N-(1-{[2-(4-hydroxyphenyl)-1-phosphonoethyl]-C-hydroxycarbonimidoyl}-2-phenylethyl)-3-methyl-2-(methylamino)butanimidic acid



Compound IDCDAMM00194
Common nameN-(1-{[2-(4-hydroxyphenyl)-1-phosphonoethyl]-C-hydroxycarbonimidoyl}-2-phenylethyl)-3-methyl-2-(methylamino)butanimidic acid
IUPAC name[2-(4-hydroxyphenyl)-1-[[2-[[3-methyl-2-(methylamino)butanoyl]amino]-3-phenylpropanoyl]amino]ethyl]phosphonic acid
Molecular formulaC23H32N3O6P

Experimental data

Retention time21.41
Adduct[M+H]+
Actual mz478.21
Theoretical mz478.21
Error0.08
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score4.5906

Identifiers and class information

Inchi keyQNWHLBSNWDAJMZ-UHFFFAOYSA-N
SmilesCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=C(C=C2)O)P(=O)(O)O)NC
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives

Pharmacokinetic properties

Number of descriptor values(#stars)0
Number of non-conjugated amine groups (#amine)1
Number of amidine and guanidine groups (#amidine)0
Number of carboxylic acid groups (#acid)2
Number of non-conjugated amide groups (#amide)2
Number of rotatable bonds (#rotor)14
Number of reactive functional groups (#rtvFG)0
Predicted central nervous system activity (CNS)-2
Molecular weight (mol_MW)477.496
Computed dipole moment(dipole)8.002
Total solvent accessible surface area (SASA)700.225
Hydrophobic component of SASA (FOSA)269.992
Hydrophilic component of SASA (FISA)179.095
Pie component of the SASA (PISA)249.323
Weakly polar component of the SASA (WPSA)1.815
Total solvent accesible volume (volume)1401.16
Number of hydrogen bond donors (donorHB)4.5
Number of hydrogen bond acceptors (accptHB)10.75
Free energy of solvation of dipole (dip^2/V)0.0456958
Index of cohesive interaction in solids (ACxDN^.5/SA)0.032567
Globularity descriptor (glob)0.864806
Predicted polarizability in cubic angstroms (QPpolrz)43.312
Predicted hexadecane/gas partition coefficient (QPlogPC16)15.192
Predicted octanol/gas partition coefficient (QPlogPoct)27.505
Predicted water/gas partition coefficient (QPlogPw)20.404
Predicted octanol/water partition coefficient (QPlogPo/w)-0.265
Predicted aqueous solubility (QPlogS)-1.588
Conformation-independent predicted aqueous solubility (CIQPlogS)-2.861
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)0.729
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)1.937
Predicted brain/blood partition coefficient (QPlogBB)-1.474
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)1.806
Predicted skin permeability, log Kp (QPlogKp)-4.66
PM3 calculated ionization potential (IP(ev))8.931
PM3 calculated electron affinity (EA(eV))-0.048
Number of likely metabolic reactions (#metab)6
Prediction of binding to human serum albumin (QPlogKhsa)-1.169
Predicted qualitative human oral absorption (HumanOralAbsorption)1
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)17.573
Solvent-accessible surface area of fluorine atoms (SAFluorine)0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)26.946
Van der Waals surface area (PSA)155.956
Number of nitrogen and oxygen atoms (#NandO)9
Number of violations of Lipinski’s rule of five (RuleOfFive)1
Number of violations of Jorgensen’s rule of three (RuleOfThree)1

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID Gene name Target name TTD_ID Prediction source
P00797RENReninT61622SEA
P15144ANPEPAminopeptidase NT67272SEA
P00734F2ThrombinT94033SEA
P09960LTA4HLeukotriene A4 hydrolaseT03691SEA
P06239LCKTyrosine-protein kinase LCKT12499SEA
Q9NTG7SIRT3NAD-dependent deacetylase sirtuin 3T91959SEA
P98170XIAPInhibitor of apoptosis protein 3T16769SEA
P78352DLG4Disks large homolog 4T04507SEA
P08473MMENeprilysinT05409SEA
P42261GRIA1Glutamate receptor ionotropic, AMPA 1T33584SEA
P00747PLGPlasminogenT89034SEA
P43235CTSKCathepsin KT11388SEA
Q9H4A4RNPEPAminopeptidase BT57818SEA
Q16719KYNUKynureninaseT99912SEA
P07339CTSDCathepsin DT67102SEA
P18031PTPN1Protein-tyrosine phosphatase 1BT16347SEA
P17706PTPN2T-cell protein-tyrosine phosphataseT49156SEA
Q07075ENPEPAminopeptidase AT31956SEA
P08253MMP2Matrix metalloproteinase 2T68251SEA
P22894MMP8Matrix metalloproteinase 8T08856SEA
P08254MMP3Matrix metalloproteinase 3T86702SEA
P14780MMP9Matrix metalloproteinase 9T54156SEA
P03956MMP1Matrix metalloproteinase 1T52450SEA
P17655CAPN2Calpain 2T86837SEA
P35372OPRM1Mu opioid receptorT47768SEA
P41145OPRK1Kappa Opioid receptorT60693SEA
P62993GRB2Growth factor receptor-bound protein 2T30926SEA
P56817BACE1Beta-secretase 1T79031SEA
P45452MMP13Matrix metalloproteinase 13T34296SEA
P09237MMP7Matrix metalloproteinase 7T73475SEA
P13497BMP1Bone morphogenetic protein 1T53350SEA
P04229HLA-DRB1HLA class II histocompatibility antigen DRB1-1T83611SEA
P07711CTSLCathepsin LT98691SEA
P32245MC4RMelanocortin receptor 4T72458SEA
P07858CTSBCathepsin (B and K)T61746SEA
Q92847GHSRGhrelin receptorT59604SEA
P41143OPRD1Delta opioid receptorT58992SEA
Q01726MC1RMelanocortin receptor 1T35842SEA
P41968MC3RMelanocortin receptor 3T76846SEA
P23946CMA1ChymaseT05114SEA
P00750PLATTissue-type plasminogen activatorT45299SEA
Q13489BIRC3Baculoviral IAP repeat-containing protein 3T35173SEA
P49356FNTBFarnesyl protein transferaseT13127SEA
P04035HMGCRHMG-CoA reductaseT53585SEA
P32246CCR1C-C chemokine receptor type 1T16016SEA
P49810PSEN2Gamma-secretaseT99204SEA
P29466CASP1Caspase-1T98269SEA
P12931SRCTyrosine-protein kinase SRCT85943SEA
P25774CTSSCathepsin ST68290SEA
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2T65818SEA
P06870KLK1Kallikrein 1T40000SEA
P20151KLK2Kallikrein 2T01908SEA
P20142PGCPepsinogen C (by homology)T45601SEA
P04439HLA-AHLA class I histocompatibility antigen A-3T08985SEA
P14091CTSECathepsin ET16891SEA
P79483HLA-DRB3HLA class II histocompatibility antigen DRB3-1T49146SEA
Q9ULA0DNPEPAspartyl aminopeptidaseT45287SEA
Q9BYF1ACE2Angiotensin-converting enzyme 2T27889SEA
P42892ECE1Endothelin-converting enzyme 1T50970SEA
P05556ITGB1Integrin alpha2/beta1T01851SEA
P25101EDNRAEndothelin receptor ET-AT23499SEA
P39900MMP12Matrix metalloproteinase 12T03500SEA
P06737PYGLLiver glycogen phosphorylaseT19184SEA
P42574CASP3Caspase-3T57943SEA
P41146OPRL1Nociceptin receptorT52921SEA
P25929NPY1RNeuropeptide Y receptor type 1T89213SEA
P15085CPA1Carboxypeptidase A1T33966SEA
Q99895CTRCChymotrypsin CT10118SEA
P50052AGTR2Angiotensin II receptorT09909SEA
P32239CCKBRCholecystokinin B receptor (by homology)T05849SEA
P30989NTSR1Neurotensin receptor 1T02728SEA
P50281MMP14Matrix metalloproteinase 14T65019SEA
P00749PLAUUrokinase-type plasminogen activatorT17758SEA
P32238CCKARCholecystokinin A receptorT28330SEA
Q16581C3AR1C3a anaphylatoxin chemotactic receptorT30219SEA
P03952KLKB1Plasma kallikreinT82739SEA
P28074PSMB5Proteasome Macropain subunit MB1T49031SEA
O60760HPGDSHematopoietic prostaglandin D synthaseT19433SEA
P14679TYRTyrosinaseT97035SEA
Q9Y3Q0NAALAD2NAALADase IIT70036SEA
P25116F2RProteinase-activated receptor 1T36483SEA
P21452TACR2Neurokinin 2 receptorT52790SEA
O15151MDM4Protein Mdm4T36741SEA
P26010ITGB7Integrin alpha-4/beta-7T07403SEA
P09238MMP10Matrix metalloproteinase 10T40488SEA
P01584IL1BInterleukin-1 betaT42000SEA
Q13526PIN1Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1T16308SEA
Q16549PCSK7Subtilisin/kexin type 7T33211SEA
P42226STAT6Signal transducer and activator of transcription 6T20585SEA
P29371TACR3Neurokinin 3 receptorT29683SEA
Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SEA
P28065PSMB9Proteasome subunit beta type-9T06792SEA
P28062PSMB8Proteasome subunit beta type-8T77350SEA
P43403ZAP70Tyrosine-protein kinase ZAP-70T64553SEA
P20248CCNA2CDK2/Cyclin AT58470SEA
P03951F11Coagulation factor XIT46040SEA
Q8IU80TMPRSS6Transmembrane protease serine 6T13863SEA
Q9Y5Y6ST14MatriptaseT31543SEA
O75173ADAMTS4ADAMTS4T79570SEA
Q9UNI1CELA1Elastase 1T22839SEA
P28336NMBRNeuromedin B receptorT68887SEA
O60911CTSVCathepsin (V and K)T93653SEA
P49768PSEN1Presenilin 1T93105SEA
O75908SOAT2Acyl coenzyme A:cholesterol acyltransferase 2T14463SEA
P06734FCER2Immunoglobulin epsilon Fc receptorT67207SEA
P13612ITGA4Integrin alpha-4T97587SEA
P07288KLK3Prostate specific antigenT36935SEA
Q9UBX1CTSFCathepsin FT77236SEA
Q9NZ08ERAP1Endoplasmic reticulum aminopeptidase 1T72849SEA
Q00975CACNA1BVoltage-gated N-type calcium channel alpha-1B subunitT38338SEA
Q9Y345SLC6A5Glycine transporter 2T58937SEA
Q96BI3APH1AGamma-secretaseT99840SEA
P21462FPR1Formyl peptide receptor 1T87831SEA
Q9UBY5LPAR3Lysophosphatidic acid receptor Edg-7T95923SEA
Q92633LPAR1Lysophosphatidic acid receptor Edg-2T92640SEA
Q6DWJ6GPR139Probable G-protein coupled receptor 139T84439SEA
O95931CBX7Chromobox protein homolog 7T72319SEA
Q9Y337KLK5Kallikrein 5T11808SEA
P40306PSMB1026S proteosomeT09022SEA
P08311CTSGCathepsin GT86385SEA
P09668CTSHCathepsin (H and K)T40103SEA
P04070PROCVitamin K-dependent protein CT24836SEA
O95749GGPS1GeranyltranstransferaseT86528SEA
Q04609FOLH1Glutamate carboxypeptidase IIT97071SEA
P09958FURHUMAN dibasic-processing enzymeT98945SEA
P29120PCSK1Neuroendocrine convertase 1T36445SEA
Q92824PCSK5Proprotein convertase subtilisin/kexin type 5T38581SEA
Q9GZQ6NPFFR1Neuropeptide FF receptor 1T79780SEA
Q9Y5X5NPFFR2Neuropeptide FF receptor 2T90818SEA
O60259KLK8NeuropsinT43289SEA
Q9Y5K2KLK4Kallikrein-4T79400SEA
Q9Y4G9PCSK6Proprotein convertase subtilisin/kexin type 6T86503SEA
P04632CAPNS1HUMAN calpain-1 or calpain small subunit 1 heterodimerT00099SEA
P49356FNTBFarnesyl protein transferaseT13127SEA
O95665NTSR2Neurotensin receptor type 2T95605SEA
P24347MMP11Matrix metalloproteinase-11T73180SEA
Q9ULZ9MMP17Matrix metalloproteinase-17T55616SEA
P25786PSMA1Core proteasome 20S complexT61997SEA
P28072PSMB6Proteasome beta-1T54973SEA
Q99436PSMB7Proteasome beta-2T55986SEA
Q96T53FKSG89Ghrelin O acyltransferaseT45228SEA
P55211CASP9Caspase-9T93903SEA
Q9UQ81MCH5Caspase-8T15700SEA
P23467PTPRBProtein tyrosine phosphatase betaT57034SEA
P14672GLUT4Glucose transporter type 4T67658SEA
Q92851CASP10Caspase-10T14894SEA
Q9UG96ICH2Caspase-4T53469SEA
Q96BI3APH1AGamma-secretaseT99840SEA
P16519PCSK2Neuroendocrine convertase 2T97749SEA

Target associated diseases

TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
T61622DI0190Hypertension[ICD-11: BA00-BA04]P00797REN
T67272DI0351Psoriasis[ICD-11: EA90]P15144ANPEP
T94033DI0052Bleeding disorder[ICD-11: GA20-GA21]P00734F2
T94033DI0091Coagulation defect[ICD-11: 3B10]P00734F2
T94033DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P00734F2
T94033DI0275Multiple sclerosis[ICD-11: 8A40]P00734F2
T94033DI0287Myocardial infarction[ICD-11: BA41-BA43]P00734F2
T94033DI0306Nutritional deficiency[ICD-11: 5B50-5B71]P00734F2
T94033DI0403Thrombocytopenia[ICD-11: 3B64]P00734F2
T94033DI0405Thrombosis[ICD-11: DB61-GB90]P00734F2
T03691DI0012Acute myeloid leukaemia[ICD-11: 2A60]P09960LTA4H
T12499DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P06239LCK
T16769DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]P98170XIAP
T04507DI0073Cerebral ischaemia[ICD-11: 8B1Z]P78352DLG4
T04507DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P78352DLG4
T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
T33584DI0298Neuropathy[ICD-11: 8C0Z]P42261GRIA1
T89034DI0030Angina pectoris[ICD-11: BA40]P00747PLG
T89034DI0052Bleeding disorder[ICD-11: GA20-GA21]P00747PLG
T89034DI0254Menopausal disorder[ICD-11: GA30]P00747PLG
T89034DI0287Myocardial infarction[ICD-11: BA41-BA43]P00747PLG
T89034DI0345Procedure injury[ICD-11: NE81]P00747PLG
T89034DI0357Pulmonary thromboembolism[ICD-11: BB00]P00747PLG
T11388DI0237Low bone mass disorder[ICD-11: FB83]P43235CTSK
T99912DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q16719KYNU
T99912DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q16719KYNU
T67102DI0275Multiple sclerosis[ICD-11: 8A40]P07339CTSD
T16347DI0009Acute diabete complication[ICD-11: 5A2Y]P18031PTPN1
T16347DI0062Breast cancer[ICD-11: 2C60-2C6Y]P18031PTPN1
T16347DI0308Obesity[ICD-11: 5B80-5B81]P18031PTPN1
T16347DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P18031PTPN1
T49156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P17706PTPN2
T31956DI0190Hypertension[ICD-11: BA00-BA04]Q07075ENPEP
T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
T86702DI0101Corneal disease[ICD-11: 9A76-9A78]P08254MMP3
T86702DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P08254MMP3
T86702DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P08254MMP3
T86702DI0275Multiple sclerosis[ICD-11: 8A40]P08254MMP3
T86702DI0287Myocardial infarction[ICD-11: BA41-BA43]P08254MMP3
T86702DI0320Osteoarthritis[ICD-11: FA00-FA05]P08254MMP3
T86702DI0366Rheumatoid arthritis[ICD-11: FA20]P08254MMP3
T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
T52450DI0238Lung cancer[ICD-11: 2C25]P03956MMP1
T86837DI0106COVID-19[ICD-11: 1D6Y]P17655CAPN2
T47768DI0013Acute pain[ICD-11: MG31]P35372OPRM1
T47768DI0059Bowel habit change[ICD-11: ME05]P35372OPRM1
T47768DI0087Chronic pain[ICD-11: MG30]P35372OPRM1
T47768DI0101Corneal disease[ICD-11: 9A76-9A78]P35372OPRM1
T47768DI0105Cough[ICD-11: MD12]P35372OPRM1
T47768DI0117Depression[ICD-11: 6A70-6A7Z]P35372OPRM1
T47768DI0124Digestive system disease[ICD-11: DE2Z]P35372OPRM1
T47768DI0218Irritable bowel syndrome[ICD-11: DD91]P35372OPRM1
T47768DI0228Large intestine motility disorder[ICD-11: DB32]P35372OPRM1
T47768DI0317Opioid use disorder[ICD-11: 6C43]P35372OPRM1
T47768DI0324Pain[ICD-11: MG30-MG3Z]P35372OPRM1
T47768DI0349Pruritus[ICD-11: EC90]P35372OPRM1
T47768DI0374Sensation disturbance[ICD-11: MB40]P35372OPRM1
T60693DI0304Non-specific cutaneous vascular symptom[ICD-11: ME64]P41145OPRK1
T60693DI0324Pain[ICD-11: MG30-MG3Z]P41145OPRK1
T60693DI0349Pruritus[ICD-11: EC90]P41145OPRK1
T30926DI0012Acute myeloid leukaemia[ICD-11: 2A60]P62993GRB2
T30926DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P62993GRB2
T30926DI0250Mature B-cell lymphoma[ICD-11: 2A85]P62993GRB2
T30926DI0284Myelodysplastic syndrome[ICD-11: 2A37]P62993GRB2
T30926DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P62993GRB2
T79031DI0025Alzheimer disease[ICD-11: 8A20]P56817BACE1
T34296DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45452MMP13
T73475DI0238Lung cancer[ICD-11: 2C25]P09237MMP7
T83611DI0275Multiple sclerosis[ICD-11: 8A40]P04229HLA-DRB1
T98691DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P07711CTSL
T98691DI0376Severe acute respiratory syndrome[ICD-11: 1D65]P07711CTSL
T72458DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]P32245MC4R
T72458DI0228Large intestine motility disorder[ICD-11: DB32]P32245MC4R
T72458DI0308Obesity[ICD-11: 5B80-5B81]P32245MC4R
T61746DI0023Alopecia[ICD-11: ED70]P07858CTSB
T61746DI0025Alzheimer disease[ICD-11: 8A20]P07858CTSB
T61746DI0037Asthma[ICD-11: CA23]P07858CTSB
T61746DI0055Bone cancer[ICD-11: 2B5Z]P07858CTSB
T61746DI0060Brain cancer[ICD-11: 2A00]P07858CTSB
T61746DI0067Cardiac arrest[ICD-11: MC82]P07858CTSB
T61746DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P07858CTSB
T61746DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P07858CTSB
T61746DI0087Chronic pain[ICD-11: MG30]P07858CTSB
T61746DI0110Cystic fibrosis[ICD-11: CA25]P07858CTSB
T61746DI0124Digestive system disease[ICD-11: DE2Z]P07858CTSB
T61746DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P07858CTSB
T61746DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P07858CTSB
T61746DI0253Meningioma[ICD-11: 2A01]P07858CTSB
T61746DI0262Metastatic tumour[ICD-11: 2D50-2E2Z]P07858CTSB
T61746DI0275Multiple sclerosis[ICD-11: 8A40]P07858CTSB
T61746DI0296Neurodegenerative disorder[ICD-11: 8A20-8A23]P07858CTSB
T61746DI0320Osteoarthritis[ICD-11: FA00-FA05]P07858CTSB
T61746DI0351Psoriasis[ICD-11: EA90]P07858CTSB
T61746DI0366Rheumatoid arthritis[ICD-11: FA20]P07858CTSB
T59604DI0087Chronic pain[ICD-11: MG30]Q92847GHSR
T59604DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]Q92847GHSR
T58992DI0059Bowel habit change[ICD-11: ME05]P41143OPRD1
T58992DI0218Irritable bowel syndrome[ICD-11: DD91]P41143OPRD1
T58992DI0324Pain[ICD-11: MG30-MG3Z]P41143OPRD1
T35842DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]Q01726MC1R
T35842DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]Q01726MC1R
T76846DI0308Obesity[ICD-11: 5B80-5B81]P41968MC3R
T76846DI0378Sexual dysfunction[ICD-11: HA00-HA01]P41968MC3R
T76846DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P41968MC3R
T05114DI0039Atopic eczema[ICD-11: EA80]P23946CMA1
T05114DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P23946CMA1
T05114DI0169Gram-positive bacterial infection[ICD-11: 1B74-1F40]P23946CMA1
T05114DI0175Heart failure[ICD-11: BD10-BD1Z]P23946CMA1
T05114DI0229Left ventricular failure[ICD-11: BD11]P23946CMA1
T05114DI0287Myocardial infarction[ICD-11: BA41-BA43]P23946CMA1
T45299DI0052Bleeding disorder[ICD-11: GA20-GA21]P00750PLAT
T45299DI0345Procedure injury[ICD-11: NE81]P00750PLAT
T35173DI0259Metastatic lymph node neoplasm[ICD-11: 2D60]Q13489BIRC3
T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
T53585DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P04035HMGCR
T53585DI0102Coronary atherosclerosis[ICD-11: BA52]P04035HMGCR
T53585DI0128Dyslipidemia[ICD-11: 5C80-5C81]P04035HMGCR
T53585DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P04035HMGCR
T53585DI0275Multiple sclerosis[ICD-11: 8A40]P04035HMGCR
T53585DI0287Myocardial infarction[ICD-11: BA41-BA43]P04035HMGCR
T53585DI0324Pain[ICD-11: MG30-MG3Z]P04035HMGCR
T16016DI0120Diabetes mellitus[ICD-11: 5A10]P32246CCR1
T16016DI0366Rheumatoid arthritis[ICD-11: FA20]P32246CCR1
T99204DI0320Osteoarthritis[ICD-11: FA00-FA05]P49810PSEN2
T99204DI0380Shoulder lesion[ICD-11: FB53]P49810PSEN2
T99204DI0390Soft tissue disorder[ICD-11: FB56]P49810PSEN2
T98269DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P29466CASP1
T98269DI0146Fibrosis[ICD-11: GA14-GC01]P29466CASP1
T98269DI0366Rheumatoid arthritis[ICD-11: FA20]P29466CASP1
T98269DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P29466CASP1
T85943DI0062Breast cancer[ICD-11: 2C60-2C6Y]P12931SRC
T85943DI0220Ischemia[ICD-11: 8B10-8B11]P12931SRC
T85943DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P12931SRC
T85943DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P12931SRC
T68290DI0042Autoimmune disease[ICD-11: 4A40-4A45]P25774CTSS
T68290DI0092Coeliac disease[ICD-11: DA95]P25774CTSS
T68290DI0107Crohn disease[ICD-11: DD70]P25774CTSS
T68290DI0120Diabetes mellitus[ICD-11: 5A10]P25774CTSS
T68290DI0163General pain disorder[ICD-11: 8E43]P25774CTSS
T68290DI0324Pain[ICD-11: MG30-MG3Z]P25774CTSS
T68290DI0382Sjogren syndrome[ICD-11: 4A43]P25774CTSS
T01908DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P20151KLK2
T49146DI0210Influenza[ICD-11: 1E30-1E32]P79483HLA-DRB3
T49146DI0231Leukaemia[ICD-11: 2A60-2B33]P79483HLA-DRB3
T49146DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P79483HLA-DRB3
T49146DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P79483HLA-DRB3
T45287DI0190Hypertension[ICD-11: BA00-BA04]Q9ULA0DNPEP
T27889DI0009Acute diabete complication[ICD-11: 5A2Y]Q9BYF1ACE2
T27889DI0217Intrathoracic organs injury[ICD-11: NB32]Q9BYF1ACE2
T27889DI0356Pulmonary hypertension[ICD-11: BB01]Q9BYF1ACE2
T01851DI0060Brain cancer[ICD-11: 2A00]P05556ITGB1
T01851DI0238Lung cancer[ICD-11: 2C25]P05556ITGB1
T01851DI0365Retinopathy[ICD-11: 9B71]P05556ITGB1
T23499DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25101EDNRA
T23499DI0356Pulmonary hypertension[ICD-11: BB01]P25101EDNRA
T23499DI0425Urinary system clinical symptom[ICD-11: MF8Y]P25101EDNRA
T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
T57943DI0060Brain cancer[ICD-11: 2A00]P42574CASP3
T52921DI0039Atopic eczema[ICD-11: EA80]P41146OPRL1
T52921DI0117Depression[ICD-11: 6A70-6A7Z]P41146OPRL1
T52921DI0173Headache[ICD-11: 8A80-8A84]P41146OPRL1
T52921DI0175Heart failure[ICD-11: BD10-BD1Z]P41146OPRL1
T89213DI0050Binge eating disorder[ICD-11: 6B82]P25929NPY1R
T89213DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P25929NPY1R
T89213DI0174Heart disease[ICD-11: BA41-BA42]P25929NPY1R
T89213DI0190Hypertension[ICD-11: BA00-BA04]P25929NPY1R
T89213DI0308Obesity[ICD-11: 5B80-5B81]P25929NPY1R
T09909DI0190Hypertension[ICD-11: BA00-BA04]P50052AGTR2
T09909DI0373Secondary hypertension[ICD-11: BA04]P50052AGTR2
T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
T02728DI0207Indeterminate colitis[ICD-11: DD72]P30989NTSR1
T65019DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]P50281MMP14
T17758DI0211Inherited coagulation factor deficiency[ICD-11: 3B14]P00749PLAU
T17758DI0287Myocardial infarction[ICD-11: BA41-BA43]P00749PLAU
T28330DI0210Influenza[ICD-11: 1E30-1E32]P32238CCKAR
T28330DI0328Pancreatic malfunction[ICD-11: DC30-DC3Z]P32238CCKAR
T82739DI0213Innate/adaptive immunodeficiency[ICD-11: 4A00]P03952KLKB1
T82739DI0364Retinal vascular occlusion[ICD-11: 9B74]P03952KLKB1
T19433DI0148Flatworm infection[ICD-11: 1F70-1F86]O60760HPGDS
T97035DI0007Acquired hypermelanosis[ICD-11: ED60]P14679TYR
T97035DI0008Acquired hypomelanotic disorder[ICD-11: ED63]P14679TYR
T36483DI0287Myocardial infarction[ICD-11: BA41-BA43]P25116F2R
T52790DI0218Irritable bowel syndrome[ICD-11: DD91]P21452TACR2
T36741DI0012Acute myeloid leukaemia[ICD-11: 2A60]O15151MDM4
T36741DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O15151MDM4
T36741DI0284Myelodysplastic syndrome[ICD-11: 2A37]O15151MDM4
T36741DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15151MDM4
T07403DI0107Crohn disease[ICD-11: DD70]P26010ITGB7
T42000DI0267Mineral excesses[ICD-11: 5B91]P01584IL1B
T42000DI0269Monogenic autoinflammatory syndrome[ICD-11: 4A60]P01584IL1B
T42000DI0320Osteoarthritis[ICD-11: FA00-FA05]P01584IL1B
T42000DI0366Rheumatoid arthritis[ICD-11: FA20]P01584IL1B
T16308DI0238Lung cancer[ICD-11: 2C25]Q13526PIN1
T29683DI0254Menopausal disorder[ICD-11: GA30]P29371TACR3
T77350DI0274Multiple myeloma[ICD-11: 2A83]P28062PSMB8
T58470DI0363Retina cancer[ICD-11: 2D02]P20248CCNA2
T46040DI0074Cerebral ischaemic stroke[ICD-11: 8B11]P03951F11
T46040DI0089Clotting disorder[ICD-11: 3B4Z]P03951F11
T22839DI0024Alpha-1-antitrypsin deficiency[ICD-11: 5C5A]Q9UNI1CELA1
T22839DI0065Bronchitis[ICD-11: CA20]Q9UNI1CELA1
T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
T93653DI0055Bone cancer[ICD-11: 2B5Z]O60911CTSV
T93653DI0087Chronic pain[ICD-11: MG30]O60911CTSV
T93105DI0320Osteoarthritis[ICD-11: FA00-FA05]P49768PSEN1
T93105DI0380Shoulder lesion[ICD-11: FB53]P49768PSEN1
T93105DI0390Soft tissue disorder[ICD-11: FB56]P49768PSEN1
T14463DI0017Adrenal cancer[ICD-11: 2D11]O75908SOAT2
T67207DI0231Leukaemia[ICD-11: 2A60-2B33]P06734FCER2
T97587DI0107Crohn disease[ICD-11: DD70]P13612ITGA4
T97587DI0275Multiple sclerosis[ICD-11: 8A40]P13612ITGA4
T97587DI0419Ulcerative colitis[ICD-11: DD71]P13612ITGA4
T36935DI0036Arteries/arterioles disorder[ICD-11: BD52]P07288KLK3
T36935DI0346Prostate cancer[ICD-11: 2C82]P07288KLK3
T36935DI0348Prostate hyperplasia[ICD-11: GA90]P07288KLK3
T77236DI0055Bone cancer[ICD-11: 2B5Z]Q9UBX1CTSF
T77236DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]Q9UBX1CTSF
T77236DI0087Chronic pain[ICD-11: MG30]Q9UBX1CTSF
T77236DI0124Digestive system disease[ICD-11: DE2Z]Q9UBX1CTSF
T77236DI0178Hepatic fibrosis/cirrhosis[ICD-11: DB93]Q9UBX1CTSF
T77236DI0275Multiple sclerosis[ICD-11: 8A40]Q9UBX1CTSF
T77236DI0351Psoriasis[ICD-11: EA90]Q9UBX1CTSF
T38338DI0264Migraine[ICD-11: 8A80]Q00975CACNA1B
T38338DI0305Non-thrombocytopenic purpura[ICD-11: 3B60]Q00975CACNA1B
T38338DI0324Pain[ICD-11: MG30-MG3Z]Q00975CACNA1B
T99840DI0119Desmoid tumour[ICD-11: 2F7C]Q96BI3APH1A
T87831DI0333Peptic ulcer[ICD-11: DA61]P21462FPR1
T95923DI0146Fibrosis[ICD-11: GA14-GC01]Q9UBY5LPAR3
T95923DI0399Systemic sclerosis[ICD-11: 4A42]Q9UBY5LPAR3
T92640DI0146Fibrosis[ICD-11: GA14-GC01]Q92633LPAR1
T92640DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q92633LPAR1
T92640DI0351Psoriasis[ICD-11: EA90]Q92633LPAR1
T92640DI0399Systemic sclerosis[ICD-11: 4A42]Q92633LPAR1
T84439DI0377Sex development malformative disorder[ICD-11: LD2A]Q6DWJ6GPR139
T86385DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P08311CTSG
T24836DI0084Chronic lower extremities peripheral venous insufficiency[ICD-11: BD74]P04070PROC
T24836DI0177Hemangioma[ICD-11: 2E81-2F2Y]P04070PROC
T86528DI0057Bone paget disease[ICD-11: FB85]O95749GGPS1
T86528DI0237Low bone mass disorder[ICD-11: FB83]O95749GGPS1
T86528DI0267Mineral excesses[ICD-11: 5B91]O95749GGPS1
T86528DI0281Musculoskeletal disorder[ICD-11: FA00-FC0Z]O95749GGPS1
T97071DI0122Diagnostic imaging[ICD-11: N.A.]Q04609FOLH1
T97071DI0346Prostate cancer[ICD-11: 2C82]Q04609FOLH1
T98945DI0263Middle East Respiratory Syndrome[ICD-11: 1D64]P09958FUR
T00099DI0106COVID-19[ICD-11: 1D6Y]P04632CAPNS1
T13127DI0342Premature ageing appearance[ICD-11: LD2B]P49356FNTB
T45228DI0308Obesity[ICD-11: 5B80-5B81]Q96T53FKSG89
T45228DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q96T53FKSG89
T93903DI0110Cystic fibrosis[ICD-11: CA25]P55211CASP9
T15700DI0120Diabetes mellitus[ICD-11: 5A10]Q9UQ81MCH5
T15700DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9UQ81MCH5
T57034DI0081Chronic arterial occlusive disease[ICD-11: BD4Z]P23467PTPRB
T57034DI0365Retinopathy[ICD-11: 9B71]P23467PTPRB
T67658DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P14672GLUT4
T99840DI0119Desmoid tumour[ICD-11: 2F7C]Q96BI3APH1A

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