Phenylacetic acid



Compound IDCDAMM00022
Common namePhenylacetic acid
IUPAC name2-phenylacetic acid
Molecular formulaC8H8O2

Experimental data

Retention time16.73
Adduct[M+H]+
Actual mz137.059
Theoretical mz137.06
Error2.91
Ionizaton modePositive
Instrument typeLC-MS/MS-QTOF, spectrum predicted by MS-DIAL v4.9 integrated with MS-FINDER 3.60
Score7.2003

Identifiers and class information

Inchi keyWLJVXDMOQOGPHL-UHFFFAOYSA-N
SmilesC1=CC=C(C=C1)CC(=O)O
SuperclassBenzenoids
ClassBenzene and substituted derivatives

Pharmacokinetic properties

Number of descriptor values(#stars)1
Number of non-conjugated amine groups (#amine)0
Number of amidine and guanidine groups (#amidine)0
Number of carboxylic acid groups (#acid)1
Number of non-conjugated amide groups (#amide)0
Number of rotatable bonds (#rotor)2
Number of reactive functional groups (#rtvFG)0
Predicted central nervous system activity (CNS)-1
Molecular weight (mol_MW)136.15
Computed dipole moment(dipole)5.838
Total solvent accessible surface area (SASA)333.971
Hydrophobic component of SASA (FOSA)43.091
Hydrophilic component of SASA (FISA)98.754
Pie component of the SASA (PISA)192.126
Weakly polar component of the SASA (WPSA)0
Total solvent accesible volume (volume)519.251
Number of hydrogen bond donors (donorHB)1
Number of hydrogen bond acceptors (accptHB)2
Free energy of solvation of dipole (dip^2/V)0.0656352
Index of cohesive interaction in solids (ACxDN^.5/SA)0.0059885
Globularity descriptor (glob)0.935494
Predicted polarizability in cubic angstroms (QPpolrz)15.177
Predicted hexadecane/gas partition coefficient (QPlogPC16)5.529
Predicted octanol/gas partition coefficient (QPlogPoct)7.932
Predicted water/gas partition coefficient (QPlogPw)5.495
Predicted octanol/water partition coefficient (QPlogPo/w)2.159
Predicted aqueous solubility (QPlogS)-1.727
Conformation-independent predicted aqueous solubility (CIQPlogS)-1.551
Predicted IC50 value for blockage of HERG K+ channels (QPlogHERG)-1.685
Predicted apparent Caco-2 cell permeability in nm/sec (QPPCaco)290.412
Predicted brain/blood partition coefficient (QPlogBB)-0.309
Predicted apparent MDCK cell permeability in nm/sec (QPPMDCK)165.337
Predicted skin permeability, log Kp (QPlogKp)-2.471
PM3 calculated ionization potential (IP(ev))9.836
PM3 calculated electron affinity (EA(eV))0.05
Number of likely metabolic reactions (#metab)1
Prediction of binding to human serum albumin (QPlogKhsa)-0.581
Predicted qualitative human oral absorption (HumanOralAbsorption)3
Predicted human oral absorption on 0 to 100% scale (PercentHumanOralAbsorption)83.671
Solvent-accessible surface area of fluorine atoms (SAFluorine)0
Solvent-accessible surface area of amide oxygen atoms (SAamideO)0
Van der Waals surface area (PSA)50.442
Number of nitrogen and oxygen atoms (#NandO)2
Number of violations of Lipinski’s rule of five (RuleOfFive)0
Number of violations of Jorgensen’s rule of three (RuleOfThree)0

Compound-target network

Cytoscape Graph

Protein targets associated with phytocompound

Uniprot ID Gene name Target name TTD_ID Prediction source
O43570CA12Carbonic anhydrase XIIT16987SEA
Q16790CA9Carbonic anhydrase IXT64567SEA
Q16853AOC3Amine oxidase, copper containingT69619SEA
Q99720SIGMAR1Sigma opioid receptorT46360SEA
Q8TDS4HCAR2Hydroxycarboxylic acid receptor 2T88185SEA
P24046GABRR1GABA receptor rho-1 subunitT99665SEA
Q96KS0EIT6HIF-prolyl hydroxylase 1T53904SEA
P15144ANPEPAminopeptidase NT67272SEA
P09960LTA4HLeukotriene A4 hydrolaseT03691SEA
O15379HDAC3Histone deacetylase 3T05090SEA
P00915CA1Carbonic anhydrase IT13201SEA
P02766TTRTransthyretinT86462SEA
P00918CA2Carbonic anhydrase IIT20401SEA
Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
P14555PLA2G2APhospholipase A2 group IIAT19160SEA
Q96RI1NR1H4Bile acid receptor FXRT51426SEA
P08473MMENeprilysinT05409SEA
P31213SRD5A2Steroid 5-alpha-reductase 2T71390SEA
P34913EPHX2Epoxide hydrataseT35734SEA
P43166CA7Carbonic anhydrase VIIT37541SEA
Q9ULX7CA14Carbonic anhydrase XIVT31992SEA
Q96RJ0TAAR1Trace amine-associated receptor 1 (by homology)T99524SEA
P43005SLC1A1Excitatory amino acid transporter 3T31721SEA
Q14832GRM3Metabotropic glutamate receptor 3T02719SEA
P15121AKR1B1Aldose reductaseT26623SEA
Q9UQL6HDAC5Histone deacetylase 5T07930SEA
Q8WUI4HDAC7Histone deacetylase 7T98698SEA
P56524HDAC4Histone deacetylase 4T63816SEA
Q9UKV0HDAC9Histone deacetylase 9T03687SEA
Q92769HDAC2Histone deacetylase 2T51191SEA
Q9H3R0KDM4CLysine-specific demethylase 4CT73863SEA
P23141CES1Acyl coenzyme A:cholesterol acyltransferaseT76369SEA
P10145CXCL8Interleukin-8T22658SEA
P42330AKR1C3Aldo-keto-reductase family 1 member C3T60857SEA
Q9H4A4RNPEPAminopeptidase BT57818SEA
P14920DAOD-amino-acid oxidaseT33124SEA
O75164KDM4ALysine-specific demethylase 4AT18904SEA
Q16719KYNUKynureninaseT99912SEA
O00519FAAHAnandamide amidohydrolaseT11754SEA
Q07075ENPEPAminopeptidase AT31956SEA
Q01650SLC7A5L-type amino acid transporter 1 (by homology)T48330SEA
P14902IDO1Indoleamine 2,3-dioxygenaseT89697SEA
P15090FABP4Fatty acid binding protein adipocyteT07217SEA
Q07869PPARAPeroxisome proliferator-activated receptor alphaT86591SEA
Q01469FABP5Fatty acid binding protein epidermalT21507SEA
Q03181PPARDPeroxisome proliferator-activated receptor deltaT36557SEA
O14842FFAR1Free fatty acid receptor 1T25608SEA
P08575PTPRCLeukocyte common antigenT43115SEA
P08253MMP2Matrix metalloproteinase 2T68251SEA
P22894MMP8Matrix metalloproteinase 8T08856SEA
P14780MMP9Matrix metalloproteinase 9T54156SEA
Q13133NR1H3LXR-alphaT52297SEA
P09917ALOX5Arachidonate 5-lipoxygenaseT00140SEA
Q9Y4C1KDM3ALysine-specific demethylase 3AT25362SEA
O15054KDM6BLysine-specific demethylase 6BT56057SEA
P00338LDHAL-lactate dehydrogenase A chainT15053SEA
P07195LDHBL-lactate dehydrogenase B chainT88057SEA
P21731TBXA2RThromboxane A2 receptorT76198SEA
P10827THRAThyroid hormone receptor alphaT79591SEA
P10828THRBThyroid hormone receptor beta-1T98933SEA
P27695APEX1DNA-(apurinic or apyrimidinic site) lyaseT13348SEA
P23946CMA1ChymaseT05114SEA
P37231PPARGPeroxisome proliferator-activated receptor gammaT58921SEA
Q08499PDE4DPhosphodiesterase 4DT02001SEA
P43116PTGER2Prostanoid EP2 receptorT38529SEA
Q96S37SLC22A12Solute carrier family 22 member 12T86057SEA
Q9Y5Y4PTGDR2G protein-coupled receptor 44T61722SEA
Q15722LTB4RLeukotriene B4 receptor 1T59626SEA
Q99685MGLLMonoglyceride lipaseT18664SEA
P16581SELESelectin ET72835SEA
P29466CASP1Caspase-1T98269SEA
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2T65818SEA
P47712PLA2G4ACytosolic phospholipase A2T14834SEA
P35408PTGER4Prostanoid EP4 receptorT18876SEA
P43115PTGER3Prostanoid EP3 receptorT85467SEA
Q9ULA0DNPEPAspartyl aminopeptidaseT45287SEA
Q9BYF1ACE2Angiotensin-converting enzyme 2T27889SEA
P30307CDC25CDual specificity phosphatase Cdc25CT40569SEA
P34995PTGER1Prostanoid EP1 receptorT15497SEA
P39900MMP12Matrix metalloproteinase 12T03500SEA
P42574CASP3Caspase-3T57943SEA
P15085CPA1Carboxypeptidase A1T33966SEA
P16109SELPP-selectinT10965SEA
P14151SELLLeukocyte adhesion molecule-1T60526SEA
Q9Y4D2DAGLASn1-specific diacylglycerol lipase alphaT03150SEA
Q9H228S1PR5Sphingosine 1-phosphate receptor Edg-8T50089SEA
P00390GSRGlutathione reductaseT30803SEA
O94925GLSGlutaminase kidney isoform, mitochondrialT86734SEA
O75908SOAT2Acyl coenzyme A:cholesterol acyltransferase 2T14463SEA
Q9Y3Q0NAALAD2NAALADase IIT70036SEA
Q92820GGHGamma-glutamyl hydrolaseT71646SEA
P09238MMP10Matrix metalloproteinase 10T40488SEA
P09601HMOX1Heme oxygenase 1 (by homology)T25703SEA
Q07343PDE4BPhosphodiesterase 4B (by homology)T10265SEA
P40189IL6STInterleukin-6 receptor subunit betaT93440SEA
Q13224GRIN2BGlutamate [NMDA] receptor subunit epsilon 2T76414SEA
P51512MMP16Matrix metalloproteinase 16T35824SEA
Q13822ENPP2AutotaxinT63512SEA
Q96DB2HDAC11Histone deacetylase 11T97903SEA
P55055NR1H2LXR-betaT13714SEA
Q969S8HDAC10Histone deacetylase 10T94324SEA
Q9Y345SLC6A5Glycine transporter 2T58937SEA
Q13546RIPK1Receptor-interacting serine/threonine-protein kinase 1T99340SEA
Q03405PLAURUrokinase plasminogen activator surface receptorT74363SEA
Q92633LPAR1Lysophosphatidic acid receptor Edg-2T92640SEA
Q9UJM8HAO1Hydroxyacid oxidase 1T63170SEA
O95822MLYCDMalonyl-CoA decarboxylaseT98078SEA
P45974USP5Ubiquitin carboxyl-terminal hydrolase 5T17067SEA
Q99571P2RX4P2X purinoceptor 4T60330SEA
O95749GGPS1GeranyltranstransferaseT86528SEA
P24557TBXAS1Thromboxane-A synthaseT78356SEA
P49019HCAR3Hydroxycarboxylic acid receptor 3T00890SEA
Q04609FOLH1Glutamate carboxypeptidase IIT97071SEA
Q4U2R8SLC22A6Solute carrier family 22 member 6 (by homology)T70680SEA
P32249EBI2EBV-induced G-protein coupled receptor 2T59577SEA
Q9BY41HDAC8Histone deacetylase 8T28887SEA
P09172DBHDopamine beta hydroxylaseT74937SEA
Q9UBS0RPS6KB2Ribosomal protein S6 kinase beta-2T42760SEA
P04632CAPNS1HUMAN calpain-1 or calpain small subunit 1 heterodimerT00099SEA
P28476GABRR2GABA(A) receptor rho2T90682SEA
O15427SLC16A3Monocarboxylate transporter 4T31788SEA
O43526KCNQ2Voltage-gated potassium channel Kv7.2T74483SEA
P51843NR0B1Orphan nuclear receptor DAX-1T23191SEA
Q5T7T8COX1Prostaglandin G/H synthase 1T60529SEA
Q7RTX1TAS1R1Taste receptorT41263SEA
Q9GZT9EGLN1Egl nine homolog 1T32880SEA

Target associated diseases

TTD_ID Disease_ID Disease name ICD_11 Uniprot ID Gene names
T16987DI0046Bacterial infection[ICD-11: 1A00-1C4Z]O43570CA12
T16987DI0372Seborrhoeic dermatitis[ICD-11: EA81]O43570CA12
T64567DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q16790CA9
T69619DI0190Hypertension[ICD-11: BA00-BA04]Q16853AOC3
T46360DI0105Cough[ICD-11: MD12]Q99720SIGMAR1
T88185DI0203Inborn lipid metabolism error[ICD-11: 5C52]Q8TDS4HCAR2
T53904DI0010Acute disease anaemia[ICD-11: 3A90]Q96KS0EIT6
T67272DI0351Psoriasis[ICD-11: EA90]P15144ANPEP
T03691DI0012Acute myeloid leukaemia[ICD-11: 2A60]P09960LTA4H
T05090DI0241Lymphoma[ICD-11: 2A80-2A86]O15379HDAC3
T05090DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O15379HDAC3
T13201DI0166Glaucoma[ICD-11: 9C61]P00915CA1
T13201DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00915CA1
T86462DI0026Amyloidosis[ICD-11: 5D00]P02766TTR
T20401DI0046Bacterial infection[ICD-11: 1A00-1C4Z]P00918CA2
T20401DI0137Essential hypertension[ICD-11: BA00]P00918CA2
T20401DI0166Glaucoma[ICD-11: 9C61]P00918CA2
T20401DI0175Heart failure[ICD-11: BD10-BD1Z]P00918CA2
T20401DI0214Insomnia[ICD-11: 7A00-7A0Z]P00918CA2
T20401DI0372Seborrhoeic dermatitis[ICD-11: EA81]P00918CA2
T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
T19160DI0062Breast cancer[ICD-11: 2C60-2C6Y]P14555PLA2G2A
T51426DI0043Autoimmune liver disease[ICD-11: DB96]Q96RI1NR1H4
T51426DI0077Cholelithiasis[ICD-11: DC11]Q96RI1NR1H4
T51426DI0320Osteoarthritis[ICD-11: FA00-FA05]Q96RI1NR1H4
T05409DI0175Heart failure[ICD-11: BD10-BD1Z]P08473MME
T71390DI0348Prostate hyperplasia[ICD-11: GA90]P31213SRD5A2
T35734DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P34913EPHX2
T35734DI0190Hypertension[ICD-11: BA00-BA04]P34913EPHX2
T31992DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q9ULX7CA14
T31992DI0204Inborn metabolism deficiency[ICD-11: 5C50-5C59]Q9ULX7CA14
T99524DI0040Attention deficit hyperactivity disorder[ICD-11: 6A05]Q96RJ0TAAR1
T99524DI0149Focal/segmental autonomic disorder[ICD-11: 8D8A]Q96RJ0TAAR1
T99524DI0290Narcolepsy[ICD-11: 7A20]Q96RJ0TAAR1
T02719DI0370Schizophrenia[ICD-11: 6A20]Q14832GRM3
T26623DI0298Neuropathy[ICD-11: 8C0Z]P15121AKR1B1
T26623DI0366Rheumatoid arthritis[ICD-11: FA20]P15121AKR1B1
T63816DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P56524HDAC4
T51191DI0241Lymphoma[ICD-11: 2A80-2A86]Q92769HDAC2
T51191DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q92769HDAC2
T76369DI0335Peroxisomal disease[ICD-11: 5C57]P23141CES1
T76369DI0398Synthesis disorder[ICD-11: 5C52-5C59]P23141CES1
T22658DI0324Pain[ICD-11: MG30-MG3Z]P10145CXCL8
T60857DI0145Female pelvic pain[ICD-11: GA34]P42330AKR1C3
T33124DI0038Ataxic disorder[ICD-11: 8A03]P14920DAO
T33124DI0370Schizophrenia[ICD-11: 6A20]P14920DAO
T99912DI0046Bacterial infection[ICD-11: 1A00-1C4Z]Q16719KYNU
T99912DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q16719KYNU
T11754DI0101Corneal disease[ICD-11: 9A76-9A78]O00519FAAH
T31956DI0190Hypertension[ICD-11: BA00-BA04]Q07075ENPEP
T89697DI0117Depression[ICD-11: 6A70-6A7Z]P14902IDO1
T86591DI0187Hyperlipidemia[ICD-11: 5C80]Q07869PPARA
T86591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q07869PPARA
T86591DI0417Type 2 diabetes mellitus[ICD-11: 5A11]Q07869PPARA
T36557DI0302Non-alcoholic fatty liver disease[ICD-11: DB92]Q03181PPARD
T36557DI0308Obesity[ICD-11: 5B80-5B81]Q03181PPARD
T25608DI0417Type 2 diabetes mellitus[ICD-11: 5A11]O14842FFAR1
T43115DI0012Acute myeloid leukaemia[ICD-11: 2A60]P08575PTPRC
T43115DI0414Transplanted organ/tissue[ICD-11: QB63]P08575PTPRC
T68251DI0238Lung cancer[ICD-11: 2C25]P08253MMP2
T08856DI0366Rheumatoid arthritis[ICD-11: FA20]P22894MMP8
T54156DI0219Ischaemic/haemorrhagic stroke[ICD-11: 8B20]P14780MMP9
T54156DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P14780MMP9
T54156DI0395Stomach cancer[ICD-11: 2B72]P14780MMP9
T54156DI0419Ulcerative colitis[ICD-11: DD71]P14780MMP9
T52297DI0117Depression[ICD-11: 6A70-6A7Z]Q13133NR1H3
T00140DI0037Asthma[ICD-11: CA23]P09917ALOX5
T00140DI0147Filariasis[ICD-11: 1F66]P09917ALOX5
T00140DI0403Thrombocytopenia[ICD-11: 3B64]P09917ALOX5
T76198DI0102Coronary atherosclerosis[ICD-11: BA52]P21731TBXA2R
T76198DI0121Diabetic foot ulcer[ICD-11: BD54]P21731TBXA2R
T76198DI0287Myocardial infarction[ICD-11: BA41-BA43]P21731TBXA2R
T76198DI0378Sexual dysfunction[ICD-11: HA00-HA01]P21731TBXA2R
T79591DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10827THRA
T79591DI0197Hypo-thyroidism[ICD-11: 5A00]P10827THRA
T98933DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P10828THRB
T13348DI0365Retinopathy[ICD-11: 9B71]P27695APEX1
T13348DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P27695APEX1
T05114DI0039Atopic eczema[ICD-11: EA80]P23946CMA1
T05114DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P23946CMA1
T05114DI0169Gram-positive bacterial infection[ICD-11: 1B74-1F40]P23946CMA1
T05114DI0175Heart failure[ICD-11: BD10-BD1Z]P23946CMA1
T05114DI0229Left ventricular failure[ICD-11: BD11]P23946CMA1
T05114DI0287Myocardial infarction[ICD-11: BA41-BA43]P23946CMA1
T58921DI0009Acute diabete complication[ICD-11: 5A2Y]P37231PPARG
T58921DI0025Alzheimer disease[ICD-11: 8A20]P37231PPARG
T58921DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P37231PPARG
T02001DI0411Tonus and reflex abnormality[ICD-11: MB47]Q08499PDE4D
T38529DI0003Abortion[ICD-11: JA00]P43116PTGER2
T38529DI0102Coronary atherosclerosis[ICD-11: BA52]P43116PTGER2
T38529DI0121Diabetic foot ulcer[ICD-11: BD54]P43116PTGER2
T38529DI0166Glaucoma[ICD-11: 9C61]P43116PTGER2
T38529DI0356Pulmonary hypertension[ICD-11: BB01]P43116PTGER2
T38529DI0378Sexual dysfunction[ICD-11: HA00-HA01]P43116PTGER2
T38529DI0413Transplant rejection[ICD-11: NE84]P43116PTGER2
T86057DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q96S37SLC22A12
T61722DI0102Coronary atherosclerosis[ICD-11: BA52]Q9Y5Y4PTGDR2
T59626DI0184Human immunodeficiency virus disease[ICD-11: 1C60-1C62]Q15722LTB4R
T59626DI0355Pulmonary disease[ICD-11: 1B10-1F85]Q15722LTB4R
T59626DI0361Renal cell carcinoma[ICD-11: 2C90]Q15722LTB4R
T18664DI0163General pain disorder[ICD-11: 8E43]Q99685MGLL
T18664DI0409Tic disorder[ICD-11: 8A05]Q99685MGLL
T72835DI0012Acute myeloid leukaemia[ICD-11: 2A60]P16581SELE
T72835DI0037Asthma[ICD-11: CA23]P16581SELE
T72835DI0039Atopic eczema[ICD-11: EA80]P16581SELE
T72835DI0086Chronic obstructive pulmonary disease[ICD-11: CA22]P16581SELE
T72835DI0088Circulatory system disease[ICD-11: BE2Z]P16581SELE
T72835DI0190Hypertension[ICD-11: BA00-BA04]P16581SELE
T72835DI0351Psoriasis[ICD-11: EA90]P16581SELE
T98269DI0134Epilepsy/seizure[ICD-11: 8A61-8A6Z]P29466CASP1
T98269DI0146Fibrosis[ICD-11: GA14-GC01]P29466CASP1
T98269DI0366Rheumatoid arthritis[ICD-11: FA20]P29466CASP1
T98269DI0417Type 2 diabetes mellitus[ICD-11: 5A11]P29466CASP1
T14834DI0039Atopic eczema[ICD-11: EA80]P47712PLA2G4A
T18876DI0037Asthma[ICD-11: CA23]P35408PTGER4
T18876DI0175Heart failure[ICD-11: BD10-BD1Z]P35408PTGER4
T18876DI0264Migraine[ICD-11: 8A80]P35408PTGER4
T18876DI0303Non-small-cell lung cancer[ICD-11: 2C25]P35408PTGER4
T18876DI0324Pain[ICD-11: MG30-MG3Z]P35408PTGER4
T18876DI0360Rectum cancer[ICD-11: 2B92]P35408PTGER4
T18876DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P35408PTGER4
T18876DI0414Transplanted organ/tissue[ICD-11: QB63]P35408PTGER4
T85467DI0166Glaucoma[ICD-11: 9C61]P43115PTGER3
T85467DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P43115PTGER3
T85467DI0414Transplanted organ/tissue[ICD-11: QB63]P43115PTGER3
T45287DI0190Hypertension[ICD-11: BA00-BA04]Q9ULA0DNPEP
T27889DI0009Acute diabete complication[ICD-11: 5A2Y]Q9BYF1ACE2
T27889DI0217Intrathoracic organs injury[ICD-11: NB32]Q9BYF1ACE2
T27889DI0356Pulmonary hypertension[ICD-11: BB01]Q9BYF1ACE2
T15497DI0405Thrombosis[ICD-11: DB61-GB90]P34995PTGER1
T03500DI0037Asthma[ICD-11: CA23]P39900MMP12
T03500DI0238Lung cancer[ICD-11: 2C25]P39900MMP12
T03500DI0361Renal cell carcinoma[ICD-11: 2C90]P39900MMP12
T57943DI0060Brain cancer[ICD-11: 2A00]P42574CASP3
T10965DI0088Circulatory system disease[ICD-11: BE2Z]P16109SELP
T10965DI0381Sickle-cell disorder[ICD-11: 3A51]P16109SELP
T60526DI0037Asthma[ICD-11: CA23]P14151SELL
T60526DI0088Circulatory system disease[ICD-11: BE2Z]P14151SELL
T50089DI0275Multiple sclerosis[ICD-11: 8A40]Q9H228S1PR5
T30803DI0062Breast cancer[ICD-11: 2C60-2C6Y]P00390GSR
T86734DI0062Breast cancer[ICD-11: 2C60-2C6Y]O94925GLS
T86734DI0231Leukaemia[ICD-11: 2A60-2B33]O94925GLS
T86734DI0361Renal cell carcinoma[ICD-11: 2C90]O94925GLS
T86734DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]O94925GLS
T14463DI0017Adrenal cancer[ICD-11: 2D11]O75908SOAT2
T25703DI0294Neonatal hyperbilirubinaemia[ICD-11: KA87]P09601HMOX1
T10265DI0037Asthma[ICD-11: CA23]Q07343PDE4B
T10265DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q07343PDE4B
T10265DI0265Mild neurocognitive disorder[ICD-11: 6D71]Q07343PDE4B
T93440DI0366Rheumatoid arthritis[ICD-11: FA20]P40189IL6ST
T76414DI0024Alpha-1-antitrypsin deficiency[ICD-11: 5C5A]Q13224GRIN2B
T63512DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q13822ENPP2
T13714DI0039Atopic eczema[ICD-11: EA80]P55055NR1H2
T94324DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q969S8HDAC10
T99340DI0025Alzheimer disease[ICD-11: 8A20]Q13546RIPK1
T99340DI0109Cutaneous lupus erythematosus[ICD-11: EB50-EB5Z]Q13546RIPK1
T99340DI0273Motor neuron disease[ICD-11: 8B60]Q13546RIPK1
T99340DI0295Nervous system paraneoplastic/autoimmune disorder[ICD-11: 8E4A]Q13546RIPK1
T99340DI0326Pancreatic cancer[ICD-11: 2C10]Q13546RIPK1
T99340DI0351Psoriasis[ICD-11: EA90]Q13546RIPK1
T99340DI0366Rheumatoid arthritis[ICD-11: FA20]Q13546RIPK1
T99340DI0419Ulcerative colitis[ICD-11: DD71]Q13546RIPK1
T74363DI0286Myeloproliferative neoplasm[ICD-11: 2A20]Q03405PLAUR
T74363DI0404Thrombocytosis[ICD-11: 3B63]Q03405PLAUR
T92640DI0146Fibrosis[ICD-11: GA14-GC01]Q92633LPAR1
T92640DI0199Idiopathic interstitial pneumonitis[ICD-11: CB03]Q92633LPAR1
T92640DI0351Psoriasis[ICD-11: EA90]Q92633LPAR1
T92640DI0399Systemic sclerosis[ICD-11: 4A42]Q92633LPAR1
T63170DI0201Inborn carbohydrate metabolism error[ICD-11: 5C51]Q9UJM8HAO1
T17067DI0339Postoperative inflammation[ICD-11: 1A00-CA43]P45974USP5
T17067DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]P45974USP5
T86528DI0057Bone paget disease[ICD-11: FB85]O95749GGPS1
T86528DI0237Low bone mass disorder[ICD-11: FB83]O95749GGPS1
T86528DI0267Mineral excesses[ICD-11: 5B91]O95749GGPS1
T86528DI0281Musculoskeletal disorder[ICD-11: FA00-FC0Z]O95749GGPS1
T78356DI0030Angina pectoris[ICD-11: BA40]P24557TBXAS1
T00890DI0070Cardiovascular disease[ICD-11: BA00-BE2Z]P49019HCAR3
T00890DI0128Dyslipidemia[ICD-11: 5C80-5C81]P49019HCAR3
T00890DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]P49019HCAR3
T00890DI0351Psoriasis[ICD-11: EA90]P49019HCAR3
T97071DI0122Diagnostic imaging[ICD-11: N.A.]Q04609FOLH1
T97071DI0346Prostate cancer[ICD-11: 2C82]Q04609FOLH1
T70680DI0167Gout[ICD-11: FA25]Q4U2R8SLC22A6
T70680DI0206Inborn purine/pyrimidine/nucleotide metabolism error[ICD-11: 5C55]Q4U2R8SLC22A6
T70680DI0310Ocular disease[ICD-11: N.A.]Q4U2R8SLC22A6
T28887DI0391Solid tumour/cancer[ICD-11: 2A00-2F9Z]Q9BY41HDAC8
T74937DI0175Heart failure[ICD-11: BD10-BD1Z]P09172DBH
T74937DI0341Post-traumatic stress disorder[ICD-11: 6B40]P09172DBH
T42760DI0062Breast cancer[ICD-11: 2C60-2C6Y]Q9UBS0RPS6KB2
T00099DI0106COVID-19[ICD-11: 1D6Y]P04632CAPNS1
T74483DI0324Pain[ICD-11: MG30-MG3Z]O43526KCNQ2
T60529DI0141Eye anterior segment structural developmental anomaly[ICD-11: LA11]Q5T7T8COX1
T60529DI0145Female pelvic pain[ICD-11: GA34]Q5T7T8COX1
T60529DI0188Hyper-lipoproteinaemia[ICD-11: 5C80]Q5T7T8COX1
T60529DI0207Indeterminate colitis[ICD-11: DD72]Q5T7T8COX1
T60529DI0306Nutritional deficiency[ICD-11: 5B50-5B71]Q5T7T8COX1
T60529DI0320Osteoarthritis[ICD-11: FA00-FA05]Q5T7T8COX1
T60529DI0324Pain[ICD-11: MG30-MG3Z]Q5T7T8COX1
T60529DI0339Postoperative inflammation[ICD-11: 1A00-CA43]Q5T7T8COX1
T60529DI0366Rheumatoid arthritis[ICD-11: FA20]Q5T7T8COX1
T60529DI0372Seborrhoeic dermatitis[ICD-11: EA81]Q5T7T8COX1
T60529DI0416Tuberculosis[ICD-11: 1B10-1B12]Q5T7T8COX1
T60529DI0419Ulcerative colitis[ICD-11: DD71]Q5T7T8COX1
T41263DI0078Cholera[ICD-11: 1A00]Q7RTX1TAS1R1

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