In 1CMDb classified all SNPs present in one carbon metabolism pathway into, synonymous and non-synonymous, and further subclassified non synonymous into sense or missense. We annotated SNPs with their respective CNVs,CpG islands and miRNAs. Insilico prediction of SNPs to sort disease causing SNPs from neutral SNPs. The present study, we compiled 11336 SNPs, 546 CNVs, 50 CpG Islands and 50 miRNAs. A detailed data of SNPs, CNVs, CpG islands and miRNAs for 53 riboflavin pathway genes were compiled. Also compiled for all pathway genes were the SNPs in CNVs, CpG, miRNA.