5-(carbamoylamino)-2-{2-[2-(7-hydroxy-4,8-dimethyl-2-oxo-2H-chromen-3-yl)acetamido]-3-phenylpropanamido}pentanoic acid



Compound IDCDAMM00220
Common name5-(carbamoylamino)-2-{2-[2-(7-hydroxy-4,8-dimethyl-2-oxo-2H-chromen-3-yl)acetamido]-3-phenylpropanamido}pentanoic acid
IUPAC name5-(carbamoylamino)-2-[[2-[[2-(7-hydroxy-4,8-dimethyl-2-oxochromen-3-yl)acetyl]amino]-3-phenylpropanoyl]amino]pentanoic acid
Molecular formulaC28H32N4O8

Experimental data

Retention time43.06
Adduct[M+NH4]+
Actual mz570.257
Theoretical mz570.256
Error1.35
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score4.6453

Identifiers and class information

Inchi keyLQBFLYKFUMMQIK-UHFFFAOYSA-N
SmilesCC1=C(C(=O)OC2=C1C=CC(=C2C)O)CC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCNC(=O)N)C(=O)O
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives

Pharmacokinetic properties

Number of descriptor values(#stars)6
Number of non-conjugated amine groups (#amine)0
Number of amidine and guanidine groups (#amidine)0
Number of carboxylic acid groups (#acid)1
Number of non-conjugated amide groups (#amide)3
Number of rotatable bonds (#rotor)13
Number of reactive functional groups (#rtvFG)1
Predicted central nervous system activity (CNS)-2
Molecular weight (mol_MW)552.583
Computed dipole moment(dipole)19.426
Total solvent accessible surface area (SASA)893.086
Hydrophobic component of SASA (FOSA)303.283
Hydrophilic component of SASA (FISA)336.819
Pie component of the SASA (PISA)252.984
Weakly polar component of the SASA (WPSA)0
Total solvent accesible volume (volume)1655.05
Number of hydrogen bond donors (donorHB)5.5
Number of hydrogen bond acceptors (accptHB)10.75
Free energy of solvation of dipole (dip^2/V)0.228017
Index of cohesive interaction in solids (ACxDN^.5/SA)0.0282291
Globularity descriptor (glob)0.757667
Predicted polarizability in cubic angstroms (QPpolrz)54.15
Predicted hexadecane/gas partition coefficient (QPlogPC16)19.292
Predicted octanol/gas partition coefficient (QPlogPoct)35.657
Predicted water/gas partition coefficient (QPlogPw)26.527
Predicted octanol/water partition coefficient (QPlogPo/w)1.064
Predicted aqueous solubility (QPlogS)-3.831
Conformation-independent predicted aqueous solubility (CIQPlogS)-4.844
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-0.729
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)0.48
Predicted brain/blood partition coefficient (QPlogBB)-4.132
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)0.6
Predicted skin permeability, log Kp (QPlogKp)-5.588
PM3 calculated ionization potential (IP(ev))9.081
PM3 calculated electron affinity (EA(eV))0.81
Number of likely metabolic reactions (#metab)8
Prediction of binding to human serum albumin (QPlogKhsa)-0.923
Predicted qualitative human oral absorption (HumanOralAbsorption)1
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)0
Solvent-accessible surface area of fluorine atoms (SAFluorine)0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)65.813
Van der Waals surface area (PSA)233.376
Number of nitrogen and oxygen atoms (#NandO)12
Number of violations of Lipinski’s rule of five (RuleOfFive)3
Number of violations of Jorgensen’s rule of three (RuleOfThree)2

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID Gene name Target name TTD_ID Prediction source
P00797RENReninT61622SEA
P15144ANPEPAminopeptidase NT67272SEA
P00734F2ThrombinT94033SEA
Q9NTG7SIRT3NAD-dependent deacetylase sirtuin 3T91959SEA
Q8IXJ6SIRT2NAD-dependent deacetylase sirtuin 2T83904SEA
P08514ITGA2BIntegrin alpha-IIb/beta-3T50688SEA
P98170XIAPInhibitor of apoptosis protein 3T16769SEA
P08473MMENeprilysinT05409SEA
P34913EPHX2Epoxide hydrataseT35734SEA
P42261GRIA1Glutamate receptor ionotropic, AMPA 1T33584SEA
P00747PLGPlasminogenT89034SEA
Q9UQL6HDAC5Histone deacetylase 5T07930SEA
Q8WUI4HDAC7Histone deacetylase 7T98698SEA
Q92731ESR2Estrogen receptor betaT80896SEA
P07339CTSDCathepsin DT67102SEA
P18031PTPN1Protein-tyrosine phosphatase 1BT16347SEA
P17706PTPN2T-cell protein-tyrosine phosphataseT49156SEA
Q07075ENPEPAminopeptidase AT31956SEA
Q01650SLC7A5L-type amino acid transporter 1 (by homology)T48330SEA
P08253MMP2Matrix metalloproteinase 2T68251SEA
P22894MMP8Matrix metalloproteinase 8T08856SEA
P08254MMP3Matrix metalloproteinase 3T86702SEA
P14780MMP9Matrix metalloproteinase 9T54156SEA
P03372ESR1Estrogen receptor alphaT02506SEA
P03956MMP1Matrix metalloproteinase 1T52450SEA
P17655CAPN2Calpain 2T86837SEA
P35372OPRM1Mu opioid receptorT47768SEA
P41145OPRK1Kappa Opioid receptorT60693SEA
P62993GRB2Growth factor receptor-bound protein 2T30926SEA
P09237MMP7Matrix metalloproteinase 7T73475SEA
P04229HLA-DRB1HLA class II histocompatibility antigen DRB1-1T83611SEA
P07711CTSLCathepsin LT98691SEA
P32245MC4RMelanocortin receptor 4T72458SEA
P07858CTSBCathepsin (B and K)T61746SEA
Q92847GHSRGhrelin receptorT59604SEA
P41143OPRD1Delta opioid receptorT58992SEA
Q01726MC1RMelanocortin receptor 1T35842SEA
P41968MC3RMelanocortin receptor 3T76846SEA
P23946CMA1ChymaseT05114SEA
P00742F10Thrombin and coagulation factor XT84631SEA
Q06124PTPN11Protein-tyrosine phosphatase 2CT13057SEA
P24385CCND1Cyclin-dependent kinase 4/cyclin D1T12355SEA
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2T65818SEA
P06870KLK1Kallikrein 1T40000SEA
P20142PGCPepsinogen C (by homology)T45601SEA
P04439HLA-AHLA class I histocompatibility antigen A-3T08985SEA
Q9ULA0DNPEPAspartyl aminopeptidaseT45287SEA
Q9BYF1ACE2Angiotensin-converting enzyme 2T27889SEA
P42892ECE1Endothelin-converting enzyme 1T50970SEA
P05556ITGB1Integrin alpha2/beta1T01851SEA
Q99523SORT1Neurotensin receptor 3T63233SEA
Q9ULW8PADI3Protein-arginine deiminase type-3T36612SEA
Q9UM07PADI4Protein-arginine deiminase type-4T50429SEA
P25101EDNRAEndothelin receptor ET-AT23499SEA
P39900MMP12Matrix metalloproteinase 12T03500SEA
P55085F2RL1Proteinase-activated receptor 2T62841SEA
P21730C5AR1C5a anaphylatoxin chemotactic receptorT15439SEA
P41146OPRL1Nociceptin receptorT52921SEA
P25929NPY1RNeuropeptide Y receptor type 1T89213SEA
P15085CPA1Carboxypeptidase A1T33966SEA
P32239CCKBRCholecystokinin B receptor (by homology)T05849SEA
P30989NTSR1Neurotensin receptor 1T02728SEA
P20839IMPDH1Inosine-5'-monophosphate dehydrogenase 1T40111SEA
P32238CCKARCholecystokinin A receptorT28330SEA
Q16581C3AR1C3a anaphylatoxin chemotactic receptorT30219SEA
P03952KLKB1Plasma kallikreinT82739SEA
P08709F7Coagulation factor VIIT43332SEA
P28074PSMB5Proteasome Macropain subunit MB1T49031SEA
P24530EDNRBEndothelin receptor ET-BT92828SEA
P14679TYRTyrosinaseT97035SEA
Q9Y3Q0NAALAD2NAALADase IIT70036SEA
P25116F2RProteinase-activated receptor 1T36483SEA
P21452TACR2Neurokinin 2 receptorT52790SEA
Q9GZQ4NMUR2Neuromedin-U receptor 2T04210SEA
Q16549PCSK7Subtilisin/kexin type 7T33211SEA
P42226STAT6Signal transducer and activator of transcription 6T20585SEA
P29371TACR3Neurokinin 3 receptorT29683SEA
Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SEA
P98073TMPRSS15EnteropeptidaseT75772SEA
P28065PSMB9Proteasome subunit beta type-9T06792SEA
P28062PSMB8Proteasome subunit beta type-8T77350SEA
P61964WDR5WD repeat-containing protein 5T77393SEA
P20248CCNA2CDK2/Cyclin AT58470SEA
Q15661TPSAB1Tryptase beta-1T14558SEA
P03951F11Coagulation factor XIT46040SEA
Q8IU80TMPRSS6Transmembrane protease serine 6T13863SEA
Q9Y5Y6ST14MatriptaseT31543SEA
P28336NMBRNeuromedin B receptorT68887SEA
P28336NMBRNeuromedin B receptorT68887SEA
P47901AVPR1BVasopressin V1b receptorT59881SEA
P06734FCER2Immunoglobulin epsilon Fc receptorT67207SEA
P13612ITGA4Integrin alpha-4T97587SEA
P07288KLK3Prostate specific antigenT36935SEA
Q9NZ08ERAP1Endoplasmic reticulum aminopeptidase 1T72849SEA
P21462FPR1Formyl peptide receptor 1T87831SEA
O95931CBX7Chromobox protein homolog 7T72319SEA
Q9Y337KLK5Kallikrein 5T11808SEA
P40306PSMB1026S proteosomeT09022SEA
P08311CTSGCathepsin GT86385SEA
Q04756HGFACHepatocyte growth factor activatorT38584SEA
Q14145KEAP1Kelch-like ECH-associated protein 1T83198SEA
O60235TMPRSS11DTransmembrane protease serine 11DT00302SEA
O14786NRP1Neuropilin-1 (by homology)T15023SEA
P04070PROCVitamin K-dependent protein CT24836SEA
P00748F12Coagulation factor XIIT38509SEA
P49862KLK7Kallikrein-7T79155SEA
Q04609FOLH1Glutamate carboxypeptidase IIT97071SEA
P09958FURHUMAN dibasic-processing enzymeT98945SEA
P29120PCSK1Neuroendocrine convertase 1T36445SEA
Q92824PCSK5Proprotein convertase subtilisin/kexin type 5T38581SEA
Q9GZQ6NPFFR1Neuropeptide FF receptor 1T79780SEA
Q9Y5X5NPFFR2Neuropeptide FF receptor 2T90818SEA
O60259KLK8NeuropsinT43289SEA
Q9Y5K2KLK4Kallikrein-4T79400SEA
Q9Y4G9PCSK6Proprotein convertase subtilisin/kexin type 6T86503SEA
P04632CAPNS1HUMAN calpain-1 or calpain small subunit 1 heterodimerT00099SEA
P17342NPR3Natriuretic peptide receptorT92963SEA
P16066NPR1Atrial natriuretic peptide receptor AT71230SEA
P05106ITGB3Integrin beta-3T26457SEA
P42263GRIA3Glutamate receptor AMPA 3T62391SEA
O95665NTSR2Neurotensin receptor type 2T95605SEA
Q9HB89NMUR1Neuromedin-U receptor 1T83382SEA
Q9HAN5TRP1Cationic trypsinogenT27602SEA
Q9BX92CFBComplement factor BT66011SEA
P05981HPNSerine protease hepsinT73471SEA
Q9ULZ9MMP17Matrix metalloproteinase-17T55616SEA
P25786PSMA1Core proteasome 20S complexT61997SEA
P28072PSMB6Proteasome beta-1T54973SEA
Q99436PSMB7Proteasome beta-2T55986SEA
Q96T53FKSG89Ghrelin O acyltransferaseT45228SEA
P14672GLUT4Glucose transporter type 4T67658SEA
P01589IL2RAInterleukin 2 receptor alphaT03313SEA
P16519PCSK2Neuroendocrine convertase 2T97749SEA
P50391NPY4RNeuropeptide Y receptor type 4T27944SEA

Target associated diseases

TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
T61622DI0190Hypertension[ICD-11: BA00-BA04]P00797REN
T67272DI0351Psoriasis[ICD-11: EA90]P15144ANPEP
T94033DI0052Bleeding disorder[ICD-11: GA20-GA21]P00734F2
T94033DI0091Coagulation defect[ICD-11: 3B10]P00734F2
T94033DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P00734F2
T94033DI0275Multiple sclerosis[ICD-11: 8A40]P00734F2
T94033DI0287Myocardial infarction[ICD-11: BA41-BA43]P00734F2
T94033DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00734F2
T94033DI0403Thrombocytopenia[ICD-11: 3B64]P00734F2
T94033DI0405Thrombosis[ICD-11: DB61-GB90]P00734F2
T83904DI0365Retinopathy[ICD-11: 9B71]Q8IXJ6SIRT2
T50688DI0007Acquired hypermelanosis[ICD-11: ED60]P08514ITGA2B
T50688DI0030Angina pectoris[ICD-11: BA40]P08514ITGA2B
T50688DI0287Myocardial infarction[ICD-11: BA41-BA43]P08514ITGA2B
T16769DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]P98170XIAP
T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
T33584DI0298Neuropathy[ICD-11: 8C0Z]P42261GRIA1
T89034DI0030Angina pectoris[ICD-11: BA40]P00747PLG
T89034DI0052Bleeding disorder[ICD-11: GA20-GA21]P00747PLG
T89034DI0254Menopausal disorder[ICD-11: GA30]P00747PLG
T89034DI0287Myocardial infarction[ICD-11: BA41-BA43]P00747PLG
T89034DI0345Procedure injury[ICD-11: NE81]P00747PLG
T89034DI0357Pulmonary thromboembolism[ICD-11: BB00]P00747PLG
T80896DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q92731ESR2
T80896DI0108Cushing syndrome[ICD-11: 5A70]Q92731ESR2
T80896DI0254Menopausal disorder[ICD-11: GA30]Q92731ESR2
T80896DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]Q92731ESR2
T67102DI0275Multiple sclerosis[ICD-11: 8A40]P07339CTSD
T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
T49156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P17706PTPN2
T31956DI0190Hypertension[ICD-11: BA00-BA04]Q07075ENPEP
T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
T02506DI0106COVID-19[ICD-11: 1D6Y]P03372ESR1
T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
T86837DI0106COVID-19[ICD-11: 1D6Y]P17655CAPN2
T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
T60693DI0304Non-specific cutaneous vascular symptom[ICD-11: ME64]P41145OPRK1
T60693DI0324Pain[ICD-11: MG30-MG3Z]P41145OPRK1
T60693DI0349Pruritus[ICD-11: EC90]P41145OPRK1
T30926DI0012Acute myeloid leukaemia[ICD-11: 2A60]P62993GRB2
T30926DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P62993GRB2
T30926DI0250Mature B-cell lymphoma[ICD-11: 2A85]P62993GRB2
T30926DI0284Myelodysplastic syndrome[ICD-11: 2A37]P62993GRB2
T30926DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P62993GRB2
T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
T83611DI0275Multiple sclerosis[ICD-11: 8A40]P04229HLA-DRB1
T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
T72458DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]P32245MC4R
T72458DI0228Large intestine motility disorder[ICD-11: DB32]P32245MC4R
T72458DI0308Obesity[ICD-11: 5B80-5B81]P32245MC4R
T61746DI0023Alopecia[ICD-11: ED70]P07858CTSB
T61746DI0025Alzheimer disease[ICD-11: 8A20]P07858CTSB
T61746DI0037Asthma[ICD-11: CA23]P07858CTSB
T61746DI0055Bone cancer[ICD-11: 2B5Z]P07858CTSB
T61746DI0060Brain cancer[ICD-11: 2A00]P07858CTSB
T61746DI0067Cardiac arrest[ICD-11: MC82]P07858CTSB
T61746DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P07858CTSB
T61746DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07858CTSB
T61746DI0087Chronic pain[ICD-11: MG30]P07858CTSB
T61746DI0110Cystic fibrosis[ICD-11: CA25]P07858CTSB
T61746DI0124Digestive system disease[ICD-11: DE2Z]P07858CTSB
T61746DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P07858CTSB
T61746DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P07858CTSB
T61746DI0253Meningioma[ICD-11: 2A01]P07858CTSB
T61746DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P07858CTSB
T61746DI0275Multiple sclerosis[ICD-11: 8A40]P07858CTSB
T61746DI0296Neurodegenerative disorder[ICD-11: 8A20-8A23]P07858CTSB
T61746DI0320Osteoarthritis[ICD-11: FA00-FA05]P07858CTSB
T61746DI0351Psoriasis[ICD-11: EA90]P07858CTSB
T61746DI0366Rheumatoid arthritis[ICD-11: FA20]P07858CTSB
T59604DI0087Chronic pain[ICD-11: MG30]Q92847GHSR
T59604DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]Q92847GHSR
T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
T35842DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]Q01726MC1R
T35842DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]Q01726MC1R
T76846DI0308Obesity[ICD-11: 5B80-5B81]P41968MC3R
T76846DI0378Sexual dysfunction[ICD-11: HA00-HA01]P41968MC3R
T76846DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P41968MC3R
T05114DI0039Atopic eczema[ICD-11: EA80]P23946CMA1
T05114DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P23946CMA1
T05114DI0169Gram-positive bacterial infection[ICD-11: 1B74-1F40]P23946CMA1
T05114DI0175Heart failure[ICD-11: BD10-BD1Z]P23946CMA1
T05114DI0229Left ventricular failure[ICD-11: BD11]P23946CMA1
T05114DI0287Myocardial infarction[ICD-11: BA41-BA43]P23946CMA1
T84631DI0053Blood-forming organ disease[ICD-11: 3C0Z]P00742F10
T84631DI0080Christmas disease[ICD-11: 3B11]P00742F10
T84631DI0091Coagulation defect[ICD-11: 3B10]P00742F10
T84631DI0103Coronary thrombosis[ICD-11: BA43]P00742F10
T84631DI0114Deep vein thrombosis[ICD-11: BD71]P00742F10
T84631DI0397Supraventricular tachyarrhythmia[ICD-11: BC81]P00742F10
T84631DI0405Thrombosis[ICD-11: DB61-GB90]P00742F10
T84631DI0433Venous thromboembolism[ICD-11: BD72]P00742F10
T13057DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06124PTPN11
T12355DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P24385CCND1
T45287DI0190Hypertension[ICD-11: BA00-BA04]Q9ULA0DNPEP
T27889DI0009Acute diabete complication[ICD-11: 5A2Y]Q9BYF1ACE2
T27889DI0217Intrathoracic organs injury[ICD-11: NB32]Q9BYF1ACE2
T27889DI0356Pulmonary hypertension[ICD-11: BB01]Q9BYF1ACE2
T01851DI0060Brain cancer[ICD-11: 2A00]P05556ITGB1
T01851DI0238Lung cancer[ICD-11: 2C25]P05556ITGB1
T01851DI0365Retinopathy[ICD-11: 9B71]P05556ITGB1
T63233DI0153Frontotemporal dementia[ICD-11: 6D83]Q99523SORT1
T23499DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25101EDNRA
T23499DI0356Pulmonary hypertension[ICD-11: BB01]P25101EDNRA
T23499DI0425Urinary system clinical symptom[ICD-11: MF8Y]P25101EDNRA
T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
T62841DI0087Chronic pain[ICD-11: MG30]P55085F2RL1
T15439DI0431Vasculitis[ICD-11: 4A44]P21730C5AR1
T52921DI0039Atopic eczema[ICD-11: EA80]P41146OPRL1
T52921DI0117Depression[ICD-11: 6A70-6A7Z]P41146OPRL1
T52921DI0173Headache[ICD-11: 8A80-8A84]P41146OPRL1
T52921DI0175Heart failure[ICD-11: BD10-BD1Z]P41146OPRL1
T89213DI0050Binge eating disorder[ICD-11: 6B82]P25929NPY1R
T89213DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25929NPY1R
T89213DI0174Heart disease[ICD-11: BA41-BA42]P25929NPY1R
T89213DI0190Hypertension[ICD-11: BA00-BA04]P25929NPY1R
T89213DI0308Obesity[ICD-11: 5B80-5B81]P25929NPY1R
T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
T02728DI0207Indeterminate colitis[ICD-11: DD72]P30989NTSR1
T40111DI0062Breast cancer[ICD-11: 2C60-2C6Y]P20839IMPDH1
T40111DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P20839IMPDH1
T40111DI0250Mature B-cell lymphoma[ICD-11: 2A85]P20839IMPDH1
T40111DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P20839IMPDH1
T40111DI0413Transplant rejection[ICD-11: NE84]P20839IMPDH1
T28330DI0210Influenza[ICD-11: 1E30-1E32]P32238CCKAR
T28330DI0328Pancreatic malfunction[ICD-11: DC30-DC3Z]P32238CCKAR
T82739DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P03952KLKB1
T82739DI0364Retinal vascular occlusion[ICD-11: 9B74]P03952KLKB1
T43332DI0091Coagulation defect[ICD-11: 3B10]P08709F7
T92828DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P24530EDNRB
T92828DI0356Pulmonary hypertension[ICD-11: BB01]P24530EDNRB
T97035DI0007Acquired hypermelanosis[ICD-11: ED60]P14679TYR
T97035DI0008Acquired hypomelanotic disorder[ICD-11: ED63]P14679TYR
T36483DI0287Myocardial infarction[ICD-11: BA41-BA43]P25116F2R
T52790DI0218Irritable bowel syndrome[ICD-11: DD91]P21452TACR2
T29683DI0254Menopausal disorder[ICD-11: GA30]P29371TACR3
T77350DI0274Multiple myeloma[ICD-11: 2A83]P28062PSMB8
T58470DI0363Retina cancer[ICD-11: 2D02]P20248CCNA2
T14558DI0155Fungal infection[ICD-11: 1F29-1F2F]Q15661TPSAB1
T14558DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q15661TPSAB1
T46040DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P03951F11
T46040DI0089Clotting disorder[ICD-11: 3B4Z]P03951F11
T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
T59881DI0009Acute diabete complication[ICD-11: 5A2Y]P47901AVPR1B
T59881DI0041Autism spectrum disorder[ICD-11: 6A02]P47901AVPR1B
T59881DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P47901AVPR1B
T67207DI0231Leukaemia[ICD-11: 2A60-2B33]P06734FCER2
T97587DI0107Crohn disease[ICD-11: DD70]P13612ITGA4
T97587DI0275Multiple sclerosis[ICD-11: 8A40]P13612ITGA4
T97587DI0419Ulcerative colitis[ICD-11: DD71]P13612ITGA4
T36935DI0036Arteries/arterioles disorder[ICD-11: BD52]P07288KLK3
T36935DI0346Prostate cancer[ICD-11: 2C82]P07288KLK3
T36935DI0348Prostate hyperplasia[ICD-11: GA90]P07288KLK3
T87831DI0333Peptic ulcer[ICD-11: DA61]P21462FPR1
T86385DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P08311CTSG
T83198DI0356Pulmonary hypertension[ICD-11: BB01]Q14145KEAP1
T83198DI0425Urinary system clinical symptom[ICD-11: MF8Y]Q14145KEAP1
T15023DI0365Retinopathy[ICD-11: 9B71]O14786NRP1
T24836DI0084Chronic lower extremities peripheral venous insufficiency[ICD-11: BD74]P04070PROC
T24836DI0177Hemangioma[ICD-11: 2E81-2F2Y]P04070PROC
T38509DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P00748F12
T97071DI0122Diagnostic imaging[ICD-11: N.A.]Q04609FOLH1
T97071DI0346Prostate cancer[ICD-11: 2C82]Q04609FOLH1
T98945DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P09958FUR
T00099DI0106COVID-19[ICD-11: 1D6Y]P04632CAPNS1
T92963DI0175Heart failure[ICD-11: BD10-BD1Z]P17342NPR3
T71230DI0175Heart failure[ICD-11: BD10-BD1Z]P16066NPR1
T62391DI0298Neuropathy[ICD-11: 8C0Z]P42263GRIA3
T27602DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q9HAN5TRP1
T27602DI0274Multiple myeloma[ICD-11: 2A83]Q9HAN5TRP1
T66011DI0170Haemolytic anemia[ICD-11: 3A20-3A2Z]Q9BX92CFB
T45228DI0308Obesity[ICD-11: 5B80-5B81]Q96T53FKSG89
T45228DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q96T53FKSG89
T67658DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14672GLUT4
T03313DI0413Transplant rejection[ICD-11: NE84]P01589IL2RA
T27944DI0009Acute diabete complication[ICD-11: 5A2Y]P50391NPY4R
T27944DI0308Obesity[ICD-11: 5B80-5B81]P50391NPY4R
T27944DI0370Schizophrenia[ICD-11: 6A20]P50391NPY4R

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