(2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-2-propanamine



Compound IDCDAMM00172
Common name(2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-indazol-5-yl)-3-pyridinyl]oxy]-2-propanamine
IUPAC name1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine
Molecular formulaC24H23N5O

Experimental data

Retention time28.56
Adduct[M+H]+
Actual mz398.197
Theoretical mz398.198
Error0.57
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score4.6738

Identifiers and class information

Inchi keyYWTBGJGMTBHQTM-TWYLJJHKNA-N
SmilesCC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OCC(CC4=CNC5=CC=CC=C54)N
SuperclassOrganoheterocyclic compounds
ClassIndoles and derivatives

Pharmacokinetic properties

Number of descriptor values(#stars)0
Number of non-conjugated amine groups (#amine)1
Number of amidine and guanidine groups (#amidine)0
Number of carboxylic acid groups (#acid)0
Number of non-conjugated amide groups (#amide)0
Number of rotatable bonds (#rotor)7
Number of reactive functional groups (#rtvFG)0
Predicted central nervous system activity (CNS)-2
Molecular weight (mol_MW)397.479
Computed dipole moment(dipole)3.633
Total solvent accessible surface area (SASA)645.562
Hydrophobic component of SASA (FOSA)119.99
Hydrophilic component of SASA (FISA)171.674
Pie component of the SASA (PISA)353.898
Weakly polar component of the SASA (WPSA)0
Total solvent accesible volume (volume)1214.59
Number of hydrogen bond donors (donorHB)4
Number of hydrogen bond acceptors (accptHB)4.25
Free energy of solvation of dipole (dip^2/V)0.0108646
Index of cohesive interaction in solids (ACxDN^.5/SA)0.0131668
Globularity descriptor (glob)0.852802
Predicted polarizability in cubic angstroms (QPpolrz)41.339
Predicted hexadecane/gas partition coefficient (QPlogPC16)14.121
Predicted octanol/gas partition coefficient (QPlogPoct)22.328
Predicted water/gas partition coefficient (QPlogPw)13.348
Predicted octanol/water partition coefficient (QPlogPo/w)3.233
Predicted aqueous solubility (QPlogS)-3.576
Conformation-independent predicted aqueous solubility (CIQPlogS)-5.633
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-6.328
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)58.186
Predicted brain/blood partition coefficient (QPlogBB)-1.034
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)25.301
Predicted skin permeability, log Kp (QPlogKp)-4.827
PM3 calculated ionization potential (IP(ev))8.435
PM3 calculated electron affinity (EA(eV))0.46
Number of likely metabolic reactions (#metab)7
Prediction of binding to human serum albumin (QPlogKhsa)0.542
Predicted qualitative human oral absorption (HumanOralAbsorption)2
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)77.463
Solvent-accessible surface area of fluorine atoms (SAFluorine)0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
Van der Waals surface area (PSA)90.955
Number of nitrogen and oxygen atoms (#NandO)6
Number of violations of Lipinski’s rule of five (RuleOfFive)0
Number of violations of Jorgensen’s rule of three (RuleOfThree)1

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID Gene name Target name TTD_ID Prediction source
O15379HDAC3Histone deacetylase 3T05090SEA
Q15118PDK1Pyruvate dehydrogenase kinase isoform 1T20891SEA
Q92769HDAC2Histone deacetylase 2T51191SEA
P53779MAPK10c-Jun N-terminal kinase 3T85421SEA
P04150NR3C1Glucocorticoid receptorT40016SEA
P49137MAPKAPK2MAP kinase-activated protein kinase 2T21307SEA
P08253MMP2Matrix metalloproteinase 2T68251SEA
P22894MMP8Matrix metalloproteinase 8T08856SEA
P14780MMP9Matrix metalloproteinase 9T54156SEA
P11309PIM1Serine/threonine-protein kinase PIM1T50594SEA
P53667LIMK1LIM domain kinase 1T70840SEA
P24941CDK2Cyclin-dependent kinase 2T70176SEA
P36888FLT3Tyrosine-protein kinase receptor FLT3T74312SEA
Q9P1W9PIM2Serine/threonine-protein kinase PIM2T07279SEA
Q86V86PIM3Serine/threonine-protein kinase PIM3T16596SEA
P35270SPRSubstance-P receptorT47094SEA
P32245MC4RMelanocortin receptor 4T72458SEA
Q92847GHSRGhrelin receptorT59604SEA
Q01726MC1RMelanocortin receptor 1T35842SEA
P41968MC3RMelanocortin receptor 3T76846SEA
O75116ROCK2Rho-associated protein kinase 2T06093SEA
P31749AKT1Serine/threonine-protein kinase AKTT67619SEA
P49841GSK3BGlycogen synthase kinase-3 betaT70977SEA
O96017CHEK2Serine/threonine-protein kinase Chk2T28713SEA
P41743PRKCIProtein kinase C iotaT83174SEA
Q02156PRKCEProtein kinase C epsilonT00895SEA
P35916FLT4Vascular endothelial growth factor receptor 3T07303SEA
Q9HBH9MKNK2MAP kinase signal-integrating kinase 2T99160SEA
O00444PLK4Serine/threonine-protein kinase PLK4T71374SEA
Q9Y463DYRK1BDual specificity tyrosine-phosphorylation-regulated kinase 1BT82720SEA
Q14289PTK2BProtein tyrosine kinase 2 betaT07087SEA
O00311CDC7CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)T81358SEA
P42892ECE1Endothelin-converting enzyme 1T50970SEA
Q9NWZ3IRAK4Interleukin-1 receptor-associated kinase 4T55398SEA
P28482MAPK1MAP kinase ERK2T58970SEA
P23443RPS6KB1Ribosomal protein S6 kinase 1T94479SEA
Q9HAZ1CLK4Dual specificity protein kinase CLK4T98225SEA
P06493CDK1Cyclin-dependent kinase 1/cyclin B1T49898SEA
P49840GSK3AGlycogen synthase kinase-3 alphaT76910SEA
P50613CDK7Cyclin-dependent kinase 7T58449SEA
Q00535CDK5Cyclin-dependent kinase 5/CDK5 activator 1T20973SEA
P49760CLK2Dual specificity protein kinase CLK2T73725SEA
Q07002CDK18Serine/threonine-protein kinase PCTAIRE-3T27577SEA
P16591FERTyrosine-protein kinase FERT16993SEA
P07332FESTyrosine-protein kinase FEST29083SEA
P08922ROS1Proto-oncogene tyrosine-protein kinase ROST69128SEA
Q16288NTRK3NT-3 growth factor receptorT51076SEA
P35346SSTR5Somatostatin receptor 5T64830SEA
P49336CDK8Cell division protein kinase 8T10822SEA
P30874SSTR2Somatostatin receptor 2T53024SEA
P31391SSTR4Somatostatin receptor 4T62974SEA
P30872SSTR1Somatostatin receptor 1T16633SEA
P32745SSTR3Somatostatin receptor 3T13644SEA
P32239CCKBRCholecystokinin B receptor (by homology)T05849SEA
P31751AKT2Serine/threonine-protein kinase AKT2T94621SEA
Q9Y243AKT3Serine/threonine-protein kinase AKTT71266SEA
Q13976PRKG1cGMP-dependent protein kinase 1 betaT78543SEA
P68400CSNK2A1Casein kinase II alphaT51565SEA
Q9UQM7CAMK2ACaM kinase II alphaT18299SEA
Q96GD4AURKBSerine/threonine-protein kinase Aurora-BT46781SEA
P14679TYRTyrosinaseT97035SEA
O15111CHUKInhibitor of NF-kappa-B kinase (IKK)T78429SEA
O75582RPS6KA5Ribosomal protein S6 kinase alpha 5T50224SEA
Q13153PAK1Serine/threonine-protein kinase PAK 1T37961SEA
P51812RPS6KA3Ribosomal protein S6 kinase alpha 3T03279SEA
P19525EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinaseT04831SEA
Q14680MELKMaternal embryonic leucine zipper kinaseT96892SEA
O95819MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4T71367SEA
Q9UIQ6LNPEPCystinyl aminopeptidaseT97537SEA
P15735PHKG2Phosphorylase kinase gamma subunit 2T69208SEA
Q9HCP0CSNK1G1Casein kinase I gamma 1T41702SEA
O43293DAPK3Death-associated protein kinase 3T81623SEA
P78368CSNK1G2Casein kinase I gamma 2T82773SEA
P48729CSNK1A1Casein kinase I alphaT13075SEA
P48730CSNK1DCasein kinase I deltaT87109SEA
Q13237PRKG2cGMP-dependent protein kinase 2T23606SEA
Q9UK32RPS6KA6Ribosomal protein S6 kinase alpha 6T95878SEA
P51617IRAK1Interleukin-1 receptor-associated kinase 1T63846SEA
Q2M2I8AAK1Adaptor-associated kinaseT32764SEA
Q7KZI7MARK2MAP/microtubule affinity-regulating kinase 2T01396SEA
Q13464ROCK1Rho-associated protein kinase 1T51282SEA
P17612PRKACAcAMP-dependent protein kinase alpha-catalytic subunitT12808SEA
Q9BYT3STK33Serine/threonine-protein kinase 33T17552SEA
Q96KB5PBKPDZ-binding kinaseT98642SEA
Q05513PRKCZProtein kinase C (PKC)T59190SEA
P53778MAPK12MAP kinase p38 gammaT79798SEA
Q14004CDK13Cyclin-dependent kinase 13T74839SEA
P05129PRKCGProtein kinase C gammaT47107SEA
P30530AXLTyrosine-protein kinase receptor UFOT82383SEA
Q5VT25CDC42BPASerine or threonine-protein kinase MRCK-AT00075SEA
O96013PAK4Serine/threonine-protein kinase PAK 4T98293SEA
P28336NMBRNeuromedin B receptorT68887SEA
Q16512PKN1Protein kinase N1T60003SEA
Q9UQM7CAMK2ACaM kinase II alphaT18299SEA
P28336NMBRNeuromedin B receptorT68887SEA
Q16513PKN2Protein kinase N2T94197SEA
Q9UQM7CAMK2ACaM kinase II alphaT18299SEA
Q96SB4SRPK1Serine/threonine-protein kinase SRPK1T94201SEA
Q9NSY1BMP2KBMP-2-inducible protein kinaseT90961SEA
Q8N5S9CAMKK1CaM-kinase kinase alphaT38134SEA
Q96RR4CAMKK2CaM-kinase kinase betaT82262SEA
Q12851MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2T07191SEA
P27448MARK3Serine/threonine-protein kinase c-TAK1T90553SEA
Q9H093NUAK2NUAK family SNF1-like kinase 2T55005SEA
Q9NZ08ERAP1Endoplasmic reticulum aminopeptidase 1T72849SEA
Q7L7X3TAOK1Serine/threonine-protein kinase TAO1T97016SEA
Q09013DMPKMyotonin-protein kinaseT68766SEA
Q13177PAK2Serine/threonine-protein kinase PAK 2T07766SEA
O00418EEF2KSerine/threonine-protein kinase EEF2KT92494SEA
P35499SCN4ASodium channel protein type IV alpha subunitT02546SEA
Q9H2X6HIPK2Homeodomain-interacting protein kinase 2T53952SEA
Q96PF2TSSK2Testis-specific serine/threonine-protein kinase 2T04413SEA
O43781DYRK3Dual-specificity tyrosine-phosphorylation regulated kinase 3T97149SEA
Q9H2G2SLKSerine/threonine-protein kinase 2T57307SEA
Q9UEE5STK17ASerine/threonine-protein kinase 17AT91323SEA
O14578CITCitron Rho-interacting kinaseT91397SEA
Q06609RAD51DNA repair protein RAD51 homolog 1T63083SEA
Q9NR20DYRK4Dual-specificity tyrosine-phosphorylation regulated kinase 4T20542SEA
Q96BR1SGK3Serum-and glucocorticoid-inducible kinase SGKT64102SEA
Q8TDC3BRSK1BR serine/threonine kinase 1T20053SEA
Q9Y6M4CSNK1G3Casein kinase I gamma-3T29728SEA
O15075DCLK1Doublecortin-like kinase 1T42447SEA
P78362SRPK2SRSF protein kinase 2T58924SEA
Q9NYE9HCCS4MLK-related kinaseT97821SEA
Q96BR1SGK3Serum-and glucocorticoid-inducible kinase SGKT64102SEA
Q9NRM7LATS2Large tumor suppressor homolog 2T18390SEA
Q99755PIP5K1APtdIns(4)P-5-kinase 1 alphaT14630SEA
Q92772CDKL2Cyclin-dependent kinase-like 2T44341SEA
O75385KIAA0722Serine/threonine-protein kinase ULK1T79307SEA

Target associated diseases

TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
T05090DI0241Lymphoma[ICD-11: 2A80-2A86]O15379HDAC3
T05090DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15379HDAC3
T20891DI0241Lymphoma[ICD-11: 2A80-2A86]Q15118PDK1
T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
T85421DI0125Dissociative neurological symptom disorder[ICD-11: 6B60]P53779MAPK10
T40016DI0016Adaptive immunity immunodeficiency[ICD-11: 4A01]P04150NR3C1
T40016DI0022Allergic/hypersensitivity disorder[ICD-11: 4A80-4A8Z]P04150NR3C1
T40016DI0037Asthma[ICD-11: CA23]P04150NR3C1
T40016DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P04150NR3C1
T40016DI0108Cushing syndrome[ICD-11: 5A70]P04150NR3C1
T40016DI0280Muscular dystrophy[ICD-11: 8C70]P04150NR3C1
T40016DI0314Oesophagitis[ICD-11: DA24]P04150NR3C1
T40016DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P04150NR3C1
T40016DI0366Rheumatoid arthritis[ICD-11: FA20]P04150NR3C1
T40016DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P04150NR3C1
T40016DI0432Vasomotor/allergic rhinitis[ICD-11: CA08]P04150NR3C1
T21307DI0011Acute laryngitis/tracheitis[ICD-11: CA05]P49137MAPKAPK2
T21307DI0181Hidradenitis suppurativa[ICD-11: ED92]P49137MAPKAPK2
T21307DI0269Monogenic autoinflammatory syndrome[ICD-11: 4A60]P49137MAPKAPK2
T21307DI0334Peritoneal cancer[ICD-11: 2C51]P49137MAPKAPK2
T21307DI0352Psoriatic arthritis[ICD-11: FA21]P49137MAPKAPK2
T21307DI0366Rheumatoid arthritis[ICD-11: FA20]P49137MAPKAPK2
T21307DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P49137MAPKAPK2
T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
T50594DI0012Acute myeloid leukaemia[ICD-11: 2A60]P11309PIM1
T50594DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P11309PIM1
T70176DI0060Brain cancer[ICD-11: 2A00]P24941CDK2
T70176DI0062Breast cancer[ICD-11: 2C60-2C6Y]P24941CDK2
T70176DI0238Lung cancer[ICD-11: 2C25]P24941CDK2
T70176DI0241Lymphoma[ICD-11: 2A80-2A86]P24941CDK2
T70176DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P24941CDK2
T70176DI0303Non-small-cell lung cancer[ICD-11: 2C25]P24941CDK2
T70176DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P24941CDK2
T70176DI0406Thymoma[ICD-11: 2C27]P24941CDK2
T74312DI0012Acute myeloid leukaemia[ICD-11: 2A60]P36888FLT3
T74312DI0058Bone/articular cartilage neoplasm[ICD-11: 2F7B]P36888FLT3
T74312DI0095Colorectal cancer[ICD-11: 2B91]P36888FLT3
T74312DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]P36888FLT3
T74312DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]P36888FLT3
T74312DI0248Mastocytosis[ICD-11: 2A21]P36888FLT3
T74312DI0250Mature B-cell lymphoma[ICD-11: 2A85]P36888FLT3
T74312DI0286Myeloproliferative neoplasm[ICD-11: 2A20]P36888FLT3
T07279DI0274Multiple myeloma[ICD-11: 2A83]Q9P1W9PIM2
T07279DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9P1W9PIM2
T47094DI0117Depression[ICD-11: 6A70-6A7Z]P35270SPR
T47094DI0293Nausea/vomiting[ICD-11: MD90]P35270SPR
T72458DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]P32245MC4R
T72458DI0228Large intestine motility disorder[ICD-11: DB32]P32245MC4R
T72458DI0308Obesity[ICD-11: 5B80-5B81]P32245MC4R
T59604DI0087Chronic pain[ICD-11: MG30]Q92847GHSR
T59604DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]Q92847GHSR
T35842DI0192Hypoactive sexual desire dysfunction[ICD-11: HA00]Q01726MC1R
T35842DI0205Inborn porphyrin/heme metabolism error[ICD-11: 5C58]Q01726MC1R
T76846DI0308Obesity[ICD-11: 5B80-5B81]P41968MC3R
T76846DI0378Sexual dysfunction[ICD-11: HA00-HA01]P41968MC3R
T76846DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P41968MC3R
T06093DI0168Graft-versus-host disease[ICD-11: 4B24]O75116ROCK2
T67619DI0062Breast cancer[ICD-11: 2C60-2C6Y]P31749AKT1
T70977DI0288Myotonic disorder[ICD-11: 8C71]P49841GSK3B
T28713DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O96017CHEK2
T83174DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P41743PRKCI
T00895DI0033Anxiety disorder[ICD-11: 6B00-6B0Z]Q02156PRKCE
T00895DI0243Malaria[ICD-11: 1F40-1F45]Q02156PRKCE
T07303DI0361Renal cell carcinoma[ICD-11: 2C90]P35916FLT4
T99160DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9HBH9MKNK2
T99160DI0095Colorectal cancer[ICD-11: 2B91]Q9HBH9MKNK2
T99160DI0235Liver cancer[ICD-11: 2C12]Q9HBH9MKNK2
T99160DI0241Lymphoma[ICD-11: 2A80-2A86]Q9HBH9MKNK2
T99160DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9HBH9MKNK2
T71374DI0062Breast cancer[ICD-11: 2C60-2C6Y]O00444PLK4
T81358DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O00311CDC7
T81358DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O00311CDC7
T55398DI0039Atopic eczema[ICD-11: EA80]Q9NWZ3IRAK4
T55398DI0109Cutaneous lupus erythematosus[ICD-11: EB50-EB5Z]Q9NWZ3IRAK4
T55398DI0241Lymphoma[ICD-11: 2A80-2A86]Q9NWZ3IRAK4
T55398DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q9NWZ3IRAK4
T55398DI0351Psoriasis[ICD-11: EA90]Q9NWZ3IRAK4
T55398DI0366Rheumatoid arthritis[ICD-11: FA20]Q9NWZ3IRAK4
T58970DI0036Arteries/arterioles disorder[ICD-11: BD52]P28482MAPK1
T58970DI0252Melanoma[ICD-11: 2C30]P28482MAPK1
T58970DI0326Pancreatic cancer[ICD-11: 2C10]P28482MAPK1
T58970DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28482MAPK1
T94479DI0025Alzheimer disease[ICD-11: 8A20]P23443RPS6KB1
T94479DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P23443RPS6KB1
T94479DI0419Ulcerative colitis[ICD-11: DD71]P23443RPS6KB1
T49898DI0062Breast cancer[ICD-11: 2C60-2C6Y]P06493CDK1
T49898DI0238Lung cancer[ICD-11: 2C25]P06493CDK1
T49898DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P06493CDK1
T49898DI0250Mature B-cell lymphoma[ICD-11: 2A85]P06493CDK1
T49898DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P06493CDK1
T76910DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P49840GSK3A
T58449DI0062Breast cancer[ICD-11: 2C60-2C6Y]P50613CDK7
T58449DI0238Lung cancer[ICD-11: 2C25]P50613CDK7
T58449DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P50613CDK7
T58449DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P50613CDK7
T20973DI0308Obesity[ICD-11: 5B80-5B81]Q00535CDK5
T69128DI0238Lung cancer[ICD-11: 2C25]P08922ROS1
T69128DI0303Non-small-cell lung cancer[ICD-11: 2C25]P08922ROS1
T51076DI0303Non-small-cell lung cancer[ICD-11: 2C25]Q16288NTRK3
T51076DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16288NTRK3
T64830DI0108Cushing syndrome[ICD-11: 5A70]P35346SSTR5
T10822DI0012Acute myeloid leukaemia[ICD-11: 2A60]P49336CDK8
T10822DI0284Myelodysplastic syndrome[ICD-11: 2A37]P49336CDK8
T53024DI0108Cushing syndrome[ICD-11: 5A70]P30874SSTR2
T53024DI0122Diagnostic imaging[ICD-11: N.A.]P30874SSTR2
T53024DI0337Pituitary gland disorder[ICD-11: 5A60-5A61]P30874SSTR2
T62974DI0087Chronic pain[ICD-11: MG30]P31391SSTR4
T62974DI0179Hepatitis virus infection[ICD-11: 1E50-1E51]P31391SSTR4
T16633DI0108Cushing syndrome[ICD-11: 5A70]P30872SSTR1
T16633DI0395Stomach cancer[ICD-11: 2B72]P30872SSTR1
T13644DI0108Cushing syndrome[ICD-11: 5A70]P32745SSTR3
T05849DI0122Diagnostic imaging[ICD-11: N.A.]P32239CCKBR
T05849DI0327Pancreatic internal secretion disorder[ICD-11: 5A4Y]P32239CCKBR
T71266DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9Y243AKT3
T51565DI0104Coronavirus infection[ICD-11: 1D92]P68400CSNK2A1
T51565DI0235Liver cancer[ICD-11: 2C12]P68400CSNK2A1
T51565DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P68400CSNK2A1
T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
T46781DI0009Acute diabete complication[ICD-11: 5A2Y]Q96GD4AURKB
T46781DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q96GD4AURKB
T97035DI0007Acquired hypermelanosis[ICD-11: ED60]P14679TYR
T97035DI0008Acquired hypomelanotic disorder[ICD-11: ED63]P14679TYR
T78429DI0250Mature B-cell lymphoma[ICD-11: 2A85]O15111CHUK
T03279DI0249Mature B-cell leukaemia[ICD-11: 2A82]P51812RPS6KA3
T96892DI0012Acute myeloid leukaemia[ICD-11: 2A60]Q14680MELK
T96892DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q14680MELK
T96892DI0249Mature B-cell leukaemia[ICD-11: 2A82]Q14680MELK
T96892DI0250Mature B-cell lymphoma[ICD-11: 2A85]Q14680MELK
T96892DI0284Myelodysplastic syndrome[ICD-11: 2A37]Q14680MELK
T96892DI0286Myeloproliferative neoplasm[ICD-11: 2A20]Q14680MELK
T13075DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]P48729CSNK1A1
T13075DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P48729CSNK1A1
T87109DI0249Mature B-cell leukaemia[ICD-11: 2A82]P48730CSNK1D
T87109DI0326Pancreatic cancer[ICD-11: 2C10]P48730CSNK1D
T95878DI0249Mature B-cell leukaemia[ICD-11: 2A82]Q9UK32RPS6KA6
T32764DI0163General pain disorder[ICD-11: 8E43]Q2M2I8AAK1
T51282DI0166Glaucoma[ICD-11: 9C61]Q13464ROCK1
T12808DI0279Muscular atrophy[ICD-11: 8B61]P17612PRKACA
T98642DI0291Nasopharyngeal cancer[ICD-11: 2B6B]Q96KB5PBK
T59190DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q05513PRKCZ
T79798DI0403Thrombocytopenia[ICD-11: 3B64]P53778MAPK12
T74839DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q14004CDK13
T47107DI0012Acute myeloid leukaemia[ICD-11: 2A60]P05129PRKCG
T47107DI0248Mastocytosis[ICD-11: 2A21]P05129PRKCG
T82383DI0012Acute myeloid leukaemia[ICD-11: 2A60]P30530AXL
T98293DI0245Malignant haematopoietic neoplasm[ICD-11: 2B33]O96013PAK4
T98293DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O96013PAK4
T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
T68887DI0062Breast cancer[ICD-11: 2C60-2C6Y]P28336NMBR
T68887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P28336NMBR
T18299DI0366Rheumatoid arthritis[ICD-11: FA20]Q9UQM7CAMK2A
T94201DI0365Retinopathy[ICD-11: 9B71]Q96SB4SRPK1
T07191DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q12851MAP4K2
T90553DI0334Peritoneal cancer[ICD-11: 2C51]P27448MARK3
T90553DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P27448MARK3
T68766DI0288Myotonic disorder[ICD-11: 8C71]Q09013DMPK
T92494DI0062Breast cancer[ICD-11: 2C60-2C6Y]O00418EEF2K
T02546DI0281Musculoskeletal disorder[ICD-11: FA00-FC0Z]P35499SCN4A
T63083DI0048B-cell lymphoma[ICD-11: 2A86]Q06609RAD51
T63083DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q06609RAD51

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