Compound details

L-Phenylalanine

Compound ID	CDAMM00256
Common name	L-Phenylalanine
IUPAC name	(2S)-2-amino-3-phenylpropanoic acid
Molecular formula	C₉H₁₁NO₂

Experimental data

Retention time	15.739
Adduct	[M+H]+
Actual mz	166.087
Theoretical mz	166.086
Error	2.67
Ionizaton mode	Positive
Instrument type	LC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score	7.57

Identifiers and class information

Inchi key	BLGXFZZNTVWLAY-SCYLSFHTSA-N
Smiles	C1=CC=C(C=C1)CC(C(=O)O)N
Superclass	Alkaloids and derivatives
Class	Yohimbine alkaloids

Plant source

Tribulus terrestris L.

Pedalium murex L.

Plumbago zeylanica Linn.

Moeroris amara (Schumach. & Thonn.) R.W.Bouman

External sources

HMDB ID	HMDB0000159
KNApSAcK ID	C00001386
FooDB ID	FDB004940
DrugBank ID	DB00120
ChEBI ID	CHEBI:16998
Pubchem Compound ID	6140
PlantCyc ID	CPD-216
UNPD ID	UNPD26171
Coconut ID
LipidMAPS ID
NANPDB ID

Pharmacokinetic properties

Number of descriptor values(#stars)	0
Number of non-conjugated amine groups (#amine)	1
Number of amidine and guanidine groups (#amidine)	0
Number of carboxylic acid groups (#acid)	1
Number of non-conjugated amide groups (#amide)	0
Number of rotatable bonds (#rotor)	4
Number of reactive functional groups (#rtvFG)	0
Predicted central nervous system activity (CNS)	-1
Molecular weight (mol_MW)	165.191
Computed dipole moment(dipole)	5.993
Total solvent accessible surface area (SASA)	375.327
Hydrophobic component of SASA (FOSA)	49.112
Hydrophilic component of SASA (FISA)	140.434
Pie component of the SASA (PISA)	185.781
Weakly polar component of the SASA (WPSA)	0
Total solvent accesible volume (volume)	600.742
Number of hydrogen bond donors (donorHB)	3
Number of hydrogen bond acceptors (accptHB)	3
Free energy of solvation of dipole (dip^2/V)	0.0597952
Index of cohesive interaction in solids (ACxDN^.5/SA)	0.0138444
Globularity descriptor (glob)	0.917377
Predicted polarizability in cubic angstroms (QPpolrz)	17.094
Predicted hexadecane/gas partition coefficient (QPlogPC16)	6.919
Predicted octanol/gas partition coefficient (QPlogPoct)	12.071
Predicted water/gas partition coefficient (QPlogPw)	9.308
Predicted octanol/water partition coefficient (QPlogPo/w)	-1.145
Predicted aqueous solubility (QPlogS)	-0.732
Conformation-independent predicted aqueous solubility (CIQPlogS)	-0.655
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)	-2.674
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)	29.152
Predicted brain/blood partition coefficient (QPlogBB)	-0.392
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)	15.246
Predicted skin permeability, log Kp (QPlogKp)	-5.132
PM3 calculated ionization potential (IP(ev))	9.422
PM3 calculated electron affinity (EA(eV))	-0.321
Number of likely metabolic reactions (#metab)	4
Prediction of binding to human serum albumin (QPlogKhsa)	-0.725
Predicted qualitative human oral absorption (HumanOralAbsorption)	2
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)	46.456
Solvent-accessible surface area of fluorine atoms (SAFluorine)	0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)	0
Van der Waals surface area (PSA)	72.905
Number of nitrogen and oxygen atoms (#NandO)	3
Number of violations of Lipinski’s rule of five (RuleOfFive)	0
Number of violations of Jorgensen’s rule of three (RuleOfThree)	0

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID	Gene name	Target name	TTD_ID	Prediction source
P06241	FYN	Tyrosine-protein kinase FYN	T17980	SwissTargetPrediction
P00533	EGFR	Epidermal growth factor receptor erbB1	T59328	SwissTargetPrediction
Q86X55	CARM1	Histone-arginine methyltransferase CARM1	T12837	SEA
O43570	CA12	Carbonic anhydrase XII	T16987	SEA
Q16790	CA9	Carbonic anhydrase IX	T64567	SEA
P29475	NOS1	Nitric-oxide synthase, brain	T16117	SEA
P35228	NOS2	Nitric oxide synthase, inducible	T02703	SEA
P29474	NOS3	Nitric-oxide synthase, endothelial	T06046	SEA
Q16853	AOC3	Amine oxidase, copper containing	T69619	SEA
Q99720	SIGMAR1	Sigma opioid receptor	T46360	SEA
P24046	GABRR1	GABA receptor rho-1 subunit	T99665	SwissTargetPrediction
P15144	ANPEP	Aminopeptidase N	T67272	SwissTargetPrediction and SEA
O75899	GABBR2	GABA-B receptor	T42446	SwissTargetPrediction
P00734	F2	Thrombin	T94033	SEA
P09960	LTA4H	Leukotriene A4 hydrolase	T03691	SEA
O75899	GABBR2	GABA-B receptor	T42446	SwissTargetPrediction
P54289	CACNA2D1	Voltage-gated calcium channel alpha2/delta subunit 1 (by homology)	T84316	SwissTargetPrediction
P0DMS8	ADORA3	Adenosine A3 receptor	T36059	SwissTargetPrediction
Q14833	GRM4	Metabotropic glutamate receptor 4	T99402	SEA
O00222	GRM8	Metabotropic glutamate receptor 8	T77548	SEA
P00915	CA1	Carbonic anhydrase I	T13201	SEA
P00918	CA2	Carbonic anhydrase II	T20401	SEA
P06239	LCK	Tyrosine-protein kinase LCK	T12499	SwissTargetPrediction
Q9NTG7	SIRT3	NAD-dependent deacetylase sirtuin 3	T91959	SEA
Q8IXJ6	SIRT2	NAD-dependent deacetylase sirtuin 2	T83904	SEA
Q4U2R8	SLC22A6	Solute carrier family 22 member 6 (by homology)	T70680	SEA
P08514	ITGA2B	Integrin alpha-IIb/beta-3	T50688	SEA
P27487	DPP4	Dipeptidyl peptidase IV	T31391	SEA
P98170	XIAP	Inhibitor of apoptosis protein 3	T16769	SEA
P08473	MME	Neprilysin	T05409	SEA
P34913	EPHX2	Epoxide hydratase	T35734	SEA
P43166	CA7	Carbonic anhydrase VII	T37541	SEA
P23280	CA6	Carbonic anhydrase VI	T06569	SEA
Q9ULX7	CA14	Carbonic anhydrase XIV	T31992	SEA
O60341	KDM1A	Lysine-specific histone demethylase 1	T16739	SwissTargetPrediction
P31645	SLC6A4	Serotonin transporter (by homology)	T27812	SwissTargetPrediction
Q96RJ0	TAAR1	Trace amine-associated receptor 1 (by homology)	T99524	SwissTargetPrediction and SEA
P08913	ADRA2A	Alpha-2a adrenergic receptor	T11448	SwissTargetPrediction
P43005	SLC1A1	Excitatory amino acid transporter 3	T31721	SEA
P39086	GRIK1	Glutamate receptor ionotropic kainate 1	T73495	SEA
Q13002	GRIK2	Glutamate receptor ionotropic kainate 2	T58178	SEA
Q14832	GRM3	Metabotropic glutamate receptor 3	T02719	SEA
O15303	GRM6	Metabotropic glutamate receptor 6	T55956	SEA
P42261	GRIA1	Glutamate receptor ionotropic, AMPA 1	T33584	SEA
Q16478	GRIK5	Glutamate receptor ionotropic kainate 5	T87930	SEA
Q13003	GRIK3	Glutamate receptor ionotropic kainate 3	T68876	SEA
P42262	GRIA2	Glutamate receptor ionotropic, AMPA 2	T42392	SEA
P43235	CTSK	Cathepsin K	T11388	SEA
Q92769	HDAC2	Histone deacetylase 2	T51191	SEA
Q9H3R0	KDM4C	Lysine-specific demethylase 4C	T73863	SwissTargetPrediction
P23141	CES1	Acyl coenzyme A:cholesterol acyltransferase	T76369	SEA
P10145	CXCL8	Interleukin-8	T22658	SEA
Q9H4A4	RNPEP	Aminopeptidase B	T57818	SEA
Q6B0I6	KDM4D	Lysine-specific demethylase 4D	T17036	SwissTargetPrediction
Q96IY4	CPB2	Carboxypeptidase B2 isoform A	T98022	SwissTargetPrediction and SEA
P12955	PEPD	Xaa-Pro dipeptidase	T94823	SwissTargetPrediction and SEA
O15229	KMO	Kynurenine 3-monooxygenase	T50973	SEA
P07101	TH	Tyrosine 3-hydroxylase	T62390	SwissTargetPrediction and SEA
Q16719	KYNU	Kynureninase	T99912	SEA
P18031	PTPN1	Protein-tyrosine phosphatase 1B	T16347	SEA
Q07075	ENPEP	Aminopeptidase A	T31956	SwissTargetPrediction and SEA
Q01650	SLC7A5	L-type amino acid transporter 1 (by homology)	T48330	SwissTargetPrediction and SEA
P14902	IDO1	Indoleamine 2,3-dioxygenase	T89697	SEA
Q07869	PPARA	Peroxisome proliferator-activated receptor alpha	T86591	SEA
Q03181	PPARD	Peroxisome proliferator-activated receptor delta	T36557	SEA
O14842	FFAR1	Free fatty acid receptor 1	T25608	SEA
Q04609	FOLH1	Glutamate carboxypeptidase II	T97071	SwissTargetPrediction
P08253	MMP2	Matrix metalloproteinase 2	T68251	SEA
P22894	MMP8	Matrix metalloproteinase 8	T08856	SEA
P08254	MMP3	Matrix metalloproteinase 3	T86702	SEA
P14780	MMP9	Matrix metalloproteinase 9	T54156	SEA
P09917	ALOX5	Arachidonate 5-lipoxygenase	T00140	SEA
P03956	MMP1	Matrix metalloproteinase 1	T52450	SEA
P17655	CAPN2	Calpain 2	T86837	SEA
P23975	SLC6A2	Norepinephrine transporter	T21945	SwissTargetPrediction
P35372	OPRM1	Mu opioid receptor	T47768	SEA
P41145	OPRK1	Kappa Opioid receptor	T60693	SEA
P10827	THRA	Thyroid hormone receptor alpha	T79591	SEA
P10828	THRB	Thyroid hormone receptor beta-1	T98933	SEA
P27695	APEX1	DNA-(apurinic or apyrimidinic site) lyase	T13348	SEA
P15086	CPB1	Carboxypeptidase B	T36725	SEA
P52732	KIF11	Kinesin-like protein 1	T28484	SEA
P09237	MMP7	Matrix metalloproteinase 7	T73475	SEA
P35270	SPR	Substance-P receptor	T47094	SwissTargetPrediction and SEA
P04229	HLA-DRB1	HLA class II histocompatibility antigen DRB1-1	T83611	SEA
P07711	CTSL	Cathepsin L	T98691	SEA
P07858	CTSB	Cathepsin (B and K)	T61746	SEA
P41143	OPRD1	Delta opioid receptor	T58992	SEA
P23946	CMA1	Chymase	T05114	SEA
P37231	PPARG	Peroxisome proliferator-activated receptor gamma	T58921	SEA
P49356	FNTB	Farnesyl protein transferase	T13127	SEA
Q9UHL4	DPP7	Dipeptidyl peptidase II	T50773	SEA
P35348	ADRA1A	Alpha-1a adrenergic receptor	T92609	SwissTargetPrediction
P31749	AKT1	Serine/threonine-protein kinase AKT	T67619	SEA
Q12884	FAP	Fibroblast activation protein alpha (by homology)	T53764	SEA
P25774	CTSS	Cathepsin S	T68290	SEA
P09211	GSTP1	Glutathione S-transferase Pi	T21669	SEA
Q6P179	ERAP2	Endoplasmic reticulum aminopeptidase 2	T65818	SEA
P06870	KLK1	Kallikrein 1	T40000	SEA
P20151	KLK2	Kallikrein 2	T01908	SEA
P48039	MTNR1A	Melatonin receptor 1A	T97613	SEA
P49286	MTNR1B	Melatonin receptor 1B	T48268	SEA
P18089	ADRA2B	Alpha-2b adrenergic receptor	T41580	SwissTargetPrediction
P00813	ADA	Adenosine deaminase	T03661	SEA
P04439	HLA-A	HLA class I histocompatibility antigen A-3	T08985	SEA
P50579	METAP2	Methionine aminopeptidase 2	T75596	SEA
Q9ULA0	DNPEP	Aspartyl aminopeptidase	T45287	SEA
Q9BYF1	ACE2	Angiotensin-converting enzyme 2	T27889	SEA
P42892	ECE1	Endothelin-converting enzyme 1	T50970	SEA
P30307	CDC25C	Dual specificity phosphatase Cdc25C	T40569	SEA
P05556	ITGB1	Integrin alpha2/beta1	T01851	SEA
Q9ULW8	PADI3	Protein-arginine deiminase type-3	T36612	SEA
Q9UM07	PADI4	Protein-arginine deiminase type-4	T50429	SEA
P15085	CPA1	Carboxypeptidase A1	T33966	SEA
Q99895	CTRC	Chymotrypsin C	T10118	SEA
P31751	AKT2	Serine/threonine-protein kinase AKT2	T94621	SEA
Q9Y243	AKT3	Serine/threonine-protein kinase AKT	T71266	SEA
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	T30219	SEA
P03952	KLKB1	Plasma kallikrein	T82739	SEA
O60760	HPGDS	Hematopoietic prostaglandin D synthase	T19433	SEA
P14679	TYR	Tyrosinase	T97035	SEA
P43003	SLC1A3	Excitatory amino acid transporter 1	T86582	SEA
P46059	SLC15A1	Oligopeptide transporter small intestine isoform	T91180	SwissTargetPrediction
Q9Y3Q0	NAALAD2	NAALADase II	T70036	SEA
Q92820	GGH	Gamma-glutamyl hydrolase	T71646	SEA
O15151	MDM4	Protein Mdm4	T36741	SEA
Q14524	SCN5A	Sodium channel protein type V alpha subunit	T39716	SEA
Q13526	PIN1	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	T16308	SEA
P29371	TACR3	Neurokinin 3 receptor	T29683	SEA
Q9UIQ6	LNPEP	Cystinyl aminopeptidase	T97537	SEA
P41240	CSK	Tyrosine-protein kinase CSK	T08741	SEA
Q9UK32	RPS6KA6	Ribosomal protein S6 kinase alpha 6	T95878	SEA
Q04760	GLO1	Glyoxalase I	T88285	SEA
P20248	CCNA2	CDK2/Cyclin A	T58470	SEA
P03951	F11	Coagulation factor XI	T46040	SEA
Q9UNI1	CELA1	Elastase 1	T22839	SEA
P53634	CTSC	Dipeptidyl peptidase I	T70490	SEA
O75908	SOAT2	Acyl coenzyme A:cholesterol acyltransferase 2	T14463	SEA
Q9H1C0	LPAR5	Lysophosphatidic acid receptor 5	T18616	SEA
P05089	ARG1	Arginase-1 (by homology)	T63224	SEA
P06734	FCER2	Immunoglobulin epsilon Fc receptor	T67207	SEA
P12004	PCNA	Proliferating cell nuclear antigen	T21782	SEA
P13612	ITGA4	Integrin alpha-4	T97587	SEA
Q9NZ08	ERAP1	Endoplasmic reticulum aminopeptidase 1	T72849	SEA
Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	T99340	SEA
P21462	FPR1	Formyl peptide receptor 1	T87831	SEA
Q03405	PLAUR	Urokinase plasminogen activator surface receptor	T74363	SEA
Q6DWJ6	GPR139	Probable G-protein coupled receptor 139	T84439	SEA
Q9Y337	KLK5	Kallikrein 5	T11808	SEA
P08311	CTSG	Cathepsin G	T86385	SEA
P35499	SCN4A	Sodium channel protein type IV alpha subunit	T02546	SEA
Q16881	TXNRD1	Thioredoxin reductase 1	T84581	SEA
P15169	CPN1	Carboxypeptidase N, catalytic subunit	T34471	SEA
O43895	XPNPEP2	Xaa-Pro aminopeptidase 2	T68320	SEA
P09668	CTSH	Cathepsin (H and K)	T40103	SEA
O95822	MLYCD	Malonyl-CoA decarboxylase	T98078	SEA
O95551	TDP2	Tyrosyl-DNA phosphodiesterase 2	T04696	SEA
Q99571	P2RX4	P2X purinoceptor 4	T60330	SEA
Q8IWU9	TPH2	Tryptophan hydroxylase	T51593	SEA
Q9UPY5	SLC7A11	Cystine/glutamate transporter	T11615	SEA
Q04609	FOLH1	Glutamate carboxypeptidase II	T97071	SEA
Q4U2R8	SLC22A6	Solute carrier family 22 member 6 (by homology)	T70680	SEA
Q6V1X1	DPP8	Dipeptidyl peptidase VIII	T15855	SEA
Q86TI2	DPP9	Dipeptidyl peptidase IX	T66252	SEA
Q9BWQ3	ASCT2	Alanine/serine/cysteine transporter 2	T59493	SEA
Q9GZQ6	NPFFR1	Neuropeptide FF receptor 1	T79780	SEA
Q9Y5X5	NPFFR2	Neuropeptide FF receptor 2	T90818	SEA
O60259	KLK8	Neuropsin	T43289	SEA
Q9BY41	HDAC8	Histone deacetylase 8	T28887	SEA
Q9Y5K2	KLK4	Kallikrein-4	T79400	SEA
P37088	SCNN1A	Amiloride-sensitive sodium channel	T52173	SEA
P04632	CAPNS1	HUMAN calpain-1 or calpain small subunit 1 heterodimer	T00099	SEA
P00480	OTC	Ornithine transcarbamylase	T52098	SEA
P42263	GRIA3	Glutamate receptor AMPA 3	T62391	SEA
Q6ZQN7	SLCO4C1	Organic anion transporter M1	T36053	SEA
P49356	FNTB	Farnesyl protein transferase	T13127	SEA
Q8IWU9	TPH2	Tryptophan hydroxylase	T51593	SEA

Target associated diseases

TTD_ID	Disease_ID	Disease name	ICD_11	Uniprot ID	Gene names
T17980	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P06241	FYN
T59328	DI0030	Angina pectoris	[ICD-11: BA40]	P00533	EGFR
T59328	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P00533	EGFR
T59328	DI0095	Colorectal cancer	[ICD-11: 2B91]	P00533	EGFR
T59328	DI0121	Diabetic foot ulcer	[ICD-11: BD54]	P00533	EGFR
T59328	DI0220	Ischemia	[ICD-11: 8B10-8B11]	P00533	EGFR
T59328	DI0238	Lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0303	Non-small-cell lung cancer	[ICD-11: 2C25]	P00533	EGFR
T59328	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P00533	EGFR
T59328	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P00533	EGFR
T59328	DI0420	Unspecific body region injury	[ICD-11: ND56]	P00533	EGFR
T16987	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	O43570	CA12
T16987	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	O43570	CA12
T64567	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q16790	CA9
T16117	DI0173	Headache	[ICD-11: 8A80-8A84]	P29475	NOS1
T16117	DI0264	Migraine	[ICD-11: 8A80]	P29475	NOS1
T02703	DI0083	Chronic kidney disease	[ICD-11: GB61]	P35228	NOS2
T02703	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P35228	NOS2
T02703	DI0375	Sepsis	[ICD-11: 1G40-1G41]	P35228	NOS2
T02703	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P35228	NOS2
T06046	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P29474	NOS3
T69619	DI0190	Hypertension	[ICD-11: BA00-BA04]	Q16853	AOC3
T46360	DI0105	Cough	[ICD-11: MD12]	Q99720	SIGMAR1
T67272	DI0351	Psoriasis	[ICD-11: EA90]	P15144	ANPEP
T42446	DI0117	Depression	[ICD-11: 6A70-6A7Z]	O75899	GABBR2
T42446	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	O75899	GABBR2
T42446	DI0275	Multiple sclerosis	[ICD-11: 8A40]	O75899	GABBR2
T42446	DI0290	Narcolepsy	[ICD-11: 7A20]	O75899	GABBR2
T94033	DI0052	Bleeding disorder	[ICD-11: GA20-GA21]	P00734	F2
T94033	DI0091	Coagulation defect	[ICD-11: 3B10]	P00734	F2
T94033	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P00734	F2
T94033	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P00734	F2
T94033	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P00734	F2
T94033	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P00734	F2
T94033	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P00734	F2
T94033	DI0405	Thrombosis	[ICD-11: DB61-GB90]	P00734	F2
T03691	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P09960	LTA4H
T42446	DI0117	Depression	[ICD-11: 6A70-6A7Z]	O75899	GABBR2
T42446	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	O75899	GABBR2
T42446	DI0275	Multiple sclerosis	[ICD-11: 8A40]	O75899	GABBR2
T42446	DI0290	Narcolepsy	[ICD-11: 7A20]	O75899	GABBR2
T84316	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P54289	CACNA2D1
T84316	DI0190	Hypertension	[ICD-11: BA00-BA04]	P54289	CACNA2D1
T36059	DI0351	Psoriasis	[ICD-11: EA90]	P0DMS8	ADORA3
T36059	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P0DMS8	ADORA3
T99402	DI0331	Parkinsonism	[ICD-11: 8A00]	Q14833	GRM4
T13201	DI0166	Glaucoma	[ICD-11: 9C61]	P00915	CA1
T13201	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00915	CA1
T20401	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P00918	CA2
T20401	DI0137	Essential hypertension	[ICD-11: BA00]	P00918	CA2
T20401	DI0166	Glaucoma	[ICD-11: 9C61]	P00918	CA2
T20401	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P00918	CA2
T20401	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P00918	CA2
T20401	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P00918	CA2
T12499	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	P06239	LCK
T83904	DI0365	Retinopathy	[ICD-11: 9B71]	Q8IXJ6	SIRT2
T70680	DI0167	Gout	[ICD-11: FA25]	Q4U2R8	SLC22A6
T70680	DI0206	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Q4U2R8	SLC22A6
T70680	DI0310	Ocular disease	[ICD-11: N.A.]	Q4U2R8	SLC22A6
T50688	DI0007	Acquired hypermelanosis	[ICD-11: ED60]	P08514	ITGA2B
T50688	DI0030	Angina pectoris	[ICD-11: BA40]	P08514	ITGA2B
T50688	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P08514	ITGA2B
T31391	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P27487	DPP4
T31391	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P27487	DPP4
T16769	DI0259	Metastatic lymph node neoplasm	[ICD-11: 2D60]	P98170	XIAP
T05409	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P08473	MME
T35734	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P34913	EPHX2
T35734	DI0190	Hypertension	[ICD-11: BA00-BA04]	P34913	EPHX2
T06569	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	P23280	CA6
T06569	DI0372	Seborrhoeic dermatitis	[ICD-11: EA81]	P23280	CA6
T31992	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q9ULX7	CA14
T31992	DI0204	Inborn metabolism deficiency	[ICD-11: 5C50-5C59]	Q9ULX7	CA14
T16739	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	O60341	KDM1A
T16739	DI0025	Alzheimer disease	[ICD-11: 8A20]	O60341	KDM1A
T16739	DI0138	Ewing sarcoma	[ICD-11: 2B52]	O60341	KDM1A
T16739	DI0238	Lung cancer	[ICD-11: 2C25]	O60341	KDM1A
T16739	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	O60341	KDM1A
T16739	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	O60341	KDM1A
T16739	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	O60341	KDM1A
T16739	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	O60341	KDM1A
T16739	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O60341	KDM1A
T27812	DI0033	Anxiety disorder	[ICD-11: 6B00-6B0Z]	P31645	SLC6A4
T27812	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P31645	SLC6A4
T27812	DI0087	Chronic pain	[ICD-11: MG30]	P31645	SLC6A4
T27812	DI0096	concerning food/fluid intake symptom	[ICD-11: MG43]	P31645	SLC6A4
T27812	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P31645	SLC6A4
T27812	DI0105	Cough	[ICD-11: MD12]	P31645	SLC6A4
T27812	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P31645	SLC6A4
T27812	DI0264	Migraine	[ICD-11: 8A80]	P31645	SLC6A4
T27812	DI0301	Nicotine use disorder	[ICD-11: 6C4A]	P31645	SLC6A4
T27812	DI0308	Obesity	[ICD-11: 5B80-5B81]	P31645	SLC6A4
T27812	DI0324	Pain	[ICD-11: MG30-MG3Z]	P31645	SLC6A4
T99524	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	Q96RJ0	TAAR1
T99524	DI0149	Focal/segmental autonomic disorder	[ICD-11: 8D8A]	Q96RJ0	TAAR1
T99524	DI0290	Narcolepsy	[ICD-11: 7A20]	Q96RJ0	TAAR1
T11448	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P08913	ADRA2A
T11448	DI0317	Opioid use disorder	[ICD-11: 6C43]	P08913	ADRA2A
T11448	DI0396	Substance abuse	[ICD-11: 6C40]	P08913	ADRA2A
T73495	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	P39086	GRIK1
T73495	DI0396	Substance abuse	[ICD-11: 6C40]	P39086	GRIK1
T02719	DI0370	Schizophrenia	[ICD-11: 6A20]	Q14832	GRM3
T33584	DI0298	Neuropathy	[ICD-11: 8C0Z]	P42261	GRIA1
T42392	DI0298	Neuropathy	[ICD-11: 8C0Z]	P42262	GRIA2
T11388	DI0237	Low bone mass disorder	[ICD-11: FB83]	P43235	CTSK
T51191	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	Q92769	HDAC2
T51191	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q92769	HDAC2
T76369	DI0335	Peroxisomal disease	[ICD-11: 5C57]	P23141	CES1
T76369	DI0398	Synthesis disorder	[ICD-11: 5C52-5C59]	P23141	CES1
T22658	DI0324	Pain	[ICD-11: MG30-MG3Z]	P10145	CXCL8
T98022	DI0073	Cerebral ischaemia	[ICD-11: 8B1Z]	Q96IY4	CPB2
T98022	DI0074	Cerebral ischaemic stroke	[ICD-11: 8B11]	Q96IY4	CPB2
T98022	DI0405	Thrombosis	[ICD-11: DB61-GB90]	Q96IY4	CPB2
T62390	DI0019	Adrenomedullary hyperfunction	[ICD-11: 5A75]	P07101	TH
T62390	DI0306	Nutritional deficiency	[ICD-11: 5B50-5B71]	P07101	TH
T99912	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q16719	KYNU
T99912	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q16719	KYNU
T16347	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P18031	PTPN1
T16347	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P18031	PTPN1
T16347	DI0308	Obesity	[ICD-11: 5B80-5B81]	P18031	PTPN1
T16347	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P18031	PTPN1
T31956	DI0190	Hypertension	[ICD-11: BA00-BA04]	Q07075	ENPEP
T89697	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P14902	IDO1
T86591	DI0187	Hyperlipidemia	[ICD-11: 5C80]	Q07869	PPARA
T86591	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	Q07869	PPARA
T86591	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	Q07869	PPARA
T36557	DI0302	Non-alcoholic fatty liver disease	[ICD-11: DB92]	Q03181	PPARD
T36557	DI0308	Obesity	[ICD-11: 5B80-5B81]	Q03181	PPARD
T25608	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	O14842	FFAR1
T97071	DI0122	Diagnostic imaging	[ICD-11: N.A.]	Q04609	FOLH1
T97071	DI0346	Prostate cancer	[ICD-11: 2C82]	Q04609	FOLH1
T68251	DI0238	Lung cancer	[ICD-11: 2C25]	P08253	MMP2
T08856	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P22894	MMP8
T86702	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P08254	MMP3
T86702	DI0179	Hepatitis virus infection	[ICD-11: 1E50-1E51]	P08254	MMP3
T86702	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P08254	MMP3
T86702	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P08254	MMP3
T86702	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P08254	MMP3
T86702	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P08254	MMP3
T86702	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P08254	MMP3
T54156	DI0219	Ischaemic/haemorrhagic stroke	[ICD-11: 8B20]	P14780	MMP9
T54156	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P14780	MMP9
T54156	DI0395	Stomach cancer	[ICD-11: 2B72]	P14780	MMP9
T54156	DI0419	Ulcerative colitis	[ICD-11: DD71]	P14780	MMP9
T00140	DI0037	Asthma	[ICD-11: CA23]	P09917	ALOX5
T00140	DI0147	Filariasis	[ICD-11: 1F66]	P09917	ALOX5
T00140	DI0403	Thrombocytopenia	[ICD-11: 3B64]	P09917	ALOX5
T52450	DI0238	Lung cancer	[ICD-11: 2C25]	P03956	MMP1
T86837	DI0106	COVID-19	[ICD-11: 1D6Y]	P17655	CAPN2
T21945	DI0013	Acute pain	[ICD-11: MG31]	P23975	SLC6A2
T21945	DI0040	Attention deficit hyperactivity disorder	[ICD-11: 6A05]	P23975	SLC6A2
T21945	DI0087	Chronic pain	[ICD-11: MG30]	P23975	SLC6A2
T21945	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P23975	SLC6A2
T21945	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P23975	SLC6A2
T21945	DI0166	Glaucoma	[ICD-11: 9C61]	P23975	SLC6A2
T21945	DI0264	Migraine	[ICD-11: 8A80]	P23975	SLC6A2
T21945	DI0301	Nicotine use disorder	[ICD-11: 6C4A]	P23975	SLC6A2
T21945	DI0308	Obesity	[ICD-11: 5B80-5B81]	P23975	SLC6A2
T21945	DI0324	Pain	[ICD-11: MG30-MG3Z]	P23975	SLC6A2
T21945	DI0395	Stomach cancer	[ICD-11: 2B72]	P23975	SLC6A2
T47768	DI0013	Acute pain	[ICD-11: MG31]	P35372	OPRM1
T47768	DI0059	Bowel habit change	[ICD-11: ME05]	P35372	OPRM1
T47768	DI0087	Chronic pain	[ICD-11: MG30]	P35372	OPRM1
T47768	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	P35372	OPRM1
T47768	DI0105	Cough	[ICD-11: MD12]	P35372	OPRM1
T47768	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P35372	OPRM1
T47768	DI0124	Digestive system disease	[ICD-11: DE2Z]	P35372	OPRM1
T47768	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P35372	OPRM1
T47768	DI0228	Large intestine motility disorder	[ICD-11: DB32]	P35372	OPRM1
T47768	DI0317	Opioid use disorder	[ICD-11: 6C43]	P35372	OPRM1
T47768	DI0324	Pain	[ICD-11: MG30-MG3Z]	P35372	OPRM1
T47768	DI0349	Pruritus	[ICD-11: EC90]	P35372	OPRM1
T47768	DI0374	Sensation disturbance	[ICD-11: MB40]	P35372	OPRM1
T60693	DI0304	Non-specific cutaneous vascular symptom	[ICD-11: ME64]	P41145	OPRK1
T60693	DI0324	Pain	[ICD-11: MG30-MG3Z]	P41145	OPRK1
T60693	DI0349	Pruritus	[ICD-11: EC90]	P41145	OPRK1
T79591	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P10827	THRA
T79591	DI0197	Hypo-thyroidism	[ICD-11: 5A00]	P10827	THRA
T98933	DI0188	Hyper-lipoproteinaemia	[ICD-11: 5C80]	P10828	THRB
T13348	DI0365	Retinopathy	[ICD-11: 9B71]	P27695	APEX1
T13348	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P27695	APEX1
T28484	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	P52732	KIF11
T28484	DI0172	Head and neck cancer	[ICD-11: 2D42]	P52732	KIF11
T28484	DI0241	Lymphoma	[ICD-11: 2A80-2A86]	P52732	KIF11
T28484	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P52732	KIF11
T28484	DI0274	Multiple myeloma	[ICD-11: 2A83]	P52732	KIF11
T28484	DI0321	Ovarian cancer	[ICD-11: 2C73]	P52732	KIF11
T28484	DI0361	Renal cell carcinoma	[ICD-11: 2C90]	P52732	KIF11
T28484	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P52732	KIF11
T73475	DI0238	Lung cancer	[ICD-11: 2C25]	P09237	MMP7
T47094	DI0117	Depression	[ICD-11: 6A70-6A7Z]	P35270	SPR
T47094	DI0293	Nausea/vomiting	[ICD-11: MD90]	P35270	SPR
T83611	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P04229	HLA-DRB1
T98691	DI0263	Middle East Respiratory Syndrome	[ICD-11: 1D64]	P07711	CTSL
T98691	DI0376	Severe acute respiratory syndrome	[ICD-11: 1D65]	P07711	CTSL
T61746	DI0023	Alopecia	[ICD-11: ED70]	P07858	CTSB
T61746	DI0025	Alzheimer disease	[ICD-11: 8A20]	P07858	CTSB
T61746	DI0037	Asthma	[ICD-11: CA23]	P07858	CTSB
T61746	DI0055	Bone cancer	[ICD-11: 2B5Z]	P07858	CTSB
T61746	DI0060	Brain cancer	[ICD-11: 2A00]	P07858	CTSB
T61746	DI0067	Cardiac arrest	[ICD-11: MC82]	P07858	CTSB
T61746	DI0074	Cerebral ischaemic stroke	[ICD-11: 8B11]	P07858	CTSB
T61746	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P07858	CTSB
T61746	DI0087	Chronic pain	[ICD-11: MG30]	P07858	CTSB
T61746	DI0110	Cystic fibrosis	[ICD-11: CA25]	P07858	CTSB
T61746	DI0124	Digestive system disease	[ICD-11: DE2Z]	P07858	CTSB
T61746	DI0178	Hepatic fibrosis/cirrhosis	[ICD-11: DB93]	P07858	CTSB
T61746	DI0199	Idiopathic interstitial pneumonitis	[ICD-11: CB03]	P07858	CTSB
T61746	DI0253	Meningioma	[ICD-11: 2A01]	P07858	CTSB
T61746	DI0262	Metastatic tumour	[ICD-11: 2D50-2E2Z]	P07858	CTSB
T61746	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P07858	CTSB
T61746	DI0296	Neurodegenerative disorder	[ICD-11: 8A20-8A23]	P07858	CTSB
T61746	DI0320	Osteoarthritis	[ICD-11: FA00-FA05]	P07858	CTSB
T61746	DI0351	Psoriasis	[ICD-11: EA90]	P07858	CTSB
T61746	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	P07858	CTSB
T58992	DI0059	Bowel habit change	[ICD-11: ME05]	P41143	OPRD1
T58992	DI0218	Irritable bowel syndrome	[ICD-11: DD91]	P41143	OPRD1
T58992	DI0324	Pain	[ICD-11: MG30-MG3Z]	P41143	OPRD1
T05114	DI0039	Atopic eczema	[ICD-11: EA80]	P23946	CMA1
T05114	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P23946	CMA1
T05114	DI0169	Gram-positive bacterial infection	[ICD-11: 1B74-1F40]	P23946	CMA1
T05114	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P23946	CMA1
T05114	DI0229	Left ventricular failure	[ICD-11: BD11]	P23946	CMA1
T05114	DI0287	Myocardial infarction	[ICD-11: BA41-BA43]	P23946	CMA1
T58921	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	P37231	PPARG
T58921	DI0025	Alzheimer disease	[ICD-11: 8A20]	P37231	PPARG
T58921	DI0417	Type 2 diabetes mellitus	[ICD-11: 5A11]	P37231	PPARG
T13127	DI0342	Premature ageing appearance	[ICD-11: LD2B]	P49356	FNTB
T92609	DI0190	Hypertension	[ICD-11: BA00-BA04]	P35348	ADRA1A
T92609	DI0348	Prostate hyperplasia	[ICD-11: GA90]	P35348	ADRA1A
T67619	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	P31749	AKT1
T53764	DI0300	Neutropenia	[ICD-11: 4B00]	Q12884	FAP
T68290	DI0042	Autoimmune disease	[ICD-11: 4A40-4A45]	P25774	CTSS
T68290	DI0092	Coeliac disease	[ICD-11: DA95]	P25774	CTSS
T68290	DI0107	Crohn disease	[ICD-11: DD70]	P25774	CTSS
T68290	DI0120	Diabetes mellitus	[ICD-11: 5A10]	P25774	CTSS
T68290	DI0163	General pain disorder	[ICD-11: 8E43]	P25774	CTSS
T68290	DI0324	Pain	[ICD-11: MG30-MG3Z]	P25774	CTSS
T68290	DI0382	Sjogren syndrome	[ICD-11: 4A43]	P25774	CTSS
T21669	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P09211	GSTP1
T01908	DI0213	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	P20151	KLK2
T97613	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P48039	MTNR1A
T48268	DI0214	Insomnia	[ICD-11: 7A00-7A0Z]	P49286	MTNR1B
T41580	DI0396	Substance abuse	[ICD-11: 6C40]	P18089	ADRA2B
T03661	DI0016	Adaptive immunity immunodeficiency	[ICD-11: 4A01]	P00813	ADA
T03661	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	P00813	ADA
T03661	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	P00813	ADA
T75596	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	P50579	METAP2
T45287	DI0190	Hypertension	[ICD-11: BA00-BA04]	Q9ULA0	DNPEP
T27889	DI0009	Acute diabete complication	[ICD-11: 5A2Y]	Q9BYF1	ACE2
T27889	DI0217	Intrathoracic organs injury	[ICD-11: NB32]	Q9BYF1	ACE2
T27889	DI0356	Pulmonary hypertension	[ICD-11: BB01]	Q9BYF1	ACE2
T01851	DI0060	Brain cancer	[ICD-11: 2A00]	P05556	ITGB1
T01851	DI0238	Lung cancer	[ICD-11: 2C25]	P05556	ITGB1
T01851	DI0365	Retinopathy	[ICD-11: 9B71]	P05556	ITGB1
T71266	DI0062	Breast cancer	[ICD-11: 2C60-2C6Y]	Q9Y243	AKT3
T82739	DI0213	Innate/adaptive immunodeficiency	[ICD-11: 4A00]	P03952	KLKB1
T82739	DI0364	Retinal vascular occlusion	[ICD-11: 9B74]	P03952	KLKB1
T19433	DI0148	Flatworm infection	[ICD-11: 1F70-1F86]	O60760	HPGDS
T97035	DI0007	Acquired hypermelanosis	[ICD-11: ED60]	P14679	TYR
T97035	DI0008	Acquired hypomelanotic disorder	[ICD-11: ED63]	P14679	TYR
T36741	DI0012	Acute myeloid leukaemia	[ICD-11: 2A60]	O15151	MDM4
T36741	DI0245	Malignant haematopoietic neoplasm	[ICD-11: 2B33]	O15151	MDM4
T36741	DI0284	Myelodysplastic syndrome	[ICD-11: 2A37]	O15151	MDM4
T36741	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	O15151	MDM4
T39716	DI0046	Bacterial infection	[ICD-11: 1A00-1C4Z]	Q14524	SCN5A
T39716	DI0068	Cardiac arrhythmia	[ICD-11: BC9Z]	Q14524	SCN5A
T39716	DI0101	Corneal disease	[ICD-11: 9A76-9A78]	Q14524	SCN5A
T39716	DI0105	Cough	[ICD-11: MD12]	Q14524	SCN5A
T39716	DI0134	Epilepsy/seizure	[ICD-11: 8A61-8A6Z]	Q14524	SCN5A
T39716	DI0264	Migraine	[ICD-11: 8A80]	Q14524	SCN5A
T39716	DI0324	Pain	[ICD-11: MG30-MG3Z]	Q14524	SCN5A
T39716	DI0434	Ventricular tachyarrhythmia	[ICD-11: BC71]	Q14524	SCN5A
T16308	DI0238	Lung cancer	[ICD-11: 2C25]	Q13526	PIN1
T29683	DI0254	Menopausal disorder	[ICD-11: GA30]	P29371	TACR3
T95878	DI0249	Mature B-cell leukaemia	[ICD-11: 2A82]	Q9UK32	RPS6KA6
T88285	DI0210	Influenza	[ICD-11: 1E30-1E32]	Q04760	GLO1
T58470	DI0363	Retina cancer	[ICD-11: 2D02]	P20248	CCNA2
T46040	DI0074	Cerebral ischaemic stroke	[ICD-11: 8B11]	P03951	F11
T46040	DI0089	Clotting disorder	[ICD-11: 3B4Z]	P03951	F11
T22839	DI0024	Alpha-1-antitrypsin deficiency	[ICD-11: 5C5A]	Q9UNI1	CELA1
T22839	DI0065	Bronchitis	[ICD-11: CA20]	Q9UNI1	CELA1
T70490	DI0064	Bronchiectasis	[ICD-11: CA24]	P53634	CTSC
T14463	DI0017	Adrenal cancer	[ICD-11: 2D11]	O75908	SOAT2
T63224	DI0258	Metabolism inborn error	[ICD-11: 5C50]	P05089	ARG1
T67207	DI0231	Leukaemia	[ICD-11: 2A60-2B33]	P06734	FCER2
T21782	DI0308	Obesity	[ICD-11: 5B80-5B81]	P12004	PCNA
T97587	DI0107	Crohn disease	[ICD-11: DD70]	P13612	ITGA4
T97587	DI0275	Multiple sclerosis	[ICD-11: 8A40]	P13612	ITGA4
T97587	DI0419	Ulcerative colitis	[ICD-11: DD71]	P13612	ITGA4
T99340	DI0025	Alzheimer disease	[ICD-11: 8A20]	Q13546	RIPK1
T99340	DI0109	Cutaneous lupus erythematosus	[ICD-11: EB50-EB5Z]	Q13546	RIPK1
T99340	DI0273	Motor neuron disease	[ICD-11: 8B60]	Q13546	RIPK1
T99340	DI0295	Nervous system paraneoplastic/autoimmune disorder	[ICD-11: 8E4A]	Q13546	RIPK1
T99340	DI0326	Pancreatic cancer	[ICD-11: 2C10]	Q13546	RIPK1
T99340	DI0351	Psoriasis	[ICD-11: EA90]	Q13546	RIPK1
T99340	DI0366	Rheumatoid arthritis	[ICD-11: FA20]	Q13546	RIPK1
T99340	DI0419	Ulcerative colitis	[ICD-11: DD71]	Q13546	RIPK1
T87831	DI0333	Peptic ulcer	[ICD-11: DA61]	P21462	FPR1
T74363	DI0286	Myeloproliferative neoplasm	[ICD-11: 2A20]	Q03405	PLAUR
T74363	DI0404	Thrombocytosis	[ICD-11: 3B63]	Q03405	PLAUR
T84439	DI0377	Sex development malformative disorder	[ICD-11: LD2A]	Q6DWJ6	GPR139
T86385	DI0086	Chronic obstructive pulmonary disease	[ICD-11: CA22]	P08311	CTSG
T02546	DI0281	Musculoskeletal disorder	[ICD-11: FA00-FC0Z]	P35499	SCN4A
T84581	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q16881	TXNRD1
T51593	DI0066	Carcinoid syndrome	[ICD-11: 5B10]	Q8IWU9	TPH2
T51593	DI0389	Small intestine developmental anomaly	[ICD-11: DA90]	Q8IWU9	TPH2
T11615	DI0054	Body-focused behaviour disorder	[ICD-11: 6B25]	Q9UPY5	SLC7A11
T97071	DI0122	Diagnostic imaging	[ICD-11: N.A.]	Q04609	FOLH1
T97071	DI0346	Prostate cancer	[ICD-11: 2C82]	Q04609	FOLH1
T70680	DI0167	Gout	[ICD-11: FA25]	Q4U2R8	SLC22A6
T70680	DI0206	Inborn purine/pyrimidine/nucleotide metabolism error	[ICD-11: 5C55]	Q4U2R8	SLC22A6
T70680	DI0310	Ocular disease	[ICD-11: N.A.]	Q4U2R8	SLC22A6
T15855	DI0300	Neutropenia	[ICD-11: 4B00]	Q6V1X1	DPP8
T66252	DI0300	Neutropenia	[ICD-11: 4B00]	Q86TI2	DPP9
T28887	DI0391	Solid tumour/cancer	[ICD-11: 2A00-2F9Z]	Q9BY41	HDAC8
T52173	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	P37088	SCNN1A
T52173	DI0190	Hypertension	[ICD-11: BA00-BA04]	P37088	SCNN1A
T52173	DI0311	Oedema	[ICD-11: MG29]	P37088	SCNN1A
T00099	DI0106	COVID-19	[ICD-11: 1D6Y]	P04632	CAPNS1
T52098	DI0258	Metabolism inborn error	[ICD-11: 5C50]	P00480	OTC
T62391	DI0298	Neuropathy	[ICD-11: 8C0Z]	P42263	GRIA3
T36053	DI0068	Cardiac arrhythmia	[ICD-11: BC9Z]	Q6ZQN7	SLCO4C1
T36053	DI0175	Heart failure	[ICD-11: BD10-BD1Z]	Q6ZQN7	SLCO4C1
T13127	DI0342	Premature ageing appearance	[ICD-11: LD2B]	P49356	FNTB
T51593	DI0066	Carcinoid syndrome	[ICD-11: 5B10]	Q8IWU9	TPH2
T51593	DI0389	Small intestine developmental anomaly	[ICD-11: DA90]	Q8IWU9	TPH2