| S.no. | Gene Symbol | Locus | Exon Count | Function | HGNC Id | Chromosome | Start | End | Strand | ENSEMBL Id | PMID |
|---|
| 1 | ABCB1 | 7q21.12 | 32 | Folate transport | 40 | 7 | 87133179 | 87342639 | -1 | ENSG00000085563 | Williams.et.al |
| 2 | ABCC1 | 16p13.1 | 34 | Folate transport | 51 | 16 | 16043434 | 16236930 | 1 | ENSG00000103222 | 15041471
|
| 3 | ABCC2 | 10q24 | 34 | Cellular export of natural folates | 53 | 10 | 101542463 | 101611662 | 1 | ENSG00000023839 | 20386493
|
| 4 | AHCY | 20q11.22 | 17 | Adenosylhomocysteinase | 343 | 20 | 32868071 | 32891215 | -1 | ENSG00000101444 | 21765920
|
| 5 | ALDH1L1 | 3q21.2 | 26 | Distribution of one carbon units | 3978 | 3 | 125822404 | 125900029 | -1 | ENSG00000144908 | 21765920
|
| 6 | AMPD1 | 1p13 | 16 | Purine biosynthesis DNA synthesis | 468 | 1 | 115215720 | 115238239 | -1 | ENSG00000116748 | 19902562
|
| 7 | AMT | 3p21.31 | 9 | Distribution of one carbon units glycine cleavage | 473 | 3 | 49454211 | 49460111 | -1 | ENSG00000145020 | 21765920
|
| 8 | ATIC | 2q35 | 17 | Purine biosynthesis - DNA synthesis | 794 | 2 | 216176679 | 216214496 | 1 | ENSG00000138363 | 21765920
|
| 9 | BHMT | 5q14.1 | 8 | Homocysteine remethylation | 1047 | 5 | 78407604 | 78428113 | 1 | ENSG00000145692 | 21765920
|
| 10 | CBS | 21q22.3 | 24 | catalyse the formation of hydrogen sulfide | 1550 | 21 | 44473301 | 44496472 | -1 | ENSG00000160200 | 17548676
|
| 11 | CD320 | 19p13.3-p13.2 | 5 | Vitamin B12 cellular receptor | 16692 | 19 | 8367011 | 8373240 | -1 | ENSG00000167775 | 21765920
|
| 12 | CUBN | 10p12 | 71 | Vitamin B12 intestinal receptor | 2548 | 10 | 16865965 | 17171816 | -1 | ENSG00000107611 | 21765920
|
| 13 | DHFR | 5q14.1 | 6 | Folate homeostasis | 2861 | 5 | 79922045 | 79950800 | -1 | ENSG00000228716 | 21765920
|
| 14 | DMGDH | 5q14.1 | 18 | Distribution of one | 24475 | 5 | 78293429 | 78365449 | -1 | ENSG00000132837 | 21765920
|
| 15 | DNMT1 | 19p13.2 | 41 | DNA methylation | 2976 | 19 | 10244022 | 10305755 | -1 | ENSG00000130816 | 21765920
|
| 16 | DNMT3A | 2p23 | 34 | DNA methylation | 2978 | 2 | 25455830 | 25564784 | -1 | ENSG00000119772 | 21765920
|
| 17 | DNMT3B | 20q11.2 | 24 | DNA methylation | 2979 | 20 | 31350191 | 31397162 | 1 | ENSG00000088305 | 21765920
|
| 18 | FOLH1 | 11p11.2 | 21 | Folate hydrolysis (intestinal) | 3788 | 11 | 49168187 | 49230222 | -1 | ENSG00000086205 | 21765920
|
| 19 | FOLR1 | 11q13.3-q14.1 | 7 | Cellular folate uptake | 3791 | 11 | 71900602 | 71907367 | 1 | ENSG00000110195 | 21765920
|
| 20 | FPGS | 9q34.11 | 17 | Folate homeostasis | 3824 | 9 | 130565154 | 130576556 | 1 | ENSG00000136877 | 21765920
|
| 21 | FTCD | 21q22.3 | 16 | Provision of one-carbon units | 3974 | 21 | 47556176 | 47575481 | -1 | ENSG00000160282 | 21765920
|
| 22 | GART | 21q22.11 | 23 | Purine biosynthesis DNA synthesis | 4163 | 21 | 34876238 | 34914464 | -1 | ENSG00000262473 | 21765920
|
| 23 | GGH | 8q12.3 | 10 | Folate hydrolysis (lysosomal) | 4248 | 8 | 63927639 | 63951610 | -1 | ENSG00000137563 | 21765920
|
| 24 | GIF | 11q12.1 | 9 | B12 absorbtion | 4268 | 11 | 59596746 | 59612974 | -1 | ENSG00000134812 | 21765920
|
| 25 | GNMT | 6p12 | 6 | Glycine methylation | 4415 | 6 | 42928500 | 42931618 | 1 | ENSG00000124713 | 21765920
|
| 26 | ITPA | 20p | 12 | Hydrolyzes non-canonical purine to their respective monophosphate derivatives | 6176 | 20 | 3190006 | 3204516 | 1 | ENSG00000125877 | 22838948
|
| 27 | MAT1A | 10q22 | 9 | Synthesis of SAM - methylation | 6903 | 10 | 82031576 | 82049434 | -1 | ENSG00000151224 | 21765920
|
| 28 | MAT2A | 2p11.2 | 9 | Synthesis of SAM - methylation | 6904 | 2 | 85766101 | 85772403 | 1 | ENSG00000168906 | 21765920
|
| 29 | MAT2B | 5q34 | 8 | Synthesis of SAM - methylation | 6905 | 5 | 162932534 | 162946359 | 1 | ENSG00000038274 | 21765920
|
| 30 | MMAB | 12q24 | 13 | B12 metabolism | 19331 | 3 | 129149787 | 129159022 | -1 | ENSG00000139428 | 21765920
|
| 31 | MTFMT | 15q22.31 | 9 | Mitochondrial protein synthesis | 29666 | 15 | 65293850 | 65321977 | -1 | ENSG00000103707 | 21765920
|
| 32 | MTHFD1 | 14q24 | 28 | distribution of one carbon unit | 7432 | 14 | 64854759 | 64926725 | 1 | ENSG00000100714 | 21765920
|
| 33 | MTHFD1L | 6q25.1 | 42 | distribution of one carbon unit | 21055 | 6 | 151186815 | 151423023 | 1 | ENSG00000120254 | 21765920
|
| 34 | MTHFD2 | 2p13.1 | 9 | distribution of one carbon unit | 7434 | 2 | 74425690 | 74442424 | 1 | ENSG00000065911 | 21765920
|
| 35 | MTHFD2L | 4q13.3 | 26 | distribution of one carbon unit | 31865 | 4 | 75023829 | 75168814 | 1 | ENSG00000163738 | 21765920
|
| 36 | MTHFR | 1p36.3 | 13 | 5,10-Methylene-tetrahydrofolate reductase | 7436 | 1 | 11845787 | 11866160 | -1 | ENSG00000177000 | 21765920
|
| 37 | MTHFS | 15q24.3 | 4 | distribution of one carbon unit | 7437 | 1 | 80135889 | 80189391 | -1 | ENSG00000136371 | 21765920
|
| 38 | MTR | 1q43 | 33 | Homocysteine remethylation | 31865 | 1 | 236958581 | 237067281 | 1 | ENSG00000116984 | 21765920
|
| 39 | MTRR | 5p15.31 | 21 | Homocysteine remethylation | 7436 | 5 | 7869217 | 7901235 | 1 | ENSG00000124275 | 21765920
|
| 40 | SARDH | 9q33-q34 | 26 | distribution of one carbon unit | 10536 | 9 | 136528684 | 136603479 | -1 | ENSG00000123453 | 21765920
|
| 41 | SHMT1 | 17p11.2 | 14 | Provision of one-carbon units | 10850 | 17 | 18231187 | 18266856 | -1 | ENSG00000176974 | 21765920
|
| 42 | SHMT2 | 12q12-q14 | 14 | Provision of one-carbon units | 10852 | 12 | 57623356 | 57628718 | 1 | ENSG00000182199 | 21765920
|
| 43 | SLC19A1 | 21q22.3 | 17 | Reduced folate carrier | 10937 | 21 | 46934629 | 46962385 | -1 | ENSG00000173638 | 21765920
|
| 44 | SLC25A32 | 8q22.3 | 8 | Mitochondrial folate transporter | 29863 | 8 | 104410866 | 104427563 | -1 | ENSG00000164933 | 21765920
|
| 45 | SLC46A1 | 17q11.2 | 6 | Proton coupled folate transporter | 30521 | 17 | 26721661 | 26733230 | -1 | ENSG00000262186 | 21765920
|
| 46 | TCN1 | 11q11-q12 | 9 | B12 transport protein | 1162 | 11 | 59620281 | 59634041 | -1 | ENSG00000134827 | 21765920
|
| 47 | TCN2 | 22q12.2 | 9 | B12 transport protein | 11653 | 22 | 31003070 | 31023047 | 1 | ENSG00000185339 | 21765920
|
| 48 | TYMS | 18p11.31-p11.21 | 8 | Thymidylate biosynthesis | 12441 | 18 | 657604 | 673499 | 1 | ENSG00000176890 | 21765920
|
