Asn-Trp-Asp-Ser



Compound IDCDAMM00209
Common nameAsn-Trp-Asp-Ser
IUPAC name(3S)-4-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-[[(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-oxobutanoic acid
Molecular formulaC22H28N6O9

Experimental data

Retention time29.47
Adduct[M+H]+
Actual mz521.199
Theoretical mz521.199
Error0.09
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score5.3306

Identifiers and class information

Inchi keyWSNSZZGIMVHDHF-TUUVXOQKSA-N
SmilesC1=CC=C2C(=C1)C(=CN2)CC(C(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CC(=O)N)N
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives

Pharmacokinetic properties

Number of descriptor values(#stars)9
Number of non-conjugated amine groups (#amine)1
Number of amidine and guanidine groups (#amidine)0
Number of carboxylic acid groups (#acid)2
Number of non-conjugated amide groups (#amide)4
Number of rotatable bonds (#rotor)16
Number of reactive functional groups (#rtvFG)0
Predicted central nervous system activity (CNS)-2
Molecular weight (mol_MW)520.498
Computed dipole moment(dipole)8.787
Total solvent accessible surface area (SASA)777.813
Hydrophobic component of SASA (FOSA)161.399
Hydrophilic component of SASA (FISA)425.93
Pie component of the SASA (PISA)190.484
Weakly polar component of the SASA (WPSA)0
Total solvent accesible volume (volume)1474.84
Number of hydrogen bond donors (donorHB)6.5
Number of hydrogen bond acceptors (accptHB)12.2
Free energy of solvation of dipole (dip^2/V)0.0523572
Index of cohesive interaction in solids (ACxDN^.5/SA)0.0399891
Globularity descriptor (glob)0.805602
Predicted polarizability in cubic angstroms (QPpolrz)44.415
Predicted hexadecane/gas partition coefficient (QPlogPC16)17.741
Predicted octanol/gas partition coefficient (QPlogPoct)32.501
Predicted water/gas partition coefficient (QPlogPw)31.166
Predicted octanol/water partition coefficient (QPlogPo/w)-3.797
Predicted aqueous solubility (QPlogS)0.503
Conformation-independent predicted aqueous solubility (CIQPlogS)-1.523
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)2.8
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)0.002
Predicted brain/blood partition coefficient (QPlogBB)-4.378
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)0.005
Predicted skin permeability, log Kp (QPlogKp)-9.225
PM3 calculated ionization potential (IP(ev))8.147
PM3 calculated electron affinity (EA(eV))-0.135
Number of likely metabolic reactions (#metab)11
Prediction of binding to human serum albumin (QPlogKhsa)-2.119
Predicted qualitative human oral absorption (HumanOralAbsorption)1
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)0
Solvent-accessible surface area of fluorine atoms (SAFluorine)0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)99.661
Van der Waals surface area (PSA)308.12
Number of nitrogen and oxygen atoms (#NandO)15
Number of violations of Lipinski’s rule of five (RuleOfFive)3
Number of violations of Jorgensen’s rule of three (RuleOfThree)2

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID Gene name Target name TTD_ID Prediction source
P00797RENReninT61622SEA
P15144ANPEPAminopeptidase NT67272SEA
O15379HDAC3Histone deacetylase 3T05090SEA
P08514ITGA2BIntegrin alpha-IIb/beta-3T50688SEA
P08473MMENeprilysinT05409SEA
Q92769HDAC2Histone deacetylase 2T51191SEA
P08235NR3C2Mineralocorticoid receptorT72168SEA
P04150NR3C1Glucocorticoid receptorT40016SEA
P18031PTPN1Protein-tyrosine phosphatase 1BT16347SEA
P17706PTPN2T-cell protein-tyrosine phosphataseT49156SEA
Q07075ENPEPAminopeptidase AT31956SEA
P08253MMP2Matrix metalloproteinase 2T68251SEA
P22894MMP8Matrix metalloproteinase 8T08856SEA
P08254MMP3Matrix metalloproteinase 3T86702SEA
P14780MMP9Matrix metalloproteinase 9T54156SEA
P03956MMP1Matrix metalloproteinase 1T52450SEA
P17655CAPN2Calpain 2T86837SEA
P35372OPRM1Mu opioid receptorT47768SEA
P62993GRB2Growth factor receptor-bound protein 2T30926SEA
P06276BCHEButyrylcholinesteraseT99799SEA
P45452MMP13Matrix metalloproteinase 13T34296SEA
P09237MMP7Matrix metalloproteinase 7T73475SEA
P13497BMP1Bone morphogenetic protein 1T53350SEA
P35270SPRSubstance-P receptorT47094SEA
P04229HLA-DRB1HLA class II histocompatibility antigen DRB1-1T83611SEA
P07711CTSLCathepsin LT98691SEA
P32245MC4RMelanocortin receptor 4T72458SEA
P07858CTSBCathepsin (B and K)T61746SEA
Q92847GHSRGhrelin receptorT59604SEA
P41143OPRD1Delta opioid receptorT58992SEA
Q01726MC1RMelanocortin receptor 1T35842SEA
P41968MC3RMelanocortin receptor 3T76846SEA
P31749AKT1Serine/threonine-protein kinase AKTT67619SEA
P29466CASP1Caspase-1T98269SEA
P24385CCND1Cyclin-dependent kinase 4/cyclin D1T12355SEA
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2T65818SEA
P04439HLA-AHLA class I histocompatibility antigen A-3T08985SEA
Q13443ADAM9ADAM9T03672SEA
P79483HLA-DRB3HLA class II histocompatibility antigen DRB3-1T49146SEA
P25090FPR2Lipoxin A4 receptor (by homology)T97917SEA
Q9BYF1ACE2Angiotensin-converting enzyme 2T27889SEA
P42892ECE1Endothelin-converting enzyme 1T50970SEA
P25101EDNRAEndothelin receptor ET-AT23499SEA
P39900MMP12Matrix metalloproteinase 12T03500SEA
P42574CASP3Caspase-3T57943SEA
P21730C5AR1C5a anaphylatoxin chemotactic receptorT15439SEA
P35346SSTR5Somatostatin receptor 5T64830SEA
P30874SSTR2Somatostatin receptor 2T53024SEA
P31391SSTR4Somatostatin receptor 4T62974SEA
P30872SSTR1Somatostatin receptor 1T16633SEA
P32745SSTR3Somatostatin receptor 3T13644SEA
P15085CPA1Carboxypeptidase A1T33966SEA
P32239CCKBRCholecystokinin B receptor (by homology)T05849SEA
P50281MMP14Matrix metalloproteinase 14T65019SEA
P20839IMPDH1Inosine-5'-monophosphate dehydrogenase 1T40111SEA
P32238CCKARCholecystokinin A receptorT28330SEA
Q16581C3AR1C3a anaphylatoxin chemotactic receptorT30219SEA
P28074PSMB5Proteasome Macropain subunit MB1T49031SEA
P24530EDNRBEndothelin receptor ET-BT92828SEA
P14679TYRTyrosinaseT97035SEA
Q9Y3Q0NAALAD2NAALADase IIT70036SEA
P21452TACR2Neurokinin 2 receptorT52790SEA
P09238MMP10Matrix metalloproteinase 10T40488SEA
P29371TACR3Neurokinin 3 receptorT29683SEA
Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SEA
P98073TMPRSS15EnteropeptidaseT75772SEA
P28065PSMB9Proteasome subunit beta type-9T06792SEA
P28062PSMB8Proteasome subunit beta type-8T77350SEA
P20248CCNA2CDK2/Cyclin AT58470SEA
Q8IU80TMPRSS6Transmembrane protease serine 6T13863SEA
Q9Y5Y6ST14MatriptaseT31543SEA
P51511MMP15Matrix metalloproteinase 15T81658SEA
P28336NMBRNeuromedin B receptorT68887SEA
Q96DB2HDAC11Histone deacetylase 11T97903SEA
P33032MC5RMelanocortin receptor 5T95302SEA
P28336NMBRNeuromedin B receptorT68887SEA
P06734FCER2Immunoglobulin epsilon Fc receptorT67207SEA
P30550GRPRGastrin releasing peptide receptorT99816SEA
Q969S8HDAC10Histone deacetylase 10T94324SEA
Q9H2K8TAOK3Serine/threonine-protein kinase TAO3T63682SEA
P07288KLK3Prostate specific antigenT36935SEA
Q9NZ08ERAP1Endoplasmic reticulum aminopeptidase 1T72849SEA
P21462FPR1Formyl peptide receptor 1T87831SEA
O95931CBX7Chromobox protein homolog 7T72319SEA
P23284PPIBCyclophilin BT25847SEA
Q04756HGFACHepatocyte growth factor activatorT38584SEA
O60235TMPRSS11DTransmembrane protease serine 11DT00302SEA
P09958FURHUMAN dibasic-processing enzymeT98945SEA
P29120PCSK1Neuroendocrine convertase 1T36445SEA
Q92824PCSK5Proprotein convertase subtilisin/kexin type 5T38581SEA
Q06609RAD51DNA repair protein RAD51 homolog 1T63083SEA
Q9Y4G9PCSK6Proprotein convertase subtilisin/kexin type 6T86503SEA
P04632CAPNS1HUMAN calpain-1 or calpain small subunit 1 heterodimerT00099SEA
O60603TLR2Toll-like receptor 2T82078SEA
P05106ITGB3Integrin beta-3T26457SEA
P42263GRIA3Glutamate receptor AMPA 3T62391SEA
Q16348PEPT2Solute carrier family 15 member 2T52067SEA
O95622ADCY5Adenylate cyclase type 5T19531SEA
Q9HAN5TRP1Cationic trypsinogenT27602SEA
P24347MMP11Matrix metalloproteinase-11T73180SEA
P05981HPNSerine protease hepsinT73471SEA
Q9ULZ9MMP17Matrix metalloproteinase-17T55616SEA
Q96T53FKSG89Ghrelin O acyltransferaseT45228SEA
P55211CASP9Caspase-9T93903SEA

Target associated diseases

TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
T61622DI0190Hypertension[ICD-11: BA00-BA04]P00797REN
T67272DI0351Psoriasis[ICD-11: EA90]P15144ANPEP
T05090DI0241Lymphoma[ICD-11: 2A80-2A86]O15379HDAC3
T05090DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15379HDAC3
T50688DI0007Acquired hypermelanosis[ICD-11: ED60]P08514ITGA2B
T50688DI0030Angina pectoris[ICD-11: BA40]P08514ITGA2B
T50688DI0287Myocardial infarction[ICD-11: BA41-BA43]P08514ITGA2B
T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
T72168DI0018Adrenocortical insufficiency[ICD-11: 5A74]P08235NR3C2
T72168DI0083Chronic kidney disease[ICD-11: GB61]P08235NR3C2
T72168DI0100Contraceptive management[ICD-11: QA21]P08235NR3C2
T72168DI0175Heart failure[ICD-11: BD10-BD1Z]P08235NR3C2
T72168DI0190Hypertension[ICD-11: BA00-BA04]P08235NR3C2
T72168DI0194Hypo-osmolality/hyponatraemia[ICD-11: 5C72]P08235NR3C2
T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
T49156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P17706PTPN2
T31956DI0190Hypertension[ICD-11: BA00-BA04]Q07075ENPEP
T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
T86837DI0106COVID-19[ICD-11: 1D6Y]P17655CAPN2
T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
T30926DI0012Acute myeloid leukaemia[ICD-11: 2A60]P62993GRB2
T30926DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P62993GRB2
T30926DI0250Mature B-cell lymphoma[ICD-11: 2A85]P62993GRB2
T30926DI0284Myelodysplastic syndrome[ICD-11: 2A37]P62993GRB2
T30926DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P62993GRB2
T99799DI0324Pain[ICD-11: MG30-MG3Z]P06276BCHE
T99799DI0411Tonus and reflex abnormality[ICD-11: MB47]P06276BCHE
T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
T47094DI0117Depression[ICD-11: 6A70-6A7Z]P35270SPR
T47094DI0293Nausea/vomiting[ICD-11: MD90]P35270SPR
T83611DI0275Multiple sclerosis[ICD-11: 8A40]P04229HLA-DRB1
T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
T72458DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]P32245MC4R
T72458DI0228Large intestine motility disorder[ICD-11: DB32]P32245MC4R
T72458DI0308Obesity[ICD-11: 5B80-5B81]P32245MC4R
T61746DI0023Alopecia[ICD-11: ED70]P07858CTSB
T61746DI0025Alzheimer disease[ICD-11: 8A20]P07858CTSB
T61746DI0037Asthma[ICD-11: CA23]P07858CTSB
T61746DI0055Bone cancer[ICD-11: 2B5Z]P07858CTSB
T61746DI0060Brain cancer[ICD-11: 2A00]P07858CTSB
T61746DI0067Cardiac arrest[ICD-11: MC82]P07858CTSB
T61746DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P07858CTSB
T61746DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07858CTSB
T61746DI0087Chronic pain[ICD-11: MG30]P07858CTSB
T61746DI0110Cystic fibrosis[ICD-11: CA25]P07858CTSB
T61746DI0124Digestive system disease[ICD-11: DE2Z]P07858CTSB
T61746DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P07858CTSB
T61746DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P07858CTSB
T61746DI0253Meningioma[ICD-11: 2A01]P07858CTSB
T61746DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P07858CTSB
T61746DI0275Multiple sclerosis[ICD-11: 8A40]P07858CTSB
T61746DI0296Neurodegenerative disorder[ICD-11: 8A20-8A23]P07858CTSB
T61746DI0320Osteoarthritis[ICD-11: FA00-FA05]P07858CTSB
T61746DI0351Psoriasis[ICD-11: EA90]P07858CTSB
T61746DI0366Rheumatoid arthritis[ICD-11: FA20]P07858CTSB
T59604DI0087Chronic pain[ICD-11: MG30]Q92847GHSR
T59604DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]Q92847GHSR
T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
T35842DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]Q01726MC1R
T35842DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]Q01726MC1R
T76846DI0308Obesity[ICD-11: 5B80-5B81]P41968MC3R
T76846DI0378Sexual dysfunction[ICD-11: HA00-HA01]P41968MC3R
T76846DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P41968MC3R
T67619DI0062Breast cancer[ICD-11: 2C60-2C6Y]P31749AKT1
T98269DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P29466CASP1
T98269DI0146Fibrosis[ICD-11: GA14-GC01]P29466CASP1
T98269DI0366Rheumatoid arthritis[ICD-11: FA20]P29466CASP1
T98269DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P29466CASP1
T12355DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P24385CCND1
T03672DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q13443ADAM9
T49146DI0210Influenza[ICD-11: 1E30-1E32]P79483HLA-DRB3
T49146DI0231Leukaemia[ICD-11: 2A60-2B33]P79483HLA-DRB3
T49146DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P79483HLA-DRB3
T49146DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P79483HLA-DRB3
T97917DI0025Alzheimer disease[ICD-11: 8A20]P25090FPR2
T27889DI0009Acute diabete complication[ICD-11: 5A2Y]Q9BYF1ACE2
T27889DI0217Intrathoracic organs injury[ICD-11: NB32]Q9BYF1ACE2
T27889DI0356Pulmonary hypertension[ICD-11: BB01]Q9BYF1ACE2
T23499DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25101EDNRA
T23499DI0356Pulmonary hypertension[ICD-11: BB01]P25101EDNRA
T23499DI0425Urinary system clinical symptom[ICD-11: MF8Y]P25101EDNRA
T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
T57943DI0060Brain cancer[ICD-11: 2A00]P42574CASP3
T15439DI0431Vasculitis[ICD-11: 4A44]P21730C5AR1
T64830DI0108Cushing syndrome[ICD-11: 5A70]P35346SSTR5
T53024DI0108Cushing syndrome[ICD-11: 5A70]P30874SSTR2
T53024DI0122Diagnostic imaging[ICD-11: N.A.]P30874SSTR2
T53024DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30874SSTR2
T62974DI0087Chronic pain[ICD-11: MG30]P31391SSTR4
T62974DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P31391SSTR4
T16633DI0108Cushing syndrome[ICD-11: 5A70]P30872SSTR1
T16633DI0395Stomach cancer[ICD-11: 2B72]P30872SSTR1
T13644DI0108Cushing syndrome[ICD-11: 5A70]P32745SSTR3
T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
T65019DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P50281MMP14
T40111DI0062Breast cancer[ICD-11: 2C60-2C6Y]P20839IMPDH1
T40111DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P20839IMPDH1
T40111DI0250Mature B-cell lymphoma[ICD-11: 2A85]P20839IMPDH1
T40111DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P20839IMPDH1
T40111DI0413Transplant rejection[ICD-11: NE84]P20839IMPDH1
T28330DI0210Influenza[ICD-11: 1E30-1E32]P32238CCKAR
T28330DI0328Pancreatic malfunction[ICD-11: DC30-DC3Z]P32238CCKAR
T92828DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P24530EDNRB
T92828DI0356Pulmonary hypertension[ICD-11: BB01]P24530EDNRB
T97035DI0007Acquired hypermelanosis[ICD-11: ED60]P14679TYR
T97035DI0008Acquired hypomelanotic disorder[ICD-11: ED63]P14679TYR
T52790DI0218Irritable bowel syndrome[ICD-11: DD91]P21452TACR2
T29683DI0254Menopausal disorder[ICD-11: GA30]P29371TACR3
T77350DI0274Multiple myeloma[ICD-11: 2A83]P28062PSMB8
T58470DI0363Retina cancer[ICD-11: 2D02]P20248CCNA2
T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
T95302DI0005Acne vulgaris[ICD-11: ED80]P33032MC5R
T95302DI0371Sebaceous gland disorder[ICD-11: ED91]P33032MC5R
T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
T67207DI0231Leukaemia[ICD-11: 2A60-2B33]P06734FCER2
T99816DI0062Breast cancer[ICD-11: 2C60-2C6Y]P30550GRPR
T99816DI0218Irritable bowel syndrome[ICD-11: DD91]P30550GRPR
T99816DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P30550GRPR
T94324DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q969S8HDAC10
T36935DI0036Arteries/arterioles disorder[ICD-11: BD52]P07288KLK3
T36935DI0346Prostate cancer[ICD-11: 2C82]P07288KLK3
T36935DI0348Prostate hyperplasia[ICD-11: GA90]P07288KLK3
T87831DI0333Peptic ulcer[ICD-11: DA61]P21462FPR1
T25847DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P23284PPIB
T98945DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P09958FUR
T63083DI0048B-cell lymphoma[ICD-11: 2A86]Q06609RAD51
T63083DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06609RAD51
T00099DI0106COVID-19[ICD-11: 1D6Y]P04632CAPNS1
T82078DI0346Prostate cancer[ICD-11: 2C82]O60603TLR2
T62391DI0298Neuropathy[ICD-11: 8C0Z]P42263GRIA3
T27602DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q9HAN5TRP1
T27602DI0274Multiple myeloma[ICD-11: 2A83]Q9HAN5TRP1
T45228DI0308Obesity[ICD-11: 5B80-5B81]Q96T53FKSG89
T45228DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q96T53FKSG89
T93903DI0110Cystic fibrosis[ICD-11: CA25]P55211CASP9

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