/threonine-protein kinase Chk2	T28713	SwissTargetPrediction
P05771	PRKCB	Protein kinase C beta	T40276	SwissTargetPrediction
P47871	GCGR	Glucagon receptor	T60182	SEA
O15111	CHUK	Inhibitor of NF-kappa-B kinase (IKK)	T78429	SwissTargetPrediction
Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	T99057	SwissTargetPrediction
P08581	MET	Hepatocyte growth factor receptor	T40474	SEA
P05362	ICAM1	Intercellular adhesion molecule-1	T26203	SEA
P16581	SELE	Selectin E	T72835	SEA
Q9HBH9	MKNK2	MAP kinase signal-integrating kinase 2	T99160	SwissTargetPrediction
Q9NR96	TLR9	Toll-like receptor (TLR7/TLR9)	T11451	SEA
P29597	TYK2	Tyrosine-protein kinase TYK2	T78932	SwissTargetPrediction
P48039	MTNR1A	Melatonin receptor 1A	T97613	SwissTargetPrediction and SEA
P49286	MTNR1B	Melatonin receptor 1B	T48268	SwissTargetPrediction and SEA
Q9Y251	HPSE	Heparanase	T47623	SEA
P35408	PTGER4	Prostanoid EP4 receptor	T18876	SEA
P50579	METAP2	Methionine aminopeptidase 2	T75596	SwissTargetPrediction and SEA
Q9NWZ3	IRAK4	Interleukin-1 receptor-associated kinase 4	T55398	SwissTargetPrediction
Q9Y2K7	KDM2A	Lysine-specific demethylase 2A	T71949	SwissTargetPrediction
P06493	CDK1	Cyclin-dependent kinase 1/cyclin B1	T49898	SwissTargetPrediction
P06737	PYGL	Liver glycogen phosphorylase	T19184	SEA
Q13258	PTGDR	Prostanoid DP receptor	T68782	SEA
P32239	CCKBR	Cholecystokinin B receptor (by homology)	T05849	SEA
Q9Y243	AKT3	Serine/threonine-protein kinase AKT	T71266	SwissTargetPrediction
Q13976	PRKG1	cGMP-dependent protein kinase 1 beta	T78543	SwissTargetPrediction
Q04759	PRKCQ	Protein kinase C theta	T23995	SwissTargetPrediction
P30837	ALDH1B1	Acetaldehyde dehydrogenase	T99641	SwissTargetPrediction
Q9NUW8	TDP1	Tyrosyl-DNA phosphodiesterase 1	T33492	SwissTargetPrediction
P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	T40111	SEA
P12268	IMPDH2	Inosine-5'-monophosphate dehydrogenase 2	T89360	SEA
P68400	CSNK2A1	Casein kinase II alpha	T51565	SwissTargetPrediction
Q6V1X1	DPP8	Dipeptidyl peptidase VIII	T15855	SwissTargetPrediction
Q86TI2	DPP9	Dipeptidyl peptidase IX	T66252	SwissTargetPrediction
P19784	CSNK2A2	Casein kinase II alpha (prime)	T80526	SwissTargetPrediction
Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	T23787	SwissTargetPrediction
Q9UQM7	CAMK2A	CaM kinase II alpha	T18299	SwissTargetPrediction
P03952	KLKB1	Plasma kallikrein	T82739	SwissTargetPrediction
Q9UNQ0	ABCG2	ATP-binding cassette sub-family G member 2	T56556	SEA
O15111	CHUK	Inhibitor of NF-kappa-B kinase (IKK)	T78429	SwissTargetPrediction
O75582	RPS6KA5	Ribosomal protein S6 kinase alpha 5	T50224	SwissTargetPrediction
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha 3	T03279	SwissTargetPrediction
Q14680	MELK	Maternal embryonic leucine zipper kinase	T96892	SwissTargetPrediction
Q15418	RPS6KA1	Ribosomal protein S6 kinase alpha 1	T83202	SwissTargetPrediction
P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	T63846	SwissTargetPrediction
Q13464	ROCK1	Rho-associated protein kinase 1	T51282	SwissTargetPrediction
Q16678	CYP1B1	Cytochrome P450 1B1	T92521	SEA
P10636	MAPT	Microtubule-associated protein tau	T45593	SEA
Q04760	GLO1	Glyoxalase I	T88285	SEA
P09769	FGR	Tyrosine-protein kinase FGR	T49925	SwissTargetPrediction
Q96KB5	PBK	PDZ-binding kinase	T98642	SwissTargetPrediction
Q99873	PRMT1	Protein-arginine N-methyltransferase 1	T16808	SwissTargetPrediction
P43403	ZAP70	Tyrosine-protein kinase ZAP-70	T64553	SwissTargetPrediction
Q13224	GRIN2B	Glutamate [NMDA] receptor subunit epsilon 2	T76414	SEA
P42681	TXK	Tyrosine-protein kinase TXK	T32590	SwissTargetPrediction
P19438	TNFRSF1A	Tumor necrosis factor receptor R1	T86552	SEA
Q16236	NFE2L2	Nuclear factor erythroid 2-related factor 2	T88505	SEA
P33032	MC5R	Melanocortin receptor 5	T95302	SEA
Q6PL18	ATAD2	ATPase family AAA domain-containing protein 2	T82467	SwissTargetPrediction
Q13882	PTK6	Tyrosine-protein kinase BRK	T73694	SwissTargetPrediction
Q9H2K8	TAOK3	Serine/threonine-protein kinase TAO3	T63682	SEA
Q96PY6	NEK1	Serine/threonine-protein kinase Nek1	T43031	SwissTargetPrediction
P21709	EPHA1	Ephrin type-A receptor 1	T28418	SwissTargetPrediction
Q9H4B7	TUBB1	Tubulin beta-1 chain	T84397	SEA
P41586	ADCYAP1R1	Pituitary adenylate cyclase-activating polypeptide type I receptor	T92185	SEA
Q15466	NR0B2	Nuclear receptor subfamily 0 group B member 2	T89859	SEA
P11717	IGF2R	Insulin-like growth factor II receptor	T59550	SEA
Q9BY41	HDAC8	Histone deacetylase 8	T28887	SEA
P42263	GRIA3	Glutamate receptor AMPA 3	T62391	SEA
P01100	FOS	Proto-oncogene c-Fos	T28025	SEA
Q9NZQ8	TRPM5	Long transient receptor potential channel 5	T85545	SEA
Q9NR20	DYRK4	Dual-specificity tyrosine-phosphorylation regulated kinase 4	T20542	SEA
Q8N183	NDUFAF2	HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2	T01453	SEA
Q9P0J0	NDUFA13	Mitochondrial complex I	T82391	SEA
Q9Y6M9	NDUFB9	HUMAN NADH:ubiquinone oxidoreductase subunit B9	T01465	SEA
Q8N183	NDUFAF2	HUMAN NADH:ubiquinone oxidoreductase complex assembly factor 2	T01453	SEA
P03897	MT-ND3	NADH dehydrogenase	T77195	SEA
O75751	EMTH	Organic cation transporter 3	T55948	SEA
Q9GZT9	EGLN1	Egl nine homolog 1	T32880	SwissTargetPrediction

Target associated diseases

TTD_ID	Disease_ID	Disease name	ICD_11	Uniprot ID	Gene names
T59328	DI0030	Angina pectoris	[ICD-11: BA40]	P00533	EGFR
T59328	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P00533	EGFR
T59328	DI0095	Colorectal cancer	[ICD-11: 2B91]	P00533	EGFR
T59328	DI0121	Diabetic foot ulcer	[ICD-11: BD54]	P00533	EGFR
T59328	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P00533	EGFR
T59328	DI0238	Lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P00533	EGFR
T59328	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P00533	EGFR
T59328	DI0420	Unspecific body region injury	[ICD-11: ND56]	P00533	EGFR
T30082	DI0025	Alzheimer disease	[ICD-11: 8A20]	P22303	ACHE
T30082	DI0166	Glaucoma	[ICD-11: 9C61]	P22303	ACHE
T30082	DI0282	Myasthenia gravis	[ICD-11: 8C6Y]	P22303	ACHE
T30082	DI0313	Oesophageal/gastroduodenal disorder	[ICD-11: DD90]	P22303	ACHE
T30082	DI0332	Pediculosis	[ICD-11: 1G00]	P22303	ACHE
T30082	DI0421	Unspecific substance harmful effect	[ICD-11: NE6Z]	P22303	ACHE
T16987	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	O43570	CA12
T16987	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	O43570	CA12
T64567	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q16790	CA9
T14912	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q07820	MCL1
T14912	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	Q07820	MCL1
T14912	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q07820	MCL1
T14912	DI0252	Melanoma	[ICD-11: 2C30]	Q07820	MCL1
T14912	DI0274	Multiple myeloma	[ICD-11: 2A83]	Q07820	MCL1
T14912	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q07820	MCL1
T06273	DI0006	Acquired cutaneous blood vessel malformation	[ICD-11: EF20]	P09874	PARP1
T06273	DI0143	Fallopian tube cancer	[ICD-11: 2C74]	P09874	PARP1
T06273	DI0321	Ovarian cancer	[ICD-11: 2C73]	P09874	PARP1
T06273	DI0334	Peritoneal cancer	[ICD-11: 2C51]	P09874	PARP1
T69619	DI0190	Hypertension	[ICD-11: BA00-BA04]	Q16853	AOC3
T53904	DI0010	Acute disease anaemia	[ICD-11: 3A90]	Q96KS0	EIT6
T05090	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O15379	HDAC3
T05090	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O15379	HDAC3
T83875	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P21397	MAOA
T83875	DI0331	Parkinsonism	[ICD-11: 8A00]	P21397	MAOA
T13201	DI0166	Glaucoma	[ICD-11: 9C61]	P00915	CA1
T13201	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00915	CA1
T86462	DI0026	Amyloidosis	[ICD-11: 5D00]	P02766	TTR
T87024	DI0025	Alzheimer disease	[ICD-11: 8A20]	P05067	APP
T87024	DI0122	Diagnostic imaging	[ICD-11: N.A.]	P05067	APP
T20401	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P00918	CA2
T20401	DI0137	Essential hypertension	[ICD-11: BA00]	P00918	CA2
T20401	DI0166	Glaucoma	[ICD-11: 9C61]	P00918	CA2
T20401	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P00918	CA2
T20401	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P00918	CA2
T20401	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00918	CA2
T62431	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P43405	SYK
T67162	DI0022	Allergic/hypersensitivity disorder	[ICD-11: 4A80-4A8Z]	P14416	DRD2
T67162	DI0025	Alzheimer disease	[ICD-11: 8A20]	P14416	DRD2
T67162	DI0037	Asthma	[ICD-11: CA23]	P14416	DRD2
T67162	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P14416	DRD2
T67162	DI0051	Bipolar disorder	[ICD-11: 6A60]	P14416	DRD2
T67162	DI0063	Breathing abnormality	[ICD-11: MD11]	P14416	DRD2
T67162	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	P14416	DRD2
T67162	DI0073	Cerebral ischaemia	[ICD-11: 8B1Z]	P14416	DRD2
T67162	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P14416	DRD2
T67162	DI0124	Digestive system disease	[ICD-11: DE2Z]	P14416	DRD2
T67162	DI0137	Essential hypertension	[ICD-11: BA00]	P14416	DRD2
T67162	DI0142	Faecal incontinence	[ICD-11: ME07]	P14416	DRD2
T67162	DI0156	Gangrene	[ICD-11: MC85]	P14416	DRD2
T67162	DI0166	Glaucoma	[ICD-11: 9C61]	P14416	DRD2
T67162	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P14416	DRD2
T67162	DI0185	Hyperaemia	[ICD-11: 9A61-9B7Y]	P14416	DRD2
T67162	DI0190	Hypertension	[ICD-11: BA00-BA04]	P14416	DRD2
T67162	DI0196	Hypotension	[ICD-11: BA20-BA21]	P14416	DRD2
T67162	DI0205	Inborn porphyrin/heme metabolism error	[ICD-11: 5C58]	P14416	DRD2
T67162	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P14416	DRD2
T67162	DI0222	Itching	[ICD-11: 1F28-1G07]	P14416	DRD2
T67162	DI0264	Migraine	[ICD-11: 8A80]	P14416	DRD2
T67162	DI0293	Nausea/vomiting	[ICD-11: MD90]	P14416	DRD2
T67162	DI0324	Pain	[ICD-11: MG30-MG3Z]	P14416	DRD2
T67162	DI0331	Parkinsonism	[ICD-11: 8A00]	P14416	DRD2
T67162	DI0337	Pituitary gland disorder	[ICD-11: 5A60-5A61]	P14416	DRD2
T67162	DI0340	Postpartum haemorrhage	[ICD-11: JA43]	P14416	DRD2
T67162	DI0354	Psychotic disorder	[ICD-11: 6A20-6A25]	P14416	DRD2
T67162	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P14416	DRD2
T67162	DI0370	Schizophrenia	[ICD-11: 6A20]	P14416	DRD2
T67162	DI0396	Substance abuse	[ICD-11: 6C40]	P14416	DRD2
T67162	DI0408	Thyrotoxicosis	[ICD-11: 5A02]	P14416	DRD2
T67162	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P14416	DRD2
T83145	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P19838	NFKB1
T83145	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P19838	NFKB1
T61339	DI0201	Inborn carbohydrate metabolism error	[ICD-11: 5C51]	P06280	GLA
T62276	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q05586	GRIN1
T62276	DI0182	HIV-infected patients with tuberculosis	[ICD-11: 1B10-1B14]	Q05586	GRIN1
T22285	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	Q12879	GRIN2A
T06569	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P23280	CA6
T06569	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P23280	CA6
T31992	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q9ULX7	CA14
T31992	DI0204	Inborn metabolism deficiency	[ICD-11: 5C50-5C59]	Q9ULX7	CA14
T53378	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P22748	CA4
T53378	DI0166	Glaucoma	[ICD-11: 9C61]	P22748	CA4
T53378	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P22748	CA4
T83011	DI0115	Dementia	[ICD-11: 6D80-6D8Z]	P27338	MAOB
T83011	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P27338	MAOB
T83011	DI0190	Hypertension	[ICD-11: BA00-BA04]	P27338	MAOB
T83011	DI0243	Malaria	[ICD-11: 1F40-1F45]	P27338	MAOB
T83011	DI0264	Migraine	[ICD-11: 8A80]	P27338	MAOB
T83011	DI0331	Parkinsonism	[ICD-11: 8A00]	P27338	MAOB
T20891	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q15118	PDK1
T33584	DI0298	Neuropathy	[ICD-11: 8C0Z]	P42261	GRIA1
T26623	DI0298	Neuropathy	[ICD-11: 8C0Z]	P15121	AKR1B1
T26623	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P15121	AKR1B1
T63816	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P56524	HDAC4
T23471	DI0229	Left ventricular failure	[ICD-11: BD11]	P05164	MPO
T23471	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	P05164	MPO
T51191	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q92769	HDAC2
T51191	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q92769	HDAC2
T66665	DI0087	Chronic pain	[ICD-11: MG30]	P35354	PTGS2
T66665	DI0145	Female pelvic pain	[ICD-11: GA34]	P35354	PTGS2
T66665	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P35354	PTGS2
T66665	DI0207	Indeterminate colitis	[ICD-11: DD72]	P35354	PTGS2
T66665	DI0227	Knee osteoarthritis	[ICD-11: FA01]	P35354	PTGS2
T66665	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P35354	PTGS2
T66665	DI0324	Pain	[ICD-11: MG30-MG3Z]	P35354	PTGS2
T66665	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P35354	PTGS2
T66665	DI0416	Tuberculosis	[ICD-11: 1B10-1B12]	P35354	PTGS2
T60857	DI0145	Female pelvic pain	[ICD-11: GA34]	P42330	AKR1C3
T60366	DI0020	African trypanosomiasis	[ICD-11: 1F51]	P11926	ODC1
T40097	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P45983	MAPK8
T85421	DI0125	Dissociative neurological symptom disorder	[ICD-11: 6B60]	P53779	MAPK10
T83193	DI0163	General pain disorder	[ICD-11: 8E43]	Q8NER1	TRPV1
T02562	DI0025	Alzheimer disease	[ICD-11: 8A20]	O14684	PTGES
T16347	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P18031	PTPN1
T16347	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P18031	PTPN1
T16347	DI0308	Obesity	[ICD-11: 5B80-5B81]	P18031	PTPN1
T16347	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P18031	PTPN1
T26500	DI0037	Asthma	[ICD-11: CA23]	Q9H3N8	HRH4
T26500	DI0039	Atopic eczema	[ICD-11: EA80]	Q9H3N8	HRH4
T26500	DI0351	Psoriasis	[ICD-11: EA90]	Q9H3N8	HRH4
T26500	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9H3N8	HRH4
T26500	DI0432	Vasomotor/allergic rhinitis	[ICD-11: CA08]	Q9H3N8	HRH4
T21307	DI0011	Acute laryngitis/tracheitis	[ICD-11: CA05]	P49137	MAPKAPK2
T21307	DI0181	Hidradenitis suppurativa	[ICD-11: ED92]	P49137	MAPKAPK2
T21307	DI0269	Monogenic autoinflammatory syndrome	[ICD-11: 4A60]	P49137	MAPKAPK2
T21307	DI0334	Peritoneal cancer	[ICD-11: 2C51]	P49137	MAPKAPK2
T21307	DI0352	Psoriatic arthritis	[ICD-11: FA21]	P49137	MAPKAPK2
T21307	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P49137	MAPKAPK2
T21307	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P49137	MAPKAPK2
T68251	DI0238	Lung cancer	[ICD-11: 2C25]	P08253	MMP2
T54156	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P14780	MMP9
T54156	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P14780	MMP9
T54156	DI0395	Stomach cancer	[ICD-11: 2B72]	P14780	MMP9
T54156	DI0419	Ulcerative colitis	[ICD-11: DD71]	P14780	MMP9
T00140	DI0037	Asthma	[ICD-11: CA23]	P09917	ALOX5
T00140	DI0147	Filariasis	[ICD-11: 1F66]	P09917	ALOX5
T00140	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P09917	ALOX5
T52450	DI0238	Lung cancer	[ICD-11: 2C25]	P03956	MMP1
T72702	DI0075	Cervical cancer	[ICD-11: 2C77]	P13726	F3
T02551	DI0051	Bipolar disorder	[ICD-11: 6A60]	P35462	DRD3
T02551	DI0331	Parkinsonism	[ICD-11: 8A00]	P35462	DRD3
T59679	DI0161	Gastro-oesophageal reflux disease	[ICD-11: DA22]	Q13639	HTR4
T59679	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	Q13639	HTR4
T25258	DI0238	Lung cancer	[ICD-11: 2C25]	P08183	ABCB1
T82668	DI0265	Mild neurocognitive disorder	[ICD-11: 6D71]	Q8N5Z0	AADAT
T82668	DI0370	Schizophrenia	[ICD-11: 6A20]	Q8N5Z0	AADAT
T28484	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P52732	KIF11
T28484	DI0172	Head and neck cancer	[ICD-11: 2D42]	P52732	KIF11
T28484	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P52732	KIF11
T28484	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P52732	KIF11
T28484	DI0274	Multiple myeloma	[ICD-11: 2A83]	P52732	KIF11
T28484	DI0321	Ovarian cancer	[ICD-11: 2C73]	P52732	KIF11
T28484	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P52732	KIF11
T28484	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P52732	KIF11
T62449	DI0027	Anal cancer	[ICD-11: 2C00]	O14757	CHEK1
T62449	DI0172	Head and neck cancer	[ICD-11: 2D42]	O14757	CHEK1
T62449	DI0183	Hodgkin lymphoma	[ICD-11: 2B30]	O14757	CHEK1
T62449	DI0238	Lung cancer	[ICD-11: 2C25]	O14757	CHEK1
T62449	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O14757	CHEK1
T62449	DI0321	Ovarian cancer	[ICD-11: 2C73]	O14757	CHEK1
T62449	DI0326	Pancreatic cancer	[ICD-11: 2C10]	O14757	CHEK1
T62449	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O14757	CHEK1
T63505	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P00519	ABL1
T63505	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P00519	ABL1
T63505	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P00519	ABL1
T63505	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P00519	ABL1
T99799	DI0324	Pain	[ICD-11: MG30-MG3Z]	P06276	BCHE
T99799	DI0411	Tonus and reflex abnormality	[ICD-11: MB47]	P06276	BCHE
T69991	DI0321	Ovarian cancer	[ICD-11: 2C73]	P30291	WEE1
T69991	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P30291	WEE1
T69991	DI0429	Uterine ligament/parametrium/uterine adnexa neoplasm	[ICD-11: 2C72]	P30291	WEE1
T70176	DI0060	Brain cancer	[ICD-11: 2A00]	P24941	CDK2
T70176	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P24941	CDK2
T70176	DI0238	Lung cancer	[ICD-11: 2C25]	P24941	CDK2
T70176	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P24941	CDK2
T70176	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P24941	CDK2
T70176	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P24941	CDK2
T70176	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P24941	CDK2
T70176	DI0406	Thymoma	[ICD-11: 2C27]	P24941	CDK2
T79031	DI0025	Alzheimer disease	[ICD-11: 8A20]	P56817	BACE1
T87023	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P25105	PTAFR
T83145	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P19838	NFKB1
T83145	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P19838	NFKB1
T38529	DI0003	Abortion	[ICD-11: JA00]	P43116	PTGER2
T38529	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	P43116	PTGER2
T38529	DI0121	Diabetic foot ulcer	[ICD-11: BD54]	P43116	PTGER2
T38529	DI0166	Glaucoma	[ICD-11: 9C61]	P43116	PTGER2
T38529	DI0356	Pulmonary hypertension	[ICD-11: BB01]	P43116	PTGER2
T38529	DI0378	Sexual dysfunction	[ICD-11: HA00-HA01]	P43116	PTGER2
T38529	DI0413	Transplant rejection	[ICD-11: NE84]	P43116	PTGER2
T59626	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	Q15722	LTB4R
T59626	DI0355	Pulmonary disease	[ICD-11: 1B10-1F85]	Q15722	LTB4R
T59626	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	Q15722	LTB4R
T17048	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P11388	TOP2A
T17048	DI0225	Kaposi sarcoma	[ICD-11: 2B57]	P11388	TOP2A
T17048	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P11388	TOP2A
T89988	DI0083	Chronic kidney disease	[ICD-11: GB61]	P13500	CCL2
T89988	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P13500	CCL2
T89988	DI0087	Chronic pain	[ICD-11: MG30]	P13500	CCL2
T89988	DI0184	Human immunodeficiency virus disease	[ICD-11: 1C60-1C62]	P13500	CCL2
T89988	DI0252	Melanoma	[ICD-11: 2C30]	P13500	CCL2
T89988	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	P13500	CCL2
T89988	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P13500	CCL2
T89988	DI0326	Pancreatic cancer	[ICD-11: 2C10]	P13500	CCL2
T89988	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P13500	CCL2
T89988	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P13500	CCL2
T06093	DI0168	Graft-versus-host disease	[ICD-11: 4B24]	O75116	ROCK2
T25956	DI0346	Prostate cancer	[ICD-11: 2C82]	Q09472	EP300
T25956	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q09472	EP300
T18477	DI0015	Acute upper respiratory infection	[ICD-11: CA07]	P07900	HSP90AA1
T18477	DI0037	Asthma	[ICD-11: CA23]	P07900	HSP90AA1
T28713	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O96017	CHEK2
T40276	DI0123	Diffuse large B-cell lymphoma	[ICD-11: 2A81]	P05771	PRKCB
T40276	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P05771	PRKCB
T40276	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P05771	PRKCB
T60182	DI0193	Hypo-glycaemia	[ICD-11: 5A41]	P47871	GCGR
T78429	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	O15111	CHUK
T99057	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	Q02750	MAP2K1
T99057	DI0336	Phakomatoses/hamartoneoplastic syndrome	[ICD-11: LD2D]	Q02750	MAP2K1
T40474	DI0238	Lung cancer	[ICD-11: 2C25]	P08581	MET
T40474	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P08581	MET
T40474	DI0407	Thyroid cancer	[ICD-11: 2D10]	P08581	MET
T26203	DI0436	Visual system disease	[ICD-11: 9E1Z]	P05362	ICAM1
T72835	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P16581	SELE
T72835	DI0037	Asthma	[ICD-11: CA23]	P16581	SELE
T72835	DI0039	Atopic eczema	[ICD-11: EA80]	P16581	SELE
T72835	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P16581	SELE
T72835	DI0088	Circulatory system disease	[ICD-11: BE2Z]	P16581	SELE
T72835	DI0190	Hypertension	[ICD-11: BA00-BA04]	P16581	SELE
T72835	DI0351	Psoriasis	[ICD-11: EA90]	P16581	SELE
T99160	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q9HBH9	MKNK2
T99160	DI0095	Colorectal cancer	[ICD-11: 2B91]	Q9HBH9	MKNK2
T99160	DI0235	Liver cancer	[ICD-11: 2C12]	Q9HBH9	MKNK2
T99160	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q9HBH9	MKNK2
T99160	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9HBH9	MKNK2
T11451	DI0095	Colorectal cancer	[ICD-11: 2B91]	Q9NR96	TLR9
T11451	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	Q9NR96	TLR9
T11451	DI0252	Melanoma	[ICD-11: 2C30]	Q9NR96	TLR9
T11451	DI0346	Prostate cancer	[ICD-11: 2C82]	Q9NR96	TLR9
T78932	DI0351	Psoriasis	[ICD-11: EA90]	P29597	TYK2
T97613	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P48039	MTNR1A
T48268	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P49286	MTNR1B
T47623	DI0020	African trypanosomiasis	[ICD-11: 1F51]	Q9Y251	HPSE
T47623	DI0310	Ocular disease	[ICD-11: N.A.]	Q9Y251	HPSE
T18876	DI0037	Asthma	[ICD-11: CA23]	P35408	PTGER4
T18876	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P35408	PTGER4
T18876	DI0264	Migraine	[ICD-11: 8A80]	P35408	PTGER4
T18876	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P35408	PTGER4
T18876	DI0324	Pain	[ICD-11: MG30-MG3Z]	P35408	PTGER4
T18876	DI0360	Rectum cancer	[ICD-11: 2B92]	P35408	PTGER4
T18876	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P35408	PTGER4
T18876	DI0414	Transplanted organ/tissue	[ICD-11: QB63]	P35408	PTGER4
T75596	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P50579	METAP2
T55398	DI0039	Atopic eczema	[ICD-11: EA80]	Q9NWZ3	IRAK4
T55398	DI0109	Cutaneous lupus erythematosus	[ICD-11: EB50-EB5Z]	Q9NWZ3	IRAK4
T55398	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q9NWZ3	IRAK4
T55398	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	Q9NWZ3	IRAK4
T55398	DI0351	Psoriasis	[ICD-11: EA90]	Q9NWZ3	IRAK4
T55398	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9NWZ3	IRAK4
T49898	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P06493	CDK1
T49898	DI0238	Lung cancer	[ICD-11: 2C25]	P06493	CDK1
T49898	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P06493	CDK1
T49898	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P06493	CDK1
T49898	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P06493	CDK1
T68782	DI0102	Coronary atherosclerosis	[ICD-11: BA52]	Q13258	PTGDR
T05849	DI0122	Diagnostic imaging	[ICD-11: N.A.]	P32239	CCKBR
T05849	DI0327	Pancreatic internal secretion disorder	[ICD-11: 5A4Y]	P32239	CCKBR
T71266	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q9Y243	AKT3
T23995	DI0413	Transplant rejection	[ICD-11: NE84]	Q04759	PRKCQ
T99641	DI0396	Substance abuse	[ICD-11: 6C40]	P30837	ALDH1B1
T40111	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P20839	IMPDH1
T40111	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P20839	IMPDH1
T40111	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	P20839	IMPDH1
T40111	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P20839	IMPDH1
T40111	DI0413	Transplant rejection	[ICD-11: NE84]	P20839	IMPDH1
T89360	DI0413	Transplant rejection	[ICD-11: NE84]	P12268	IMPDH2
T51565	DI0104	Coronavirus infection	[ICD-11: 1D92]	P68400	CSNK2A1
T51565	DI0235	Liver cancer	[ICD-11: 2C12]	P68400	CSNK2A1
T51565	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P68400	CSNK2A1
T15855	DI0300	Neutropenia	[ICD-11: 4B00]	Q6V1X1	DPP8
T66252	DI0300	Neutropenia	[ICD-11: 4B00]	Q86TI2	DPP9
T23787	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q16875	PFKFB3
T18299	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9UQM7	CAMK2A
T82739	DI0213	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	P03952	KLKB1
T82739	DI0364	Retinal vascular occlusion	[ICD-11: 9B74]	P03952	KLKB1
T56556	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	Q9UNQ0	ABCG2
T56556	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q9UNQ0	ABCG2
T78429	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	O15111	CHUK
T03279	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	P51812	RPS6KA3
T96892	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	Q14680	MELK
T96892	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q14680	MELK
T96892	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	Q14680	MELK
T96892	DI0250	Mature B-cell lymphoma	[ICD-11: 2A85]	Q14680	MELK
T96892	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	Q14680	MELK
T96892	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	Q14680	MELK
T83202	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	Q15418	RPS6KA1
T51282	DI0166	Glaucoma	[ICD-11: 9C61]	Q13464	ROCK1
T45593	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P10636	MAPT
T45593	DI0025	Alzheimer disease	[ICD-11: 8A20]	P10636	MAPT
T45593	DI0265	Mild neurocognitive disorder	[ICD-11: 6D71]	P10636	MAPT
T88285	DI0210	Influenza	[ICD-11: 1E30-1E32]	Q04760	GLO1
T98642	DI0291	Nasopharyngeal cancer	[ICD-11: 2B6B]	Q96KB5	PBK
T16808	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q99873	PRMT1
T76414	DI0024	Alpha-1-antitrypsin deficiency	[ICD-11: 5C5A]	Q13224	GRIN2B
T86552	DI0060	Brain cancer	[ICD-11: 2A00]	P19438	TNFRSF1A
T86552	DI0321	Ovarian cancer	[ICD-11: 2C73]	P19438	TNFRSF1A
T88505	DI0038	Ataxic disorder	[ICD-11: 8A03]	Q16236	NFE2L2
T95302	DI0005	Acne vulgaris	[ICD-11: ED80]	P33032	MC5R
T95302	DI0371	Sebaceous gland disorder	[ICD-11: ED91]	P33032	MC5R
T73694	DI0070	Cardiovascular disease	[ICD-11: BA00-BE2Z]	Q13882	PTK6
T73694	DI0339	Postoperative inflammation	[ICD-11: 1A00-CA43]	Q13882	PTK6
T84397	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9H4B7	TUBB1
T92185	DI0264	Migraine	[ICD-11: 8A80]	P41586	ADCYAP1R1
T59550	DI0146	Fibrosis	[ICD-11: GA14-GC01]	P11717	IGF2R
T59550	DI0368	Sarcoidosis	[ICD-11: 4B20]	P11717	IGF2R
T28887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9BY41	HDAC8
T62391	DI0298	Neuropathy	[ICD-11: 8C0Z]	P42263	GRIA3
T82391	DI0069	Cardiomyopathy	[ICD-11: BC43]	Q9P0J0	NDUFA13
T77195	DI0331	Parkinsonism	[ICD-11: 8A00]	P03897	MT-ND3